medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-33-64-75medalphabet-2329Research ArticleРЕВМАТОЛОГИЯRHEUMATOLOGYОстеопороз при ревматических заболеванияхOsteoporosis in rheumatic diseaseshttps://orcid.org/0000-0003-4010-1888ЕвстигнееваЛ. П.EvstigneevaL. P.

Евстигнеева Людмила Петровна, д. м. н., зав. ревматологическим отделением

Екатеринбург

Evstigneeva Lyudmila P., DM Sci (habil.), head of Rheumatology Dept.

Ekaterinburg

levstigneyeva@mail.ruГАУЗ СО «Свердловская областная клиническая больница № 1»РоссияSverdlovsk Regional Clinical Hospital No. 1Russian Federation202113122021033Ревматология в общей врачебной практике (2)6475Copyright © Евстигнеева Л.П., 20212021Евстигнеева Л.П.Evstigneeva L.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2329

Представлен обзор исследований, в которых изучался остеопороз при ревматических заболеваниях, включая ревматоидный артрит, спондилоартрит, псориатический артрит, системные заболевания соединительной ткани и системные васкулиты. В обзоре освещены вопросы патогенеза, диагностики и лечения остеопороза при данных заболеваниях, представлены результаты эпидемиологических исследований, оценивающих факторы риска и распространенность остеопороза при ревматических заболеваниях. Отмечена высокая распространенность остеопороза и переломов при ревматических заболеваниях, превышающая популяционную, связанная прежде всего с системным и локальным воспалением, а также с приемом глюкокортикоидов. Указано, что существующие стратегии лечения ревматических заболеваний, направленные на подавление воспаления, в какой-то степени тормозят резорбцию костной ткани, но длительный прием глюкокортикоидов, напротив, усиливает ее. В обзоре представлены данные об основных препаратах для лечения остеопороза и подходы к лечению глюкокортикоидного остеопороза.

The article presents a review of studies that have examined osteoporosis in rheumatic diseases, including rheumatoid arthritis, spondylarthritis, psoriatic arthritis, systemic connective tissue diseases, and systemic vasculitis. The review discusses the pathogenesis, diagnosis and treatment of osteoporosis in these diseases, presents the results of epidemiological studies assessing the risk factors and the prevalence of osteoporosis in rheumatic diseases. There was a high prevalence of osteoporosis and fractures in rheumatic diseases, exceeding the population, associated primarily with systemic and local inflammation, as well as with the intake of glucocorticoids. It is indicated that the existing strategies for the treatment of rheumatic diseases may partially reduce bone loss, but long-term administration of glucocorticoids, on the contrary, increase bone resorption. The review presents data on the medications for the treatment of osteoporosis and approaches to the treatment of glucocorticoid osteoporosis.

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The authors declare that there are no conflicts of interest present.