medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-14-26-31medalphabet-2060Research ArticleСтатьиЗрительные галлюцинации при болезни Гентингтона: офтальмологическая валидация «Северо-восточного опросника зрительных галлюцинаций»Visual hallucinations in Gentington's disease: ophthalmic validation of ‘North-East Visual Hallucinations Interviewhttps://orcid.org/0000-0002-7472-4883СветозарскийС. Н.SvetozarskyS. N.

Светозарский Сергей Николаевич, к.м.н., врач‑офтальмолог офтальмологического отделения

Нижний Новгород

Svetozarsky Sergei N., PhD Med, ophthalmologist of Ophthalmological Dept.

Nizhni Novgorod

svetozarskij@rambler.ruhttps://orcid.org/0000-0003-0926-7724КопишинскаяС. В.KopishinskayaS. V.

Копишинская Светлана Васильевна, к.м.н., доцент, доцент кафедры неврологии и нейрохирургии

Киров; Самара

Kopishinskaya Svetlana V., PhD Med, associate prof. at Dept of Neurology and Neurosurgery

Kirov; Samara

kopishinskaya@gmail.comhttps://orcid.org/0000-0002-6745-2445КоротышМ. А.KorotyshM. A.

Коротыш Мария Анатольевна, врач‑невролог, нейропсихолог

Самара

Korotysh Maria A., neurologist, neuropsychologist

Samara

korotysh.ma@gmail.comhttps://orcid.org/0000-0002-6013-6634ВеличкоИ. А.VelichkoI. A.

Величко Иван Александрович, ассистент кафедры нервных болезней и нейрохирургии, невролог

Краснодар

Velichko Ivan A., assistant at Dept of Nervous Diseases and Neurosurgery, Neurologist

Krasnodar

md.velichko@mail.ruhttps://orcid.org/0000-0002-9591-4918СмирноваД. А.SmirnovaD. A.

Смирнова Дарья Александровна, к.м.н., врач‑психиатр

Самара

Smirnova Daria A., PhD Med, psychiatrist

Samara

d.a.smirnova@samsmu.ruФБУЗ «Приволжский окружной медицинский центр» ФМБА РоссииРоссияVolga District Medical CentreRussian FederationФГБОУ ВО «Кировский государственный медицинский университет» Минздрава России; Международный научно-образовательный центр нейропсихиатрии ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РоссииРоссияKirov State Medical University; Samara State Medical UniversityRussian FederationООО «Геном»РоссияGenom Co.Russian FederationФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава РоссииРоссияKuban State Medical UniversityRussian FederationМеждународный научно-образовательный центр нейропсихиатрии ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РоссииРоссияSamara State Medical UniversityRussian Federation202128062021014Неврология и психиатрия (2)2631Copyright © Светозарский С.Н., Копишинская С.В., Коротыш М.А., Величко И.А., Смирнова Д.А., 20212021Светозарский С.Н., Копишинская С.В., Коротыш М.А., Величко И.А., Смирнова Д.А.Svetozarsky S.N., Kopishinskaya S.V., Korotysh M.A., Velichko I.A., Smirnova D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2060

Болезнь Гентингтона (БГ) – неуклонно прогрессирующее нейродегенеративное заболевание, вызванное мутацией в гене гентингтина, с прогрессирующими двигательными, когнитивными и психическими нарушениями.

Целью данного исследования явилось определение валидности «Северо‑восточного опросника зрительных галлюцинаций» (North‑East Visual Hallucinations Interview, NEVHI) на российской выборке пациентов.

Материалы и методы

Материалы и методы. Обследовано 78 субъектов – 26 пациентов на манифестной стадии БГ, 21 преманифестный носитель гена БГ и 31 доброволец контрольной группы.

Результаты

Результаты. Низкая встречаемость зрительных галлюцинаций, по данным анкеты NEVHI, не позволяет сделать вывод об их специфичности для БГ. Недостижение уровня статистической значимости в данном случае предполагает высокий риск ошибки второго рода, связанный с низкой встречаемостью симптома и относительно малым размером группы.

Вывод

Вывод. Исследование показало, что опросник NEVHI может служить адекватной методикой для диагностики зрительных галлюцинаций при БГ.

Huntington's disease (HD) is a steadily progressive neurodegenerative disease caused by a mutation in the huntingtin gene, with progressive motor, cognitive and mental impairments.

The aim of the study is to determine the validity of the North‑East Visual Hallucinations Interview (NEVHI) in a Russian sample of patients.

Materials and methods

Materials and methods. 78 subjects were examined: 26 patients at the manifest stage of HD, 21 pre‑manifest carriers of the HD gene and 31 volunteers of the control group.

Results

Results. The low incidence of visual hallucinations according to the NEVHI does not allow us to conclude about their specificity for HD. Failure to achieve the level of statistical significance in this case suggests a high risk of type II error associated with the low occurrence of the symptom and the relatively small group size.

Conclusion

Conclusion. The study showed that the NEVHI questionnaire can serve as an adequate method for the diagnosis of visual hallucinations in HD.

болезнь Гентингтоназрительные галлюцинациивалидизацияопросникHuntington's diseasevisual hallucinationsvalidationquestionnaireReferencesИллариошкин, С. Н. Болезнь Гентингтона: Монография. С. Н. Иллариошкин, С.А. Клюшников, Ю.А. Селиверстов. М.: ООО «Издательское предприятие «Ат мосфера», 2018. 472 с. https://doi.org/10.12731/978-5-902123-69-9Illarioshkin, S.N. Huntington’s Disease: A Monograph. S.N. Illarioshkin, S.A. Klyushnikov, Yu.A. Seliverstov. M.: Publishing company «Atmosphere», 2018. 472 p. https://doi.org/10.12731/978-5-902123-69-9Jindahra P., Petrie A., Plant G.T. Retrograde trans synaptic retinal ganglion cell loss identified by optical coherence tomography. Brain. 2009 Mar; 132 (Pt 3): 628–34. https://doi.org/10.1093/brain/awp00Jindahra P., Petrie A., Plant G.T. Retrograde trans synaptic retinal ganglion cell loss identified by optical coherence tomography. Brain. 2009 Mar; 132 (Pt 3): 628–34. https://doi.org/10.1093/brain/awp001Burghaus L, Eggers C., Timmermann L., Fink G.R., Diederich N.J. Hallucinations in neurodegenerative diseases. CNS Neurosci Ther. 2012 Feb; 18 (2): 149–59. https://doi.org/10.1111/j.1755–5949.2011.00247.x.Burghaus L, Eggers C., Timmermann L., Fink G.R., Diederich N.J. Hallucinations in neurodegenerative diseases. CNS Neurosci Ther. 2012 Feb; 18 (2): 149–59. https://doi.org/10.1111/j.1755–5949.2011.00247.x.Barnes J., David A.S. Visual hallucinations in Parkinson's disease: a review and phenomenological survey. J Neurol Neurosurg Psychiatry. 2001 Jun; 70 (6): 727–33. https://doi.org/10.1136/jnnp.70.6.727Barnes J., David A.S. Visual hallucinations in Parkinson's disease: a review and phenom enological survey. J Neurol Neurosurg Psychiatry. 2001 Jun; 70 (6): 727–33. https://doi.org/10.1136/jnnp.70.6.727Manford M., Andermann F. Complex visual hallucinations. Clinical and neurobiological insights. Brain. 1998 Oct; 121 (Pt 10): 1819–40. https://doi.org/10.1093/brain/121.10.1819Manford M., Andermann F. Complex visual hallucinations. Clinical and neurobiological insights. Brain. 1998 Oct; 121 (Pt 10): 1819–40. https://doi.org/10.1093/brain/121.10.1819Rocha N. P., Mwangi B., Gutierrez Candano C. A., Sampaio C., Furr Stimming E., Teixeira A. L. The Clinical Picture of Psychosis in Manifest Huntington's Disease: A Comprehensive Analysis of the Enroll HD Database. Front Neurol. 2018 Nov 6; 9: 930. https://doi.org/10.3389/fneur.2018.00930Rocha N. P., Mwangi B., Gutierrez Candano C. A., Sampaio C., Furr Stimming E., Teixeira A. L. The Clinical Picture of Psychosis in Manifest Huntington's Disease: A Comprehensive Analysis of the Enroll HD Database. Front Neurol. 2018 Nov 6; 9: 930. https://doi.org/10.3389/fneur.2018.00930Psychosis in Huntington’s disease [Электронный ресурс]. J. Perez–Perez et al. Mov Disord. 2016. Vol. 31 (suppl. 2). Режим доступа: http://www.mdsabstracts.org/abstract/psychosis-in-huntingtons-disease/ Accessed May 14, 2018.Psychosis in Huntington’s disease [Электронный ресурс]. J. Perez–Perez et al. Mov Disord. 2016. Vol. 31 (suppl. 2). Режим доступа: http://www.mdsabstracts.org/abstract/psychosis-in-huntingtons-disease/ Accessed May 14, 2018.Anderson K.E., Marshall F.J. Behavioral symptoms associated with Huntington's disease. Adv Neurol. 2005; 96: 197–208Anderson K.E., Marshall F.J. Behavioral symptoms associated with Huntington's disease. Adv Neurol. 2005; 96: 197–208Mosimann U.P., Collerton D., Dudley R., Meyer T.D., Graham G., Dean J.L., Bearn D., Killen A., Dickinson L., Clarke M.P., McKeith I.G. A semi structured interview to assess visual hallucinations in older people. Int J Geriatr Psychiatry. 2008 Jul; 23 (7): 712–8. https://doi.org/10.1002/gps.1965Mosimann U.P., Collerton D., Dudley R., Meyer T.D., Graham G., Dean J.L., Bearn D., Killen A., Dickinson L., Clarke M.P., McKeith I.G. A semi structured interview to assess visual hallucinations in older people. Int J Geriatr Psychiatry. 2008 Jul; 23 (7): 712–8. https://doi.org/10.1002/gps.1965Williams D.R., Warren J.D., Lees A.J. Using the presence of visual hallucinations to dif ferentiate Parkinson's disease from atypical parkinsonism. J Neurol Neurosurg Psychiatry. 2008 Jun; 79 (6): 652–5. https://doi.org/10.1136/jnnp.2007.124677Williams D.R., Warren J.D., Lees A.J. Using the presence of visual hallucinations to dif ferentiate Parkinson's disease from atypical parkinsonism. J Neurol Neurosurg Psychiatry. 2008 Jun; 79 (6): 652–5. https://doi.org/10.1136/jnnp.2007.124677Santhouse A. M., Howard R. J., ffytche D. H. Visual hallucinatory syndromes and the anatomy of the visual brain. Brain. 2000 Oct; 123 (Pt 10): 2055–64. https://doi.org/10.1093/brain/123.10.2055Santhouse A. M., Howard R. J., ffytche D. H. Visual hallucinatory syndromes and the anatomy of the visual brain. Brain. 2000 Oct; 123 (Pt 10): 2055–64. https://doi.org/10.1093/brain/123.10.2055Dudley R., Wood M., Spencer H., Brabban A., Mosimann U.P., Collerton D. Identifying specific interpretations and use of safety behaviours in people with distressing visual hallucinations: an exploratory study. Behav Cogn Psychother. 2012 May; 40 (3): 367–75. https://doi.org/10.1017/S1352465811000750Dudley R., Wood M., Spencer H., Brabban A., Mosimann U.P., Collerton D. Identifying specific interpretations and use of safety behaviours in people with distressing visual hallucinations: an exploratory study. Behav Cogn Psychother. 2012 May; 40 (3): 367–75. https://doi.org/10.1017/S1352465811000750Dudley R., Collerton D., Nicholson M., Mosimann U. Clinical characteristics of disclosed visual hallucinations in users of an Early Intervention in Psychosis Service, Psychosis, 2013 5:2, 127–133, https://doi.org/10.1080/17522439.2012.699543Dudley R., Collerton D., Nicholson M., Mosimann U. Clinical characteristics of disclosed visual hallucinations in users of an Early Intervention in Psychosis Service, Psychosis, 2013 5:2, 127–133, https://doi.org/10.1080/17522439.2012.699543Aynsworth C., Collerton D., Dudley R. Measures of visual hallucinations: Review and recommendations. Clin Psychol Rev. 2017 Nov; 57: 164–182. https://doi.org/10.1016/j.cpr.2017.05.001Aynsworth C., Collerton D., Dudley R. Measures of visual hallucinations: Review and recom mendations. Clin Psychol Rev. 2017 Nov; 57: 164–182. https://doi.org/10.1016/j.cpr.2017.05.001Khundakar A.A., Hanson P.S., Erskine D., Lax N.Z., Roscamp J., Karyka E., Tsefou E., Singh P., Cockell S.J., Gribben A., Ramsay L., Blain P.G., Mosimann U.P., Lett D.J., Elstner M., Turnbull D.M., Xiang C.C., Brownstein M.J., O'Brien J.T., Taylor J.P., Attems J, Thomas A.J., McKeith I.G., Morris C.M. Analysis of primary visual cortex in dementia with Lewy bodies indi cates GABAergic involvement associated with recurrent complex visual hallucinations. Acta Neuropathol Commun. 2016 Jun 30; 4 (1): 66. https://doi.org/10.1186/s40478-016-0334-3Khundakar A.A., Hanson P.S., Erskine D., Lax N.Z., Roscamp J., Karyka E., Tsefou E., Singh P., Cockell S.J., Gribben A., Ramsay L., Blain P.G., Mosimann U.P., Lett D.J., Elstner M., Turnbull D.M., Xiang C.C., Brownstein M.J., O'Brien J.T., Taylor J.P., Attems J, Thomas A.J., McKeith I.G., Morris C.M. Analysis of primary visual cortex in dementia with Lewy bodies indi cates GABAergic involvement associated with recurrent complex visual hallucinations. Acta Neuropathol Commun. 2016 Jun 30; 4 (1): 66. https://doi.org/10.1186/s40478-016-0334-3Bowman A.R., Bruce V., Colbourn C.J,. Collerton D. Compensatory shifts in visual perception are associated with hallucinations in Lewy body disorders. Cogn Res Princ Implic. 2017; 2 (1): 26. https://doi.org/10.1186/s41235-017-0063-6Bowman A.R., Bruce V., Colbourn C.J,. Collerton D. Compensatory shifts in visual perception are associated with hallucinations in Lewy body disorders. Cogn Res Princ Implic. 2017; 2 (1): 26. https://doi.org/10.1186/s41235-017-0063-6Holiday K.A., Pirogovsky Turk E., Malcarne V.L., Filoteo J.V., Litvan I., Lessig S.L., Song D., Schiehser D.M. Psychometric Properties and Characteristics of the North East Visual Hallucinations Interview in Parkinson's Disease. Mov Disord Clin Pract. 2017 Sep–Oct; 4 (5): 717–723. https://doi.org/10.1002/mdc3.12479Holiday K.A., Pirogovsky Turk E., Malcarne V.L., Filoteo J.V., Litvan I., Lessig S.L., Song D., Schiehser D.M. Psychometric Properties and Characteristics of the North East Visual Hallucinations Interview in Parkinson's Disease. Mov Disord Clin Pract. 2017 Sep–Oct; 4 (5): 717–723. https://doi.org/10.1002/mdc3.12479

The authors declare that there are no conflicts of interest present.