<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2022-1-42-46</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2483</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Спорадическая гемиплегическая мигрень у детей (обзор литературы и клинические наблюдения)</article-title><trans-title-group xml:lang="en"><trans-title>Sporadic hemiplegic migraine (rare case in clinical practice)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2553-7552</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левитина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Levitina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Левитина Елена Владиславовна, д. м. н., проф. кафедры детских болезней педиатрического факультета, гл. внештатный специалист – детский невролог Департамента здравоохранения Тюменской области</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Levitina Elena V., DM Sci (habil.), professor at Dept of Children's Diseases of Pediatric Faculty, chief freelance specialist – pediatric neurologist of Dept of Health of the Tyumen Region</p><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9218-2531</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахманина</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakhmanina</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рахманина Ольга Александровна, к. м. н., доцент кафедры детских болезней педиатрического факультета</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Rakhmanina Olga A., PhD Med, associate professor at Dept of Children's Diseases of Pediatric Faculty</p><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5405-7182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedev</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедев Илья Аркадьевич, д. м. н., проф. кафедры неврологии с курсом нейрохирургии</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Lebedev Ilya A., DM Sci (habil.), professor at Dept of Neurology with a course of Neurosurgery</p><p>Tyumen</p></bio><email xlink:type="simple">lebedef@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2022</year></pub-date><volume>0</volume><issue>1</issue><issue-title>Неврология и психиатрия (1)</issue-title><fpage>42</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Левитина Е.В., Рахманина О.А., Лебедев И.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Левитина Е.В., Рахманина О.А., Лебедев И.А.</copyright-holder><copyright-holder xml:lang="en">Levitina E.V., Rakhmanina O.A., Lebedev I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2483">https://www.med-alphabet.com/jour/article/view/2483</self-uri><abstract><p>В статье описаны особенности течения редкого заболевания – спорадической гемиплегической мигрени у трех пациентов (двух мальчиков в возрасте 7 и 15 лет и девочки 12 лет). Семейный анамнез в отношении мигрени не был отягощен. Симптомы атаки также были практически одинаковыми – гемипарез, гемипарестезия, дисфазия, головная боль. В одном случае у девочки в прошлом была абсансная эпилепсия. На электроэнцефалограмме, магнитно-резонансной томографии у всех пациентов нарушения функции мозга не диагностированы. Проведен анализ данных литературы. Приведены диагностические критерии гемиплегической мигрени, ее дифференциальная диагностика. Рассмотренное описание повышает информированность врачей по вопросу, представляющему большую редкость в практической деятельности педиатра и невролога.</p></abstract><trans-abstract xml:lang="en"><p>The article describes the peculiarities of a rare disease – hemiplegic migraine in three patients (two boys aged 7 and 15 and a girl of 12 years old). The family history of migraine was not burdened. Attack symptoms were almost identical: hemiparesis, dysphasia, and headache. The electroencephalograms, magnetic resonance imaging in all patients not presented signs brain dysfunction. Analysis of the literature data has been carried out. Thediagnostic criteria for hemiplegic migraine, its differential diagnosis is described. The considered description increases the awareness of doctors on the issue, which is very rare in the practice of pediatrician and neurologist.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>гемиплегическая мигрень</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>hemiplegic migraine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Russell M. B., Ducro A. Sporadic and familial hemiplegic migraines: pathophysiological mechanisms, clinical characteristics, diagnosis and treatment. Lancet Neural. (2011) 10: 457–70. DOI: 10.1016/S 1474–4422(11)70048–5.</mixed-citation><mixed-citation xml:lang="en">Russell M. B., Ducro A. Sporadic and familial hemiplegic migraines: pathophysiological mechanisms, clinical characteristics, diagnosis and treatment. Lancet Neural. (2011) 10: 457–70. DOI: 10.1016/S 1474–4422(11)70048–5.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Headache Classification Committee of the International Headache Society (IHS). International Classification of Headaches, 3rd edition. Cephalgia. (2018) 38: 1–211. DOI: 10.1177/0333102417738202.</mixed-citation><mixed-citation xml:lang="en">Headache Classification Committee of the International Headache Society (IHS). International Classification of Headaches, 3rd edition. Cephalgia. (2018) 38: 1–211. DOI: 10.1177/0333102417738202.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Thomsen L. L., Ostergaard E., Olsen J., Russell MB. Evidence of a separate type of migraine with aura: sporadic hemiplegic migraine. Neurology (2003) 60: 595601. DOI: 10.12/01.WNL.0000046524.25369.7D.</mixed-citation><mixed-citation xml:lang="en">Thomsen L. L., Ostergaard E., Olsen J., Russell MB. Evidence of a separate type of migraine with aura: sporadic hemiplegic migraine. Neurology (2003) 60: 595601. DOI: 10.12/01.WNL.0000046524.25369.7D.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jen J. C. Familial Hemiplegic migraine. 2001 Jul 17 [updated 2021 Apr 29]. In: Ada M. P., Erdinger H. H., Pagan R. A., Wallace S. E., Beun L. J.H., Mirza A. G., Amemiya A., editors. Gene Reviews® [Internet]. Seattle (Washington): University of Washington, Seattle; 1993–2021. PMID: 20301562.</mixed-citation><mixed-citation xml:lang="en">Jen J. C. Familial Hemiplegic migraine. 2001 Jul 17 [updated 2021 Apr 29]. In: Ada M. P., Erdinger H. H., Pagan R. A., Wallace S. E., Beun L. J.H., Mirza A. G., Amemiya A., editors. Gene Reviews® [Internet]. Seattle (Washington): University of Washington, Seattle; 1993–2021. PMID: 20301562.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hiekkala M. E., Viola P., Arto V., Happola P., Happola E., Vepsyalainen S., etc. The contribution of CACNA1A, ATP1A2 and SCN 1A mutations to hemiplegic migraine: a clinical and genetic study in Finnish migraine families. Cephalgia. (2018) 38: 1849–63. DOI: 10.1177/0333102418761041.</mixed-citation><mixed-citation xml:lang="en">Hiekkala M. E., Viola P., Arto V., Happola P., Happola E., Vepsyalainen S., etc. The contribution of CACNA1A, ATP1A2 and SCN 1A mutations to hemiplegic migraine: a clinical and genetic study in Finnish migraine families. Cephalgia. (2018) 38: 1849–63. DOI: 10.1177/0333102418761041.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pelzer N., Khan J., Stam A. H., Vijfhuizen L. S., Kelvin S. K., Smagin A. et al. The clinical spectrum of hemiplegic migraine and the probability of detecting a pathogenic mutation. Neurology. (2018) 90: e575–82. DOI: 10.1212/WNL.0000000000004966.</mixed-citation><mixed-citation xml:lang="en">Pelzer N., Khan J., Stam A. H., Vijfhuizen L. S., Kelvin S. K., Smagin A. et al. The clinical spectrum of hemiplegic migraine and the probability of detecting a pathogenic mutation. Neurology. (2018) 90: e575–82. DOI: 10.1212/WNL.0000000000004966.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Thomsen L. L., Oestergaard E., Bjornsson A., Stefansson H., Fasquel A. C., Gulcher J., et al. A screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients. Cephalgia. (2008) 28: 914–21. DOI: 10.1111/j.1468–2982.2008.01599.</mixed-citation><mixed-citation xml:lang="en">Thomsen L. L., Oestergaard E., Bjornsson A., Stefansson H., Fasquel A. C., Gulcher J., et al. A screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients. Cephalgia. (2008) 28: 914–21. DOI: 10.1111/j.1468–2982.2008.01599.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Riant F., Ducros A., Platon C., Balance C., Depienne C., Tournier-Lasserve E. De novo mutations in ATP1A2 and CACNA1A are often found in sporadic hemiplegic migraines with early onset. Neurology. (2010) 75: 967–72. DOI: 10.12/WNL.0b013e3181f25e8f.</mixed-citation><mixed-citation xml:lang="en">Riant F., Ducros A., Platon C., Balance C., Depienne C., Tournier-Lasserve E. De novo mutations in ATP1A2 and CACNA1A are often found in sporadic hemiplegic migraines with early onset. Neurology. (2010) 75: 967–72. DOI: 10.12/WNL.0b013e3181f25e8f.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Richards S., Aziz N., Beatles, Back D., Das, Haustier-Foster J., Gray W. W., Hegde M., Lion E., Spectro E., Voelkerding K., Rem H. L. AMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Mad. 2015; 17: 405–24. DOI: 10.1038/gim.2015.30.</mixed-citation><mixed-citation xml:lang="en">Richards S., Aziz N., Beatles, Back D., Das, Haustier-Foster J., Gray W. W., Hegde M., Lion E., Spectro E., Voelkerding K., Rem H. L. AMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Mad. 2015; 17: 405–24. DOI: 10.1038/gim.2015.30.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rahbari R., Wuster A., Lindsay S. J., Hardwick R. J., Alexandrov L. B., Turki S. A., Dominiczak A., Morris A., Porteous D., Smith B., Stratton M. R., Hurles M. E., et al. Timing, rates and spectra of human germline mutation. Nat Genet. 2016; 48 (2): 126–133. DOI: 10.1038/ng.3469.</mixed-citation><mixed-citation xml:lang="en">Rahbari R., Wuster A., Lindsay S. J., Hardwick R. J., Alexandrov L. B., Turki S. A., Dominiczak A., Morris A., Porteous D., Smith B., Stratton M. R., Hurles M. E., et al. Timing, rates and spectra of human germline mutation. Nat Genet. 2016; 48 (2): 126–133. DOI: 10.1038/ng.3469.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ophoff R. A., Terwindt G. M., Vergouwe M. N., van Eijk R., Oefner P. J., Hoffman S. M., Lamerdin J. E., Mohrenweiser H. W., Bulman D. E., Ferrari M., Haan J., Lindhout D., van Ommen G. J., Hofker M. H., Ferrari M. D., Frants R. R. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+-channel gene CACNL1A4. Cell. 1996; 87: 543–52. DOI: 10.1016/S0092–8674(00)81373–2.</mixed-citation><mixed-citation xml:lang="en">Ophoff R. A., Terwindt G. M., Vergouwe M. N., van Eijk R., Oefner P. J., Hoffman S. M., Lamerdin J. E., Mohrenweiser H. W., Bulman D. E., Ferrari M., Haan J., Lindhout D., van Ommen G. J., Hofker M. H., Ferrari M. D., Frants R. R. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+-channel gene CACNL1A4. Cell. 1996; 87: 543–52. DOI: 10.1016/S0092–8674(00)81373–2.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">De Fusco M., Marconi R., Silvestri L., Atorino L., Rampoldi L., Morgante L., Ballabio A., Aridon P., Casari G. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003; 33: 192–6. DOI: 10.1038/ng1081.</mixed-citation><mixed-citation xml:lang="en">De Fusco M., Marconi R., Silvestri L., Atorino L., Rampoldi L., Morgante L., Ballabio A., Aridon P., Casari G. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003; 33: 192–6. DOI: 10.1038/ng1081.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Thomson L. L., Erikson M. K., Roemer S. F., Andersen I., Olsen J., Russell M. B. A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria. Brain. (2002) 125: 1379–91. DOI: 10.1093/brain/awf132.</mixed-citation><mixed-citation xml:lang="en">Thomson L. L., Erikson M. K., Roemer S. F., Andersen I., Olsen J., Russell M. B. A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria. Brain. (2002) 125: 1379–91. DOI: 10.1093/brain/awf132.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Toldo I., Brunello F., Morao V., Perissinotto E., Valeriani M., Pruna D., Tozzi E., Moscano F., Farello G., Frusciante R., Carotenuto M., Lisotto C., Ruffatti S., Maggioni F., Termine C., Di Rosa G., Nosadini M., Sartori S. and Battistella P. A. (2019) The first attack and clinical presentation of hemiplegic migraine in childhood: multicenter a retrospective study and literature review. The Front. Neural. 10: 1079. DOI: 10.3389/fneur.2019.01079.</mixed-citation><mixed-citation xml:lang="en">Toldo I., Brunello F., Morao V., Perissinotto E., Valeriani M., Pruna D., Tozzi E., Moscano F., Farello G., Frusciante R., Carotenuto M., Lisotto C., Ruffatti S., Maggioni F., Termine C., Di Rosa G., Nosadini M., Sartori S. and Battistella P. A. (2019) The first attack and clinical presentation of hemiplegic migraine in childhood: multicenter a retrospective study and literature review. The Front. Neural. 10: 1079. DOI: 10.3389/fneur.2019.01079.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Vahedi K., Denier C., Ducros A., Busson P. V., Levy C., Chabriat H., Haguenau P. M., Tournier-Lasserve E., Bousser M. G. A mutation of the CACNA1A de novo gene that causes hemiplegic migraine, coma and cerebellar atrophy. Neurology. 2000; 55: 1040–2. DOI: 10,1212/WNL.55.7.1040.</mixed-citation><mixed-citation xml:lang="en">Vahedi K., Denier C., Ducros A., Busson P. V., Levy C., Chabriat H., Haguenau P. M., Tournier-Lasserve E., Bousser M. G. A mutation of the CACNA1A de novo gene that causes hemiplegic migraine, coma and cerebellar atrophy. Neurology. 2000; 55: 1040–2. DOI: 10,1212/WNL.55.7.1040.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Нестеровский Ю. Е., Заваденко Н. Н. Мигрень и эпилепсия: коморбидность в детском возрасте. Журнал неврологии и психиатрии им. С. С. Корсакова, 2018; 4: 100–106; DOI: 10.17116/jnevro201811841100–106.</mixed-citation><mixed-citation xml:lang="en">Nesterovsky Yu.E., Zavadenko N. N. Migraine and epilepsy: comorbidity in childhood. Journal of Neurology and Psychiatry n. a. S. S. Korsakov, 2018; 4: 100–106; DOI: 10.17116/jnevro201811841100–106.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Мироненко Т. В., Мироненко М. О., Бурцева Е. М., Маругайах Викнесварар. Гемиплегическая мигрень – отдельные вопросы патогенеза, клиники, диагностики (обзор литературы и собственное наблюдение). Международный неврологический журнал 2012; 7 (53): 141–151.</mixed-citation><mixed-citation xml:lang="en">Mironenko T. V., Mironenko M. O., Burtseva E. M., Marugaiakh Vikneswarar. Hemiplegic migraine – some issues of pathogenesis, clinic, diagnosis (literature review and own observation). International Neurological Journal 2012; 7 (53): 141–151.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. G. Kenet, L. K. Lütkhoff, M. Albisetti [et al.] Circulation. 2010. 121. Р. 1838–1847. DOI: 10.1161circulationaha.109.913673.</mixed-citation><mixed-citation xml:lang="en">Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. G. Kenet, L. K. Lütkhoff, M. Albisetti [et al.] Circulation. 2010. 121. Р. 1838–1847. DOI: 10.1161circulationaha.109.913673.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bernard T. J. The roles of anatomic factors, thrombophilia, and antithrombotic therapies in childhood-onset arterial ischemic stroke. T. J. Bernard, M. J. Manco Johnson, N. A. Goldenberg. Thromb Res. 2011. January 127 (1). Р. 6–12. DOI: 10.1016/j.thromres.2010.09.014.</mixed-citation><mixed-citation xml:lang="en">Bernard T. J. The roles of anatomic factors, thrombophilia, and antithrombotic therapies in childhood-onset arterial ischemic stroke. T. J. Bernard, M. J. Manco Johnson, N. A. Goldenberg. Thromb Res. 2011. January 127 (1). Р. 6–12. DOI: 10.1016/j.thromres.2010.09.014.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Львова О. А., Гусев В. В., Кузнецов Н. Н., Баранов Д. А., Ворошилина Е. С., Партылова Е. А. Наследственные прокоагулянтные и протромботические нарушения как ведущий этиологический фактор ишемических инсультов у детей раннего возраста. Журнал неврологии и психиатрии им. С. С. Корсакова. Спецвыпуски. 2013; 113 (9–2): 13–20.</mixed-citation><mixed-citation xml:lang="en">L’vova O.A, Gusev V. V., Kuznetsov N. N., Baranov D. A., Voroshilina E. S., Partylova E A. The inherited procoagulant and prothrombotic condition as the main etiological factor for ischemic stroke in infants. Journal of Neurology and Psychiatry n. a. S. S. Korsakov. 2013; 113 (9–2): 13–20.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Influence of combined methionine synthase (MTR 2756A&gt;G) and methylentetrahydrofolate reductase (MTHFR 677 C&gt;T) polymorphisms to plasma 239 homocysteine levels in Korean patients with ischemic stroke. O. J. Kim, S. P. Hong, J. Y. Ahn [et al.]. Yonsei Med J. 2007. 48 (2). Р. 201–9. 117. DOI: 10.3349/ymj.2007.48.2.201.</mixed-citation><mixed-citation xml:lang="en">Influence of combined methionine synthase (MTR 2756A&gt;G) and methylentetrahydrofolate reductase (MTHFR 677 C&gt;T) polymorphisms to plasma 239 homocysteine levels in Korean patients with ischemic stroke. O. J. Kim, S. P. Hong, J. Y. Ahn [et al.]. Yonsei Med J. 2007. 48 (2). Р. 201–9. 117. DOI: 10.3349/ymj.2007.48.2.201.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. D. C. Herak, M. R. Antolic, J. L. Krleza [et al.]. Pediatrics. 2009 Apr. 123(4). Р. e653–60. 145. DOI: 10.1542/педс.2007–3737.</mixed-citation><mixed-citation xml:lang="en">Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. D. C. Herak, M. R. Antolic, J. L. Krleza [et al.]. Pediatrics. 2009 Apr. 123(4). Р. e653–60. 145. DOI: 10.1542/педс.2007–3737.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke. D. C. Morita, А. Donaldson, R. J. Butterfield [et al.]. Pediatr Neurol. 2009 Oct. 41 (4). Р. 247–249. DOI: 10.1016/j.pediatrneurol.2009.04.017.</mixed-citation><mixed-citation xml:lang="en">Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke. D. C. Morita, А. Donaldson, R. J. Butterfield [et al.]. Pediatr Neurol. 2009 Oct. 41 (4). Р. 247–249. DOI: 10.1016/j.pediatrneurol.2009.04.017.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Pelzer N., Stam A. H., Haan J., Farrari M. D., Terwindt G. M. Familial and sporadic hemiplegic migraine: diagnosis and treatment. Curr Treat Options Neurol. 2013; 15 (1): 13–27. DOI: 10.1007/s11940–012–0208–3.</mixed-citation><mixed-citation xml:lang="en">Pelzer N., Stam A. H., Haan J., Farrari M. D., Terwindt G. M. Familial and sporadic hemiplegic migraine: diagnosis and treatment. Curr Treat Options Neurol. 2013; 15 (1): 13–27. DOI: 10.1007/s11940–012–0208–3.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Моисеева С., Бетцлер К., Херберхольдт Т., Клюгер Г., Штаудт М. Особенности течения гемиплегической мигрени у детей. Вопросы современной педиатрии. 2015; 14 (6): 732–734. DOI: 10.15690/vsp.v14i6.1484.</mixed-citation><mixed-citation xml:lang="en">Moiseeva S., Betzler K., Herberholdt T., Kluger G., Staudt M. Features of the course of hemiplegic migraine in children. Questions of modern pediatrics. 2015; 14 (6): 732–734. DOI: 10.15690/vsp.v14i6.1484.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
