medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-41-12-16medalphabet-2415Research ArticleОБОЗРЕНИЕREVIEWНейроиммунные механизмы зуда при атопическом дерматитеNeuroimmune mechanisms of pruritus in atopic dermatitishttps://orcid.org/0000-0002-5537-5729КандрашкинаЮ. А.KandrashkinaY. A.

Кандрашкина Юлия Андреевна, аспирант кафедры аллергологии и иммунологии

Пенза

Kandrashkina Yulia A., postgraduate student of Dept of Allergology and Immunology

Penza

novikova10l@mail.ruhttps://orcid.org/0000-0002-3902-2018ОрловаЕ. А.OrlovaE. A.

Орлова Екатерина Александровна, д.м.н., проф. кафедры аллергологии и иммунологии

Пенза

Orlova Ekaterina A., DM Sci (habil.), professor at Dept of Allergology and Immunology

Penza

lisaorl@yandex.ruhttps://orcid.org/0000-0001-5278-0203ПрибытковА. А.PribytkovA. A.

Прибытков Алексей Александрович, к.м.н., доцент кафедры психиатрии, наркологии, психотерапии и сексологии

Пенза

Pribytkov Alexey A., PhD Med, associate professor of Dept of Psychiatry, Narcology, Psychotherapy and Sexology

Penza

pribytkov@bk.ruПензенский институт усовершенствования врачей – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияPenza Institute for Postgraduate Medicine – a Branch of Russian Medical Academy for Continuing Professional EducationRussian Federation202109012022041Обозрение (1)1216Copyright © Кандрашкина Ю.А., Орлова Е.А., Прибытков А.А., 20222022Кандрашкина Ю.А., Орлова Е.А., Прибытков А.А.Kandrashkina Y.A., Orlova E.A., Pribytkov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2415

Атопический дерматит представляет собой хроническое наследственное рецидивирующее заболевание кожи. Одним из наиболее ярко выраженных симптомов данного дерматоза является кожный зуд. Зуд сопровождает атопический дерматит в более чем 80% случаев. В данном обзоре представлены современные данные о механизмах образования кожного зуда при атопическом дерматите. Рассмотрены вопросы этиологических факторов, нейроиммунных взаимодействий, особенности дисфункции кожного покрова, а также роль стресса. Актуальность изучения темы обусловлена высокой распространенностью атопического дерматита среди населения, снижением качества жизни и отсутствием эффективной терапии. Анализ литературы свидетельствует о необходимости комплексной оценки патогенетических механизмов развития зуда при атопическом дерматите. Более углубленное изучение механизмов нейрогенного воспаления при атопическом дерматите будет способствовать разработке новых методов диагностики и лечения.

Atopic dermatitis is a chronic hereditary recurrent skin disease. One of the most pronounced symptoms of this dermatosis is itchy skin. Pruritus accompanies atopic dermatitis in more than 80% of cases. This review presents modern data on the mechanisms of pruritus formation in atopic dermatitis. The issues of etiological factors, neuroimmune interactions, peculiarities of skin dysfunction, as well as the role of stress are considered. The relevance of studying the topic is due to the high prevalence of atopic dermatitis among the population, a decrease in the quality of life and the lack of effective therapy. Analysis of the literature indicates the need for a comprehensive assessment of the pathogenetic mechanisms of the development of pruritus in atopic dermatitis. A more in-depth study of the mechanisms of neurogenic inflammation in atopic dermatitis will contribute to the development of new methods of diagnosis and treatment.

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The authors declare that there are no conflicts of interest present.