medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-16-53-58medalphabet-2153Research ArticleСтатьиМинеральная плотность костной ткани у женщин в постменопаузе с остеоартритом коленного суставаBone mineral density in postmenopausal women with osteoarthritis of knee jointhttps://orcid.org/0000-0002-2988-1652УсоваЕ. В.UsovaE. V.

Усова Екатерина Владимировна, аспирант

Usova Ekaterina V., postgraduate student

https://orcid.org/0000-0001-8020-4545АверкиеваЮ. В.AverkievaYu. V.

Аверкиева Юлия Валерьевна, к.м.н., ассистент

Averkieva Yulia V., PhD Med, assistant

https://orcid.org/0000-0002-5804-4298РаскинаТ. А.RaskinaT. A.

Раскина Татьяна Алексеевна, д.м.н., проф., зав. кафедрой

Raskina Tatyana A., DM Sci, professor, head of Dept

https://orcid.org/0000-0003-3907-7120ЛетаеваМ. В.LetaevaM. V.

Летаева Марина Васильевна, к.м.н., доцент

Letaeva Marina V., PhD Med, associate professor

https://orcid.org/0000-0001-6713-2049МалышенкоО. С.MalyshenkoO. S.

Малышенко Ольга Степановна, к.м.н., доцент

Malyshenko Olga S., PhD Med, associate professor

https://orcid.org/0000-0002-0184-7997КоролеваМ. В.KorolevaM. V.

Королева Марина Валерьевна, к.м.н., ассистент

Koroleva Marina V., PhD Med, assistant

ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава РоссииРоссияDept of Propedeutics of Internal Diseases of Kemerovo State Medical UniversityRussian Federation202119082021016Ревматология в общей врачебной практике5358Copyright © Усова Е.В., Аверкиева Ю.В., Раскина Т.А., Летаева М.В., Малышенко О.С., Королева М.В., 20212021Усова Е.В., Аверкиева Ю.В., Раскина Т.А., Летаева М.В., Малышенко О.С., Королева М.В.Usova E.V., Averkieva Y.V., Raskina T.A., Letaeva M.V., Malyshenko O.S., Koroleva M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2153Цель

Цель. Изучить состояние минеральной плотности кости (МПК) у женщин в постменопаузе с остеоартритом (ОА) коленного сустава в зависимости от рентгенологической стадии.

Материалы и методы

Материалы и методы. В исследование были включены 56 женщин в возрасте от 44 до 75 лет. Диагноз ОА установлен согласно диагностическим критериям Американской коллегии ревматологов (ACR, 1991). Для сравнительного анализа пациенты были разделены на две группы с учетом рентгенологической стадии: 1-я – 38 женщин с I–II рентгенологической стадией; 2-я – 18 больных с III–IV рентгенологической стадией. Рентгенография коленного сустава впереднезадней проекции проведена вфиксированном положении сгибания с использованием специальной рамки (SynaFlexer TM Plexiglass positioning frame; Synarc, США). МПК оценена методом двуэнергетической рентгеновской абсорбциометрии в шейке бедра и в поясничном отделе позвоночника.

Результаты

Результаты. Остеопенический синдром диагностирован у абсолютного большинства больных – в 52 (92,8%) случаях, из них остеопения – у 27 (48,2%) и остеопороз – у 25 (44,6%). Нормальная МПК зарегистрирована у 4 (7,1%) женщин. По частоте выявления остеопенического синдрома статистически значимых различий между исследуемыми группами не получено (р > 0,050). Установлено статистически значимое увеличение показателей МПК и Т-критерия по мере прогрессирования ОА как в шейке бедра, так и в поясничном отделе позвоночника. Результаты корреляционного анализа свидетельствуют о значимой положительной корреляционной взаимосвязи между МПК шейки бедра и рентгенологической стадией ОА (r = 501; p < 0,001).

Выводы

Выводы. Полученные данные свидетельствуют о наличии остео-пенического синдрома у абсолютного большинства женщин в постменопаузе с ОА коленного сустава. Высокие показатели МПК шейки бедра и поясничного отдела позвоночника ассоциируются с поздними рентгенологическими стадиями ОА коленного сустава. 

Objective

Objective. Study the state of mineral bone density (BMD) in postmenopausal women with osteoarthritis (OA) of the knee joint depending on the X-ray stage.

Materials and methods

Materials and methods. The study included 56 women between 44 and 75 years of age. The diagnosis of OA is established according to the diagnostic criteria of the American College of Rheumatology (ACR, 1991). For comparative analysis, patients were divided into two groups, taking into account the radiological stage: the 1st with 38 women with I–II radiology stage, the 2nd with 18 patients with III–IV radiology stage. The X-ray of the knee joint in the anterior projection is performed in a fixed bending position using a special frame (SynaFlexer TM Plexiglass positioning frame, Synarc Inc., USA). The BMD is estimated by a two-energy X-ray absorption technique in the femoral neck and lumbar spine.

Results

Results. Osteopenic syndrome is diagnosed in 52 (92.8%) of the total number of patients, 27 (48.2%) have osteopenia and 25 (44.6%) have osteoporosis. Four women (7.1%) have a normal BMD. There is no statistically significant difference in the frequency of detection of the osteopenic syndrome between the groups studied (p > 0.050). Statistically significant increases in BMD and T-criteria have been found as the OA progresses in both the femoral neck and the lumbar spine. The correlation analysis results show a significant positive correlation between the BMD femoral neck and the OA X-ray stage (r = 501; p < 0.001).

Conclusions

Conclusions. The data show the presence of the osteopenic syndrome in the vast majority in postmenopausal women with OA of the knee joint. The high BMD values of the femur neck and lumbar spine are associated with the late X-ray stages of the OA of the knee joint.

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The authors declare that there are no conflicts of interest present.