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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2021-21-94-100</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2210</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭНДОКРИНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ENDOCRINOLOGY</subject></subj-group></article-categories><title-group><article-title>β-гидрокси-β-метилбутират: роль и перспективы применения в геронтологии</article-title><trans-title-group xml:lang="en"><trans-title>β-hydroxy-β-methylbutyrate: role and prospects applications in gerontology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3220-0333</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитина Елена Александровна – кандидат медицинских наук, доцент кафедры диетологии и клинической нутрициологии.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Elena A. Nikitina - PhD Med, assistant professor of Dept of Dietetics and Clinical Nutritiology.</p><p>Moscow.</p></bio><email xlink:type="simple">nikitina-ea1@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4689-3591</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Орлова Светлана Владимировна – доктор медицинских наук, профессор, заведующая кафедрой диетологии и клинической нутрициологии.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Svetlana V. Orlova - DM Sci, professor, head of Dept of Dietetics and Clinical Nutritiology.</p><p>Moscow.</p></bio><email xlink:type="simple">rudn_nutr@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пигарёва</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pigareva</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пигарёва Юлия Анатольевна - кандидат медицинских наук, заведующая отделением клинической диетологии ГКБ им. В.В. Виноградова ДЗ Москвы; ассистент кафедры диетологии и клинической нутрициологии ФНМО медицинского института РУДН.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Yulia A. Pigareva - PhD Med, head of Dept of Clinical Dietetics.</p><p>Moscow.</p></bio><email xlink:type="simple">1092153068@rudn.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Магомедова</surname><given-names>Х. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Magomedova</surname><given-names>Kh. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Магомедова Хадижат Абдулхаликовна - ассистент кафедры диетологии и клинической нутрициологии.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Khadizhat A. Magomedova - assistant of Dept of Dietetics and Clinical Nutritiology.</p><p>Moscow.</p></bio><email xlink:type="simple">h.magomedova@ave-apteka.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples' Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Городская клиническая больница имени В.В. Виноградова Департамента здравоохранения Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital n.a. V.V. Vinogradov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>25</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>21</issue><issue-title>Диетология и нутрициология (1)</issue-title><fpage>94</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никитина Е.А., Орлова С.В., Пигарёва Ю.А., Магомедова Х.A., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Никитина Е.А., Орлова С.В., Пигарёва Ю.А., Магомедова Х.A.</copyright-holder><copyright-holder xml:lang="en">Nikitina E.A., Orlova S.V., Pigareva Y.A., Magomedova K.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2210">https://www.med-alphabet.com/jour/article/view/2210</self-uri><abstract><p>Проблема старения населения в развитых странах ставит перед медицинским сообществом новые задачи. Одной из наиболее распространенных проблем, ухудшающих качество жизни пожилых людей, увеличивающих риск инвалидности и смертности, является саркопения. В настоящее время разработаны несколько диетических подходов к профилактике и коррекции саркопении. Гидроксиметилбутират является одним из инновационных веществ, предназначенных для оптимизации рациона у пожилых пациентов, в первую очередь ведущих малоподвижный образ жизни или находящихся на постельном режиме.</p></abstract><trans-abstract xml:lang="en"><p>The problem of population aging in developed countries poses new challenges for the medical community. Sarcopenia is one of the most common problems that decrease the quality of life of older people and increase the risk of disability and death. Currently, several dietary approaches to the prevention and correction of sarcopenia have been developed. Hydroxymethyl butyrate is one of the innovative substances designed to optimize the diet of elderly patients, primarily those with a sedentary lifestyle or on bed rest.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>β-гидрокси-β-метилбутират</kwd><kwd>саркопения</kwd><kwd>пожилые</kwd><kwd>нутритивная поддержка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>beta-hydroxy-beta-methylbutyrate</kwd><kwd>sarcopenia</kwd><kwd>elderly</kwd><kwd>nutritional support</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация выполнена при поддержке Программы стратегического академического лидерства РУДН.</funding-statement><funding-statement xml:lang="en">This publication was supported by Peoples' Friendship University of Russia University Strategic Academic Leadership Program.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. 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