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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2021-29-8-12</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2254</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Эмпаглифлозин у пациента с сердечной недостаточностью и сахарным диабетом второго типа: новые возможности медикаментозной терапии</article-title><trans-title-group xml:lang="en"><trans-title>Empagliflozin in patient with heart failure and type 2 diabetes mellitus: new possibilities for drug therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7058-2008</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Седых</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sedykh</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Седых Дарья Юрьевна, к.м.н., н.с. лаборатории патологии кровообращения отдела клинической кардиологии </p><p>г. Кемерово</p></bio><bio xml:lang="en"><p>Barbarash Olga L., DM Sci, professor, corresponding member of RAS, director, head of Dept of Cardiology and Cardiovascular Surgery</p><p>Kemerovo</p></bio><email xlink:type="simple">md-sedih@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3729-616X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашталап</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashtalap</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кашталап Василий Васильевич, д.м.н., доцент, зав. отделом клинической кардиологии, проф. кафедры кардиологии и сердечно-сосудистой хирургии</p><p>г. Кемерово</p></bio><bio xml:lang="en"><p>Kashtalap Vasily V., DM Sci, associate professor, head of Dept of Clinical Cardiology</p><p>Kemerovo</p></bio><email xlink:type="simple">v_kash@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4642-3610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Барбараш Ольга Леонидовна, д.м.н., проф., член-корр. РАН, директор, зав. кафедрой кардиологии и сердечно-сосудистой хирургии</p><p>г. Кемерово</p></bio><bio xml:lang="en"><p>Barbarash Olga L., DM Sci, professor, corresponding member of RAS, director, head of Dept of Cardiology and Cardiovascular Surgery </p><p>Kemerovo</p></bio><email xlink:type="simple">olb61@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Problems of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2021</year></pub-date><volume>1</volume><issue>29</issue><issue-title>Коморбидные состояния (2)</issue-title><fpage>8</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Седых Д.Ю., Кашталап В.В., Барбараш О.Л., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Седых Д.Ю., Кашталап В.В., Барбараш О.Л.</copyright-holder><copyright-holder xml:lang="en">Sedykh D.Y., Kashtalap V.V., Barbarash O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2254">https://www.med-alphabet.com/jour/article/view/2254</self-uri><abstract><p>В статье продемонстрирован практический опыт эффективного применения представителя ингибиторов натрий-глюкозного котранспортера 2 эмплаглифлозина в составе оптимальной медикаментозной терапии у пациентов при декомпенсированной хронической сердечной недостаточности с систолической дисфункцией ишемического генеза и сахарном диабете второго типа. На основании данных доказательных исследований обозначено место данной группы лекарственных препаратов в улучшении качества жизни и прогноза у пациентов с тяжелой коморбидностью.</p></abstract><trans-abstract xml:lang="en"><p>The article demonstrates the practical experience of the effective use of inhibitor of sodium-glucose co-transporter 2 emplagliflozin as a part of optimal drug therapy in patients with decompensation of chronic heart failure with systolic dysfunction of ischemic genesis and type 2 diabetes mellitus. The place of this group of drugs in improving the quality of life and prognosis in patients with severe comorbidity has been indicated according to the data of evidence-based studies.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечная недостаточность</kwd><kwd>сахарный диабет</kwd><kwd>прогноз</kwd><kwd>ингибиторы натрий-глюкозного котранспортера 2</kwd><kwd>эмпаглифлозин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart failure</kwd><kwd>diabetes mellitus</kwd><kwd>prognosis</kwd><kwd>sodium glucose co-transporter 2 (SGLT2) inhibitors</kwd><kwd>empagliflozin</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья публикуется при поддержке ООО «Берингер Ингельхайм»</funding-statement><funding-statement xml:lang="en">This article is published with the support of Boehringer Ingelheim LLC</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Барбараш О. 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