medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-29-40-46medalphabet-2259Research ArticleСтатьиЛекарственные средства, прием которых ассоциирован с развитием лекарственно-индуцированной гипонатриемии. Антигипертензивные препараты и ингибиторы протонной помпыDrugs associated with drug-induced hyponatremia. Focus on antihypertensive drugs and proton pump inhibitorshttps://orcid.org/0000-0002-0401-1132ЛистратовА. И.ListratovA. I.

Листратов Александр Иванович, ординатор II года кафедры

Москва

Listratov Alexander I., resident of the 2st year of Dept of Therapy and Polymorbid Pathology 

Moscow

alexanderlistratoff@yandex.ruhttps://orcid.org/0000-0002-3426-5467АлешковичА. В.AleshckovichE. V.

Алешкович Елена Валерьевна, к.м.н., зав. кардиологическим отделением для больных с острым инфарктом миокарда

 

Aleshckovich Elena V., PhD Med, cardiologist, head of Dept of Cardiology for Patients with Acute Myocardial Infarction 

Moscow

elena.aleshckovitch@yandex.ruhttps://orcid.org/0000-0002-0795-8225ОстроумоваО. Д.OstroumovaO. D.

Остроумова Ольга Дмитриевна, проф., д.м.н., зав. кафедрой; проф. кафедры

еLibrary SPIN: 3910–6585

Москва

Ostroumova Olga D., DM Sci, professor, head of Dept of Therapy and Polymorbid Pathology; professor of Dept of Clinical Pharmacology and Propedeutics of Internal Diseases 

Moscow

ostroumova.olga@mail.ruКафедра терапии и полиморбидной патологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy for Continuing Professional EducationRussian FederationГБУЗ г. Москвы «Городская клиническая больница имени С.П. Боткина Департамента здравоохранения Москвы»РоссияCity Clinical Hospital n.a. S.P. BotkinRussian FederationКафедра терапии и полиморбидной патологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; Кафедра клинической фармакологии и пропедевтики внутренних болезней ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияRussian Medical Academy for Continuing Professional Education; First Moscow State Medical University n.a. I.M. SechenovRussian Federation202119102021129Коморбидные состояния (2)4046Copyright © Листратов А.И., Алешкович А.В., Остроумова О.Д., 20212021Листратов А.И., Алешкович А.В., Остроумова О.Д.Listratov A.I., Aleshckovich E.V., Ostroumova O.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2259

Гипонатриемия (ГН) является одним из ведущих водно-электролитных нарушений в повседневной врачебной практике. Снижение уровня натрия опасно развитием различных осложнений. Поэтому для эффективной профилактики ГН и ее осложнений особое внимание следует уделять модифицируемым факторам риска. Одной из важных причин, приводящих к ГН, являются лекарственные средства (ЛС). Наиболее часто ГН развивается на фоне терапии тиазидными и тиазидоподобными диуретиками. Факторами риска ее развития являются тиазид-индуцированная ГН в анамнезе, пожилой возраст, женский пол, низкая масса тела и гипокалиемия. Проблема тиазид-индуцированной ГН требует дальнейшего изучения патогенетических механизмов и определения генетических факторов, лежащих в ее основе. Необходимо также помнить о возможности развития ГН на фоне таких препаратов, широко применяемых в терапевтической практике, как блокаторы ренин-ангиотензин-альдостероновой системы (РААС) и ингибиторы протонной помпы (ИПП). У пациентов, получающих терапию перечисленными препаратами, необходимо уделять внимание возможным клиническим проявлениям ГН и определять уровень натрия в динамике, что позволит эффективно профилактировать развитие данного нарушения.

Hyponatremia (HN) is one of the leading water-electrolyte disorders in daily medical practice. A decrease in sodium level is dangerous with the development of various complications. Therefore, for effective prevention of HN and its complications, special attention should be paid to modifiable risk factors. One of the important causes leading to HN is drugs. Most often, HN develops during therapy with thiazide and thiazidelike diuretics. Risk factors for its development are history of thiazide-induced HN, advanced age, female sex, low body weight, and hypokalemia. The problem of thiazide-induced HN requires further study of the pathogenetic mechanisms and determination of the genetic factors underlying it. It is also necessary to remember about the possibility of HN development against the background of such drugs widely used in therapeutic practice as blockers of the renin-angiotensin-aldosterone system and proton pump inhibitors. In patients receiving therapy with the listed drugs, it is necessary to pay attention to the possible clinical manifestations of HN and to determine the sodium level in dynamics, which will effectively prevent the development of this disorder.

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The authors declare that there are no conflicts of interest present.