medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-10-8-15medalphabet-2054Research ArticleДИАГНОСТИКА И ОНКОТЕРАПИЯDIAGNOSTICS AND ONCOTHERAPYВинорелбин в терапии немелкоклеточного рака легкогоVinorelbine in treatment of non-small cell lung cancerhttps://orcid.org/0000-0001-7728-9533АртамоноваЕ. В.ArtamonovaE. V.

Артамонова Елена Владимировна, д.м.н., зав. химиотерапевтическим отделением № 1; проф. кафедры

Москва

Artamonova Elena V., DM Sci, head of Chemotherapy Dept No. 1; prof. at Oncology and Radiotherapy Dept

Moscow

ArtamonovaE@mail.ruФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава России; ФГAOУ ВО «Российский национальный исследовательский медицинский университет имени И. И. Пирогова» Минздрава РоссииРоссияNational Medical Research Centre of Oncology n.a. N. N. Blokhin; Russian National Research Medical University n.a. N. I. PirogovRussian Federation202128062021010«Диагностика и онкотерапия» (1)815Copyright © Артамонова Е.В., 20212021Артамонова Е.В.Artamonova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2054

Химиотерапия продолжает оставаться неотъемлемой частью системного лечения немелкоклеточного рака легкого (НМРЛ), а винорелбин доказал эффективность в адъювантной терапии в составе химиолучевых программ и в лечении метастатической формы заболевания. Пероральная форма препарата отличается значительно бóльшим удобством применения и может использоваться не только в стандартных режимах дозирования (как в монотерапии, так и в комбинации с производными платины), но и в метрономной терапии, предусматривающей более частый прием винорелбина в меньших разовых дозах. Пероральный винорелбин доказал высокую эффективность и безопасность в различных популяциях пациентов, включая подгруппы пожилых и ослабленных больных, и может широко использоваться на различных этапах лечения НМРЛ. 

Chemotherapy is important part of the systemic treatment of non-small cell lung cancer (NSCLC). Vinorelbine has proven its effectiveness in adjuvant therapy, as part of chemoradiotherapy programs, and in the treatment of metastatic disease. The oral form of the drug is significantly more convenient to use and can be used not only in standard dosage regimens (both in monotherapy and in combination with platinum derivatives), but also in metronomic therapy, which provides for more frequent administration of vinorelbine in smaller single doses. Oral vinorelbine has been shown to be highly effective and safe in various patient populations, including subgroups of elderly and patients with ECOG2, and can be widely used in various stages of NSCLC treatment.

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The authors declare that there are no conflicts of interest present.