medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-27-64-69medalphabet-2274Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCLINICAL CASEКлинический случай панникулита с летальным исходом, возникшим в результате введения липолитикаClinical case of fatal panniculitis resulting from administration of lipolytichttps://orcid.org/0000-0003-3831-0912РомановаН. В.RomanovaN. V.

Романова Надежда Витальевна, д.м.н., доцент, зав. кафедрой кожных и венерических болезней

Ярославль 

eLibrary SPIN: 4781–2770

Romanova Nadezhda V., DM Sci (habil.), assistant professor, head of Dept of Skin and Venereal Diseases

Yaroslavl

n.v.romanova@mail.ruhttps://orcid.org/0000-0002-5138-648XСоловьеваЕ. Ю.SolovyovaE. Yu.

Соловьева Елена Юрьевна, к.м.н., ассистент кафедры кожных и венерических болезней

Ярославль 

Solovyova Elena Yu., PhD Med, assistant at Dept of Skin and Venereal Diseases

Yaroslavl

trufalena@mail.ruhttps://orcid.org/0000-0001-9020-9286ТроицкийФ. Э.TroitskyF. E.

Троицкий Филипп Эдуардович, врач патологоанатомического отделения

Ярославль 

Troitsky Philip E., physician of Pathological Dept

Yaroslavl

philiptrinity.pao@gmail.comФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава РоссииРоссияYaroslavl State Medical UniversityRussian Federation202101112021027Дерматология (2)6469Copyright © Романова Н.В., Соловьева Е.Ю., Троицкий Ф.Э., 20212021Романова Н.В., Соловьева Е.Ю., Троицкий Ф.Э.Romanova N.V., Solovyova E.Y., Troitsky F.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2274

В статье описывается клинический случай пятикратного введения прямого липолитика – фосфатидилхолина / дезоксихолевой кислоты с косметической целью, результатом чего стали распространенный септальный панникулит, системная воспалительная реакция, вторичный миозит, тромботический микроангиопатический синдром, жировой некроз головки поджелудочной железы, некротический нефроз и полиорганная недостаточность, приведшие к смерти пациентки.

Материалы и методы

Материалы и методы. Анализ медицинской документации, гистологическое исследование аутопсийного материала.

Выводы

Выводы. Инъекционный липолиз с помощью фосфатидилхолин / дезоксихолат натрия вызывает неконтролируемый некроз жировой и сосудистой ткани, фиброз, что делает неопределенным отдаленные последствия введения данных препаратов для нехирургического лечения отложений подкожного жира. Фосфатидилхолин / дезоксихолат натрия не рекомендуется для использования при наличии общего ожирения, соматической патологии, а также у пожилых пациентов.

The article describes a clinical case of a five-fold administration of a direct lipolytic–phosphatidylcholine / deoxycholic acid for cosmetic purposes, which resulted in widespread septal panniculitis, systemic inflammatory reaction, secondary myositis, thrombotic microangiopathic syndrome, fatty necrosis of the pancreatic head, necrotic nephrosis and multiple organ failure, which led to death of the patient.

Materials and methods

Materials and methods. Analysis of medical records, histological examination of autopsy material.

Conclusions

Conclusions. Injection lipolysis using phosphatidylcholine / deoxycholate causes uncontrolled necrosis of adipose and vascular tissue, fibrosis, which makes the indefinitely long-term consequences of the administration of drugs for the non-surgical treatment of subcutaneous fat deposits. Phosphatidylcholine / sodium deoxycholate is not recommended for use in the presence of general obesity, somatic pathology, or in elderly patients.

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The authors declare that there are no conflicts of interest present.