medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-17-63-70medalphabet-2118Research ArticleСтатьиОмега-3 жирные кислоты как компонент нутритивно-метаболической терапии пациентов с COVID-19 и другими вирусными заболеваниями (обзор литературы)Omega-3 fatty acids as component of nutritional and metabolic treatment of patients with COVID-19 and other viral diseases (literature review)https://orcid.org/0000-0001-6975-6103ДмитриевА. В.DmitrievA. V.

Дмитриев Александр Владимирович, д.м.н., проф.

Санкт-Петербург

Dmitriev Alexander V., DM Sci, prof.

St. Petersburg

https://orcid.org/0000-0002-9466-7556МачулинаИ. А.MachulinaI. A.

Мачулина Ирина Александровна, зам. главного врача по анестезиологии и реанимации.

Москва

Machulina Irina A., deputy chief physician for anesthesiology and resuscitation.

Moscow

https://orcid.org/0000-0002-5278-7058ШестопаловА. Е.ShestopalovA. E.

Шестопалов Александр Ефимович, д.м.н., проф.

Москва

Shestopalov Alexander E., DM Sci, prof.

Moscow

ashest@yandex.ruАссоциация «Северо-Западная ассоциация парентерального и энтерального питания»РоссияNorth-West Association for Parenteral and Enteral NutritionRussian FederationГБУЗ «Городская клиническая больница № 70 имени Е. О. Мухина Департамента здравоохранения города Москвы»РоссияCity Clinical Hospital No. 70 n. a. E. O. MukhinaRussian FederationНациональная ассоциация клинического питания и метаболизма; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияNational Association for Clinical Nutrition and Metabolism; Russian Medical Academy of Continuing Professional EducationRussian Federation202118082021017Кардиология и неотложная медицина (2)6370Copyright © Дмитриев А.В., Мачулина И.А., Шестопалов А.Е., 20212021Дмитриев А.В., Мачулина И.А., Шестопалов А.Е.Dmitriev A.V., Machulina I.A., Shestopalov A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2118

У пациентов с вирусными заболеваниями, включая COVID - 19, недостаточность питания приводит к снижению эффективности специфического лечения, выживаемости и увеличению расходов на лечение. В соответствии с международными рекомендациями своевременная коррекция нутритивного статуса с помощью дополнения энтерального и парентерального питания включением омега-3 полиненасыщенных жирных кислот рыбьего жира (омега-3 ПНЖК – ЕРА и DHA) улучшает клинические результаты специфического противовирусного лечения. Выполнен аналитический обзор результатов исследований клинического применения омега-3 ПНЖК с целью профилактики и лечения COVID-19 и других вирусных инфекций. Включение омега-3 ПНЖК в состав клинического (энтерального и парентерального) питания способствует снижению выраженности симптомов заболевания, продолжительности пребывания в клинике и ускорению восстановления пациентов, зараженных вирусом SARS-CoV-2 и другими вирусами, а в сочетании с адекватным обеспечением макронутриентами позволяет устранить нутритивную недостаточность и улучшить клинические результаты.

Nutritional deficit in patients with viral diseases, including COVID-19, can reduce the efficacy of specific treatment, decrease the survival rate, and increase medical expenses. According to international guidelines, timely correction of nutritional status with supplemental enteral and parenteral nutrition containing omega-3 polyunsaturated fatty acid from fish oil (omega-3 PUFAs: ЕРА and DHA) is able to improve clinical outcomes of specific antiviral treatment. The authors conducted an analytical review to assess the results from the study of clinical use of omega-3 PUFAs for the prevention and treatment of COVID-19 and other viral infections. Supplementation of clinical (enteral and parenteral) nutrition with omega-3 PUFAs allows for symptom reduction, shorter stay in hospital, and quicker recovery of patients infected with SARS-CoV-2 and other viruses. When used in combination with adequate macronutrient support, it can reverse nutritional deficit and improve clinical outcomes.

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The authors declare that there are no conflicts of interest present.