medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-3-27-33medalphabet-1930Research ArticleНЕВРОЛОГИЯ И ПСИХИАТРИЯNEUROLOGY AND PSYCHIATRYАстенический синдром у пациентов, перенесших COVID-19: патогенез, клиника, диагностика и медицинская реабилитацияAsthenic syndrome in patients with COVID‑19: pathogenesis, clinic, diagnosis and medical rehabilitationhttps://orcid.org/0000-0003-0353-553XПетроваЛ. В.PetrovaL. V.

Петрова Людмила Владимировна, к.м.н., с.н.с., зав. отделением медицинской реабилитации

 

ludmila.v.petrova@yandex.ruhttps://orcid.org/0000-0003-0902-348XКостенкоЕ. В.KostenkoE. V.

Костенко Елена Владимировна, д.м.н., г.н.с., зав. филиалом № 71, проф. кафедры неврологии и нейрохирургии 

ekostenko58@yandex.ruhttps://orcid.org/0000-0002-3747-2111ЭнееваМ. А.EneevaM. A.

Энеева Малика Ахматовна, к.м.н., с.н.с., зав. отделением медицинской реабилитации

 

eneeva.m@yandex.ruГАУЗ «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины Департамента здравоохранения Москвы»РоссияMoscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports MedicineRussian FederationГАУЗ «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины Департамента здравоохранения Москвы»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава РоссииРоссияMoscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine; Pirogov Russian National Research Medical UniversityRussian Federation20212803202103Неврология и психиатрия (1)2733Copyright © Петрова Л.В., Костенко Е.В., Энеева М.А., 20212021Петрова Л.В., Костенко Е.В., Энеева М.А.Petrova L.V., Kostenko E.V., Eneeva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1930Цель обзора

Цель обзора. Оценка распространенности астенического синдрома (АС) у пациентов, инфицированных SARS-CoV‑2, и определении влияния АС на процесс реконвалесценции и течение коморбидных заболеваний.

Основные положения

Основные положения. АС –одно из наиболее часто встречаемых проявлений после перенесенной COVID-инфекции разной степени тяжести, который у неврологических больных может усугублять течение основного заболевания и снижать эффективность реабилитационных мероприятий. Своевременная диагностика позволяет выявить АС и провести его коррекцию с применением медикаментозных и немедикаментозных методов.

Заключение

Заключение. Ввиду ограниченного количества исследований, касающихся АС при COVID‑19, необходимы дальнейшее изучение клинических особенностей данного заболевания, разработка алгоритмов медицинской реабилитации с учетом клинической полиморфности АС.

The purpose of this review was to assess the prevalence of asthenic syndrome (AS) in patients infected with SARS-CoV‑2, and to determine the effect of AS on the process of convalescence and the course of comorbid diseases.

Main provisions

Main provisions. AS is one of the most common manifestations after a COVID infection of varying severity, which in neurological patients can aggravate the course of the underlying disease and reduce the effectiveness of rehabilitation measures. Timely diagnosis allows you to identify AS and correct it with the use of medication and non-drug methods.

Conclusion

Conclusion. Due to the limited number of studies concerning AS in COVID‑19, it is necessary to further study the clinical features of this disease, to develop algorithms for medical rehabilitation, taking into account the clinical polymorphism of AS.

COVID 19астенический синдромпсихическое здоровьемедицинская реабилитациятелемедицинаCOVID 19asthenic syndromemental healthmedical rehabilitationtelemedicineReferencesWorld Health Organization. Coronavirus disease 2019 (COVID 19) outbreak situation. Available at www.who.int/emergencies/diseases/novel-coronavirus 2019.World Health Organization. Coronavirus disease 2019 (COVID 19) outbreak situation. Available at www.who.int/emergencies/diseases/novel-coronavirus 2019.Lechien JR, Chiesa-Estomba CM, Place S, et al. Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019 [published online ahead of print, 2020 Apr 30]. J Intern Med. 2020. DOI: 10.1111/joim.13089.Lechien JR, Chiesa-Estomba CM, Place S, et al. Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019 [published online ahead of print, 2020 Apr 30]. J Intern Med. 2020. DOI: 10.1111/joim.13089.Chew NWS, Lee GKH, Tan BYQ, Jing M, Goh Y et al. A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID 19 outbreak. Brain Behav Immun. 2020 Apr 21: S0889–1591 (20) 30523–7. DOI: 10.1016/j.bbi.2020.04.049.Chew NWS, Lee GKH, Tan BYQ, Jing M, Goh Y et al. A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID 19 outbreak. Brain Behav Immun. 2020 Apr 21: S0889–1591 (20) 30523–7. DOI: 10.1016/j.bbi.2020.04.049.Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A. Coronavirus (COVID 19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus. 2020; 12 (3): e7355. DOI: 10.7759/cureus.7355.Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A. Coronavirus (COVID 19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus. 2020; 12 (3): e7355. DOI: 10.7759/cureus.7355.Orsucci D, Ienco EC, Nocita G, Napolitano A, Vista M. Neurological features of COVID 19 and their treatment: a review. Drugs Context. 2020; 9: 2020–5–1. DOI: 10.7573/dic.2020–5–1.Orsucci D, Ienco EC, Nocita G, Napolitano A, Vista M. Neurological features of COVID 19 and their treatment: a review. Drugs Context. 2020; 9: 2020–5–1. DOI: 10.7573/dic.2020–5–1.Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382 (18): 1708–1720. DOI: 10.1056/NEJMoa2002032.Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382 (18): 1708–1720. DOI: 10.1056/NEJMoa2002032.Simpson R, Robinson L. Rehabilitation after critical illness in people with COVID 19 infection. Am J Phys Med Rehabil 2020; 99: 470–474. DOI: 10.1097/PHM.000000000000144.Simpson R, Robinson L. Rehabilitation after critical illness in people with COVID 19 infection. Am J Phys Med Rehabil 2020; 99: 470–474. DOI: 10.1097/PHM.000000000000144.Wang X, Xu H, Jiang H, et al. The Clinical Features and Outcomes of Discharged Coronavirus Disease 2019 Patients-A Prospective Cohort Study [published online ahead of print, 2020 May 22]. QJM. 2020; hcaa178. DOI: 10.1093/qjmed/hcaa178.Wang X, Xu H, Jiang H, et al. The Clinical Features and Outcomes of Discharged Coronavirus Disease 2019 Patients-A Prospective Cohort Study [published online ahead of print, 2020 May 22]. QJM. 2020; hcaa178. DOI: 10.1093/qjmed/hcaa178.Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV 2 in Singapore [published online ahead of print, 2020 Mar 3] [published correction appears in DOI: 10.1001/jama.2020.4372]. JAMA. 2020; 323 (15): 1488–1494. DOI: 10.1001/jama.2020.3204.Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV 2 in Singapore [published online ahead of print, 2020 Mar 3] [published correction appears in DOI: 10.1001/jama.2020.4372]. JAMA. 2020; 323 (15): 1488–1494. DOI: 10.1001/jama.2020.3204.Rogers JP, Chesney E, Oliver D, et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID 19 pandemic. Lancet Psychiatry. 2020; 7 (7): 611–627. DOI: 10.1016/S2215–0366(20)30203–0.Rogers JP, Chesney E, Oliver D, et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID 19 pandemic. Lancet Psychiatry. 2020; 7 (7): 611–627. DOI: 10.1016/S2215–0366(20)30203–0.F.A. Klok, Gudula J.A.M. Boon, S. Barco, M. Endres, J.J. M. Geelhoed, S Knauss et al. The Post-COVID 19 Functional Status scale: a tool to measure functional status over time after COVID 19. European Respiratory Journal Jul 2020, 56 (1) 2001494; DOI: 10.1183/13993003.01494–2020.F.A. Klok, Gudula J.A.M. Boon, S. Barco, M. Endres, J.J. M. Geelhoed, S Knauss et al. The Post-COVID 19 Functional Status scale: a tool to measure functional status over time after COVID 19. European Respiratory Journal Jul 2020, 56 (1) 2001494; DOI: 10.1183/13993003.01494–2020.Rongfeng Qi, W. Chen, S. Liu, Paul M Thompson, LJ Zhang et al., Psychological Morbidities and Fatigue in Patients with Confirmed COVID 19 During Disease Outbreak: Prevalence and Associated Biopsychosocial Risk Factors medRxiv. 2020 May 11; 2020.05.08. 20031666. DOI: 10.1101/2020.05.08.20031666. Preprint.Rongfeng Qi, W. Chen, S. Liu, Paul M Thompson, LJ Zhang et al., Psychological Morbidities and Fatigue in Patients with Confirmed COVID 19 During Disease Outbreak: Prevalence and Associated Biopsychosocial Risk Factors medRxiv. 2020 May 11; 2020.05.08. 20031666. DOI: 10.1101/2020.05.08.20031666. Preprint.Li LQ, Huang T, Wang YQ, et al. COVID 19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020; 92 (6): 577–583. DOI: 10.1002/jmv.25757.Li LQ, Huang T, Wang YQ, et al. COVID 19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020; 92 (6): 577–583. DOI: 10.1002/jmv.25757.Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV 2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study [published correction appears in Lancet Respir Med. 2020 Apr; 8 (4): e26]. Lancet Respir Med. 2020; 8 (5): 475–481. DOI: 10.1016/S2213–2600(20)30079–5.Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV 2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study [published correction appears in Lancet Respir Med. 2020 Apr; 8 (4): e26]. Lancet Respir Med. 2020; 8 (5): 475–481. DOI: 10.1016/S2213–2600(20)30079–5.Cheng SK, Wong CW, Tsang J, Wong KC. Psychological distress and negative appraisals in survivors of severe acute respiratory syndrome (SARS). Psychol Med. 2004; 34 (7): 1187–1195. DOI: 10.1017/s0033291704002272.Cheng SK, Wong CW, Tsang J, Wong KC. Psychological distress and negative appraisals in survivors of severe acute respiratory syndrome (SARS). Psychol Med. 2004; 34 (7): 1187–1195. DOI: 10.1017/s0033291704002272.Mak IW, Chu CM, Pan PC, Yiu MG, Chan VL. Long-term psychiatric morbidities among SARS survivors. Gen Hosp Psychiatry. 2009; 31 (4): 318–326. DOI: 10.1016/j. genhosppsych.2009.03.001.Mak IW, Chu CM, Pan PC, Yiu MG, Chan VL. Long-term psychiatric morbidities among SARS survivors. Gen Hosp Psychiatry. 2009; 31 (4): 318–326. DOI: 10.1016/j. genhosppsych.2009.03.001.Neufeld KJ, Leoutsakos JS, Yan H, et al. Fatigue Symptoms During the First Year Following ARDS. Chest. 2020; S 0012–3692 (20) 30686–3. DOI: 10.1016/j. chest.2020.03.059.Neufeld KJ, Leoutsakos JS, Yan H, et al. Fatigue Symptoms During the First Year Following ARDS. Chest. 2020; S 0012–3692 (20) 30686–3. DOI: 10.1016/j. chest.2020.03.059.Ngai JC, Ko FW, Ng SS, To KW, Tong M, Hui DS. The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status. Respirology. 2010; 15 (3): 543–550. DOI: 10.1111/j.1440–1843.2010.01720.x.Ngai JC, Ko FW, Ng SS, To KW, Tong M, Hui DS. The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status. Respirology. 2010; 15 (3): 543–550. DOI: 10.1111/j.1440–1843.2010.01720.x.Tansey CM, Louie M, Loeb M, et al. One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome. Arch Intern Med. 2007; 167 (12): 1312–1320. DOI: 10.1001/archinte.167.12.1312.Tansey CM, Louie M, Loeb M, et al. One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome. Arch Intern Med. 2007; 167 (12): 1312–1320. DOI: 10.1001/archinte.167.12.1312.Lam MH, Wing YK, Yu MW, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med. 2009; 169 (22): 2142–2147. DOI: 10.1001/archinternmed.2009.384.Lam MH, Wing YK, Yu MW, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med. 2009; 169 (22): 2142–2147. DOI: 10.1001/archinternmed.2009.384.Hui DS. An overview on severe acute respiratory syndrome (SARS). Monaldi Arch Chest Dis. 2005; 63 (3): 149–157. DOI: 10.4081/monaldi.2005.632.Hui DS. An overview on severe acute respiratory syndrome (SARS). Monaldi Arch Chest Dis. 2005; 63 (3): 149–157. DOI: 10.4081/monaldi.2005.632.Batawi S, Tarazan N, Al-Raddadi R, et al. Quality of life reported by survivors after hospitalization for Middle East respiratory syndrome (MERS). Health Qual Life Outcomes. 2019; 17 (1): 101. DOI: 10.1186/s12955–019–1165–2.Batawi S, Tarazan N, Al-Raddadi R, et al. Quality of life reported by survivors after hospitalization for Middle East respiratory syndrome (MERS). Health Qual Life Outcomes. 2019; 17 (1): 101. DOI: 10.1186/s12955–019–1165–2.Kim HC, Yoo SY, Lee BH, Lee SH, Shin HS. Psychiatric Findings in Suspected and Confirmed Middle East Respiratory Syndrome Patients Quarantined in Hospital: A Retrospective Chart Analysis. Psychiatry Investig. 2018; 15 (4): 355–360. DOI: 10.30773/pi.2017.10.25.1.Kim HC, Yoo SY, Lee BH, Lee SH, Shin HS. Psychiatric Findings in Suspected and Confirmed Middle East Respiratory Syndrome Patients Quarantined in Hospital: A Retrospective Chart Analysis. Psychiatry Investig. 2018; 15 (4): 355–360. DOI: 10.30773/pi.2017.10.25.1.Griffiths RD, Jones C. Seven lessons from 20 years of follow-up of intensive care unit survivors. Curr Opin Crit Care. 2007; 13 (5): 508–513. DOI: 10.1097/MCC.0b013e3282efae05.Griffiths RD, Jones C. Seven lessons from 20 years of follow-up of intensive care unit survivors. Curr Opin Crit Care. 2007; 13 (5): 508–513. DOI: 10.1097/MCC.0b013e3282efae05.Lam MH, Wing YK, Yu MW, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med. 2009; 169 (22): 2142–2147. DOI: 10.1001/archinternmed.2009.384.Lam MH, Wing YK, Yu MW, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med. 2009; 169 (22): 2142–2147. DOI: 10.1001/archinternmed.2009.384.O'Connor CM. COVID 19 Fatigue: Not So Fast. JACC Heart Fail. 2020; 8 (7): 592–594. DOI: 10.1016/j.jchf.2020.06.001.O'Connor CM. COVID 19 Fatigue: Not So Fast. JACC Heart Fail. 2020; 8 (7): 592–594. DOI: 10.1016/j.jchf.2020.06.001.Grácio S, Koçer S. La réhabilitation: indispensable pour les survivants d’un COVID 19 sévère [Rehabilitation is crucial for severe COVID 19 survivors]. Rev Med Suisse. 2020; 16 (696): 1170–1173.Grácio S, Koçer S. La réhabilitation: indispensable pour les survivants d’un COVID 19 sévère [Rehabilitation is crucial for severe COVID 19 survivors]. Rev Med Suisse. 2020; 16 (696): 1170–1173.Бурчинський С.Г. Астенический синдром и цереброваскулярная патология: возможности патогенетической фармакотерапии. Междунар. неврол. журн.; 2014. № 7 (69). URL: https://cyberleninka.ru/article/n/astenicheskiy-sindrom-i-tserebrovaskulyarnaya-patologiya-vozmozhnosti-patogeneticheskoy-farmakoterapii (дата обращения: 21.07.2020).Burchins`kij S.G. Astenicheskij sindrom i cerebrovaskulyarnaya patologiya: vozmozhnosti patogeneticheskoj farmakoterapii. Mezhdunar. nevrol. zhurn.; 2014. N7 (69). URL: https://cyberleninka.ru/article/n/astenicheskiy-sindrom-i-tserebrovaskulyarnaya-patologiya-vozmozhnosti-patogeneticheskoy-farmakoterapii (data obrashheniya: 21.07.2020) (in Russian)Лебедев М. А. Палатов С. Ю. Ковров Г. В. Щукина Е. П., Биняминов Х. Т. Астения – симптом, синдром, болезнь. Эффективная фармакотерапия. Неврология и психиатрия № 1. https://umedp.ru/articles/asteniya_simptom_sindrom_bolezn.html.Lebedev M.A. Palatov S. Yu. Kovrov G.V. Shhukina E.P., Binyaminov X.T Asteniya – simptom, sindrom, bolezn` «E`ffektivnaya farmakoterapiya. Nevrologiya i psixiatriya» N1. https://umedp.ru/articles/asteniya_simptom_sindrom_bolezn.html. (in Russian)Lewis G, Wessely S. The epidemiology of fatigue: more questions than answers. J Epidemiol Community Health. 1992; 46 (2): 92–97. DOI: 10.1136/jech.46.2.92.Lewis G, Wessely S. The epidemiology of fatigue: more questions than answers. J Epidemiol Community Health. 1992; 46 (2): 92–97. DOI: 10.1136/jech.46.2.92.Finsterer J, Mahjoub SZ. Fatigue in healthy and diseased individuals. Am J Hosp Palliat Care. 2014; 31 (5): 562–575. DOI: 10.1177/10499091134947480.Finsterer J, Mahjoub SZ. Fatigue in healthy and diseased individuals. Am J Hosp Palliat Care. 2014; 31 (5): 562–575. DOI: 10.1177/10499091134947480.Sohrabi C, Alsafi Z, O'Neill N, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID 19) [published correction appears in Int J Surg. 2020 May; 77: 217]. Int J Surg. 2020; 76: 71–76. DOI: 10.1016/j.ijsu.2020.02.034.Sohrabi C, Alsafi Z, O'Neill N, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID 19) [published correction appears in Int J Surg. 2020 May; 77: 217]. Int J Surg. 2020; 76: 71–76. DOI: 10.1016/j.ijsu.2020.02.034.Wang C, Pan R, Wan X, et al. Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID 19) Int J Environ Res Public Health. 2020; 17 (5): 1729. Published 2020 Mar 6. DOI: 10.3390/ijerph17051729.Wang C, Pan R, Wan X, et al. Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID 19) Int J Environ Res Public Health. 2020; 17 (5): 1729. Published 2020 Mar 6. DOI: 10.3390/ijerph17051729.Lai J, Ma S, Wang Y, et al. Factors Associated with Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. JAMA Netw Open. 2020; 3 (3): e203976. Published 2020 Mar 2. DOI: 10.1001/jamanetworkopen.2020.3976.Lai J, Ma S, Wang Y, et al. Factors Associated with Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. JAMA Netw Open. 2020; 3 (3): e203976. Published 2020 Mar 2. DOI: 10.1001/jamanetworkopen.2020.3976.Matias T, Dominski FH, Marks DF. Human needs in COVID 19 isolation. J Health Psychol. 2020; 25 (7): 871–882. DOI: 10.1177/1359105320925149.Matias T, Dominski FH, Marks DF. Human needs in COVID 19 isolation. J Health Psychol. 2020; 25 (7): 871–882. DOI: 10.1177/1359105320925149.Brugliera L, Spina A, Castellazzi P, et al. Rehabilitation of COVID 19 patients. J Rehabil Med. 2020; 52 (4): jrm00046. Published 2020 Apr 15. DOI: 10.2340/16501977–267.Brugliera L, Spina A, Castellazzi P, et al. Rehabilitation of COVID 19 patients. J Rehabil Med. 2020; 52 (4): jrm00046. Published 2020 Apr 15. DOI: 10.2340/16501977–267.Herridge MS, Moss M, Hough CL, et al. Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Med. 2016; 42 (5): 725–738. DOI: 10.1007/s00134–016–4321–8.Herridge MS, Moss M, Hough CL, et al. Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Med. 2016; 42 (5): 725–738. DOI: 10.1007/s00134–016–4321–8.Morgul E, Bener A, Atak M, et al. COVID 19 pandemic and psychological fatigue in Turkey [published online ahead of print, 2020 Jul 10]. Int J Soc Psychiatry. 2020. DOI: 10.1177/0020764020941889.Morgul E, Bener A, Atak M, et al. COVID 19 pandemic and psychological fatigue in Turkey [published online ahead of print, 2020 Jul 10]. Int J Soc Psychiatry. 2020. DOI: 10.1177/0020764020941889.Белкин А.А., Алексеева Е.В., Алашеев А.М. и др. Оценка циркадности для прогноза исхода вегетативного состояния. Cons. Med. 2017; 19 (2): 1–4.Belkin A.A., Alekseeva E.V., Alasheev A.M., et al. Otsenka tsirkadnosti dlya prognoza ishoda vegetativnogo sostoyaniya. Cons. Med. 2017; 19 (2): 1–4. (in Russian) e-mail: medalfavit@mail.ru Медицинский алфавит №3/2021. Неврология и психиатрия (1) 33Kamdar BB, King LM, Collop NA, et al. The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med. 2013; 41 (3): 800–809. DOI: 10.1097/CCM.0b013e3182746442.Kamdar BB, King LM, Collop NA, et al. The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med. 2013; 41 (3): 800–809. DOI: 10.1097/CCM.0b013e3182746442.Cavallazzi R, Saad M, Marik PE. Delirium in the ICU: an overview. Ann Intensive Care. 2012; 2 (1): 49. Published 2012 Dec 27. DOI: 10.1186/2110–5820–2–49.Cavallazzi R, Saad M, Marik PE. Delirium in the ICU: an overview. Ann Intensive Care. 2012; 2 (1): 49. Published 2012 Dec 27. DOI: 10.1186/2110–5820–2–49.Шмонин А.А., Мальцева М.Н., Мельникова Е.В., Мишина И.Е., Иванова Г.Е. Медицинская реабилитация при коронавирусной инфекции: новые задачи для физической и реабилитационной медицины в России. Вестник восстановительной медицины № 3 (97) 2020, 14–20, DOI: 10.38025/2078–1962–2020–97–3–14–21.Shmonin A. A., Mal`ceva M.N., Mel`nikova E.V., Mishina I. E., Ivanova G.E. Medicinskaya reabilitaciya pri koronavirusnoj infekcii: novy`e zadachi dlya fizicheskoj i reabilitacionnoj mediciny` v Rossii. Vestnik vosstanovitel`noj mediciny` N3 (97) 2020, 14–20, DOI: 10.38025/2078–1962–2020–97–3–14–21. (in Russian)Rimes KA, Chalder T. Treatments for chronic fatigue syndrome. Occup Med (Lond). 2005; 55 (1): 32–39. DOI: 10.1093/occmed/kqi015.Rimes KA, Chalder T. Treatments for chronic fatigue syndrome. Occup Med (Lond). 2005; 55 (1): 32–39. DOI: 10.1093/occmed/kqi015.Дюкова Г.М. Астенический синдром: проблемы диагностики и терапии. Журнал неврологии и психиатрии № 1; 2012; c. 16–22. https://medi.ru/info/3099/.Dyukova G.M. Astenicheskij sindrom: problemy` diagnostiki i terapii. Zhurnal nevrologii i psixiatrii N1; 2012; str. 16–22. https://medi.ru/info/3099/ (in Russian)Старческая астения. Клинические рекомендации. Профессиональные ассоциации: Российская ассоциация геронтологов и гериатров 2018 год. http://yakmed.ru/wp-content/uploads/2018/07/Asteniya_recomend.pdfStarcheskaya asteniya. Klinicheskie rekomendacii. Professional`ny`e associacii: Rossijskaya associaciya gerontologov i geriatrov 2018 god. http://yakmed.ru/ wp-content/uploads/2018/07/Asteniya_recomend.pdf. (in Russian)Barazzoni R, Bischoff SC, Breda J, et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV 2 infection. Clin Nutr. 2020; 39 (6): 1631–1638. DOI: 10.1016/j.clnu.2020.03.022.Barazzoni R, Bischoff SC, Breda J, et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV 2 infection. Clin Nutr. 2020; 39 (6): 1631–1638. DOI: 10.1016/j.clnu.2020.03.022.Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395 (10227): 912–20. PMC – PubMed.Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395 (10227): 912–20. PMC – PubMed.Siu JY. The SARS-associated stigma of SARS victims in the post-SARS era of Hong Kong. Qual Health Res. 2008; 18 (6): 729–738. DOI: 10.1177/1049732308318372.Siu JY. The SARS-associated stigma of SARS victims in the post-SARS era of Hong Kong. Qual Health Res. 2008; 18 (6): 729–738. DOI: 10.1177/1049732308318372.Yeo TJ, Wang YL, Low TT. Have a heart during the COVID 19 crisis: Making the case for cardiac rehabilitation in the face of an ongoing pandemic. Eur J Prev Cardiol. 2020; 27 (9): 903–905. DOI: 10.1177/2047487320915665.Yeo TJ, Wang YL, Low TT. Have a heart during the COVID 19 crisis: Making the case for cardiac rehabilitation in the face of an ongoing pandemic. Eur J Prev Cardiol. 2020; 27 (9): 903–905. DOI: 10.1177/2047487320915665.Kaniasty K, Norris FH. Longitudinal linkages between perceived social support and posttraumatic stress symptoms: sequential roles of social causation and social selection. J Trauma Stress. 2008; 21 (3): 274–281. DOI: 10.1002/jts.20334.Kaniasty K, Norris FH. Longitudinal linkages between perceived social support and posttraumatic stress symptoms: sequential roles of social causation and social selection. J Trauma Stress. 2008; 21 (3): 274–281. DOI: 10.1002/jts.20334.

The authors declare that there are no conflicts of interest present.