medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-30-7-11medalphabet-2291Research ArticleСОВРЕМЕННАЯ ЛАБОРАТОРИЯMODERN LABORATORYДинамика уровня антител класса G к SARS-CoV-2 после перенесенной новой коронавирусной инфекции COVID-19Dynamics of level of class G antibodies to SARS-CoV-2 after new coronavirus infection COVID-19АлексанинС. С.AleksaninS. S.

Алексанин Сергей Сергеевич, д. м. н., проф., член-корр. РАН, директор

Санкт-Петербург

Aleksanin Sergey S., DM Sci (habil.), professor, corresponding member of RAS, director

Saint Petersburg

medicine@nrcerm.ruАлхутоваН. А.AlkhutovaN. A.

Алхутова Наталья Александровна, к. б. н., с. н. с. лаборатории серологических исследований и аллергодиагностики отдела лабораторной диагностики

Санкт-Петербург

Alkhutova Natalia A., PhD Bio, senior researcher of Laboratory of Serological Research and Allergy Diagnostics of the Laboratory Diagnostics Dept

Saint Petersburg

nalhutova@yandex.ruКовязинаН. А.KovyazinaN. A.

Ковязина Надежда Алексеевна, к. м. н., зав. лабораторией серологических исследований и аллергодиагностики отдела лабораторной диагностики

Санкт-Петербург

Kovyazina Nadezhda A., PhD Med, head of Laboratory of Serological Research and Allergy Diagnostics of the Laboratory Diagnostics Dept

Saint Petersburg

nakovzn@gmail.comРыбниковВ. Ю.RybnikovV. Yu.

Рыбников Виктор Юрьевич, д.псх.н., д. б. н., проф., зам. директора по научной и учебной работе

Санкт-Петербург

Rybnikov Viktor Yu., Dr. of Psychology (habil.), Dr. of Biological Sciences, professor, deputy director for research and academic affairs

Saint Petersburg

ФГБУ «Всероссийский центр экстренной и радиационной медицины имени А. М. Никифорова» МЧС РоссииРоссияAll-Russian Centre for Emergency and Radiation Medicine n. a. A. M. NikiforovRussian Federation202101122021130Современная лаборатория (2)711Copyright © Алексанин С.С., Алхутова Н.А., Ковязина Н.А., Рыбников В.Ю., 20212021Алексанин С.С., Алхутова Н.А., Ковязина Н.А., Рыбников В.Ю.Aleksanin S.S., Alkhutova N.A., Kovyazina N.A., Rybnikov V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2291

В статье представлены результаты лабораторного динамического мониторинга уровня антител класса G к SARS-CoV-2 у 160 пациентов в течение 3–10 месяцев после перенесенной новой коронавирусной инфекции COVID-19. Выявлено отсутствие снижения уровня антител класса G к SARS-CoV-2 до пороговых значений и ниже у 91,2% обследованных.

The article presents the results of laboratory dynamic monitoring of the level of class G antibodies to SARS-CoV-2 in 160 patients within 3–10 months after the new coronavirus infection COVID-19. There was no decrease in the level of class G antibodies to SARS-CoV-2 to the threshold values and below in 91.2% of the examined patients.

новая коронавирусная инфекцияантитела к SARS-CoV-2IgGCOVID-19new coronavirus infectionantibodies SARS-CoV-2IgGCOVID-19ReferencesПопова А.Ю. Популяционный иммунитет к вирусу SARS-COV-2 среди населения Санкт-Петербурга в активную фазу эпидемии COVID-19. А.Ю. Попова [и др.]. Проблемы особо опасных инфекций. 2020. № 3. С. 124–130. DOI: 10.21055/0370–1069–2020–3–124–130.Popova A. Yu. Population immunity to the SARS-COV-2 virus among the population of St. Petersburg in the active phase of the COVID-19 epidemic. A. Yu. Popova [and others]. Problems of especially dangerous infections. 2020. No. 3. P. 124–130. DOI: 10.21055/0370–1069–2020–3–124–130.Bao L, Deng W, Gao H, et al. Lack of reinfection in rhesus macaques infected with SARS-CoV-2. bioRxiv. Preprint posted May 1, 2020. DOI: 10.1101/2020.03.13.00–226.Bao L, Deng W, Gao H, et al. Lack of reinfection in rhesus macaques infected with SARS-CoV-2. bioRxiv. Preprint posted May 1, 2020. DOI: 10.1101/2020.03.13.00–226.Garcia LF. Immune response, inflammation, and the clinical spectrum of СОVID-19. Front Immunol. 2020; 11: 1441. DOI: 10.3389/fmmu.2020.01441.Garcia LF. Immune response, inflammation, and the clinical spectrum of СОVID-19. Front Immunol. 2020; 11: 1441. DOI: 10.3389/fmmu.2020.01441.Liu J, Guo J, Xu Q, Cai G, Chen D, Shen Y. Detection of IgG antibody during the follow-up in patients with COVID-19 infection. Crit Care. 2020; 24(1): 448. DOI: 10.1186/s13054–020–03138–4.Liu J, Guo J, Xu Q, Cai G, Chen D, Shen Y. Detection of IgG antibody during the follow-up in patients with COVID-19 infection. Crit Care. 2020; 24(1): 448. DOI: 10.1186/s13054–020–03138–4.Maggi E, Canonica GW, Moretta L. Covid-19: Unanswered questions on immune response and pathogenesis. J Allergy Clin Immunol. 2020; 146 (1): 18–22. DOI: 10.1016/j.jaci.2020.05.001.Maggi E, Canonica GW, Moretta L. Covid-19: Unanswered questions on immune response and pathogenesis. J Allergy Clin Immunol. 2020; 146 (1): 18–22. DOI: 10.1016/j.jaci.2020.05.001.To KK, Tsang OT, Leung WS, et al. Temporal profles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020; 20 (5): 565–574. DOI: 10.1016/S1473–3099(20)30196–1PubMedGoogleScholarCrossref.To KK, Tsang OT, Leung WS, et al. Temporal profles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020; 20 (5): 565–574. DOI: 10.1016/S1473–3099(20)30196–1PubMedGoogleScholarCrossref.Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. Published online April 1, 2020 DOI: 10.1038/s41586–020–2196-xPubMedGoogle Scholar.Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. Published online April 1, 2020 DOI: 10.1038/s41586–020–2196-xPubMedGoogle Scholar.Wu L-P, Wang N-C, Chang Y-H, et al. Duration of antibody responses after severe acute respiratory syndrome. Emerg Infect Dis. 2007; 13 (10): 1562–1564. DOI: 10.3201/eid1310.070576PubMedGoogleScholarCrossref.Wu L-P, Wang N-C, Chang Y-H, et al. Duration of antibody responses after severe acute respiratory syndrome. Emerg Infect Dis. 2007; 13 (10): 1562–1564. DOI: 10.3201/eid1310.070576PubMedGoogleScholarCrossref.Zhao J, Yuan Q, Wang H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 Clin Infect Dis. Published online March 28, 2020. DOI: 10.1093/cid/ciaa344PubMedGoogle Scholar.Zhao J, Yuan Q, Wang H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 Clin Infect Dis. Published online March 28, 2020. DOI: 10.1093/cid/ciaa344PubMedGoogle Scholar.

The authors declare that there are no conflicts of interest present.