medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-26-47-49medalphabet-2181Research ArticleСОВРЕМЕННАЯ ГИНЕКОЛОГИЯMODERN GYNECOLOGYКогнитивные расстройства у женщин в период перименопаузыCognitive disorders in perimenopausal womenhttps://orcid.org/0000-0002-1935-4277ТкаченкоЛ. В.TkachenkoL. V.

Ткаченко Людмила Владимировна, доктор медицинских наук, профессор, заведующая кафедрой акушерства и гинекологии Института непрерывного медицинского и фармацевтического образования

Волгоград

Tkachenko Lyudmila V., DM Sci, professor, head of Dept of Obstetrics and Gynecology, Institute of Continuing Medical and Pharmaceutical Education

Volgograd

tkachenko.fuv@mail.ruhttps://orcid.org/0000-0003-4364-0123КурушинаО. В.KurushinaO. V.

Курушина Ольга Викторовна, доктор медицинских наук, доцент, главный внештатный специалист – невролог Южного федерального округа, заведующая кафедрой неврологии, нейрохирургии, медицинской генетики

Волгоград

Kurushina Olga V., DM Sci, associate professor, chief freelance specialistneurologist of Southern Federal District, head of Dept of Neurology, Neurosurgery, Medical Genetics

Volgograd

ovkurushina@mail.ruhttps://orcid.org/0000-0001-6286-0485ВоробьеваЮ. С.VorobyovaYu. S.

Воробьева Юлия Сергеевна, аспирант, врач-невролог, ассистент кафедры неврологии, нейрохирургии, медицинской генетики

Волгоград

Vorobyova Yuliya S., postgraduate student, neurologist, assistant professor at Dept of Neurology, Neurosurgery, Medical Genetics

Volgograd

ysvorobyeva34@gmail.comФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава РоссииРоссияVolgograd State Medical UniversityRussian Federation202124092021026Современная гинекология (2)4749Copyright © Ткаченко Л.В., Курушина О.В., Воробьева Ю.С., 20212021Ткаченко Л.В., Курушина О.В., Воробьева Ю.С.Tkachenko L.V., Kurushina O.V., Vorobyova Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2181

Статья посвящена обсуждению возможных механизмов развития когнитивных расстройств, возникновения и прогрессии нейродегенеративных заболеваний и уровня половых гормонов у женщин в период перименопаузы – состоянии, связанном с эндокринными изменениями, вызванными уменьшением фолликулярной массы яичников и, как следствие, снижением уровня стероидных гормонов (в частности, эстрогена). Известно, что эстроген оказывает нейропротективное воздействие, влияет на психическую и когнитивную сферы. Снижение его в перименопаузальный период способствует появлению вегетативных симптомов (приливы, бессонница, изменения настроения и пр.), повышает риск развития депрессивнотревожных симптомов, когнитивных расстройств. С целью их коррекции и препятствия развития нейродегенеративных заболеваний возможно применение заместительной гормональной терапии для продления нейропротективного эффекта эстрогенов в организме женщины.

The article is devoted to the discussion of possible mechanisms of the development of cognitive disorders, the onset and progression of neurodegenerative diseases and the level of sex hormones in women during perimenopause, a condition associated with endocrine changes caused by a decrease in the follicular mass of the ovaries, and, as a consequence, a decrease in the level of their steroid hormones (in particular, estrogen). It is known that estrogen has a neuroprotective effect, affects the mental and cognitive spheres. Reducing it in the perimenopausal period contributes to the appearance of vegetative symptoms (hot flashes, insomnia, mood changes, etc.), increases the risk of developing depressive-anxiety symptoms, cognitive disorders. In order to correct them and prevent the development of neurodegenerative diseases, it is possible to use hormone replacement therapy to prolong the neuroprotective effect of estrogens in a woman’s body.

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The authors declare that there are no conflicts of interest present.