<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2273</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group></article-categories><title-group><article-title>Потеря волос, ассоциированная с COVID‑19: проблема и пути решения</article-title><trans-title-group xml:lang="en"><trans-title>Hair loss associated with COVID‑19: problem and solutions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2027-5987</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сакания</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sakania</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сакания Луиза Руслановна, врач-дерматовенеролог1, младший научный сотрудник2</p><p>Москва</p></bio><bio xml:lang="en"><p>Sakania Luiza R., dermatovenerologist1, junior researcher2</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0522-3225</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельниченко</surname><given-names>О. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnichenko</surname><given-names>O. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мельниченко Ольга Олеговна, к.м.н., врач-дерматовенеролог</p><p>Москва</p></bio><bio xml:lang="en"><p>Melnichenko Olga O., PhD Med, dermatovenerologist</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8039-8474</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирузян</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Piruzyan</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пирузян Анастас Левонович, д.м.н., проф., г.н.с.</p><p>Москва</p></bio><bio xml:lang="en"><p>Piruzyan Anastas L., DM Sci (habil.), professor, senior researcher</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6583-0318</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корсунская</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Korsunskaya</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корсунская Ирина Марковна, проф., зав. лабораторией1, г.н.с.2</p><p>Москва</p></bio><bio xml:lang="en"><p>Korsunskaya Irina M., professor, head of laboratory1, researcher2</p><p>Moscow</p></bio><email xlink:type="simple">marykor@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУН «Центр теоретических проблем физико-химической фармакологии» Российской академии наук; ГБУЗ г. Москвы «Московский научно-практический центр дерматовенерологии и косметологии Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Centre for Theoretical Problems of Physicochemical Pharmacology;Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ г. Москвы «Московский научно-практический центр дерматовенерологии и косметологии Департамента&#13;
здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУН «Центр теоретических проблем физико-химической фармакологии» Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Centre for Theoretical Problems of Physicochemical Pharmacology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2021</year></pub-date><volume>0</volume><issue>27</issue><issue-title>Дерматология (2)</issue-title><fpage>61</fpage><lpage>63</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сакания Л.Р., Мельниченко О.О., Пирузян А.Л., Корсунская И.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Сакания Л.Р., Мельниченко О.О., Пирузян А.Л., Корсунская И.М.</copyright-holder><copyright-holder xml:lang="en">Sakania L.R., Melnichenko O.O., Piruzyan A.L., Korsunskaya I.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2273">https://www.med-alphabet.com/jour/article/view/2273</self-uri><abstract><p>Сведения обэпидемиологии, клинических проявлениях, профилактике и лечении новой коронавирусной инфекции COVID-19 постоянно обновляются. Описаны клинические проявления COVID‑19 на коже, включающие ангииты, акродерматит (акроангиит), папуло-везикулезные высыпания, папулосквамозные высыпания, розовый лишай, кореподобную сыпь, токсикодермию, обострение хронических дерматозов, артифициальные поражения кожи и, наконец, выпадение волос. Одним из значимых провоцирующих факторов выпадения волос является стресс. Мировая пандемия COVID‑19 для многих как раз и стала таким фактором. На сегодняшний день отсутствует полное понимание патогенеза потери волос, ассоциированной с COVID‑19. Многие авторы предполагают, что в роли причин телогенового выпадения волос и андрогенной алопеции при COVID‑19 могут выступать как сама инфекция и связанное с ней психоэмоциональное состояние, так и проводимая терапия заболевания. Ряд исследований демонстрируют связь между андрогенами, участвующими в патогенезе COVID‑19, и возможным развитием андрогенной алопеции. Другие авторы наблюдают случаи развития телогенового выпадения волос, связанного с заболеванием COVID‑19. В своей практике мы также сталкиваемся с диффузным поредением волос, предположительно, спровоцированным COVID‑19. Зачастую пациенты не считают нужным обращаться к врачу по поводу выпадения волос и впервые записываются на прием только после безрезультатного самолечения. Попытки самостоятельного лечения, не дающие никаких результатов, могут формировать негативное отношение к ряду лекарственных препаратов. Задачей врача в таком случае является адекватная оценка состояния пациента и подбор оптимальной схемы терапии в каждой конкретной клинической ситуации.</p></abstract><trans-abstract xml:lang="en"><p>Information on the epidemiology, clinical manifestations, prevention and treatment of the new coronavirus infection COVID‑19 is constantly updated. Clinical manifestations of COVID‑19 on the skin have been described, including angiitis, acrodermatitis (acroangiitis), papulo-vesicular rashes, papulosquamous rashes, lichen rosacea, measles-like rash, toxicoderma, exacerbation of chronic dermatoses of the skin, hair and artifical lesions. One of the most significant triggers of hair loss is stress. The global COVID‑19 pandemic has become such a factor for many. To date, there is no complete understanding of the pathogenesis of hair loss associated with COVID‑19. Many authors suggest that both the infection itself and the associated psychoemotional state, and the therapy of the disease, can act as the causes of telogen hair loss and androgenic alopecia in COVID‑19. A number of studies demonstrate a link between androgens involved in the pathogenesis of COVID‑19 and the possible development of androgenic alopecia. Other authors have observed cases of telogen hair loss associated with COVID‑19 disease. In our practice, we also encounter diffuse hair thinning, presumably caused by COVID‑19. Often, patients do not consider it necessary to consult a doctor for hair loss, and for the first time make an appointment only after self-medication is ineffective. Self-treatment attempts that do not give any results can form a negative attitude towards a number of drugs. In this case, the doctor’s task is to adequately assess the patient’s condition and select the optimal therapy regimen for each specific clinical situation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>потеря волос</kwd><kwd>андрогенная алопеция</kwd><kwd>диффузное поредение волос</kwd><kwd>телогеновое выпадение волос</kwd><kwd>COVID 19</kwd><kwd>стимуляторы роста волос</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hair loss</kwd><kwd>androgenic alopecia</kwd><kwd>diffuse hair thinning</kwd><kwd>telogen hair loss</kwd><kwd>COVID 19</kwd><kwd>hair growth stimulants</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wollina U, Karadağ AS, Rowland-Payne C, Chiriac A, Lotti T. Cutaneous signs in COVID 19 patients: A review. Dermatol Ther. 2020; 33(5): e13549. DOI: 10.1111/dth.13549.</mixed-citation><mixed-citation xml:lang="en">Wollina U, Karadağ AS, Rowland-Payne C, Chiriac A, Lotti T. Cutaneous signs in COVID 19 patients: A review. Dermatol Ther. 2020; 33(5): e13549. DOI: 10.1111/dth.13549.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. J Eur Acad Dermatol Venereol. 2020. DOI: 10.1111/jdv.16387.</mixed-citation><mixed-citation xml:lang="en">Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. J Eur Acad Dermatol Venereol. 2020. DOI: 10.1111/jdv.16387.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mungmungpuntipantip R, Wiwanitkit V. COVID-19 and cutaneous manifestations. J Eur Acad Dermatol Venereol. 2020. DOI: 10.1111/jdv.16483.</mixed-citation><mixed-citation xml:lang="en">Mungmungpuntipantip R, Wiwanitkit V. COVID-19 and cutaneous manifestations. J Eur Acad Dermatol Venereol. 2020. DOI: 10.1111/jdv.16483.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lei Y, Huang X, Bamu S, et al. Clinical features of imported cases of coronavirus disease 2019 in Tibetan patients in the plateau area. Infect Dis Poverty. 2020. DOI: 10.21203/rs.3.rs 22978/v1</mixed-citation><mixed-citation xml:lang="en">Lei Y, Huang X, Bamu S, et al. Clinical features of imported cases of coronavirus disease 2019 in Tibetan patients in the plateau area. Infect Dis Poverty. 2020. DOI: 10.21203/rs.3.rs 22978/v1</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Freeman EE, McMahon DE, Fitzgerald ME, et al. The AAD COVID-19 registry: crowdsourcing dermatology in the age of COVID-19. J Am Acad Dermatol. 2020. DOI: 10.1016/j.jaad.2020.04.045.</mixed-citation><mixed-citation xml:lang="en">Freeman EE, McMahon DE, Fitzgerald ME, et al. The AAD COVID-19 registry: crowdsourcing dermatology in the age of COVID-19. J Am Acad Dermatol. 2020. DOI: 10.1016/j.jaad.2020.04.045.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Клиническая характеристика кожных проявлений при новой коронавирусной инфекции COVID 19, вызванной SARS-CoV 2. ГБУЗ «Московский научно-практический центр дерматовенерологии и косметологии ДЗМ», ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России», ФГАОУ ВО «Российский университет дружбы народов Минобрнауки России». Москва, электронное издание, 2020, 41 с.</mixed-citation><mixed-citation xml:lang="en">Clinical characteristics of skin manifestations in the new coronavirus infection COVID 19 caused by SARS-CoV 2. Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology, Russian National Research Medical University named after N.I. Pirogova, Peoples’ Friendship University of Russia. Moscow, electronic edition, 2020, 41 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Olds H, Liu J, Luk K, Lim HW, Ozog D, Rambhatla PV. Telogen effluvium associated with COVID 19 infection. Dermatol Ther. 2021 Mar; 34 (2): e14761. https://doi.org/10.1111/dth.14761 Epub 2021 Jan 14</mixed-citation><mixed-citation xml:lang="en">Olds H, Liu J, Luk K, Lim HW, Ozog D, Rambhatla PV. Telogen effluvium associated with COVID 19 infection. Dermatol Ther. 2021 Mar; 34 (2): e14761. https://doi.org/10.1111/dth.14761 Epub 2021 Jan 14</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Asghar F, Shamim N, Farooque U, Sheikh H, Aqeel R. Telogen effluvium: a review of the literature. Cureus. 2020; 12 (5): e8320 https://doi.org/10.7759/cureus.8320</mixed-citation><mixed-citation xml:lang="en">Asghar F, Shamim N, Farooque U, Sheikh H, Aqeel R. Telogen effluvium: a review of the literature. Cureus. 2020; 12 (5): e8320 https://doi.org/10.7759/cureus.8320</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kaufman KD. Androgens and alopecia. Mol Cell Endocrinol. 2002; 198 (1–2): 89–95. PMID: 12573818.</mixed-citation><mixed-citation xml:lang="en">Kaufman KD. Androgens and alopecia. Mol Cell Endocrinol. 2002; 198 (1–2): 89–95. PMID: 12573818.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sawaya ME, Price VH. Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol. 1997; 109 (3): 296–300. PMID: 9284093.</mixed-citation><mixed-citation xml:lang="en">Sawaya ME, Price VH. Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol. 1997; 109 (3): 296–300. PMID: 9284093.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">K. Hamada, V.A. Randall. Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness. British Journal of Dermatology. 2006–04–01. Vol. 154, Iss. 4. P. 609–618. ISSN1365–2133. DOI: 10.1111/j.1365–2133.2006.07144.x.</mixed-citation><mixed-citation xml:lang="en">K. Hamada, V.A. Randall. Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness. British Journal of Dermatology. 2006–04–01. Vol. 154, Iss. 4. P. 609–618. ISSN1365–2133. DOI: 10.1111/j.1365–2133.2006.07144.x.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181: 271. e8–280.e8.</mixed-citation><mixed-citation xml:lang="en">Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181: 271. e8–280.e8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Li LQ, Huang T, Wang YQ, et al. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020. 10.1002/jmv.25757.</mixed-citation><mixed-citation xml:lang="en">Li LQ, Huang T, Wang YQ, et al. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020. 10.1002/jmv.25757.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382 (8): 727–733.</mixed-citation><mixed-citation xml:lang="en">Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382 (8): 727–733.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sabharwal N, Sharifi N. HSD3B1 genotypes conferring adrenal-restrictive and adrenal-permissive phenotypes in prostate cancer and beyond. Endocrinology. 2019; 160: 2180–2188.</mixed-citation><mixed-citation xml:lang="en">Sabharwal N, Sharifi N. HSD3B1 genotypes conferring adrenal-restrictive and adrenal-permissive phenotypes in prostate cancer and beyond. Endocrinology. 2019; 160: 2180–2188.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Goren A, Vaño-Galván S, Wambier CG, et al. A preliminary observation: male pattern hair loss among hospitalized COVID-19 patients in Spain – a potential clue to the role of androgens in COVID-19 severity. J Cosmet Dermatol. 2020; 19 (7): 1545–1547.</mixed-citation><mixed-citation xml:lang="en">Goren A, Vaño-Galván S, Wambier CG, et al. A preliminary observation: male pattern hair loss among hospitalized COVID-19 patients in Spain – a potential clue to the role of androgens in COVID-19 severity. J Cosmet Dermatol. 2020; 19 (7): 1545–1547.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wambier CG, Vano-Galvan S, McCoy J, et al. Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients – the ‘Gabrin sign’. J Am Acad Dermatol. 2020; 69: 680–682.</mixed-citation><mixed-citation xml:lang="en">Wambier CG, Vano-Galvan S, McCoy J, et al. Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients – the ‘Gabrin sign’. J Am Acad Dermatol. 2020; 69: 680–682.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Müller Ramos P., Ianhez M. and Amante Miot H. (2020). Alopecia and grey hair are associated with COVID-19 severity. Exp Dermatol, 29: 1250–1252. https://doi.org/10.1111/exd.14220</mixed-citation><mixed-citation xml:lang="en">Müller Ramos P., Ianhez M. and Amante Miot H. (2020). Alopecia and grey hair are associated with COVID-19 severity. Exp Dermatol, 29: 1250–1252. https://doi.org/10.1111/exd.14220</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
