medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-6-32-34medalphabet-2004Research ArticleСтатьиОсобенности использования НПВС в условиях пандемии. Взгляд гастроэнтерологаFeatures of NSAIDs' use in pandemic. Gastroenterologist's viewСасЕ. И.SasE. I.

Сас Евгений Иванович, проф. 2-й кафедры (терапии, усовершенствования врачей)

Санкт-Петербург

Sas Evgeniy I., prof. at 2nd Dept (Advanced Therapy, Therapy for Doctors)

Saint Petersburg

doctorsas@rambler.ruФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова» Минобороны РоссииРоссияMilitary Medical Academy n.a. S.M. KirovRussian Federation20210706202116Практическая гастроэнтерология (1)3234Copyright © Сас Е.И., 20212021Сас Е.И.Sas E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2004

Нестероидные противовоспалительные препараты (НПВП) – средства, используемые для терапии острой и хронической боли, связанной преимущественно с воспалительными изменениями. Данная группа препаратов широко используется в неврологии, ревматологии, травматологии и т.д. Основной механизм действия препаратов связан с воздействием на циклооксигеназу-2 (ЦОГ-2) и блокадой синтеза провоспалительных простагландинов (ПГ), а также воздействием на ЦОГ-1 и подавлением синтеза цитопротективных ПГ, что определяет возможность возникновения побочных эффектов со стороны желудочно-кишечного тракта. В условиях пандемии использование данной группы препаратов увеличилось многократно. Особенности клинического течения как самой вирусной инфекции, так и использования других лекарственных средств, приводят к значительному изменению фармакодинамики и фармакокинетики НПВП, что может повлечь за собой развитие нежелательных побочных явлений.

Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs used to treat acute and chronic pain associated primarily with inflammatory changes. This group of drugs is widely used in neurology, rheumatology, traumatology, etc. The main mechanism of action of the drugs is associated with the effect on cyclooxygenase-2 (COX-2) and blockade of the synthesis of pro-inflammatory prostaglandins (PG), as well as the effect on COX-1 and suppression of the synthesis of cytoprotective PG, which determines the possibility of side effects from the gastrointestinal tract. In the pandemic, the use of this group of drugs has increased many times over. Features of the clinical course of both the viral infection itself and the use of other drugs leads to a significant change in the pharmacodynamics and pharmacokinetics of NSAIDs, which may lead to the development of undesirable side effects.

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The authors declare that there are no conflicts of interest present.