medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-24-9-13medalphabet-2192Research ArticleСтатьиПерспективы применения коллагенсодержащих матриксов в направленной тканевой регенерации. Обзор литературыProspects for the use of collagen-containing matrices in directed tissue regeneration. Literature reviewhttps://orcid.org/0000-0002-1827-8487БойкоЕ. М.BoykoЕ. М.

Е. М. Бойко , к.м.н., преподаватель 

 Ставрополь

E.M. Boyko, teacher Essentuki branch

Stavropol

https://orcid.org/0000-0002-6352-6750ДолгалевА. А.DolgalevA. A.

А. А. Долгалев, д.м.н., доцент, начальник центра инноваций и трансфера технологий, проф. кафедры стоматологии общей практики и детской стоматологии, проф. кафедры клинической стоматологии с курсом ХС и ЧЛХ

Ставрополь

A. A. Dolgalev, PhD, MD, Head of the Center for Innovation and Technology Transfer, Professor of the Department of General Practice Dentistry and Pediatric Dentistry, Professor of the Department of Clinical Dentistry with a course of OS and MFS

Stavropol

https://orcid.org/0000-0002-3271-971XСтоматовД. В.StomatovD. V.

Д. В. Стоматов, к.м.н., доцент кафедры челюстно-лицевой хирургии

Пенза

D. V. Stomatov, candidate of Medical Sciences, Associate Professor of the Department of Maxillofacial Surgery

Penza

https://orcid.org/0000-0001-6995-8629ИвашкевичС. Г.IvashkevihS. G.

С. Г. Ивашкевич, к.м.н., доцент кафедры челюстно-лицевой хирургии и хирургической стоматологиМосква

 

S. G. Ivashkevih, Lecturer of the department, Oral and Maxillofacial surgery department

Moscow

https://orcid.org/0000-0003-4625-6266ЧагаровА. А.ChagarovA. A.

А. А. Чагаров, заочный аспирант кафедры стоматологии общей практики и детской стоматологииСтаврополь

 

A. A. Chagarov, Postgraduate Student, Department of General Practice and Pediatric Dentistry

Stavropol

https://orcid.org/0000-0002-0765-0108МусаевМ. Г.MusaevМ. G.

М. Г. Мусаев, заочный аспирант кафедры стоматологии общей практики и детской стоматологииСтаврополь

 

M. G. Musaev, Stavropol State Medical University, Stavropol, Russia, Postgraduate of the Department of general and pediatric

Stavropol

https://orcid.org/0000-0002-1711-1415ЭдишерашвилиУ. Б.EdisherashviliU. B.

У. Б. Эдишерашвили, заочный аспирант кафедры стоматологии общей практики и детской стоматологииСтаврополь

 

U. B. Edisherashvili, Stavropol State Medical University, Stavropol, Russia, Postgraduate of the Department of general and pediatric dentistry

Stavropol

ГабриелянН. Г.GabrielianN. G.

Н. Г. Габриелян, аспирант кафедры стоматологии общей практики и детской стоматологии

Ставрополь

N. G. Gabrielian, Post-graduate student of the Department of Dentistry of General Practice and Pediatric Dentistry

Stavropol

Ставропольский государственный медицинский университет Министерства здравоохранения РФРоссияStavropol state medical university of the Ministry of Health of the Russian FederationRussian FederationСтавропольский государственный медицинский университет Министерства здравоохранения РФРоссияStavropol state medical university of the Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Пензенский государственный университет»РоссияPenza State UniversityRussian FederationФГАОУ ВО Российский университет дружбы народовРоссияPeoples ‘ Friendship University of RussiaRussian FederationСтавропольский государственный медицинский университет Министерства здравоохранения РФРоссияStavropol state medical university of the Ministry of Health of the Russian Federation StavropolRussian Federation202125092021024Стоматология (3)913Copyright © Бойко Е.М., Долгалев А.А., Стоматов Д.В., Ивашкевич С.Г., Чагаров А.А., Мусаев М.Г., Эдишерашвили У.Б., Габриелян Н.Г., 20212021Бойко Е.М., Долгалев А.А., Стоматов Д.В., Ивашкевич С.Г., Чагаров А.А., Мусаев М.Г., Эдишерашвили У.Б., Габриелян Н.Г.Boyko Е.М., Dolgalev A.A., Stomatov D.V., Ivashkevih S.G., Chagarov A.A., Musaev М.G., Edisherashvili U.B., Gabrielian N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2192

Исследования последних десятилетий убедительно показывают, что коллаген в соединительной ткани играет не только структурную роль. В 80-х годах XX века А. Пишингером и Х. Хайне была предположена информативно-регуляторная роль коллагена в составе экстрацеллюлярного матрикса (A. Pischinger, 1990). В последние годы активно изучается морфогенетическая функция коллагена, осуществление которой возможно за счет наличия рецепторов к коллагену на поверхности различных клеточных популяций, таких как тромбоциты и фибробласты. Коллаген регулирует ремоделирование экстрацеллюлярного матрикса (J.D. San Antonio et al., 2020). При этом, вероятно, большое значение имеют продукты его распада, стимулирующие рост по механизму отрицательной обратной связи. В целом принципиальное значение для регуляции роста соединительной ткани имеет отношение между синтезом и распадом коллагена.

Studies of recent decades have convincingly shown that collagen in connective tissue plays not only a structural role. In the 80s of the XX centu[1]ry, A. Pishinger and H. Heine suggested the informative-regulatory role of collagen in the extracellular matrix (A. Pischinger, 1990). In recent years, the morphogenetic function of collagen has been actively studied, the implementation of which is possible due to the presence of collagen re[1]ceptors on the surface of various cell populations, such as platelets and fibroblasts. Collagen regulates the remodeling of the extracellular matrix (J. D. San Antonio et al., 2020). At the same time, its decay products, which stimulate growth by the negative feedback mechanism, are probably of great importance. In general, the relationship between the synthesis and breakdown of collagen is of fundamental importance for the regulation of connective tissue growth.

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The authors declare that there are no conflicts of interest present.