medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-23-79-91medalphabet-2232Research ArticleСОВРЕМЕННАЯ ПОЛИКЛИНИКАMODERN POLYCLINICЛекарственно-индуцированная гипофосфатемияDrug-induced hypophosphatemiaОстроумоваО. Д.OstroumovaO. D.

Ольга Дмитриевна Остроумова, д. м. н., проф., зав. кафедрой терапии и полиморбидной патологии

Москва

Olga D. Ostroumova, DM Sci, professor head of the Department of Therapy andPolymorbid Pathology

Moscow

ostroumova.olga@mail.ruБлизнюкС. А.BliznyukS. A.

Светлана Александровна Близнюк, к. м. н., врач-кардиолог кардиологического отделения для больных с инфарктом миокарда № 28

Москва

Svetlana A. Bliznyuk, PhD Med, cardiologist of the Cardiology Department for Patients with Myocardial Infarction No. 28

Moscow

sabliznyuk@mail.ruКочетковА. И.KochetkovA. I.

Алексей Иванович Кочетков,  к. м. н., доцент кафедры терапии и полиморбидной патологии

Москва

Alexey I. Kochetkov, PhD Med, associate professor of the Department of Therapy and Polymorbid Pathology

Moscow

ak_info@list.ruКомароваА. Г.KomarovаA. G.

Анна Григорьевна Комарова, к. м. н., врач-кардиолог, зам. главного врача по региональному сосудистому центру

Москва

Anna G. Komarova, PhD Med, cardiologist, deputy chief physician for the Regional Vascular Center

Moscow

bellis-06@mail.ruФГБОУ ДПО «Российская медицинская академия непрерывного последипломного образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Medical Education of the Russian Ministry of HealthRussian FederationГБУЗ г. Москвы «Городская клиническая больница имени С. П. Боткина Департамента здравоохранения МосквыРоссияS. P. Botkin City Clinical Hospital of the Moscow Department of HealthRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного последипломного образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Medical Education of the Russian Ministry of HealthRussian Federation202128092021023Современная поликлиника (3)7991Copyright © Остроумова О.Д., Близнюк С.А., Кочетков А.И., Комарова А.Г., 20212021Остроумова О.Д., Близнюк С.А., Кочетков А.И., Комарова А.Г.Ostroumova O.D., Bliznyuk S.A., Kochetkov A.I., Komarovа A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2232

Гипофосфатемия (ГФ) определяется как снижение уровня неорганического фосфора в сыворотке крови ниже 2,5 мг/дл (0,81 ммоль/л). Одной из причин развития ГФ является прием ряда лекарственных средств: диуретиков, некоторых антибактериальных препаратов, инсулина, антацидов, растворов глюкозы для парентерального введения, противоопухолевых препаратов. Истинная распространенность лекарственно-индуцированной (ЛИ) ГФ неизвестна, потому что оценка уровня фосфатов не проводится рутинно, а лишь при подозрении на ГФ. Наиболее частым механизмом развития ЛИ ГФ является повышение экскреции фосфатов почками. В большинстве случаев ЛИ ГФ протекает бессимптомно и регрессирует после прекращения приема препарата-индуктора. Для восполнения фосфатного дефицита используют немедикаментозные методы (диета) и фармакотерапию. Профилактика ЛИ ГФ предполагает отказ от применения ЛС, прием которых ассоциирован с развитием ЛИ ГФ, особенно у пациентов из групп риска развития ГФ.

Hypophosphatemia (GF) is defined as a decrease in the level of inorganic phosphorus in the blood serum below 2.5 mg/dl (0.81 mmol/L). One of the reasons for the development of GF can be the use of a number of medications: diuretics, some antibacterial drugs, insulin, antacids, glucose solutions for parenteral administration, antitumor drugs. The true prevalence of drug-induced (DI) HB is unknown, because the phosphate level is not evaluated routinely, but only when GF is suspected. The most common mechanism for the development of DI GF is an increase in the excretion of phosphates by the kidneys. In most cases, DI GF is asymptomatic and regresses after discontinuation of the inducer drug. To compensate for the phosphate deficiency, non-drug methods (diet) and pharmacotherapy are used. Prevention of DI GF involves avoiding the use of drugs, the reception of which is associated with the development of DI GF, especially in patients at risk of developing GF.

нарушения электролитного балансаэлектролитный дисбаланслекарственно-индуцированные нарушения электролитного балансагипофосфатемиялекарственно-индуцированная гипофосфатемиялекарственные средстванежелательные лекарственные реакцииelectrolytes abnormalitiesdrug-induced electrolytes abnormalitieshypophosphatemiadrug-induced hypophosphatemiahypokalemiadrugsadverse drug reactionsReferencesChristov M., Juppner H. Phosphate homeostasis disorders. Best Pract Res Clin Endocrinol Metab. 2018;32(5):685-706. https://doi.org/10.1016/j.beem.2018.06.004.Christov M., Juppner H. Phosphate homeostasis disorders. Best Pract Res Clin Endocrinol Metab. 2018;32(5):685-706. https://doi.org/10.1016/j.beem.2018.06.004.Moe S. M. Disorders involving calcium, phosphorus, and magnesium. Prim Care. 2008;35(2):215-37. https://doi.org/10.1016/j.pop.2008.01.007.Moe S. M. Disorders involving calcium, phosphorus, and magnesium. Prim Care. 2008;35(2):215-37. https://doi.org/10.1016/j.pop.2008.01.007.Liamis G., Milionis H. J., Elisaf M. Medication-induced hypophosphatemia: a review. Q. J. M. 2010;103(7):449-59. https://doi.org/10.1093/qjmed/hcq039Liamis G., Milionis H. J., Elisaf M. Medication-induced hypophosphatemia: a review. Q. J. M. 2010;103(7):449-59. https://doi.org/10.1093/qjmed/hcq039Megapanou E., Florentin M., Milionis H., Elisaf M., Liamis G. Drug-Induced Hypophosphatemia: Current Insights. Drug Saf. 2020;43(3):197-210. https://doi.org/10.1007/s40264-019-00888-1.Megapanou E., Florentin M., Milionis H., Elisaf M., Liamis G. Drug-Induced Hypophosphatemia: Current Insights. Drug Saf. 2020;43(3):197-210. https://doi.org/10.1007/s40264-019-00888-1.Tsimberidou A. M., O ’Brien S. M., Cortes J. E., Faderl S., Andreeff M., Kantarjian H. M. et al. Phase il study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and gM-CSF (FACPGM) in patients with richter’s syndrome or refractory lymphoproliferative disorders. Leuk Lymphoma. 2002;43:767-2. https://doi.org/10.1080/10428190290016872.Tsimberidou A. M., O ’Brien S. M., Cortes J. E., Faderl S., Andreeff M., Kantarjian H. M. et al. Phase il study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and gM-CSF (FACPGM) in patients with richter’s syndrome or refractory lymphoproliferative disorders. Leuk Lymphoma. 2002;43:767-2. https://doi.org/10.1080/10428190290016872.Perazella M. A. Onco-nephrology: renal toxicities of chemotherapeutic agents. Clin J Am Soc Nephrol. 2012;7:1713-21. https://doi.org/10.2215/CJN.02780312.Perazella M. A. Onco-nephrology: renal toxicities of chemotherapeutic agents. Clin J Am Soc Nephrol. 2012;7:1713-21. https://doi.org/10.2215/CJN.02780312.Stava C. J., Jimenez C., Hu M. I., Vassilopoulou-Sellin R. Skeletal sequelae of cancer and cancer treatment. J Cancer Surviv. 2009; 3:75-88. https://doi.org/10.1007/s11764-009-0083-4.Stava C. J., Jimenez C., Hu M. I., Vassilopoulou-Sellin R. Skeletal sequelae of cancer and cancer treatment. J Cancer Surviv. 2009; 3:75-88. https://doi.org/10.1007/s11764-009-0083-4.Ledeganck K. J., Boulet G. A., Bogers J. J.., Verpooten GA., De Winter B. Y. The TRPM6/EGF pathway is downregulated in a rat model of cisplatin nephrotoxicity. PLoS One. 2013;8(2): e57016. https://doi.org/10.1371/joumal.pone.0057016.Ledeganck K. J., Boulet G. A., Bogers J. J.., Verpooten GA., De Winter B. Y. The TRPM6/EGF pathway is downregulated in a rat model of cisplatin nephrotoxicity. PLoS One. 2013;8(2): e57016. https://doi.org/10.1371/joumal.pone.0057016.Yamamoto Y., Akashi Y., Minami T., Nozawa M., Kiba K., Yoshikawa M. et al. Serious hypokalemia associated with abiraterone acetate in patients with castration-Resistant prostate cancer. Case Rep Urol. 208;2018:1414395. https://dx.doi.org/10.1155%2F2018%2F1414395.Yamamoto Y., Akashi Y., Minami T., Nozawa M., Kiba K., Yoshikawa M. et al. Serious hypokalemia associated with abiraterone acetate in patients with castration-Resistant prostate cancer. Case Rep Urol. 208;2018:1414395. https://dx.doi.org/10.1155%2F2018%2F1414395.Madison D. L., Beer T. M., Bliziotes M. M. Acute estramustine induced hypocalcemia unmasking severe vitamin d deficiency. Am J Med. 2002;112:680-1. https://doi.org/10.1016/S0002-9343(02)01101-4.Madison D. L., Beer T. M., Bliziotes M. M. Acute estramustine induced hypocalcemia unmasking severe vitamin d deficiency. Am J Med. 2002;112:680-1. https://doi.org/10.1016/S0002-9343(02)01101-4.Kondo R., Watanabe S., Shoji S., Ichikawa K., Abe T., Baba J. et al. A phase il study of irinotecan for patients with previously treated small-Cell lung cancer. Oncology. 2018;94:223-32. https://doi.org/10.1159/000486622.Kondo R., Watanabe S., Shoji S., Ichikawa K., Abe T., Baba J. et al. A phase il study of irinotecan for patients with previously treated small-Cell lung cancer. Oncology. 2018;94:223-32. https://doi.org/10.1159/000486622.Berrman E., Nicolaides M., Maki R. G. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med. 2006;354:2006-13. https://doi.org/10.1056/NEJMoa051140.Berrman E., Nicolaides M., Maki R. G. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med. 2006;354:2006-13. https://doi.org/10.1056/NEJMoa051140.Frangois H., Coppo P., Hayman J. P., Fouqueray B., Mougenot B., Ronco P. Partial fanconi syndrome induced by imatinib therapy: a novel cause of urinary phosphate loss. Am J Kidney Dis. 2008;51:298-301. https://doi.org/10.1053/j.ajkd.2007.10.039.Frangois H., Coppo P., Hayman J. P., Fouqueray B., Mougenot B., Ronco P. Partial fanconi syndrome induced by imatinib therapy: a novel cause of urinary phosphate loss. Am J Kidney Dis. 2008;51:298-301. https://doi.org/10.1053/j.ajkd.2007.10.039.Mir O., Coriat R., Boudou-Rouquette P., Durand J. P., Goldwasser F. Sorafenibinduced diarrhea and hypophosphatemia: mechanisms and therapeutic implications. Ann Oncol. 2012;23:280-1. https://doi.org/10.1093/annonc/mdr525.Mir O., Coriat R., Boudou-Rouquette P., Durand J. P., Goldwasser F. Sorafenibinduced diarrhea and hypophosphatemia: mechanisms and therapeutic implications. Ann Oncol. 2012;23:280-1. https://doi.org/10.1093/annonc/mdr525.Wanchoo R., Jhaveri K. D., Deray G., Launay-Vacher V. Renal effects of bRAF inhibitors: a systematic review by the cancer and the kidney international network. Clin Kidney J. 2016;9:245-51. https://doi.org/10.1093/ckj/sfv149.Wanchoo R., Jhaveri K. D., Deray G., Launay-Vacher V. Renal effects of bRAF inhibitors: a systematic review by the cancer and the kidney international network. Clin Kidney J. 2016;9:245-51. https://doi.org/10.1093/ckj/sfv149.Micetich K. C., Futscher B., Koch D., Fisher R. I., Erickson L. C. Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer. J Natl Cancer Inst 1992;84:256-60. https://doi.org/10.1093/jnci/84.4.256.Micetich K. C., Futscher B., Koch D., Fisher R. I., Erickson L. C. Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer. J Natl Cancer Inst 1992;84:256-60. https://doi.org/10.1093/jnci/84.4.256.Rago R. P., Miles J. M., Sufit R. L., Spriggs D. R., Wilding G. Suramin-induced weakness from hypophosphatemia and mitochondrial myopathy. Association of suramin with mitochondrial toxicity in humans. Cancer 1994;73:1954 9. https://doi.org/10.1002/1097-0142(19940401)73:7%3C1954::aid-cncr2820730729%3E3.0.co;2-h.Rago R. P., Miles J. M., Sufit R. L., Spriggs D. R., Wilding G. Suramin-induced weakness from hypophosphatemia and mitochondrial myopathy. Association of suramin with mitochondrial toxicity in humans. Cancer 1994;73:1954 9. https://doi.org/10.1002/1097-0142(19940401)73:7%3C1954::aid-cncr2820730729%3E3.0.co;2-h.Zekri J. M., Robinson M. H., Woll P. J. Relative hypocalcaemia and muscle cramps in patients receiving imatinib for gastrointestinal stromal tumour. Sarcoma. 2006;2006:/-3. https://doi.org//10.1155/srcm/2006/48948.Zekri J. M., Robinson M. H., Woll P. J. Relative hypocalcaemia and muscle cramps in patients receiving imatinib for gastrointestinal stromal tumour. Sarcoma. 2006;2006:/-3. https://doi.org//10.1155/srcm/2006/48948.Popat R., Brown S. R., Flanagan L., Hall A., Gregory W., Kishore B. et al. Bortezomib, thalidomide, dexamethasone and panobinostat for patients with relapsed multiple myeloma (MUK-six): a multicentre, open-label, phase 112 trial. Lancet Haematol. 20/6;3: e572-e80. https://doi.org/10.1016/S2352-3026(16)30165-X.Popat R., Brown S. R., Flanagan L., Hall A., Gregory W., Kishore B. et al. Bortezomib, thalidomide, dexamethasone and panobinostat for patients with relapsed multiple myeloma (MUK-six): a multicentre, open-label, phase 112 trial. Lancet Haematol. 20/6;3: e572-e80. https://doi.org/10.1016/S2352-3026(16)30165-X.Glezerman I. G., Kewalramani T., Jhaveri K. Reversible fanconi syndrome due to lenalidomide. NDTPlus. 2008;/:2/5-7. https://doi.org/10.1093/ndtplus/sfn044.Glezerman I. G., Kewalramani T., Jhaveri K. Reversible fanconi syndrome due to lenalidomide. NDTPlus. 2008;/:2/5-7. https://doi.org/10.1093/ndtplus/sfn044.Tie Y., Ma X., Zhu C., Mao Y., Shen K., Wei X. et al. Safety and efficacy of nivolumab in the treatment of cancers: a meta-analysis of 27 prospective clinical trials. Int J Cancer. 2017;140:948-58. https://doi.org/10.1002/ijc.30501.Tie Y., Ma X., Zhu C., Mao Y., Shen K., Wei X. et al. Safety and efficacy of nivolumab in the treatment of cancers: a meta-analysis of 27 prospective clinical trials. Int J Cancer. 2017;140:948-58. https://doi.org/10.1002/ijc.30501.Delbaldo C.., Raymond E, Vera K., Hammershaimb L., Kaucic K., Lozahic S. et al. Phase i and pharmacokinetic study of etaracizumab (AbegrinTM), a humanized monoclonal antibody against avss3 integrin receptor, in patients with advanced solid tumors. Invest New Drugs. 2008;26:35-43. https://doi.org/10.1007/s10637-007-9077-0.Delbaldo C.., Raymond E, Vera K., Hammershaimb L., Kaucic K., Lozahic S. et al. Phase i and pharmacokinetic study of etaracizumab (AbegrinTM), a humanized monoclonal antibody against avss3 integrin receptor, in patients with advanced solid tumors. Invest New Drugs. 2008;26:35-43. https://doi.org/10.1007/s10637-007-9077-0.Shaikh A., Wiisanene M. E., Gunderson H. D., Leung N. Acquired fanconi syndrome after treatment with capecitabine, innotecan, and bevacizumab. Ann Pharmacother. 2009;43:1370-3. https://doi.org/10.1345/aph.1M120.Shaikh A., Wiisanene M. E., Gunderson H. D., Leung N. Acquired fanconi syndrome after treatment with capecitabine, innotecan, and bevacizumab. Ann Pharmacother. 2009;43:1370-3. https://doi.org/10.1345/aph.1M120.Schneeweiss A., Park-Simon T. W., Albanell J., Lassen U., Cortes J.., Dieras V., May M., Schindler C., Marme F., Cejalvo J. M., Martinez-Garcia M., Gonzalez I., Lopez-Martin J., Welt A., Levy C., Joly F., Michielin F, Jacob W., Adessi C., Moisan A., Meneses-Lorente G., Racek T., James I., Ceppi M., Hasmann M., Weisser M., Cervantes A. Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in hER3- positive, hER2-low metastatic breast cancer. Invest New Drugs. 2018;36:848-59. https://doi.org/10.1007/s10637-018-0562-4.Schneeweiss A., Park-Simon T. W., Albanell J., Lassen U., Cortes J.., Dieras V., May M., Schindler C., Marme F., Cejalvo J. M., Martinez-Garcia M., Gonzalez I., Lopez-Martin J., Welt A., Levy C., Joly F., Michielin F, Jacob W., Adessi C., Moisan A., Meneses-Lorente G., Racek T., James I., Ceppi M., Hasmann M., Weisser M., Cervantes A. Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in hER3- positive, hER2-low metastatic breast cancer. Invest New Drugs. 2018;36:848-59. https://doi.org/10.1007/s10637-018-0562-4.Moore K. N., Borghaei H., O'Malley D. M., Jeong W., Seward S. M., Bauer T. M.et al. Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor a-targeting antibody-drug conjugate, in patients with solid tumors. Cancer. 2017;123:3080-87. https://doi.org/10.1002/cncr.30736.Moore K. N., Borghaei H., O'Malley D. M., Jeong W., Seward S. M., Bauer T. M.et al. Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor a-targeting antibody-drug conjugate, in patients with solid tumors. Cancer. 2017;123:3080-87. https://doi.org/10.1002/cncr.30736.Chung T. L., Chen N. C., Chen C. L. Severe hypophosphatemia induced by denosumab in a patient with osteomalacia and tenofovir disoproxil fumarate-related acquired Fanconi syndrome. Osteoporos Int. 20/9;30(2):519-523. https://doi.org/10.1007/s00198-018-4679-2.Chung T. L., Chen N. C., Chen C. L. Severe hypophosphatemia induced by denosumab in a patient with osteomalacia and tenofovir disoproxil fumarate-related acquired Fanconi syndrome. Osteoporos Int. 20/9;30(2):519-523. https://doi.org/10.1007/s00198-018-4679-2.Sakurada H., Kawase Y., Mizuno H., Naito K., Yamamura M. A case of hypophosphatemia induced by administration of amrubicin in a patient with small cell lung cancer. Gan To Kagaku Ryoho. 2018;45:1369-71. https://doi.org/10.3389%2Ffonc.2020.00779.Sakurada H., Kawase Y., Mizuno H., Naito K., Yamamura M. A case of hypophosphatemia induced by administration of amrubicin in a patient with small cell lung cancer. Gan To Kagaku Ryoho. 2018;45:1369-71. https://doi.org/10.3389%2Ffonc.2020.00779.Decaux G. Tetracycline-induced renal hypophosphatemia in a patient with a syndrome of inappropriate secretion of anti- diuretic hormone. Nephron 1988; 48:40-2. https://doi.org/10.1159/000184866.Decaux G. Tetracycline-induced renal hypophosphatemia in a patient with a syndrome of inappropriate secretion of anti- diuretic hormone. Nephron 1988; 48:40-2. https://doi.org/10.1159/000184866.Alexandridis G., Liberopoulos E., Elisaf M. Aminoglycoside- induced reversible tubular dysfunction. Pharmacology 2003; 67:118-20. https://doi.org/10.1159/000067797.Alexandridis G., Liberopoulos E., Elisaf M. Aminoglycoside- induced reversible tubular dysfunction. Pharmacology 2003; 67:118-20. https://doi.org/10.1159/000067797.Min H. K., Kim E. O., Lee S. J., Chang Y. K., Suh K. S., Yang C. W., Kim S. Y., Hwang H.S. Rifampin-associated tubulointersititial nephritis and Fanconi syndrome presenting as hypokalemic paralysis. BMC Nephrol. 2013;14:13. https://doi.org/10.1186/1471-2369-14-13.Min H. K., Kim E. O., Lee S. J., Chang Y. K., Suh K. S., Yang C. W., Kim S. Y., Hwang H.S. Rifampin-associated tubulointersititial nephritis and Fanconi syndrome presenting as hypokalemic paralysis. BMC Nephrol. 2013;14:13. https://doi.org/10.1186/1471-2369-14-13.Tolman K. G., Jubiz W., Sannella J. J., Madsen J. A., Belsey R. E., Goldsmith R. S. et al. Osteomalacia associated with anticonvulsant drug therapy in mentally retarded children. Pediatrics. 1975; 56:45-50.Tolman K. G., Jubiz W., Sannella J. J., Madsen J. A., Belsey R. E., Goldsmith R. S. et al. Osteomalacia associated with anticonvulsant drug therapy in mentally retarded children. Pediatrics. 1975; 56:45-50.Heidari R., Jafari F., Khodaei F., Shirazi Yeganeh B., Niknahad H. Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney: valproic acid-induced Fanconi syndrome. Nephrology. 2018;23(4):351-61. https://doi.org/10.1111/nep.13012.Heidari R., Jafari F., Khodaei F., Shirazi Yeganeh B., Niknahad H. Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney: valproic acid-induced Fanconi syndrome. Nephrology. 2018;23(4):351-61. https://doi.org/10.1111/nep.13012.Ono H. Sodium valproate-induced Fanconi syndrome in two severely disabled patients receiving carnitine supplementation. Clin Exp Nephrol. 2019;148-149. https://doi.org/10.1007/s10157-018-1581-3.Ono H. Sodium valproate-induced Fanconi syndrome in two severely disabled patients receiving carnitine supplementation. Clin Exp Nephrol. 2019;148-149. https://doi.org/10.1007/s10157-018-1581-3.Hu C. Y., Lee B. J., Cheng H. F., Wang C. Y. Acetazolamide-related life-threatening hypophosphatemia in a glaucoma patient. J Glaucoma. 2015;24(4): e31-3. https://doi.org/10.1097/ijg.0000000000000185.Hu C. Y., Lee B. J., Cheng H. F., Wang C. Y. Acetazolamide-related life-threatening hypophosphatemia in a glaucoma patient. J Glaucoma. 2015;24(4): e31-3. https://doi.org/10.1097/ijg.0000000000000185.Itescu S., Haskell L. P., Tannenberg A. M. Thiazide-induced clinically significant hypophosphatemia. Clin Nephrol. 1987;27(3):161-2.Itescu S., Haskell L. P., Tannenberg A. M. Thiazide-induced clinically significant hypophosphatemia. Clin Nephrol. 1987;27(3):161-2.Plante G. E., Lafreniere M. C., Tam P. T., Sirois P. Effect of indapamide on phosphate metabolism and vascular reactivity. Am J Med 1988;84:26-30.Plante G. E., Lafreniere M. C., Tam P. T., Sirois P. Effect of indapamide on phosphate metabolism and vascular reactivity. Am J Med 1988;84:26-30.Milionis H. J., Alexandrides G. E., Liberopoulos E. N., Bairaktari E. T., Goudevenos J., Elisaf M. S. Hypomagnesemia and concurrent acid-base and electrolyte abnormalities in patients with congestive heart failure. Eur J Heart Fail. 2002; 4:167-73. https://doi.org/10.1016/S1388-9842(01)00234-3.Milionis H. J., Alexandrides G. E., Liberopoulos E. N., Bairaktari E. T., Goudevenos J., Elisaf M. S. Hypomagnesemia and concurrent acid-base and electrolyte abnormalities in patients with congestive heart failure. Eur J Heart Fail. 2002; 4:167-73. https://doi.org/10.1016/S1388-9842(01)00234-3.Donhowe J. M., Freier E. F., Wong E. T., Steffes M. W. Factitious hypophosphatemia related to mannitol therapy. Clin Chem. 1981;27(/0):1765-9.Donhowe J. M., Freier E. F., Wong E. T., Steffes M. W. Factitious hypophosphatemia related to mannitol therapy. Clin Chem. 1981;27(/0):1765-9.Eisenbrey A. B., Mathew R., Kiechle F. L. Mannitol interference in an automated serum phosphate assay. Clin Chem. 1987;33(12):2308-9.Eisenbrey A. B., Mathew R., Kiechle F. L. Mannitol interference in an automated serum phosphate assay. Clin Chem. 1987;33(12):2308-9.Mechanick J. I., Liu K., Nierman D. M., Stein A. Effect of a convenient single 90-mg pamidronate dose on biochemical markers of bone metabolism in patients with acute spinal cord injury. J Spinal Cord Med. 2006; 29:406-12. https://doi.org/10.1080/10790268.2006.11753890.Mechanick J. I., Liu K., Nierman D. M., Stein A. Effect of a convenient single 90-mg pamidronate dose on biochemical markers of bone metabolism in patients with acute spinal cord injury. J Spinal Cord Med. 2006; 29:406-12. https://doi.org/10.1080/10790268.2006.11753890.Body J. J., Lortholary A., Romieu G., Vigneron A. M., Ford J. A dose-finding study of zoledronate in hypercalcemic cancer patients. J Bone Miner Res 1999; 14:1557-61. https://doi.org/10.1359/jbmr.1999.14.9.1557.Body J. J., Lortholary A., Romieu G., Vigneron A. M., Ford J. A dose-finding study of zoledronate in hypercalcemic cancer patients. J Bone Miner Res 1999; 14:1557-61. https://doi.org/10.1359/jbmr.1999.14.9.1557.Faroqui S., Levi M., Soleimani M., Amlal H. Estrogen downregu-lates the proximal tubule type Ila sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. Kidney Int. 2008;73(/0):1141-50. https://doi.org/10.1038/ki.2008.33.Faroqui S., Levi M., Soleimani M., Amlal H. Estrogen downregu-lates the proximal tubule type Ila sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. Kidney Int. 2008;73(/0):1141-50. https://doi.org/10.1038/ki.2008.33.Bech A. P., Hoorn E. J., Zietse R., Wetzels J. F. M., Nijenhuis T. Yield of diagnostic tests in unexplained renal hypophosphatemia: a case series. BMC Nephrol. 2018;19(1):220. https://doi.org/10.1186/s12882-018-1017-z.Bech A. P., Hoorn E. J., Zietse R., Wetzels J. F. M., Nijenhuis T. Yield of diagnostic tests in unexplained renal hypophosphatemia: a case series. BMC Nephrol. 2018;19(1):220. https://doi.org/10.1186/s12882-018-1017-z.Aitken J. M., Hart D. M., Smith D. A. The effect of long-term mes-tranol administration on calcium and phosphorus homeosta-sis in oophorectomized women. Clin Sci. 1971; 41:233-6. https://doi.org/10.1042/cs0410233.Aitken J. M., Hart D. M., Smith D. A. The effect of long-term mes-tranol administration on calcium and phosphorus homeosta-sis in oophorectomized women. Clin Sci. 1971; 41:233-6. https://doi.org/10.1042/cs0410233.Song L. Calcium and Bone Metabolism Indices. Adv Clin Chem. 2017;82:1-46. https://doi.org/10.1016/bs.acc.2017.06.005.Song L. Calcium and Bone Metabolism Indices. Adv Clin Chem. 2017;82:1-46. https://doi.org/10.1016/bs.acc.2017.06.005.Body J. J., Cryer P. E., Offord K. P., Heath H. 3rd. Epinephrine is a hypophosphatemic hormone in man. Physiological effects of circulating epinephrine on plasma calcium, magnesium, phosphorus, parathyroid hormone, and calcitonin. J Clin Invest. 1983; 71:572-8. https://doi.org/10.1172/jci110802.Body J. J., Cryer P. E., Offord K. P., Heath H. 3rd. Epinephrine is a hypophosphatemic hormone in man. Physiological effects of circulating epinephrine on plasma calcium, magnesium, phosphorus, parathyroid hormone, and calcitonin. J Clin Invest. 1983; 71:572-8. https://doi.org/10.1172/jci110802.Santana e Meneses J. F., Leite H. P., de Carvalho W. B., Lopes E. Jr. Hypophosphatemia in critically ill children: prevalence and associated risk factors. Pediatr Crit Care Med. 2009; 10:234-8. https://doi.org/10.1097/pcc.0b0/3e318/937042.Santana e Meneses J. F., Leite H. P., de Carvalho W. B., Lopes E. Jr. Hypophosphatemia in critically ill children: prevalence and associated risk factors. Pediatr Crit Care Med. 2009; 10:234-8. https://doi.org/10.1097/pcc.0b0/3e318/937042.Arroliga A. C., Guntupalli K. K., Beaver J. S., Langholff W., Marino K., Kelly K. Pharmacokinetics and pharmacodynamics of six epoetin alfa dosing regimens in anemic critically ill patients without acute blood loss. Crit Care Med. 2009;37(4):1299-307. https://doi.org/10.1097/ccm.0b013e31819cec94.Arroliga A. C., Guntupalli K. K., Beaver J. S., Langholff W., Marino K., Kelly K. Pharmacokinetics and pharmacodynamics of six epoetin alfa dosing regimens in anemic critically ill patients without acute blood loss. Crit Care Med. 2009;37(4):1299-307. https://doi.org/10.1097/ccm.0b013e31819cec94.Hajime M., Okada Y., Mor H., Tanaka Y. A case of teriparatide-induced severe hypophosphatemia and hypercalcemia. J Bone MinerMetab. 20/4;32(5):601-4. https://doi.org/10.1007/s00774-014-0564-z.Hajime M., Okada Y., Mor H., Tanaka Y. A case of teriparatide-induced severe hypophosphatemia and hypercalcemia. J Bone MinerMetab. 20/4;32(5):601-4. https://doi.org/10.1007/s00774-014-0564-z.Andrade L., Reboucas N. A., Seguro A. C. Down-regulation of Na+ transporters and AQP2 is responsible for acyclovir- induced polyuria and hypophosphatemia. Kidney Int. 2004; 65:175-83. https://doi.org/10.1111/j.1523-1755.2004.00359.x.Andrade L., Reboucas N. A., Seguro A. C. Down-regulation of Na+ transporters and AQP2 is responsible for acyclovir- induced polyuria and hypophosphatemia. Kidney Int. 2004; 65:175-83. https://doi.org/10.1111/j.1523-1755.2004.00359.x.Monteiro J. L., De Castro I., Seguro A. C. Hypophosphatemia induced by acyclovir. Transplantation. 1993; 55:680-2.Monteiro J. L., De Castro I., Seguro A. C. Hypophosphatemia induced by acyclovir. Transplantation. 1993; 55:680-2.Kahn J., Lagakos S., Wufsohn M., Cherng D., Miller M., Cherrington J. et al. Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial. JAMA. 1999; 282:2305-12. https://doi.org/10.1001/jama.282.24.2305.Kahn J., Lagakos S., Wufsohn M., Cherng D., Miller M., Cherrington J. et al. Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial. JAMA. 1999; 282:2305-12. https://doi.org/10.1001/jama.282.24.2305.Cheng C.-Y., Chang S.-Y., Lin M.-H., Ku S.-Y., Sun N.-L., Cheng S.-H. Tenofovir disoproxil fumarate-associated hypophosphatemia as determined by fractional excretion of filtered phosphate in HIV- infected patients. J Infect Chemother. 2016;22(11):744-7. https://doi.org/10.1016/j.jiac.2016.08.008.Cheng C.-Y., Chang S.-Y., Lin M.-H., Ku S.-Y., Sun N.-L., Cheng S.-H. Tenofovir disoproxil fumarate-associated hypophosphatemia as determined by fractional excretion of filtered phosphate in HIV- infected patients. J Infect Chemother. 2016;22(11):744-7. https://doi.org/10.1016/j.jiac.2016.08.008.Saeedi R., Jiang S. Y., Holmes D. T., Kendler D. L. Fibroblast growth factor23 is elevated in tenofovir-related hypophosphatemia. Cal- cif Tissue Int. 2014;94(6):665-8. https://doi.org/10.1007/s00223-014-9854-7.Saeedi R., Jiang S. Y., Holmes D. T., Kendler D. L. Fibroblast growth factor23 is elevated in tenofovir-related hypophosphatemia. Cal- cif Tissue Int. 2014;94(6):665-8. https://doi.org/10.1007/s00223-014-9854-7.Prince R. L., Monk K. J., Kent G. N., Dick I., Thompson P. J. Effects of theophylline and salbutamol on phosphate and calcium metabolism in normal subjects. Miner Electrolyte Metab. 1988;14(5):262-5.Prince R. L., Monk K. J., Kent G. N., Dick I., Thompson P. J. Effects of theophylline and salbutamol on phosphate and calcium metabolism in normal subjects. Miner Electrolyte Metab. 1988;14(5):262-5.Raschka C., Koch H. J. Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage. Hum Exp Toxicol 1999; 18:738-9. https://doi.org/10.1191/096032799678839662.Raschka C., Koch H. J. Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage. Hum Exp Toxicol 1999; 18:738-9. https://doi.org/10.1191/096032799678839662.WebsterR., Sheriff S., Faroqui R., SiddiquiF., Hawse J. R., Amlal H. Klotho/fibroblast growth facter23- and pTH-independent estrogen receptor-alpha-mediated direct downreguation of naPi-IIa by estrogen in the mouse kidney. Am J Physiol Renal Physiol. 20/6;3//: F249-59. https://doi.org/10.1152%2Fajprenal.00542.2015.WebsterR., Sheriff S., Faroqui R., SiddiquiF., Hawse J. R., Amlal H. Klotho/fibroblast growth facter23- and pTH-independent estrogen receptor-alpha-mediated direct downreguation of naPi-IIa by estrogen in the mouse kidney. Am J Physiol Renal Physiol. 20/6;3//: F249-59. https://doi.org/10.1152%2Fajprenal.00542.2015.Schacht R. G., Feiner H. D., Gallo G. R., Lieberman A., Baldwin D. S. Nephrotoxicity of nitrosoureas. Cancer. 1981;48:1328-34. https://doi.org/10.1002/1097-0142(19810915)48:6%3C1328::AID-CNCR2820480613%3E3.0.CO;2-N.Schacht R. G., Feiner H. D., Gallo G. R., Lieberman A., Baldwin D. S. Nephrotoxicity of nitrosoureas. Cancer. 1981;48:1328-34. https://doi.org/10.1002/1097-0142(19810915)48:6%3C1328::AID-CNCR2820480613%3E3.0.CO;2-N.Peterson B. A., Collins A. J., Vogelzang N. J., Bloomfield C. D. 5- Azacytidine and renal tubular dysfunction. Blood. 1981;57:182-5.Peterson B. A., Collins A. J., Vogelzang N. J., Bloomfield C. D. 5- Azacytidine and renal tubular dysfunction. Blood. 1981;57:182-5.Abdelall W., Kantarjian H. M., Borthakur G., Garcia-Manero G., Patel K. P., Jabbour E. J. et al. The combination of quizartinib with azacitidine or low dose cytarabine is highly active in patients (Pts) with FLT3-ITD mutated myeloid leukemias: interim report of a phase I/II trial. Blood. 2006;/28:1642.Abdelall W., Kantarjian H. M., Borthakur G., Garcia-Manero G., Patel K. P., Jabbour E. J. et al. The combination of quizartinib with azacitidine or low dose cytarabine is highly active in patients (Pts) with FLT3-ITD mutated myeloid leukemias: interim report of a phase I/II trial. Blood. 2006;/28:1642.Morgan R. J., Synold T. W., Longmate J. A., Quinn D. I., Gandara D., Lenz H. J. et al. Pharmacodynamics (PD) and pharmacokinetics (PK) of e7389(eribulin, halicondrin b analog) during a phase i trial in patients with advanced solid tumors: a california cancer consortium trial. Cancer Chemother Pharmacol. 2015;76:897-907. https://doi.org/10.1007/s00280-015-2868-7.Morgan R. J., Synold T. W., Longmate J. A., Quinn D. I., Gandara D., Lenz H. J. et al. Pharmacodynamics (PD) and pharmacokinetics (PK) of e7389(eribulin, halicondrin b analog) during a phase i trial in patients with advanced solid tumors: a california cancer consortium trial. Cancer Chemother Pharmacol. 2015;76:897-907. https://doi.org/10.1007/s00280-015-2868-7.Evans T. R. J., Dean E., Molife L. R., Lopez J.., Malcom R, Fatima E. K. et al. Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomal formulation in patients with solid tumours. Br J Cancer. 2019;120:379-86. https://doi.org/10.1038%2Fs41416-019-0377-x.Evans T. R. J., Dean E., Molife L. R., Lopez J.., Malcom R, Fatima E. K. et al. Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomal formulation in patients with solid tumours. Br J Cancer. 2019;120:379-86. https://doi.org/10.1038%2Fs41416-019-0377-x.Kawamura H., Tanaka S., Uenami Y., Tani M., Ishitani M., Morii S. et al. Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats. J Med Investig. 2018;65:50-5. https://doi.org/10.2152/jmi.65.50.Kawamura H., Tanaka S., Uenami Y., Tani M., Ishitani M., Morii S. et al. Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats. J Med Investig. 2018;65:50-5. https://doi.org/10.2152/jmi.65.50.Rasmussen A. Hypophosphatemia during postoperative glucose infusion. Acta ChirScand. 1985;15/(6):497-500.Rasmussen A. Hypophosphatemia during postoperative glucose infusion. Acta ChirScand. 1985;15/(6):497-500.Bode J. C., Zelder O., Rumpelt H. J., Wittkamp U. Depletion of liver adenosine phosphates and metabolic effects of intrave-nous infusion of fructose or sorbitol in man and in the rat. Eur J Clin Investig. /973;3(5):436-4/. https://doi.org/10.1111/j.1365-2362.1973.tb02211.x.Bode J. C., Zelder O., Rumpelt H. J., Wittkamp U. Depletion of liver adenosine phosphates and metabolic effects of intrave-nous infusion of fructose or sorbitol in man and in the rat. Eur J Clin Investig. /973;3(5):436-4/. https://doi.org/10.1111/j.1365-2362.1973.tb02211.x.Liamis G., Filippatos T. D., Elisaf M. S. Correction of hypovolemia with crystalloid fluids: individualizing infusion therapy. Postgrad Med. 2015;127(4):405-12. https://doi.org/10.1080/00325481.2015.1029421.Liamis G., Filippatos T. D., Elisaf M. S. Correction of hypovolemia with crystalloid fluids: individualizing infusion therapy. Postgrad Med. 2015;127(4):405-12. https://doi.org/10.1080/00325481.2015.1029421.Kawamura H., Tanaka S., Uenami Y., Tani M., Ishitani M., Morii S. et al. Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats. J Med Investig. 20/8;65(/.2):50-5. https://doi.org/10.2152/jmi.65.50.Kawamura H., Tanaka S., Uenami Y., Tani M., Ishitani M., Morii S. et al. Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats. J Med Investig. 20/8;65(/.2):50-5. https://doi.org/10.2152/jmi.65.50.Windpessl M., Mayrbaeurl B., Baldinger C., Tiefenthaller G.., Prischl F. C., Wallner M. et al. Refeeding syndrome in oncology: report of four cases. World J Oncol. 2017;8(1):25-9. https://doi.org/10.14740/wjon1007w.Windpessl M., Mayrbaeurl B., Baldinger C., Tiefenthaller G.., Prischl F. C., Wallner M. et al. Refeeding syndrome in oncology: report of four cases. World J Oncol. 2017;8(1):25-9. https://doi.org/10.14740/wjon1007w.San E. S., Erdogan S., Bosnak M., San M. Hypophosphatemia associated risk factors in pediatric intensive care patients. Turk J Pediatr. 2017;59(1):35. https://doi.org/10.24953/turkjped.2017.01.006.San E. S., Erdogan S., Bosnak M., San M. Hypophosphatemia associated risk factors in pediatric intensive care patients. Turk J Pediatr. 2017;59(1):35. https://doi.org/10.24953/turkjped.2017.01.006.Marinella M. A. Re feeding syndrome: an important aspect of supportive oncology. J Support Oncol. 2009;7(1):11-6.Marinella M. A. Re feeding syndrome: an important aspect of supportive oncology. J Support Oncol. 2009;7(1):11-6.Fuentes E., Yeh D. D., Quraishi S. A., Johnson E. A., Kaafarani H., Lee J. et al. Hypophosphatemia in enterally fed patients in the surgical intensive care unit. NutrClin Pract. 20/7;32(2):252-7. https://doi.org/10.1177/0884533616662988.Fuentes E., Yeh D. D., Quraishi S. A., Johnson E. A., Kaafarani H., Lee J. et al. Hypophosphatemia in enterally fed patients in the surgical intensive care unit. NutrClin Pract. 20/7;32(2):252-7. https://doi.org/10.1177/0884533616662988.Kraft M. D., Btaiche I. F., Sacks G. S., Kudsk K.A. Treatment of electrolyte disorders in adult patients in the intensive care unit. Am J Health Syst Pharm. 2005;62(16):1663-82. https://doi.org/10.2146/ajhp040300.Kraft M. D., Btaiche I. F., Sacks G. S., Kudsk K.A. Treatment of electrolyte disorders in adult patients in the intensive care unit. Am J Health Syst Pharm. 2005;62(16):1663-82. https://doi.org/10.2146/ajhp040300.Tsimberidou A. M., O’Brien S. M., Cortes J. E., Fader S., Andreeff M., Kantarjian H. M. et al. Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter’s syndrome or refractory lymphoproliferative disorders. Leuk Lymphoma. 2002;43(4):767-72. https://doi.org/10.1080/10428190290016872.Tsimberidou A. M., O’Brien S. M., Cortes J. E., Fader S., Andreeff M., Kantarjian H. M. et al. Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter’s syndrome or refractory lymphoproliferative disorders. Leuk Lymphoma. 2002;43(4):767-72. https://doi.org/10.1080/10428190290016872.Wolf M., Chertow G. M., Macdougall I. C., Kaper R., Krop J., Strauss W. Randomized trial of intravenous iron-induced hypophosphatemia. JCI Insight. 2018;3(23): e/24486. https://doi.org/10.1172/jci.insight.124486Wolf M., Chertow G. M., Macdougall I. C., Kaper R., Krop J., Strauss W. Randomized trial of intravenous iron-induced hypophosphatemia. JCI Insight. 2018;3(23): e/24486. https://doi.org/10.1172/jci.insight.124486Dawson D. J., Babbs C., Warnes T. W., Neary R. H. Hypophosphataemia in acute liver failure. Br Med J (Clin Res Ed). 1987;295:1312-3. https://doi.org/10.1136/bmj.295.6609.1312.Dawson D. J., Babbs C., Warnes T. W., Neary R. H. Hypophosphataemia in acute liver failure. Br Med J (Clin Res Ed). 1987;295:1312-3. https://doi.org/10.1136/bmj.295.6609.1312.Jones A. F., Harvey J. M., Vale J. A. Hypophosphataemia and phosphaturia in paracetamol poisoning. Lancet. 1989;2:608-9. https://doi.org/10.1016/s0140-6736(89)90724-1.Jones A. F., Harvey J. M., Vale J. A. Hypophosphataemia and phosphaturia in paracetamol poisoning. Lancet. 1989;2:608-9. https://doi.org/10.1016/s0140-6736(89)90724-1.Florkowski C. M., Jones A. F., Guy J. M., Husband D. J., Stevens J. Retinol binding proteinuria and phosphaturia: markers of paracetamol-induced nephrotoxicity. Ann Clin Biochem. 1994;31:331-4. https://doi.org/10.1177%2F000456329403100404.Florkowski C. M., Jones A. F., Guy J. M., Husband D. J., Stevens J. Retinol binding proteinuria and phosphaturia: markers of paracetamol-induced nephrotoxicity. Ann Clin Biochem. 1994;31:331-4. https://doi.org/10.1177%2F000456329403100404.Wolansky L. J., Cadavid D., Punia V., Kim S., Cheriyan J., Haghighi M. et al. Hypophosphatemia is associated with the serial administration of triple-dose gadolinium to patients for brain MRI: hypophosphatemia from serial, 3-dose gadolinium. J Neuroimaging. 2015;25(3):379-83. https://doi.org/10.1111/jon.12241.Wolansky L. J., Cadavid D., Punia V., Kim S., Cheriyan J., Haghighi M. et al. Hypophosphatemia is associated with the serial administration of triple-dose gadolinium to patients for brain MRI: hypophosphatemia from serial, 3-dose gadolinium. J Neuroimaging. 2015;25(3):379-83. https://doi.org/10.1111/jon.12241.Gaasbeek A., Meinders A. E. Hypophosphatemia: an update on its etiology and treatment. Am J Med. 2005;118(W):1094-101. https://doi.org/10.1016/j.amjmed.2005.02.014.Gaasbeek A., Meinders A. E. Hypophosphatemia: an update on its etiology and treatment. Am J Med. 2005;118(W):1094-101. https://doi.org/10.1016/j.amjmed.2005.02.014.Maccubbin D., Tipping D., Kuznetsova O., Hanlon W. A., Bos- tom A. G. Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial. Clin J Am Soc Nephrol. 2010;5(4):582-9. https://doi.org/10.2215/cjn.07341009.Maccubbin D., Tipping D., Kuznetsova O., Hanlon W. A., Bos- tom A. G. Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial. Clin J Am Soc Nephrol. 2010;5(4):582-9. https://doi.org/10.2215/cjn.07341009.Ginsberg C., Ix J. H. Nicotinamide and phosphate homeostasis in chronic kidney disease. CurrOpin Nephrol Hypertens. 2016;25(4):285-91. https://doi.org/10.1097/mnh.0000000000000236.Ginsberg C., Ix J. H. Nicotinamide and phosphate homeostasis in chronic kidney disease. CurrOpin Nephrol Hypertens. 2016;25(4):285-91. https://doi.org/10.1097/mnh.0000000000000236.Edalat-Nejad M., Zameni F., Talaiei A. The effect of niacin on serum phosphorus levels in dialysis patients. Indian J Nephrol. 2012;22(3):174-178. https://dx.doi.org/10.4103%2F0971-4065.98751.Edalat-Nejad M., Zameni F., Talaiei A. The effect of niacin on serum phosphorus levels in dialysis patients. Indian J Nephrol. 2012;22(3):174-178. https://dx.doi.org/10.4103%2F0971-4065.98751.Yasmeen G., Dawani M. L., Mahboob T. Hypophosphatemic effect of niacin extended release in ischemic kidney disease. EXCLI J. 2015 Oct 14;14:1095-103. https://doi.org/10.17179/excli2015-537.Yasmeen G., Dawani M. L., Mahboob T. Hypophosphatemic effect of niacin extended release in ischemic kidney disease. EXCLI J. 2015 Oct 14;14:1095-103. https://doi.org/10.17179/excli2015-537.Choi N.-W. Kidney and phosphate metabolism. Electrolyte Blood Press. 2008; 6(2):77-85.Choi N.-W. Kidney and phosphate metabolism. Electrolyte Blood Press. 2008; 6(2):77-85.LjunghallS., Joborn H., Rastad J., Akerstrom G. Plasma potassium and phosphate concentrations-influence by adrenaline infusion, beta-blockade and physical exercise. Acta MedScand 1987;221:83-93. https://doi.org/10.1111/j.0954-6820.1987.tb01248.x.LjunghallS., Joborn H., Rastad J., Akerstrom G. Plasma potassium and phosphate concentrations-influence by adrenaline infusion, beta-blockade and physical exercise. Acta MedScand 1987;221:83-93. https://doi.org/10.1111/j.0954-6820.1987.tb01248.x.Buell J. F., Berger A. C., Plotkin J. S., Kuo P. C., Johnson L. B. The clinical implications of hypophosphatemia following major hepatic resection or cryosurgery. Arch Surg 1998; 133:757-61. https://doi.org/10.1001/archsurg.133.7.757.Buell J. F., Berger A. C., Plotkin J. S., Kuo P. C., Johnson L. B. The clinical implications of hypophosphatemia following major hepatic resection or cryosurgery. Arch Surg 1998; 133:757-61. https://doi.org/10.1001/archsurg.133.7.757.Crook M. A. Hypophosphataemia and hypokalaemia in patients with hypomagnesaemia. Br J Biomed Sci. 1994;51(1):24-7.Crook M. A. Hypophosphataemia and hypokalaemia in patients with hypomagnesaemia. Br J Biomed Sci. 1994;51(1):24-7.Liamis G., Liberopoulos E., Alexandridis G., Elisaf M. Hypomagnesemia in a department of internal medicine. Magnes Res. 2012;25(4):149-58. https://doi.org/10.1684/mrh.2012.0325.Liamis G., Liberopoulos E., Alexandridis G., Elisaf M. Hypomagnesemia in a department of internal medicine. Magnes Res. 2012;25(4):149-58. https://doi.org/10.1684/mrh.2012.0325.Liamis G., Liberopoulos E., Barkas F., Elisaf M. Diabe- tes mellitus and electrolyte disorders. World J Clin Cases. 2014;16(2):488-96. http://dx.doi.org/10.12998/wjcc.v2.i10.488Liamis G., Liberopoulos E., Barkas F., Elisaf M. Diabe- tes mellitus and electrolyte disorders. World J Clin Cases. 2014;16(2):488-96. http://dx.doi.org/10.12998/wjcc.v2.i10.488Izzedine H., Launay-Vacher V., Isnard-Bagnis C., Deray G. Drug-induced Fanconi’s syndrome. Am J Kidney Dis. 2003;41(2):292-309. https://doi.org/10.1053/ajkd.2003.50037.Izzedine H., Launay-Vacher V., Isnard-Bagnis C., Deray G. Drug-induced Fanconi’s syndrome. Am J Kidney Dis. 2003;41(2):292-309. https://doi.org/10.1053/ajkd.2003.50037.Liamis G., Milionis H. J., Elisaf M. Pharmacologically-induced metabolic acidosis: a review. Drug Saf. 2010;33(5):371-91.Liamis G., Milionis H. J., Elisaf M. Pharmacologically-induced metabolic acidosis: a review. Drug Saf. 2010;33(5):371-91.Tejeda A., Saffarian N., Uday K., Dave M. Hypophosphatemia in end stage renal disease. Nephron 1996; 73:674-8. https://doi.org/10.2165/11533790-000000000-00000.Tejeda A., Saffarian N., Uday K., Dave M. Hypophosphatemia in end stage renal disease. Nephron 1996; 73:674-8. https://doi.org/10.2165/11533790-000000000-00000.AubierM., Murciano D., Lecocguic Y., Viires N., Jacquens Y., Squara P., Pariente R.: Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. N Engl J Med. 1985; 313:420-424. https://doi.org/10.1056/nejm198508153130705.AubierM., Murciano D., Lecocguic Y., Viires N., Jacquens Y., Squara P., Pariente R.: Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. N Engl J Med. 1985; 313:420-424. https://doi.org/10.1056/nejm198508153130705.Gravelyn T. R., Brophy N., Siegert C., Peters-Golden M.: Hypophosphatemia- associated respiratory muscle weakness in a general inpatient population. Am J Med. 1988; 84:870-876. https://doi.org/10.1016/0002-9343(88)90065-4.Gravelyn T. R., Brophy N., Siegert C., Peters-Golden M.: Hypophosphatemia- associated respiratory muscle weakness in a general inpatient population. Am J Med. 1988; 84:870-876. https://doi.org/10.1016/0002-9343(88)90065-4.O’Connor L.R., Wheeler W.S., Bethune J. E.: Effect of hypophosphatemia on myocardial performance in man. N Engl J Med 1977;297:901-903. https://doi.org/10.1056/nejm197710272971702.O’Connor L.R., Wheeler W.S., Bethune J. E.: Effect of hypophosphatemia on myocardial performance in man. N Engl J Med 1977;297:901-903. https://doi.org/10.1056/nejm197710272971702.Brautbar N., Baczynski R., Carpenter C., Massry S. G.: Effects of phosphate depletion on the myocardium. Adv Exp Med Biol. 1982;151:199-207. https://doi.org/10.1007/978-1-4684-4259-5_26.Brautbar N., Baczynski R., Carpenter C., Massry S. G.: Effects of phosphate depletion on the myocardium. Adv Exp Med Biol. 1982;151:199-207. https://doi.org/10.1007/978-1-4684-4259-5_26.Cohen J., Kogan A., Sahar G., Lev S., Vidne B., Singer P.: Hypophosphatemia following open heart surgery: incidence and consequences. Eur J Cardiothorac Surg. 2004;26:306-310. https://doi.org/10.1016/j.ejcts.2004.03.004.Cohen J., Kogan A., Sahar G., Lev S., Vidne B., Singer P.: Hypophosphatemia following open heart surgery: incidence and consequences. Eur J Cardiothorac Surg. 2004;26:306-310. https://doi.org/10.1016/j.ejcts.2004.03.004.Ognibene A., Ciniglio R., Greifenstein A., Jarjoura D., Cugino A., Blend D., Whittier F.: Ventricular tachycardia in acute myocardial infarction: the role of hypophosphatemia. South Med J. 1994;87:65-69. https://doi.org/10.1097/00007611-199401000-00014.Ognibene A., Ciniglio R., Greifenstein A., Jarjoura D., Cugino A., Blend D., Whittier F.: Ventricular tachycardia in acute myocardial infarction: the role of hypophosphatemia. South Med J. 1994;87:65-69. https://doi.org/10.1097/00007611-199401000-00014.Jacob H. S., Amsden T.: Acute hemolytic anemia with rigid red cells in hypophosphatemia. N Engl J Med 1971;285:1446-1450. https://doi.org/10.1056/nejm197112232852602.Jacob H. S., Amsden T.: Acute hemolytic anemia with rigid red cells in hypophosphatemia. N Engl J Med 1971;285:1446-1450. https://doi.org/10.1056/nejm197112232852602.Melvin J.D., Watts R. G.: Severe hypophosphatemia: a rare cause of intravascular hemolysis. Am J Hematol2002;69:223-224. https://doi.org/10.1002/ajh.10071.Melvin J.D., Watts R. G.: Severe hypophosphatemia: a rare cause of intravascular hemolysis. Am J Hematol2002;69:223-224. https://doi.org/10.1002/ajh.10071.Rasmussen A., Segel E., Hessov I., Borregaard N.: Reduced function of neutrophils during routine postoperative glucose infusion. Acta ChirScand 1988;154:429-433.Rasmussen A., Segel E., Hessov I., Borregaard N.: Reduced function of neutrophils during routine postoperative glucose infusion. Acta ChirScand 1988;154:429-433.Ravenscroft A. J., Valentine J. M., Knappett P. A.: Severe hypophosphataemia and insulin resistance in diabetic ketoacidosis. Anaesthesia 1999; 54:198. https://doi.org/10.1046/j.1365-2044.1999.00783.x.Ravenscroft A. J., Valentine J. M., Knappett P. A.: Severe hypophosphataemia and insulin resistance in diabetic ketoacidosis. Anaesthesia 1999; 54:198. https://doi.org/10.1046/j.1365-2044.1999.00783.x.Singhal P. C., Kumar A., Desroches L.., Gibbons N, Mattana J.: Prevalence and predictors of rhabdomyolysis in patients with hypophosphatemia. Am J Med 1992;92:458-464. https://doi.org/10.1016/0002-9343(92)90740-3.Singhal P. C., Kumar A., Desroches L.., Gibbons N, Mattana J.: Prevalence and predictors of rhabdomyolysis in patients with hypophosphatemia. Am J Med 1992;92:458-464. https://doi.org/10.1016/0002-9343(92)90740-3.Knochel J. P., Barcenas C., Cotton J. R., Fuller T. J., Haller R., Carter N. W.: Hypophosphatemia and rhabdomyolysis. J Clin Invest 1978;62:1240-1246. https://doi.org/10.1172%2FJCI109244.Knochel J. P., Barcenas C., Cotton J. R., Fuller T. J., Haller R., Carter N. W.: Hypophosphatemia and rhabdomyolysis. J Clin Invest 1978;62:1240-1246. https://doi.org/10.1172%2FJCI109244.Michell A. W., Burn D. J., Reading P. J.: Central pontine myelinolysis temporally related to hypophosphataemia. J Neurol Neurosurg Psychiatry 2003;74:820. https://doi.org/10.1136/jnnp.74.6.820.Michell A. W., Burn D. J., Reading P. J.: Central pontine myelinolysis temporally related to hypophosphataemia. J Neurol Neurosurg Psychiatry 2003;74:820. https://doi.org/10.1136/jnnp.74.6.820.Falcone N., Compagnoni A., Meschini C., Perrone C., Nappo A.: Central pontine myelinolysis induced by hypophosphatemia following Wernicke’s encephalopathy. Neurol Sci 2004;24:407-410. https://doi.org/10.1007/s10072-003-0197-9.Falcone N., Compagnoni A., Meschini C., Perrone C., Nappo A.: Central pontine myelinolysis induced by hypophosphatemia following Wernicke’s encephalopathy. Neurol Sci 2004;24:407-410. https://doi.org/10.1007/s10072-003-0197-9.Shor R., Halabe A., Rishver S., Tilis Y., Matas Z., Fux A., Boaz M., Weinstein J.: Severe hypophosphatemia in sepsis as a mortality predictor. Ann Clin Lab Sci 2006, 36:67-72.Shor R., Halabe A., Rishver S., Tilis Y., Matas Z., Fux A., Boaz M., Weinstein J.: Severe hypophosphatemia in sepsis as a mortality predictor. Ann Clin Lab Sci 2006, 36:67-72.Cohen J., Kogan A., Sahar G., Lev S., Vidne B., Singer P.: Hypophosphatemia following open heart surgery: incidence and consequences. Eur J Cardiothorac Surg 2004, 26:306-310.Cohen J., Kogan A., Sahar G., Lev S., Vidne B., Singer P.: Hypophosphatemia following open heart surgery: incidence and consequences. Eur J Cardiothorac Surg 2004, 26:306-310.Zazzo J. F., Troche G., Ruel P., Maintenant J.: High incidence of hypophosphatemia in surgical intensive care patients: efficacy of phosphorus therapy on myocardial function. Intensive Care Med 1995;21:826-831. https://doi.org/10.1016/j.ejc.2004.03.004.Zazzo J. F., Troche G., Ruel P., Maintenant J.: High incidence of hypophosphatemia in surgical intensive care patients: efficacy of phosphorus therapy on myocardial function. Intensive Care Med 1995;21:826-831. https://doi.org/10.1016/j.ejc.2004.03.004.Hoffmann M., Zemlin A.E, Meyer W. P., Erasmus R. T.: Hypophosphataemia at a large academic hospital in South Africa. J Clin Pathol 2008;61:1104-1107. https://doi.org/10.1136/jcp.2007.054940.Hoffmann M., Zemlin A.E, Meyer W. P., Erasmus R. T.: Hypophosphataemia at a large academic hospital in South Africa. J Clin Pathol 2008;61:1104-1107. https://doi.org/10.1136/jcp.2007.054940.Wilson H. K., Keuer S. P., Lea A. S, Boyd A. E, Eknoyan G.: Phosphate therapy in diabetic ketoacidosis. Arch Intern Med 1982;142:517-520.Wilson H. K., Keuer S. P., Lea A. S, Boyd A. E, Eknoyan G.: Phosphate therapy in diabetic ketoacidosis. Arch Intern Med 1982;142:517-520.Fisher J., Magid N.., Kallman C, Fanucchi M.., Klein L, McCarthy D., Roberts I., Schulman G.: Respiratory illness and hypophosphatemia. Chest 1983;83:504-508. https://doi.org/10.1378/chest.83.3.504.Fisher J., Magid N.., Kallman C, Fanucchi M.., Klein L, McCarthy D., Roberts I., Schulman G.: Respiratory illness and hypophosphatemia. Chest 1983;83:504-508. https://doi.org/10.1378/chest.83.3.504.Woodhead M. A., Macfarlane J. T.: Legionnaires’ disease: a review of 79 community acquired cases in Nottingham. Thorax 1986;41:635-640. https://doi.org/10.1136/thx.41.8.635.Woodhead M. A., Macfarlane J. T.: Legionnaires’ disease: a review of 79 community acquired cases in Nottingham. Thorax 1986;41:635-640. https://doi.org/10.1136/thx.41.8.635.Sankaran R. T., Mattana J., Pollack S., Bhat P., Ahuja T., Patel A., Singhal P. C.: Laboratory abnormalities in patients with bacterial pneumonia. Chest 1997;111:595-600. https://doi.org/10.1378/chest.111.3.595.Sankaran R. T., Mattana J., Pollack S., Bhat P., Ahuja T., Patel A., Singhal P. C.: Laboratory abnormalities in patients with bacterial pneumonia. Chest 1997;111:595-600. https://doi.org/10.1378/chest.111.3.595.Vaidyanathan D.., Venkatesan S, Ramadesikan V. K.: Serum phosphate in acute myocardial infarction. Indian J Physiol Pharmacol2000;44:225-228.Vaidyanathan D.., Venkatesan S, Ramadesikan V. K.: Serum phosphate in acute myocardial infarction. Indian J Physiol Pharmacol2000;44:225-228.Chung P. Y., Sitrin M. D., Te H. S.: Serum phosphorus levels predict clinical outcome in fulminant hepatic failure. Liver Transpl2003;9:248-253. https://doi.org/10.1053/jlts.2003.50053.Chung P. Y., Sitrin M. D., Te H. S.: Serum phosphorus levels predict clinical outcome in fulminant hepatic failure. Liver Transpl2003;9:248-253. https://doi.org/10.1053/jlts.2003.50053.Camp M. A., Allon M. Severe hypophosphatemia in hospitalized patients. Miner Electrolyte Metab 1990; 16:365-8Camp M. A., Allon M. Severe hypophosphatemia in hospitalized patients. Miner Electrolyte Metab 1990; 16:365-8Сычев Д. А., Остроумова О. Д., Переверзев А. П. с соавт. Лекарственноиндуцированные заболевания: подходы к диагностике, коррекции и профилактике. Фармаконадзор. Фарматека. 2020;6:113-126.[Sychev D. A., Ostroumova O. D., Pereverzev A. P. et al. Drug-induced diseases: approaches to diagnosis, correction and prevention. Pharmacovigilance. Farmateka. 2020;27(6):113-126 (In Russ.).] https://dx.doi.org/10.18565/pharmateca.2020.6.113-126.Сычев Д. А., Остроумова О. Д., Переверзев А. П. с соавт. Лекарственноиндуцированные заболевания: подходы к диагностике, коррекции и профилактике. Фармаконадзор. Фарматека. 2020;6:113-126.[Sychev D. A., Ostroumova O. D., Pereverzev A. P. et al. Drug-induced diseases: approaches to diagnosis, correction and prevention. Pharmacovigilance. Farmateka. 2020;27(6):113-126 (In Russ.).] https://dx.doi.org/10.18565/pharmateca.2020.6.113-126.Остроумова О. Д., Близнюк С. А., Кочетков А. И., Комарова А. Г. Лекарственноиндуцированная гемолитическая анемия. Медицинский алфавит. 2021;(1):49-56. [Ostroumova O. D., Bliznyuk S. A., Kochetkov A. I., Komarova A. G. Drug-induced hemolytic anemia. Medical alphabet. 2021;(1):49-56. (In Russ.). https://doi.org/10.33667/2078-5631-2021-1-49-56Остроумова О. Д., Близнюк С. А., Кочетков А. И., Комарова А. Г. Лекарственноиндуцированная гемолитическая анемия. Медицинский алфавит. 2021;(1):49-56. [Ostroumova O. D., Bliznyuk S. A., Kochetkov A. I., Komarova A. G. Drug-induced hemolytic anemia. Medical alphabet. 2021;(1):49-56. (In Russ.). https://doi.org/10.33667/2078-5631-2021-1-49-56Остроумова Т. М., Толмачева В. А., Остроумова О. Д., Парфенов В. А. Лекарственно-индуцированная дистония. Неврология, нейропсихиатрия, психосоматика. 2020;12(5):4-8. [Ostroumova T.M., Tolmacheva V. A., Ostroumova O. D., Parfenov V. A. Drug-induced dystonia. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(5):4-8. (In Russ.)] https://doi.org/10.14412/2074-2711-2020-5-4-8Остроумова Т. М., Толмачева В. А., Остроумова О. Д., Парфенов В. А. Лекарственно-индуцированная дистония. Неврология, нейропсихиатрия, психосоматика. 2020;12(5):4-8. [Ostroumova T.M., Tolmacheva V. A., Ostroumova O. D., Parfenov V. A. Drug-induced dystonia. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(5):4-8. (In Russ.)] https://doi.org/10.14412/2074-2711-2020-5-4-8Остроумова О. Д., Шахова Е. Ю., Кочетков А. И. Лекарственно-индуцированная эозинофилия. Безопасность и риск фармакотерапии. 2019;7(4):176-189. [Ostroumova O. D., Shahova E. Yu., Kochetkov A. I. Drug-Induced Eosinophilia. Safety and Risk of Pharmacotherapy. 2019;7(4):176-189. (In Russ.).] https://doi.org/10.30895/2312-7821-2019-7-4-176-189Остроумова О. Д., Шахова Е. Ю., Кочетков А. И. Лекарственно-индуцированная эозинофилия. Безопасность и риск фармакотерапии. 2019;7(4):176-189. [Ostroumova O. D., Shahova E. Yu., Kochetkov A. I. Drug-Induced Eosinophilia. Safety and Risk of Pharmacotherapy. 2019;7(4):176-189. (In Russ.).] https://doi.org/10.30895/2312-7821-2019-7-4-176-189Остроумова О.Д., Кочетков А. И., Павлеева Е. Е., Кравченко Е. В. Лекарственно-индуцированные нейтропения и агранулоцитоз. Безопасность и риск фармакотерапии. 2020;8(3):109-122. [Ostroumova O. D., Kochetkov A. I., Pavleeva E. E., Kravchenko E. V. Drug-Induced Neutropenia and Agranulocytosis. Safety and Risk of Pharmacotherapy. 2020;8(3):109-122. (In Russ.). https://doi.org/10.30895/2312-7821-2020-8-3-109-122Остроумова О.Д., Кочетков А. И., Павлеева Е. Е., Кравченко Е. В. Лекарственно-индуцированные нейтропения и агранулоцитоз. Безопасность и риск фармакотерапии. 2020;8(3):109-122. [Ostroumova O. D., Kochetkov A. I., Pavleeva E. E., Kravchenko E. V. Drug-Induced Neutropenia and Agranulocytosis. Safety and Risk of Pharmacotherapy. 2020;8(3):109-122. (In Russ.). https://doi.org/10.30895/2312-7821-2020-8-3-109-122Halevy J., Bulvik S. Severe hypophosphatemia in hospitalized patients. Arch Intern Med 1988; 148:153-5.Halevy J., Bulvik S. Severe hypophosphatemia in hospitalized patients. Arch Intern Med 1988; 148:153-5.Liamis G., Liberopoulos E., Barkas F., Elisaf M. Spurious electrolyte disorders: a diagnostic challenge for clinicians. Am J Nephrol. 2013;38(1):50-7. https://doi.org/10.1159/000351804.Liamis G., Liberopoulos E., Barkas F., Elisaf M. Spurious electrolyte disorders: a diagnostic challenge for clinicians. Am J Nephrol. 2013;38(1):50-7. https://doi.org/10.1159/000351804.Brooks M. J., Melnik G. The refeeding syndrome: an approach to understanding its complications and preventing its occurrence. Pharmacotherapy 1995; 15 (6): 713-726.Brooks M. J., Melnik G. The refeeding syndrome: an approach to understanding its complications and preventing its occurrence. Pharmacotherapy 1995; 15 (6): 713-726.Волков М.М., Каюков И. Г., Смирнов А. В. Фосфорно-кальциевый обмен и его регуляция. Нефрология. 2010;14(1):91-103. [Volkov M. M., Kayukov I. G., Smirnov A. V. Phosphorus-calcium metabolism and its regulation. Nephrology (Saint-Petersburg). 2010;14(1):91-103. (In Russ.).] https://doi.org/10.24884/1561-6274-2010-14-1-91-103Волков М.М., Каюков И. Г., Смирнов А. В. Фосфорно-кальциевый обмен и его регуляция. Нефрология. 2010;14(1):91-103. [Volkov M. M., Kayukov I. G., Smirnov A. V. Phosphorus-calcium metabolism and its regulation. Nephrology (Saint-Petersburg). 2010;14(1):91-103. (In Russ.).] https://doi.org/10.24884/1561-6274-2010-14-1-91-103Paterson C. R. Hypophosphataemia: a dangerous disorder. Nutrition. 1996;12(7-8):540-1.Paterson C. R. Hypophosphataemia: a dangerous disorder. Nutrition. 1996;12(7-8):540-1.Сокорутов Д. А. Гипофосфатемия. https://www.krasotaimedicina.ru/ symptom/blood/hypophosphatemia [Sokorutov D. A. Hypophosphatemia. https://www.krasotaimedicina.ru/symptom/blood/hypophosphatemiaСокорутов Д. А. Гипофосфатемия. https://www.krasotaimedicina.ru/ symptom/blood/hypophosphatemia [Sokorutov D. A. Hypophosphatemia. https://www.krasotaimedicina.ru/symptom/blood/hypophosphatemiaShackney S., Hasson J. Precipitous fall in serum calcium, hypotension, and acute renal failure after intravenous phos- phate therapy for hypercalcemia. Report of two cases. Ann Intern Med 1967; 66:906-16.Shackney S., Hasson J. Precipitous fall in serum calcium, hypotension, and acute renal failure after intravenous phos- phate therapy for hypercalcemia. Report of two cases. Ann Intern Med 1967; 66:906-16.Winter R. J., Harris C. J., Phillips L. S.., Green O. C. Diabetic ketoacidosis. Induction of hypocalcemia and hypomagnesemia by phosphate therapy. Am J Med 1979; 67:897-900.Winter R. J., Harris C. J., Phillips L. S.., Green O. C. Diabetic ketoacidosis. Induction of hypocalcemia and hypomagnesemia by phosphate therapy. Am J Med 1979; 67:897-900.ChernowB., Rainey T. G., Georges LP., O’Brian JT. Iatrogenic hyperphosphatemia: a metabolic consideration in critical care medicine. CritCare Med 1981; 9:772-4.ChernowB., Rainey T. G., Georges LP., O’Brian JT. Iatrogenic hyperphosphatemia: a metabolic consideration in critical care medicine. CritCare Med 1981; 9:772-4.Shiber J. R. and Mattu A. Serum phosphate abnormalities in the emergency department. J Emerg Med 2002; 23: 395-400. https://doi.org/10.1016/s0736-4679(02)00578-4.Shiber J. R. and Mattu A. Serum phosphate abnormalities in the emergency department. J Emerg Med 2002; 23: 395-400. https://doi.org/10.1016/s0736-4679(02)00578-4.Miller D. W. and Slovis C. M. Hypophosphatemia in the emergency department therapeutics. Am J Emerg Med2000;18:457-461. https://doi.org/10.1053/ajem.2000.7347.Miller D. W. and Slovis C. M. Hypophosphatemia in the emergency department therapeutics. Am J Emerg Med2000;18:457-461. https://doi.org/10.1053/ajem.2000.7347.Felsenfeld A. J., Levine B. S. Approach to treatment of hypophosphatemia. Am J Kidney Dis. 2012;60(4):655-61. https://doi.org/10.1053/j.ajkd.2012.03.024Felsenfeld A. J., Levine B. S. Approach to treatment of hypophosphatemia. Am J Kidney Dis. 2012;60(4):655-61. https://doi.org/10.1053/j.ajkd.2012.03.024Cross H. S., Debiec H., Peterlik M.: Mechanism and regulation of intestinal phosphate absorption. Miner Electrolyte Metab 1990;16:115-124.Cross H. S., Debiec H., Peterlik M.: Mechanism and regulation of intestinal phosphate absorption. Miner Electrolyte Metab 1990;16:115-124.Lentz R. D.., Brown DM., Kjellstrand C. M. Treatment of severe hypophosphatemia. Ann Intern Med. 1978;89:941-944.Lentz R. D.., Brown DM., Kjellstrand C. M. Treatment of severe hypophosphatemia. Ann Intern Med. 1978;89:941-944.Subramanian R., Khardori R. Severe hypophosphatemia. Pathophysiologic implications, clinical presentations, and treatment. Medicine (Baltimore) 2000;79:1-8. https://doi.org/10.1097/00005792-200001000-00001.Subramanian R., Khardori R. Severe hypophosphatemia. Pathophysiologic implications, clinical presentations, and treatment. Medicine (Baltimore) 2000;79:1-8. https://doi.org/10.1097/00005792-200001000-00001.de Menezes F. S., Leite H. P., Fernandez J.., Benzecry S. G., de Carvalho W. B. Hypophosphatemia in critically ill children. Rev Hosp Clin Fac Med S Paulo. 2004;59:306-311. https://doi.org/10.1590/s0041-87812004000500015.de Menezes F. S., Leite H. P., Fernandez J.., Benzecry S. G., de Carvalho W. B. Hypophosphatemia in critically ill children. Rev Hosp Clin Fac Med S Paulo. 2004;59:306-311. https://doi.org/10.1590/s0041-87812004000500015.Ritz E. Acutehypophosphatemia. KidneyInt. 1982;22:84-94.Ritz E. Acutehypophosphatemia. KidneyInt. 1982;22:84-94.Broman M., Carlsson O., Friberg H., Wieslander A., Godaly G. Phosphate-containing dialysis solution prevents hypophos- phatemia during continuous renal replacement therapy. Acta Anaes- thesiol Scand. 2011;55:39-45. https://doi.org/10.1111/j.1399-6576.2010.02338.x.Broman M., Carlsson O., Friberg H., Wieslander A., Godaly G. Phosphate-containing dialysis solution prevents hypophos- phatemia during continuous renal replacement therapy. Acta Anaes- thesiol Scand. 2011;55:39-45. https://doi.org/10.1111/j.1399-6576.2010.02338.x.Datta H. K., Malik M., Neely R. D. G. Hepatic surgery-related hypophosphatemia. Clin Chim Acta. 2007;380:13-23. https://doi.org/10.1016/j.cca.2007.01.027.Datta H. K., Malik M., Neely R. D. G. Hepatic surgery-related hypophosphatemia. Clin Chim Acta. 2007;380:13-23. https://doi.org/10.1016/j.cca.2007.01.027.Manghat P., Sodi R., Swaminathan R. Phosphate homeostasis and disorders. Ann Clin Biochem. 2014Nov;51(Pt6):631-56. https://doi.org/10.1177/0004563214521399.Manghat P., Sodi R., Swaminathan R. Phosphate homeostasis and disorders. Ann Clin Biochem. 2014Nov;51(Pt6):631-56. https://doi.org/10.1177/0004563214521399.Riley M. S., Schade D. S., & Eaton R. P. Effects of insulin infusion on plasma phosphate in diabetic patients. Metabolism. 1979;28(3):191-194. https://doi.org/10.1016/0026-0495(79)90063-5Riley M. S., Schade D. S., & Eaton R. P. Effects of insulin infusion on plasma phosphate in diabetic patients. Metabolism. 1979;28(3):191-194. https://doi.org/10.1016/0026-0495(79)90063-5San E. S., Erdogan S., Bo$nak M., $an M. Hypophosphatemia associated risk factors in pediatric intensive care patients. Turk J Pediatr. 2017;59(1):35. https://doi.org/10.24953/turkjped.2017.01.006.San E. S., Erdogan S., Bo$nak M., $an M. Hypophosphatemia associated risk factors in pediatric intensive care patients. Turk J Pediatr. 2017;59(1):35. https://doi.org/10.24953/turkjped.2017.01.006.Flack J. M., Ryder K. W., Strickland D., Whang R. Metabolic cor- relates of theophylline therapy: a concentration-related phenom- enon. Ann Pharmacother. 1994;28(2):175-9. https://doi.org/10.1177/106002809402800202.Flack J. M., Ryder K. W., Strickland D., Whang R. Metabolic cor- relates of theophylline therapy: a concentration-related phenom- enon. Ann Pharmacother. 1994;28(2):175-9. https://doi.org/10.1177/106002809402800202.Brady H. R., Ryan F., Cunningham J., Tormey W., Ryan M. P., O’Neill S. Hypophosphatemia complicating bronchodilator therapy for acute severe asthma. Arch Intern Med. 1989;149(10):2367-8.Brady H. R., Ryan F., Cunningham J., Tormey W., Ryan M. P., O’Neill S. Hypophosphatemia complicating bronchodilator therapy for acute severe asthma. Arch Intern Med. 1989;149(10):2367-8.Ramachandra V., Chandran P., Philip R., Arunaachalam V., Raman G. V. Effect of mannitol on intraocular pressure in vit- rectomized and nonvitrectomized eyes: a prospective compara- tive study. J Glaucoma. 2019;28(4):318-20. https://doi.org/10.1097/ijg.0000000000001158.Ramachandra V., Chandran P., Philip R., Arunaachalam V., Raman G. V. Effect of mannitol on intraocular pressure in vit- rectomized and nonvitrectomized eyes: a prospective compara- tive study. J Glaucoma. 2019;28(4):318-20. https://doi.org/10.1097/ijg.0000000000001158.Milionis H. J., Alexandrides G. E., Liberopoulos E. N., Bairaktar E. T., Goudevenos J., Elisaf M. S. Hypomagnesemia and concurrent acid-base and electrolyte abnormalities in patients with congestive heart failure. Eur J Heart Fail. 2002;4(2):167-73. https://doi.org/10.1016/s1388-9842(01)00234-3.Milionis H. J., Alexandrides G. E., Liberopoulos E. N., Bairaktar E. T., Goudevenos J., Elisaf M. S. Hypomagnesemia and concurrent acid-base and electrolyte abnormalities in patients with congestive heart failure. Eur J Heart Fail. 2002;4(2):167-73. https://doi.org/10.1016/s1388-9842(01)00234-3.Liamis G., Milionis H., Elisaf M. Blood pressure drug therapy and electrolyte disturbances. Int J Clin Pract. 2008;62(10): 1572-80. https://doi.org/10.111 1/j.742-1241.2008.01860.x.Liamis G., Milionis H., Elisaf M. Blood pressure drug therapy and electrolyte disturbances. Int J Clin Pract. 2008;62(10): 1572-80. https://doi.org/10.111 1/j.742-1241.2008.01860.x.Aibiki M., Kawaguchi S., Maekawa N. Reversible hypophos- phatemia during moderate hypothermia therapy for brain-injured patients. Crit Care Med. 2001;29(9):1726-30. https://doi.org/10.1097/00003246-200109000-00012.Aibiki M., Kawaguchi S., Maekawa N. Reversible hypophos- phatemia during moderate hypothermia therapy for brain-injured patients. Crit Care Med. 2001;29(9):1726-30. https://doi.org/10.1097/00003246-200109000-00012.Alamin M. A., Ahmed A., Suliman A. M. Severe Electrolyte Disturbances Complicated by Seizures and Acute Kidney Injury Within 10 Days of Starting Indapamide. Cureus. 2020;12(11): e11303. https://doi.org/10.7759/cureus.11303.Alamin M. A., Ahmed A., Suliman A. M. Severe Electrolyte Disturbances Complicated by Seizures and Acute Kidney Injury Within 10 Days of Starting Indapamide. Cureus. 2020;12(11): e11303. https://doi.org/10.7759/cureus.11303.Itescu S., Haskell L. P., Tannenberg A. M. Thiazide-induced clinically significant hypophosphatemia. Clin Nephrol. 1987;27(3):161-2.Itescu S., Haskell L. P., Tannenberg A. M. Thiazide-induced clinically significant hypophosphatemia. Clin Nephrol. 1987;27(3):161-2.Clinkenbeard E. L., White K. E. Systemic control of bone homeostasis by FGF23 signaling. Curr Mol Biol Rep. 2016;2(1):62-71. https://dx.doi.org/10.1007%2Fs40610-016-0035-5.Clinkenbeard E. L., White K. E. Systemic control of bone homeostasis by FGF23 signaling. Curr Mol Biol Rep. 2016;2(1):62-71. https://dx.doi.org/10.1007%2Fs40610-016-0035-5.Andrukhova O., Zeitz U., Goetz R., Mohammadi M., Lanske B., Erben R. G. FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ErK1/2-Sg K1 signaling pathway. Bone. 2012;51(3):621-8. https://doi.org/10.1016/j.bone.2012.05.015.Andrukhova O., Zeitz U., Goetz R., Mohammadi M., Lanske B., Erben R. G. FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ErK1/2-Sg K1 signaling pathway. Bone. 2012;51(3):621-8. https://doi.org/10.1016/j.bone.2012.05.015.Jakubowiak A. J., Richardson P. G., Zimmerman T., Alsina M., Kaufman J. L., Kandarpa M. et al. Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: a phase iMutiple myeloma research consortium study. Br J Haematol. 2012;158:472-80. https://doi.org/10.1111/j.1365-2141.2012.09173.x.Jakubowiak A. J., Richardson P. G., Zimmerman T., Alsina M., Kaufman J. L., Kandarpa M. et al. Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: a phase iMutiple myeloma research consortium study. Br J Haematol. 2012;158:472-80. https://doi.org/10.1111/j.1365-2141.2012.09173.x.Liamis G., Filippatos G. D., Elisaf M. S. Electrolyte disorders associated with the use of anticancer drugs. Eur J Pharmacol. 2016;777:78-87. https://doi.org/10.1016/j.ejphar.2016.02.064.Liamis G., Filippatos G. D., Elisaf M. S. Electrolyte disorders associated with the use of anticancer drugs. Eur J Pharmacol. 2016;777:78-87. https://doi.org/10.1016/j.ejphar.2016.02.064.Miyawaki A., Ueda T., Nakao A., Adachi M., Ohya M., Yamada I., Takesue Y., Kotani J. Linezolid-induced lactic acidosis followed by severe hypophosphatemia after discontinuation of linezolid. Surg Infect (Larchmt). 2013;14(2):229-30. https://doi.org/10.1080/14740338.2017.1335305.Miyawaki A., Ueda T., Nakao A., Adachi M., Ohya M., Yamada I., Takesue Y., Kotani J. Linezolid-induced lactic acidosis followed by severe hypophosphatemia after discontinuation of linezolid. Surg Infect (Larchmt). 2013;14(2):229-30. https://doi.org/10.1080/14740338.2017.1335305.Mohammed S., Knoll S., van Amburg A. III, Mennes P. A. Cefotetan-induced hemolytic anemia causing severe hypophosphatemia. Am J Hematol 1994;46:369-370. https://doi.org/10.1002/ajh.2830460422.Mohammed S., Knoll S., van Amburg A. III, Mennes P. A. Cefotetan-induced hemolytic anemia causing severe hypophosphatemia. Am J Hematol 1994;46:369-370. https://doi.org/10.1002/ajh.2830460422.Brautbar N., Leibovici H, Massry S. G. On the mechanism of hypophosphatemia during acute hyperventilation: evidence for increased muscle glycolysis. Miner Electrolyte Metab 1983;9:45-50.Brautbar N., Leibovici H, Massry S. G. On the mechanism of hypophosphatemia during acute hyperventilation: evidence for increased muscle glycolysis. Miner Electrolyte Metab 1983;9:45-50.Lee Y.-S., Kim B.-K., Lee H.-J., Dan J. Pathologic femoral neck fracture due to fanconi syndrome induced by adefovir dipivoxil therapy for hepatitis B. Clin Orthop Surg. 2016;8(2):232. https://doi.org/10.4055/cios.2016.8.2.232.Lee Y.-S., Kim B.-K., Lee H.-J., Dan J. Pathologic femoral neck fracture due to fanconi syndrome induced by adefovir dipivoxil therapy for hepatitis B. Clin Orthop Surg. 2016;8(2):232. https://doi.org/10.4055/cios.2016.8.2.232.Shimizu Y., Hiraoka A.Yamago H., Shiraishi A., Imai Y., Tatsukawa H. et al. Hypophosphatemia in patients with hepatitis B virus infection undergoing longterm adefovir dipivoxil therapy. Hepatol Res. 2014;44(11):1081-7. https://doi.org/10.1111/hepr.12226.Shimizu Y., Hiraoka A.Yamago H., Shiraishi A., Imai Y., Tatsukawa H. et al. Hypophosphatemia in patients with hepatitis B virus infection undergoing longterm adefovir dipivoxil therapy. Hepatol Res. 2014;44(11):1081-7. https://doi.org/10.1111/hepr.12226.Wei Z., He J., Fu W., Zhang Z. Osteomalacia induced by long-term low-dose adefovir dipivoxil: clinical characteristics and genetic predictors. Bone. 2016;93:97-103. https://doi.org/10.1016/j.bone.2016.09.017.Wei Z., He J., Fu W., Zhang Z. Osteomalacia induced by long-term low-dose adefovir dipivoxil: clinical characteristics and genetic predictors. Bone. 2016;93:97-103. https://doi.org/10.1016/j.bone.2016.09.017.Yamamoto T., Maruyama Y., Ohashi N., Yasuda H., Shinozaki M. Hypophosphatemia predicts a failure to recover from adefovir- related renal injury after dose reduction in lamivudine-resistant hepatitis B patients. Hepatol Res. 2017;47(12):1272-81. https://doi.org/10.1111/hepr.12865.Yamamoto T., Maruyama Y., Ohashi N., Yasuda H., Shinozaki M. Hypophosphatemia predicts a failure to recover from adefovir- related renal injury after dose reduction in lamivudine-resistant hepatitis B patients. Hepatol Res. 2017;47(12):1272-81. https://doi.org/10.1111/hepr.12865.NasomyontN., Hornung L. N., Gordon C. M., Wasserman H. Outcomes following intravenous bisphosphonate infusion in pediatric patients: a 7-year retrospective chart review. Bone. 2019;121:60-7. https://doi.org/10.1016/j.bone.2019.01.003.NasomyontN., Hornung L. N., Gordon C. M., Wasserman H. Outcomes following intravenous bisphosphonate infusion in pediatric patients: a 7-year retrospective chart review. Bone. 2019;121:60-7. https://doi.org/10.1016/j.bone.2019.01.003.Clark S. L., Nystrom E. M. A case of severe, prolonged, refractory hypophosphatemia afterzoledronic acid administration. J Pharm Pract. 2016;29(2):172-6. https://doi.org/10.1177/0897190015624050.Clark S. L., Nystrom E. M. A case of severe, prolonged, refractory hypophosphatemia afterzoledronic acid administration. J Pharm Pract. 2016;29(2):172-6. https://doi.org/10.1177/0897190015624050.Nguyen A., Kalis J. A., Sutz T. R., Jeffers K. D. Development of a practice standard for monitoring adult patients receiving bone-modifying agents at a community cancer center. J Adv Pract Oncol. 2018;9(6):601-7.Nguyen A., Kalis J. A., Sutz T. R., Jeffers K. D. Development of a practice standard for monitoring adult patients receiving bone-modifying agents at a community cancer center. J Adv Pract Oncol. 2018;9(6):601-7.Kaur U., Chakrabarti S. S., Gambhir I. S. Zoledronate induced hypocalcemia and hypophosphatemia in osteoporosis: a cause of concern. Curr Drug Saf. 2016;11(3):267-9. https://doi.org/10.2174/1574886311666160426141647.Kaur U., Chakrabarti S. S., Gambhir I. S. Zoledronate induced hypocalcemia and hypophosphatemia in osteoporosis: a cause of concern. Curr Drug Saf. 2016;11(3):267-9. https://doi.org/10.2174/1574886311666160426141647.Elisaf M., Kalaitzidis R., Siamopoulos K. C. Multiple electro- lyte abnormalities after pamidronate administration. Nephron. 1998;79(3):337-9. https://doi.org/10.1159/000045059.Elisaf M., Kalaitzidis R., Siamopoulos K. C. Multiple electro- lyte abnormalities after pamidronate administration. Nephron. 1998;79(3):337-9. https://doi.org/10.1159/000045059.Smyth B., Ong S. Severe hypocalcaemia and hypophosphataemia following intravenous iron and denosumab: a novel drug interac- tion. Intern Med J. 2016;46(3):360-3. https://doi.org/10.1111/imj.13001.Smyth B., Ong S. Severe hypocalcaemia and hypophosphataemia following intravenous iron and denosumab: a novel drug interac- tion. Intern Med J. 2016;46(3):360-3. https://doi.org/10.1111/imj.13001.Masuda H.., Kaga K, Inahara M., Araki K., Kojima S., Naya Y. et al. Severe hypophosphatemia following denosumab administration in a hemodialysis patient with progressive prostate cancer. Urol Case Rep. 2017;13:63-5. https://dx.doi.org/10.1016%2Fj.eucr.2016.11.019.Masuda H.., Kaga K, Inahara M., Araki K., Kojima S., Naya Y. et al. Severe hypophosphatemia following denosumab administration in a hemodialysis patient with progressive prostate cancer. Urol Case Rep. 2017;13:63-5. https://dx.doi.org/10.1016%2Fj.eucr.2016.11.019.Gralow J. R., Biermann J. S., Farooki A., Fornier M. N., Gagel R. F., KumarR., Litsas G., McKay R., Podoloff D. A., Srinivas S., Van Poznak C. H. NCCN Task Force Report: bone health in cancer care. J Natl Compr Cancer Netw. 2013;11(Suppl 3): S 1-50. https://doi.org/10.6004/jnccn.2013.0215.Gralow J. R., Biermann J. S., Farooki A., Fornier M. N., Gagel R. F., KumarR., Litsas G., McKay R., Podoloff D. A., Srinivas S., Van Poznak C. H. NCCN Task Force Report: bone health in cancer care. J Natl Compr Cancer Netw. 2013;11(Suppl 3): S 1-50. https://doi.org/10.6004/jnccn.2013.0215.Van Poznak C. H., Termin S., Yee G. C., Janjan N. A.., Barlow WE., Biermann J. S. et al. American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J Clin Oncol. 2011;29(9): 1221-7. https://doi.org/10.1200/jco.2010.32.5209.Van Poznak C. H., Termin S., Yee G. C., Janjan N. A.., Barlow WE., Biermann J. S. et al. American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J Clin Oncol. 2011;29(9): 1221-7. https://doi.org/10.1200/jco.2010.32.5209.Schmidt L. E., Dalhoff K. Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity. Hepatology. 2002;36(3):659-65. https://doi.org/10.1053/jhep.2002.35069.Schmidt L. E., Dalhoff K. Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity. Hepatology. 2002;36(3):659-65. https://doi.org/10.1053/jhep.2002.35069.Bissell B. D., Davis J. E., Flannery A. H., Adkins D. A., Thompson Bastin M. L. Aggressive treatment of life-threatening hypophosphatemia during recovery from fulminant hepatic failure: a case report. J Intensive Care Med. 2018;33(6):375-9. https://doi.org/10.1177%2F0885066617738715.Bissell B. D., Davis J. E., Flannery A. H., Adkins D. A., Thompson Bastin M. L. Aggressive treatment of life-threatening hypophosphatemia during recovery from fulminant hepatic failure: a case report. J Intensive Care Med. 2018;33(6):375-9. https://doi.org/10.1177%2F0885066617738715.Shields H. M. Rapid fall of serum phosphorus secondary to antacid therapy. Gastroenterology. 1978;75(6):1137-41.Shields H. M. Rapid fall of serum phosphorus secondary to antacid therapy. Gastroenterology. 1978;75(6):1137-41.Boutsen Y., Devogelaer J. P., Malghem J., Noёl H. & Nagant de Deuxchaisnes C. Antacid-induced osteomalacia. Clinical Rheumatology. 1996;15(1):75-80. https://doi.org/10.1007/bf02231691.Boutsen Y., Devogelaer J. P., Malghem J., Noёl H. & Nagant de Deuxchaisnes C. Antacid-induced osteomalacia. Clinical Rheumatology. 1996;15(1):75-80. https://doi.org/10.1007/bf02231691.Chines A., Pacifici R. Antacid and sucralfate-induced hypophos- phatemic osteomalacia: a case report and review of the literature. Calcif Tissue Int. 1990;47(5):291-5. https://doi.org/10.1007/bf02555911.Chines A., Pacifici R. Antacid and sucralfate-induced hypophos- phatemic osteomalacia: a case report and review of the literature. Calcif Tissue Int. 1990;47(5):291-5. https://doi.org/10.1007/bf02555911.

The authors declare that there are no conflicts of interest present.