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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2021-24-44-49</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2205</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Сравнение цифрового сканирования и обычного снятия оттисков для протезов на имплантатах</article-title><trans-title-group xml:lang="en"><trans-title>Comparison of digital scanning and conventional impression taking for implant-supported prostheses</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6251-2007</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Студеникин</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Studenikin</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Р. В. Студеникин, к.м.н., главный врач стоматологической клиники «Ваш стоматолог»</p><p>Воронеж</p></bio><bio xml:lang="en"><p>R. V. Studenikin, PhD, Head Doctor</p><p> Voronezh</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7257-0991</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамедов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamedov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>А. А. Мамедов, д.м.н., проф., зав. кафедрой стоматологии детского возраста и ортодонтии</p><p>Москва</p></bio><bio xml:lang="en"><p>A. A. Mamedov, Doctor of medical science, professor, Head of the Department of Pediatric Dentistry and Orthodontics</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Стоматологическая клиника «Ваш стоматолог»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dental clinic «Vash Stomatolog»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова Минздрава России» (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>25</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>24</issue><issue-title>Стоматология (3)</issue-title><fpage>44</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Студеникин Р.В., Мамедов А.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Студеникин Р.В., Мамедов А.А.</copyright-holder><copyright-holder xml:lang="en">Studenikin R.V., Mamedov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2205">https://www.med-alphabet.com/jour/article/view/2205</self-uri><abstract><p>Влияние расхождений между слепками, полученными с помощью цифрового сканирования и обычных оттисков, на клинические показатели постоянной реставрации не изучено полностью. Тридцати пациентам были сделаны обычные оттиски и цифровые сканы единичной реставрации на имплантате. Для одного и того же имплантата были изготовлены две коронки с использованием обоих методов. Регистрировалось время, затраченное на каждую процедуру. После анализа точности и эффективности обеих коронок ставилась лучшая. Проводилось анкетирование для оценки предпочтений и комфорта при использовании коронок, изготовленных тем или другим методом. Продолжительность традиционной техники снятия оттиска в пределах 15 минут, а для техники цифрового сканирования – 10 минут. Время подготовки, включающее дезинфекцию силиконовых слепков, их транспортировку в лабораторию, заливку оттисков, застывание гипса, а также подготовку модели техником составило 4 часа для обычных оттисков. Тайминг на отправку STL-файла и моделирование конструкции длилось менее 2 часов для метода цифрового сканирования. Время изготовления коронок занимает 3 часа как для обычных оттисков, так и для цифровых. Из всех коронок, выбранных для постановки, 46,7% были изготовлены по обычным оттискам и 53,3% – по цифровым сканам. Участники предпочли технику цифрового сканирования (89%) по сравнению с традиционной техникой снятия оттисков (11%).Данные этого исследования позволяют предположить, что для единичной реставрации на имплантате использование цифрового сканирования и CAD/CAM технологии может быть более эффективным и лучше приниматься участниками исследования, чем применение обычных оттисков и гипсовых слепков.</p></abstract><trans-abstract xml:lang="en"><p>The effect of discrepancies between digital scans and conventional impressions on the clinical performance of a permanent restoration has not been fully understood.</p><p>Thirty patients received conventional impressions and digital scans of a single implant restoration. Two crowns were made for the same implant using both methods. The time taken for each procedure was recorded. After analyzing the accuracy and effectiveness of both crowns, the best one was placed. A questionnaire was conducted to assess the preferences and comfort when using crowns made by one method or another.The total time for the traditional impression technique was 15 minutes, while the time for the digital scanning technique was significantly less – 10 minutes.</p><p>The preparation time, including the disinfection of the silicone impressions, their transportation to the laboratory, the casting of the impressions, the hardening of the plaster, as well as the preparation of the model by the technician, was 4 hours for conventional impressions.The timing for sending the STL file and modeling the structure was less than 2 hours for the digital scan method. The production time of crowns takes 3 hours for both conventional impressions and digital ones.</p><p>Of all crowns selected for placement, 46.7% were made from conventional impressions and 53.3% from digital scans. Participants preferred the digital scanning technique (89%) over the traditional impression-taking technique (11%).</p><p>The data from this study suggest that digital scanning and CAD/CAM technology may be more effective and better accepted by study par-ticipants for a single implant restoration than conventional impressions and plaster casts.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>цифровое сканирование</kwd><kwd>обычные оттиски</kwd><kwd>единичная реставрация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>digital scanning</kwd><kwd>conventional impressions</kwd><kwd>single restoration</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Saponaro P.C., Yilmaz B., Heshmati R.H., McGlumphy E.A. Clinical performance of CAD-CAM-fabricated complete dentures: a cross-sectional study // The Journal of prosthetic dentistry. 2016. V. 116. No. 3. P. 431–435. DOI: 10.1016/j.prosdent.2016.03.017</mixed-citation><mixed-citation xml:lang="en">Saponaro P.C., Yilmaz B., Heshmati R.H., McGlumphy E.A. Clinical performance of CAD-CAM-fabricated complete dentures: a cross-sectional study // The Journal of prosthetic dentistry. 2016. V. 116. No. 3. P. 431–435. DOI: 10.1016/j.prosdent.2016.03.017</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J., Ahmad R., Suenaga H., Li W., Sasaki K., Swain M., Li Q. Shape optimization for additive manufacturing of removable partial dentures-a new paradigm for prosthetic CAD/CAM // PloS one. 2015. V. 10. No 7. P. e0132552. DOI: 10.1371/journal.pone.0132552</mixed-citation><mixed-citation xml:lang="en">Chen J., Ahmad R., Suenaga H., Li W., Sasaki K., Swain M., Li Q. Shape optimization for additive manufacturing of removable partial dentures-a new paradigm for prosthetic CAD/CAM // PloS one. 2015. V. 10. No 7. P. e0132552. DOI: 10.1371/journal.pone.0132552</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Barone S., Casinelli M., Frascaria M., Paoli A., Razionale, A. V. Interactive design of dental implant placements through CAD-CAM technologies: from 3D imaging to additive manufacturing // International Journal on Interactive Design and Manufacturing (IJIDeM). 2016. V. 10. No 2. P. 105–117. DOI:10.1007/s12008-014-0229-0</mixed-citation><mixed-citation xml:lang="en">Barone S., Casinelli M., Frascaria M., Paoli A., Razionale, A. V. Interactive design of dental implant placements through CAD-CAM technologies: from 3D imaging to additive manufacturing // International Journal on Interactive Design and Manufacturing (IJIDeM). 2016. V. 10. No 2. P. 105–117. DOI:10.1007/s12008-014-0229-0</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zitzmann N.U., Kovaltschuk I., Lenherr P., Dedem P., Joda T. Dental students’ perceptions of digital and conventional impression techniques: A randomized controlled trial //Journal of dental education. 2017. V. 81. No. 10. P. 1227–1232.DOI: 10.21815/JDE.017.081</mixed-citation><mixed-citation xml:lang="en">Zitzmann N.U., Kovaltschuk I., Lenherr P., Dedem P., Joda T. Dental students’ perceptions of digital and conventional impression techniques: A randomized controlled trial //Journal of dental education. 2017. V. 81. No. 10. P. 1227–1232.DOI: 10.21815/JDE.017.081</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Marti A.M., Harris B.T., Metz M.J., Morton D., Scarfe W.C., Metz C.J., Lin, W. S. Comparison of digital scanning and polyvinyl siloxane impression techniques by dental students: instructional efficiency and attitudes towards technology // European Journal of Dental Education. 2017. V. 21. No. 3. P. 200–205. DOI: 10.1111/eje.12201</mixed-citation><mixed-citation xml:lang="en">Marti A.M., Harris B.T., Metz M.J., Morton D., Scarfe W.C., Metz C.J., Lin, W. S. Comparison of digital scanning and polyvinyl siloxane impression techniques by dental students: instructional efficiency and attitudes towards technology // European Journal of Dental Education. 2017. V. 21. No. 3. P. 200–205. DOI: 10.1111/eje.12201</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cheah C., Lim C., Ma S. The dentist will scan you now: The next generation of digital-savvy graduates // European Journal of Dental Education. 2021. V. 25. No. 2. P. 232–237. https://doi.org/10.1111/eje.12596</mixed-citation><mixed-citation xml:lang="en">Cheah C., Lim C., Ma S. The dentist will scan you now: The next generation of digital-savvy graduates // European Journal of Dental Education. 2021. V. 25. No. 2. P. 232–237. https://doi.org/10.1111/eje.12596</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Giménez B., Pradíes G., Martínez-Rus F., Özcan M. Accuracy of two digital implant impression systems based on confocal microscopy with variations in customized software and clinical parameters // International Journal of Oral &amp; Maxillofacial Implants. 2015. V. 30. No. 1. DOI: 10.11607/jomi.3689</mixed-citation><mixed-citation xml:lang="en">Giménez B., Pradíes G., Martínez-Rus F., Özcan M. Accuracy of two digital implant impression systems based on confocal microscopy with variations in customized software and clinical parameters // International Journal of Oral &amp; Maxillofacial Implants. 2015. V. 30. No. 1. DOI: 10.11607/jomi.3689</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Menini M., Setti P., Pera F., Pera P., Pesce P. Accuracy of multi-unit implant impression: traditional techniques versus a digital procedure // Clinical oral investigations. 2018. V. 22. No. 3. P. 1253–1262. DOI: 10.1007/s00784-017-2217-9</mixed-citation><mixed-citation xml:lang="en">Menini M., Setti P., Pera F., Pera P., Pesce P. Accuracy of multi-unit implant impression: traditional techniques versus a digital procedure // Clinical oral investigations. 2018. V. 22. No. 3. P. 1253–1262. DOI: 10.1007/s00784-017-2217-9</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lee S.J., Jamjoom F.Z., Le T., Radics A., Gallucci G.O. A clinical study comparing digital scanning and conventional impression making for implant-supported prostheses: A crossover clinical trial // The Journal of Prosthetic Dentistry. – 2021.Feb 15:S0022-3913(21)00028-7 DOI: 10.1016/j.prosdent.2020.12.043</mixed-citation><mixed-citation xml:lang="en">Lee S.J., Jamjoom F.Z., Le T., Radics A., Gallucci G.O. A clinical study comparing digital scanning and conventional impression making for implant-supported prostheses: A crossover clinical trial // The Journal of Prosthetic Dentistry. – 2021.Feb 15:S0022-3913(21)00028-7 DOI: 10.1016/j.prosdent.2020.12.043</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ahlholm P., Sipilä K., Vallittu P., Jakonen M., Kotiranta U. Digital versus conventional impressions in fixed prosthodontics: a review // Journal of Prosthodontics. 2018. V. 27. No. 1. P. 35–41. DOI: 10.1111/jopr.12527</mixed-citation><mixed-citation xml:lang="en">Ahlholm P., Sipilä K., Vallittu P., Jakonen M., Kotiranta U. Digital versus conventional impressions in fixed prosthodontics: a review // Journal of Prosthodontics. 2018. V. 27. No. 1. P. 35–41. DOI: 10.1111/jopr.12527</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">. Flügge T.V., Schlager S., Nelson K., Nahles S., Metzger M.C. Precision of intraoral digital dental impressions with iTero and extraoral digitization with the iTero and a model scanner // American journal of orthodontics and dentofacial orthopedics. 2013. V. 144. No. 3. P. 471–478. DOI: 10.1016/j.ajodo.2013.04.017</mixed-citation><mixed-citation xml:lang="en">. Flügge T.V., Schlager S., Nelson K., Nahles S., Metzger M.C. Precision of intraoral digital dental impressions with iTero and extraoral digitization with the iTero and a model scanner // American journal of orthodontics and dentofacial orthopedics. 2013. V. 144. No. 3. P. 471–478. DOI: 10.1016/j.ajodo.2013.04.017</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Alsharbaty M.H.M., Alikhasi M., Zarrati S., Shamshiri A.R. A clinical comparative study of 3-dimensional accuracy between digital and conventional implant impression techniques // Journal of Prosthodontics. 2019. V. 28. No. 4. P. e902-e908.DOI: 10.1111/jopr.12764</mixed-citation><mixed-citation xml:lang="en">Alsharbaty M.H.M., Alikhasi M., Zarrati S., Shamshiri A.R. A clinical comparative study of 3-dimensional accuracy between digital and conventional implant impression techniques // Journal of Prosthodontics. 2019. V. 28. No. 4. P. e902-e908.DOI: 10.1111/jopr.12764</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lambert H., Durand J.C., Jacquot B., Fages M. Dental biomaterials for chairside CAD/CAM: State of the art // The journal of advanced prosthodontics. 2017. V. 9. No. 6. P. 486. DOI: 10.4047/jap.2017.9.6.486</mixed-citation><mixed-citation xml:lang="en">Lambert H., Durand J.C., Jacquot B., Fages M. Dental biomaterials for chairside CAD/CAM: State of the art // The journal of advanced prosthodontics. 2017. V. 9. No. 6. P. 486. DOI: 10.4047/jap.2017.9.6.486</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ejatidanesh F., Shakibamehr A.H., Savabi O. Comparison of Marginal and Internal Adaptation of CAD/CAM and Conventional Cement Retained Implant-Support-ed Single Crowns // Implant Dentistry. 2016. V. 25. No 1. P. 103–108. DOI: 10.1097/ID.0000000000000346.</mixed-citation><mixed-citation xml:lang="en">Ejatidanesh F., Shakibamehr A.H., Savabi O. Comparison of Marginal and Internal Adaptation of CAD/CAM and Conventional Cement Retained Implant-Support-ed Single Crowns // Implant Dentistry. 2016. V. 25. No 1. P. 103–108. DOI: 10.1097/ID.0000000000000346.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Di Fiore A., Vigolo P., Graiff L., Stellini E. Digital vs Conventional Workflow for Screw-Retained Single-Implant Crowns: A Comparison of Key Considerations // The International journal of prosthodontics. 2018. V. 31. No. 6. P. 577–579.DOI: 10.11607/ijp.5938</mixed-citation><mixed-citation xml:lang="en">Di Fiore A., Vigolo P., Graiff L., Stellini E. Digital vs Conventional Workflow for Screw-Retained Single-Implant Crowns: A Comparison of Key Considerations // The International journal of prosthodontics. 2018. V. 31. No. 6. P. 577–579.DOI: 10.11607/ijp.5938</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mizumoto R.M., Yilmaz B. Intraoral scan bodies in implant dentistry: A system-atic review // The Journal of prosthetic dentistry. 2018. V. 120. No. 3. P. 343–352. DOI: 10.1016/j.prosdent.2017.10.029</mixed-citation><mixed-citation xml:lang="en">Mizumoto R.M., Yilmaz B. Intraoral scan bodies in implant dentistry: A system-atic review // The Journal of prosthetic dentistry. 2018. V. 120. No. 3. P. 343–352. DOI: 10.1016/j.prosdent.2017.10.029</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Buda M., Bratos M., Sorensen J. A. Accuracy of 3-dimensional computer-aided manufactured single-tooth implant definitive casts // The Journal of prosthetic dentistry. 2018. V. 120. No. 6. P. 913–918. DOI: 10.1016/j.prosdent.2018.02.011</mixed-citation><mixed-citation xml:lang="en">Buda M., Bratos M., Sorensen J. A. Accuracy of 3-dimensional computer-aided manufactured single-tooth implant definitive casts // The Journal of prosthetic dentistry. 2018. V. 120. No. 6. P. 913–918. DOI: 10.1016/j.prosdent.2018.02.011</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Matta R.E., Adler W., Wichmann M., Heckmann, S.M. Accuracy of impression scanning compared with stone casts of implant impressions // The Journal of pros-thetic dentistry. 2017. V. 117. No. 4. P. 507–512. DOI: 10.1016/j.prosdent.2016.07.026</mixed-citation><mixed-citation xml:lang="en">Matta R.E., Adler W., Wichmann M., Heckmann, S.M. Accuracy of impression scanning compared with stone casts of implant impressions // The Journal of pros-thetic dentistry. 2017. V. 117. No. 4. P. 507–512. DOI: 10.1016/j.prosdent.2016.07.026</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Schepke U., Meijer H.J., Kerdijk W., Cune M.S. Digital versus analog complete-arch impressions for single-unit premolar implant crowns: Operating time and patient preference // The Journal of prosthetic dentistry. 2015. V. 114. No. 3. P. 403–406. e1.DOI: 10.1016/j.prosdent.2015.04.003</mixed-citation><mixed-citation xml:lang="en">Schepke U., Meijer H.J., Kerdijk W., Cune M.S. Digital versus analog complete-arch impressions for single-unit premolar implant crowns: Operating time and patient preference // The Journal of prosthetic dentistry. 2015. V. 114. No. 3. P. 403–406. e1.DOI: 10.1016/j.prosdent.2015.04.003</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Imburgia M., Logozzo S., Hauschild U., Veronesi G., Mangano C., Mangano F. G. Accuracy of four intraoral scanners in oral implantology: a comparative in vitro study // BMC oral health. 2017. V. 17. No. 1. P. 1–13. https://doi.org/10.1186/s12903-017-0383-4</mixed-citation><mixed-citation xml:lang="en">Imburgia M., Logozzo S., Hauschild U., Veronesi G., Mangano C., Mangano F. G. Accuracy of four intraoral scanners in oral implantology: a comparative in vitro study // BMC oral health. 2017. V. 17. No. 1. P. 1–13. https://doi.org/10.1186/s12903-017-0383-4</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Brosky M.E., Major R.J., DeLong R., Hodges J.S. Evaluation of dental arch repro-duction using three-dimensional optical digitization // The Journal of prosthetic dentistry. 2003. V. 90. No. 5. P. 434–440. DOI: 10.1016/j.prosdent.2003.08.021</mixed-citation><mixed-citation xml:lang="en">Brosky M.E., Major R.J., DeLong R., Hodges J.S. Evaluation of dental arch repro-duction using three-dimensional optical digitization // The Journal of prosthetic dentistry. 2003. V. 90. No. 5. P. 434–440. DOI: 10.1016/j.prosdent.2003.08.021</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
