medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-25-12-19medalphabet-2248Research ArticleСтатьиКардиотоксичность гипотензивных препаратов (обзор литературы) Часть I. Блокаторы кальциевых каналов и β-блокаторыCardiotoxicity with antihypertensive drugs (literature review) Part 1. Calcium channel blockers and beta-blockershttps://orcid.org/0000-0002-4940-9574ЭсауленкоА. Н.EsaulenkoA. N.

Эсауленко Анна Николаевна, клинический ординатор по специальности «кардиология»

Esaulenko Anna N., clinical intern with degree in Cardiology

Moscow

aesaulenko95@mail.ruhttps://orcid.org/0000-0003-0718-5258МоисееваА. Ю.MoiseevaA. Yu.

Моисеева Александра Юрьевна, клинический ординатор по специальности «кардиология»

Moiseeva Alexandra Yu., clinical intern with degree in Cardiology

Moscow

moiseyeva.alexandra.y@yandex.ruhttps://orcid.org/0000-0002-9738-1801ИванниковА. А.IvannikovA. A.

Иванников Александр Александрович, клинический ординатор по специальности «кардиология»

Ivannikov Alexander A., clinical intern with degree in Cardiology

Moscow

ivannikov_a95@mail.ruhttps://orcid.org/0000-0002-1050-1867БратищевИ. В.BratischevI. V.

Братищев Игорь Викторович. врач – анестезиолог-реаниматолог, преподаватель учебного центра

Bratishchev Igor V., anesthesiologist-resuscitator, teacher of Training Centre

Moscow

bratischev@mail.ruАлиджановаХ. Г.AlidzhanovaKh. G.

Алиджанова Хафиза Гафуровна, д. м. н., ст. преподаватель учебного центра

Alidzhanova Khafiza G., DM Sci, chief teacher at Training Centre

Moscow

doctorhafiza@mail.ruГБУЗ «Научно-исследовательский институт скорой помощи имени Н. В. Склифосовского Департамента здравоохранения Москвы»РоссияResearch Institute of Emergency Care n. a. N. V. SklifosovskyRussian Federation202115102021025Кардиология и неотложная медицина (3)1219Copyright © Эсауленко А.Н., Моисеева А.Ю., Иванников А.А., Братищев И.В., Алиджанова Х.Г., 20212021Эсауленко А.Н., Моисеева А.Ю., Иванников А.А., Братищев И.В., Алиджанова Х.Г.Esaulenko A.N., Moiseeva A.Y., Ivannikov A.A., Bratischev I.V., Alidzhanova K.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2248

Токсическое воздействие при передозировке гипотензивными препаратами на сердечно-сосудистую систему является малоизученной темой, объединяющей клиническую, экспериментальную фармакологию и токсикологию с проекцией на кардиологию. Имеющиеся в научной литературе описания кардиотоксичности бета-блокаторов (βБ) и блокаторов кальциевых каналов (БКК) ограничены малым количеством публикаций. Отравления этими группами препаратов проявляются схожими серьезными гемодинамическими нарушениями и миокардиальной недостаточностью, однако патофизиологические механизмы этих изменений до конца не изучены. В статье подчеркиваются трудности определения токсической концентрации и особенности клинической картины отравлений. Обсуждаются подходы к диагностике и лечению передозировки БКК и βБ.

The effect of hypotensive drugs overdose on cardiovascular system is poorly studied; it should undergo clinical, experimental pharmacology and toxicology together with cardiology. There is too little information about cardiotoxicity of beta-blockers (β-blockers) and calcium channel blockers (CCB) in existing research literature. Intoxication from these groups of drugs causes similar severe hemodynamic abnormalities and myocardial insufficiency, however pathophysiological mechanisms of these abnormalities are not thoroughly studied. The review highlights how difficult it is to identify toxic level and distinctive features of clinical evidence of intoxication. Methods of diagnosis as well as β-blockers and CCB overdose treatment are discussed.

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The authors declare that there are no conflicts of interest present.