medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-27-8-12medalphabet-2263Research ArticleОБЗОР ЛИТЕРАТУРЫФилаггрин: от истории открытия до применения модуляторов филаггрина в клинической практике (обзор литературы)Filaggrin: from history of discovery to clinical usage (literature review)https://orcid.org/0000-0002-5044-5265КругловаЛ. С.KruglovaL. S.

Круглова Лариса Сергеевна, д.м.н., проректор по учебной работе, зав. кафедрой дерматовенерологии и косметологии

Москва

Kruglova Larisa S., DM Sci (habil.), vice-rector for academic affairs, head of Dept of Dermatovenereology and Cosmetology

Moscow

kruglovals@mail.ruhttps://orcid.org/0000-0003-1563-9475ПереверзинаН. О.PereverzinaN. O.

Переверзина Наталья Олеговна, аспирант кафедры дерматовенерологии и косметологии

Москва

Pereverzina Natalya O., postgraduate student of Dept of Dermatovenereology and Cosmetology

Moscow

natalia.pereverzina@gmail.comФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РоссииРоссияCentral State Medical Academy of the Administrative Department of the President of RussiaRussian Federation202131102021027Дерматология (2)812Copyright © Круглова Л.С., Переверзина Н.О., 20212021Круглова Л.С., Переверзина Н.О.Kruglova L.S., Pereverzina N.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2263

Статья носит обзорный характер и содержит актуальную информацию об одном из основных факторов нарушения кожного барьера – дисфункции филаггрина – важнейшего структурного белка эпидермиса, влияющего на финальный этап дифференцировки кератиноцитов и являющегося основой натурального увлажняющего фактора. Данные о ведущей роли дефекта филаггрина в патогенезе ряда дерматозов делают его привлекательной мишенью для создания топических дерматокосметических средств с целью восполнения его дефицита. Филагринол – модулятор синтеза белка филаггрина, запатентованный комплекс из неомыляемых фракций растительных масел, который стимулирует созревание профилаггрина, активируя АТФазы, участвующие в дефосфорилировании профилаггрина, и индуцируя включение гистидина в зернистый слой. Ожидается, что благодаря растительным липидам формула усиливает способность кожи к обновлению, значительно замедляя процесс ее старения, и восстанавливает влагоудерживающую способность кожи, нормализуя тем самым степень гидратации. Первым зарегистрированным на сегодняшний день в РФ эмолентом с филагринолом 5% является Адмера®.

The article is of an overview nature and contains up-to-date information about one of the main factors in the violation of the skin barrier, filaggrin dysfunction, which is a component of the natural moisturizing factor. The data on the leading role of the filaggrin defect in the pathogenesis of a number of dermatoses make it an attractive target for the creation of topical dermatocosmetics in order to compensate for its deficiency. The first and only registered emollient with a modulator of filaggrin activity from unsaponifiable fractions of vegetable oils is filagrinol, which stimulates the maturation of profilaggrin by activating ATPases involved in dephosphorylation of profilaggrin and inducing the incorporation of histidine into the granular layer [30]. It is expected that thanks to plant lipids this formula enhances the skin’s ability to renew, significantly slowing down the aging process and restores the skin’s water-holding capacity, thereby normalizing the degree of hydration.

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The authors declare that there are no conflicts of interest present.