<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2021-3-14-22</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1926</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕВРОЛОГИЯ И ПСИХИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROLOGY AND PSYCHIATRY</subject></subj-group></article-categories><title-group><article-title>Клинические проявления, патогенез и лечение отдаленных последствий поражения нервной системы при COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Clinical features, pathogenesis and treatment of long-haul COVID‑19 impact on nervous system</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7146-2024</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баринов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Barinov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баринов Алексей Николаевич, к.м.н., доцент кафедры нервных болезней и нейрохирургии</p></bio><email xlink:type="simple">mmom-mc@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2076-4131</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мошхоева</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Moshkhoeva</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мошхоева Люба Султановна, к.м.н., аспирант кафедры нервных болезней и нейрохирургии </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0489-9845</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пархоменко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Parkhomenko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пархоменко Екатерина Васильевна, доцент кафедры неврологии и нейрохирургии с курсом ДПО </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1914-7566</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эмих</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Emikh</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эмих Елена Владимировна, ведущий невролог </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3429-9640</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ястребцева</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Yastrebtseva</surname><given-names>I. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ястребцева Ирина Петровна, д.м.н., доцент, проф. кафедры неврологии и нейрохирургии ORCID</p></bio><email xlink:type="simple">ip.2007@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова»&#13;
Минздрава России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University n.a. I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Altai State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Сеть клиник «Инвитро»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Invitro’ Clinics’ Network</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ivanovo State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>03</month><year>2021</year></pub-date><volume>0</volume><issue>3</issue><issue-title>Неврология и психиатрия (1)</issue-title><fpage>14</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баринов А.Н., Мошхоева Л.С., Пархоменко Е.В., Эмих Е.В., Ястребцева И.П., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Баринов А.Н., Мошхоева Л.С., Пархоменко Е.В., Эмих Е.В., Ястребцева И.П.</copyright-holder><copyright-holder xml:lang="en">Barinov A.N., Moshkhoeva L.S., Parkhomenko E.V., Emikh E.V., Yastrebtseva I.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1926">https://www.med-alphabet.com/jour/article/view/1926</self-uri><abstract><p>Во всем мире усиленно изучается болезнь, вызываемая коронавирусной инфекцией SARS-CoV‑2 (COVID‑19), но ее воздействие на нервную систему требует дополнительных исследований. Симптомы COVID‑19 у 30 % больных продолжаются более 2 недель, необходимых для реконвалесценции, а у 10% пациентов – более 12 недель; это состояние получило название «длительный COVID». Оно развивается независимо от степени тяжести заболевания. Многие больные с длительным заболеванием продолжают испытывать те же симптомы, что имели в дебюте COVID‑19 – астению, когнитивные нарушения (мозговой туман), одышку, головную боль, депрессию, нарушение сна, потерю обоняния и (или) вкуса. Лечение этих осложнений цитиколином, этилметилгидроксипиридина сукцинатом и комплексами витаминов группы В улучшает симптомы, но большинство таких пациентов нуждаются в деипохондризации посредством когнитивной терапии.</p></abstract><trans-abstract xml:lang="en"><p>The current outbreak of coronavirus SARS-CoV‑2 (COVID-19) has raised great concern worldwide, but its impact on nervous system still needs more investigation. Thirty per cent of symptomatic patients with COVID‑19 will have symptoms that last longer than the typical two weeks, 10 % have symptoms longer than 3 months and this is called ‘long-COVID’. These symptoms affect not only people with severe disease, but also those with milder cases. Many long-haulers experience the same symptoms they had during their initial fight with COVID‑19, such as fatigue, cognitive impairment (or brain fog), difficulty breathing, headache, depression, insomnia and loss of the sense of taste and\or smell. Treatment of those complications with citicoline, ethylmethylhydroxypyridine succinate and vitamin B improves these symptoms in patients but most of them also need cognitive therapy for dehypochondrisation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>SARS-CoV 2</kwd><kwd>неврологические осложнения</kwd><kwd>аносмия</kwd><kwd>паросмия</kwd><kwd>фантосмия</kwd><kwd>автономная невропатия</kwd><kwd>когнитивные нарушения</kwd><kwd>когнитивная терапия</kwd><kwd>цитиколин</kwd><kwd>этилметилгидроксипиридина сукцинат</kwd><kwd>лечение витаминами группы В</kwd></kwd-group><kwd-group xml:lang="en"><kwd>SARS-CoV 2</kwd><kwd>neurological complications</kwd><kwd>anosmia</kwd><kwd>parosmia</kwd><kwd>fantosmia</kwd><kwd>autonomic neuropathy</kwd><kwd>cognitive impairment</kwd><kwd>cognitive therapy</kwd><kwd>citicoline</kwd><kwd>ethylmethylhydroxypyridine succinate</kwd><kwd>vitamin B treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Temporary emergency guidance to US stroke centers during the coronavirus disease 2019 (COVID 19) pandemic: On Behalf of the American Heart Association / American Stroke Association Stroke Council Leadership. Stroke. 2020; 51 (6): 1910–1912. https://doi.org/10.1161/STROKEAHA.120.030023.</mixed-citation><mixed-citation xml:lang="en">Temporary emergency guidance to US stroke centers during the coronavirus disease 2019 (COVID 19) pandemic: On Behalf of the American Heart Association / American Stroke Association Stroke Council Leadership. Stroke. 2020; 51 (6): 1910–1912. https://doi.org/10.1161/STROKEAHA.120.030023.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Song E., Zhang C., Israelow B. et al. Neuroinvasion of SARS-CoV 2 in human and mouse brain. Journal of Experimental Medicine. 2021; 218 (3): e20202135. https://doi: org/10.1084/jem.20202135.</mixed-citation><mixed-citation xml:lang="en">Song E., Zhang C., Israelow B. et al. Neuroinvasion of SARS-CoV 2 in human and mouse brain. Journal of Experimental Medicine. 2021; 218 (3): e20202135. https://doi: org/10.1084/jem.20202135.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Miners S., Kehoe P.G., Love, S. Cognitive impact of COVID 19: looking beyond the short term. Alzheimers Res Therapy. 2020; 12 (1): 170. https://doi.org/10.1186/ s13195–020–00744-w.</mixed-citation><mixed-citation xml:lang="en">Miners S., Kehoe P.G., Love, S. Cognitive impact of COVID 19: looking beyond the short term. Alzheimers Res Therapy. 2020; 12 (1): 170. https://doi.org/10.1186/ s13195–020–00744-w.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ye M., Ren Y., Lv T. Encephalitis as a clinical manifestation of COVID 19. Brain, behavior, and immunity. 2020; (88): 945–946. https://doi.org/10.1016/j.bbi.2020.04.017.</mixed-citation><mixed-citation xml:lang="en">Ye M., Ren Y., Lv T. Encephalitis as a clinical manifestation of COVID 19. Brain, behavior, and immunity. 2020; (88): 945–946. https://doi.org/10.1016/j.bbi.2020.04.017.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Y.H., Jiang D., Huang J. T. SARS-CoV 2 Detected in Cerebrospinal Fluid by PCR in a Case of COVID 19. Encephalitis. Brain, behavior, and immunity. 2020; (87): 149. https://doi.org/10.1016/j.bbi.2020.05.012.</mixed-citation><mixed-citation xml:lang="en">Huang Y.H., Jiang D., Huang J. T. SARS-CoV 2 Detected in Cerebrospinal Fluid by PCR in a Case of COVID 19. Encephalitis. Brain, behavior, and immunity. 2020; (87): 149. https://doi.org/10.1016/j.bbi.2020.05.012.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Y., Xu X., Chen Z., et al. Nervous system involvement after infection with COVID 19 and other coronaviruses. Brain, behavior, and immunity. 2020; (87): 18–22. https://doi.org/10.1016/j.bbi.2020.03.031.</mixed-citation><mixed-citation xml:lang="en">Wu Y., Xu X., Chen Z., et al. Nervous system involvement after infection with COVID 19 and other coronaviruses. Brain, behavior, and immunity. 2020; (87): 18–22. https://doi.org/10.1016/j.bbi.2020.03.031.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Karuppan M., Devadoss D., Nair M., et al. SARS-CoV 2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism. Molecular neurobiology. 2021; 1–16. https://doi.org/10.1007/s12035–020–02245–1.</mixed-citation><mixed-citation xml:lang="en">Karuppan M., Devadoss D., Nair M., et al. SARS-CoV 2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism. Molecular neurobiology. 2021; 1–16. https://doi.org/10.1007/s12035–020–02245–1.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Esposito G., Pesce M., Seguella L., et al. Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion? Brain, behavior, and immunity. 2020; (87): 93–94. https://doi. org/10.1016/j.bbi.2020.04.060.</mixed-citation><mixed-citation xml:lang="en">Esposito G., Pesce M., Seguella L., et al. Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion? Brain, behavior, and immunity. 2020; (87): 93–94. https://doi. org/10.1016/j.bbi.2020.04.060.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Y., Xu X., Chen Z., et al. Nervous system involvement after infection with COVID 19 and other coronaviruses. Brain, behavior, and immunity. 2020; (87): 18–22. https://doi.org/10.1016/j.bbi.2020.03.031.</mixed-citation><mixed-citation xml:lang="en">Wu Y., Xu X., Chen Z., et al. Nervous system involvement after infection with COVID 19 and other coronaviruses. Brain, behavior, and immunity. 2020; (87): 18–22. https://doi.org/10.1016/j.bbi.2020.03.031.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hartung H.P., Aktas O. COVID 19 and management of neuroimmunological disorders. Nature reviews. Neurology. 2020; 16 (7): 347–348. https://doi.org/10.1038/ s41582–020–0368–9.</mixed-citation><mixed-citation xml:lang="en">Hartung H.P., Aktas O. COVID 19 and management of neuroimmunological disorders. Nature reviews. Neurology. 2020; 16 (7): 347–348. https://doi.org/10.1038/ s41582–020–0368–9.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta P., McAuley D.F., Brown M., et al. COVID 19: consider cytokine storm syndromes and immunosuppression. Lancet (London, England). 2020; 395 (10229): 1033–1034. https://doi.org/10.1016/S0140–6736(20)30628–0.</mixed-citation><mixed-citation xml:lang="en">Mehta P., McAuley D.F., Brown M., et al. COVID 19: consider cytokine storm syndromes and immunosuppression. Lancet (London, England). 2020; 395 (10229): 1033–1034. https://doi.org/10.1016/S0140–6736(20)30628–0.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Karuppan M., Devadoss D., Nair M., et al. SARS-CoV 2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism. Molecular neurobiology. 2021; 1–16. Advance online publication. https://doi.org/10.1007/s12035–020–02245–1.</mixed-citation><mixed-citation xml:lang="en">Karuppan M., Devadoss D., Nair M., et al. SARS-CoV 2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism. Molecular neurobiology. 2021; 1–16. Advance online publication. https://doi.org/10.1007/s12035–020–02245–1.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Torabi A., Mohammadbagheri E., Akbari Dilmaghani N., et al. Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID 19 Induced Anosmia. ACS chemical neuroscience. 2020; 11 (13): 1909–1913. https://doi.org/10.1021/ acschemneuro.0c00249.</mixed-citation><mixed-citation xml:lang="en">Torabi A., Mohammadbagheri E., Akbari Dilmaghani N., et al. Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID 19 Induced Anosmia. ACS chemical neuroscience. 2020; 11 (13): 1909–1913. https://doi.org/10.1021/ acschemneuro.0c00249.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lechien J.R., Chiesa-Estomba C. M., Beckers E., et al. Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients. J Intern Med. 2021; https://doi.org/10.1111/joim.13209 https://onlinelibrary.wiley. com/doi/10.1111/joim.13209.</mixed-citation><mixed-citation xml:lang="en">Lechien J.R., Chiesa-Estomba C. M., Beckers E., et al. Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients. J Intern Med. 2021; https://doi.org/10.1111/joim.13209 https://onlinelibrary.wiley. com/doi/10.1111/joim.13209.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gareri P., Castagna A., Cotroneo A.M., et al. The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clinical interventions in aging. 2015; (10): 1421–1429. https://doi.org/10.2147/CIA.S87886.</mixed-citation><mixed-citation xml:lang="en">Gareri P., Castagna A., Cotroneo A.M., et al. The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clinical interventions in aging. 2015; (10): 1421–1429. https://doi.org/10.2147/CIA.S87886.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Steardo L., Steardo L., Jr Zorec, R. Verkhratsky A. Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID 19. Acta physiologica. 2020; 229 (3): e13473. https://doi.org/10.1111/apha.13473.</mixed-citation><mixed-citation xml:lang="en">Steardo L., Steardo L., Jr Zorec, R. Verkhratsky A. Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID 19. Acta physiologica. 2020; 229 (3): e13473. https://doi.org/10.1111/apha.13473.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y., Li H., Fan R., et al. Coronavirus Infections in the Central Nervous System and Respiratory Tract Show Distinct Features in Hospitalized Children. Intervirology. 2016; 59 (3): 163–169. https://doi.org/10.1159/000453066.</mixed-citation><mixed-citation xml:lang="en">Li Y., Li H., Fan R., et al. Coronavirus Infections in the Central Nervous System and Respiratory Tract Show Distinct Features in Hospitalized Children. Intervirology. 2016; 59 (3): 163–169. https://doi.org/10.1159/000453066.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta P., McAuley D.F., Brown M., et al. COVID 19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020; 395 (10229): 1033–1034. https://doi.org/10.1016/S0140–6736(20)30628–0.</mixed-citation><mixed-citation xml:lang="en">Mehta P., McAuley D.F., Brown M., et al. COVID 19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020; 395 (10229): 1033–1034. https://doi.org/10.1016/S0140–6736(20)30628–0.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mahmudpour M., Roozbeh J., Keshavarz M., et al. COVID 19 cytokine storm: The anger of inflammation. Cytokine. 2020; 133: 155151. https://doi.org/10.1016/j. cyto.2020.155151.</mixed-citation><mixed-citation xml:lang="en">Mahmudpour M., Roozbeh J., Keshavarz M., et al. COVID 19 cytokine storm: The anger of inflammation. Cytokine. 2020; 133: 155151. https://doi.org/10.1016/j. cyto.2020.155151.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng Z., Peng F., Xu B., et al. Risk factors of critical &amp; mortal COVID 19 cases: A systematic literature review and meta-analysis. The Journal of infection. 2020; 81 (2): e16–e25. https://doi.org/10.1016/j.jinf.2020.04.021.</mixed-citation><mixed-citation xml:lang="en">Zheng Z., Peng F., Xu B., et al. Risk factors of critical &amp; mortal COVID 19 cases: A systematic literature review and meta-analysis. The Journal of infection. 2020; 81 (2): e16–e25. https://doi.org/10.1016/j.jinf.2020.04.021.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Строков И.А., Баринов А.Н., Новосадова М.В., Яхно Н.Н. Клинические методы оценки тяжести диабетической полиневропатии. Неврологический журнал. 2000; (5) № 5: 14–19.</mixed-citation><mixed-citation xml:lang="en">Strokov I.A., Barinov A.N., Novosadova M.V., Yakhno N.N. Clinical scales for grading the severity of diabetic neuropathy. Nevrologichesky journal. 2000; (5) N5: 14–19.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Freeman R., Low P., Tesfaye S., Valensi P. Toronto Consensus Panel on Diabetic Neuropathy. Methods of investigation for cardiac autonomic dysfunction in human research studies. Diabetes Metab Res Rev. 2011; 27 (7): 654–64. https://doi. org/10.1002/dmrr.1224. PMID: 21695761.</mixed-citation><mixed-citation xml:lang="en">Freeman R., Low P., Tesfaye S., Valensi P. Toronto Consensus Panel on Diabetic Neuropathy. Methods of investigation for cardiac autonomic dysfunction in human research studies. Diabetes Metab Res Rev. 2011; 27 (7): 654–64. https://doi. org/10.1002/dmrr.1224. PMID: 21695761.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ewing D. J., Clarke B. F. Diagnosis and management of diabetic autonomic neuropathy. British medical journal (Clinical research ed.). 1982; 285 (6346): 916–918. https://doi.org/10.1136/bmj.285.6346.916.</mixed-citation><mixed-citation xml:lang="en">Ewing D. J., Clarke B. F. Diagnosis and management of diabetic autonomic neuropathy. British medical journal (Clinical research ed.). 1982; 285 (6346): 916–918. https://doi.org/10.1136/bmj.285.6346.916.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Мошхоева Л.С., Баринов А.Н. Клинические проявления и диагностика автономной невропатии при сахарном диабете 2 типа и метаболическом синдроме. Opinion Leader 2020; № 12 (41): 90–97.</mixed-citation><mixed-citation xml:lang="en">Moshkhoeva L.S., Barinov A.N. Clinical features and diagnostics of autonomic neuropathy in patients with diabetes mellitus 2 and metabolic syndrome. Opinion Leader 2020; N12 (41): 90–97.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ахмеджанова Л. Т., Баринов А.Н., Строков И. А. Диабетические и недиабетические полиневропатии у пациентов с сахарным диабетом. Журнал неврологии и психиатрии. 2018; № 4 (118): 113–121.</mixed-citation><mixed-citation xml:lang="en">Akhmedzhanova L.T., Barinov A.N., Strokov I.A. Diabetic and other neuropathies in patients with diabetes mellitus. Journal nevrologii Ipsikhiatrii. 2018; N4 (118): 113–121.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Баринов А.Н. Вегетативная невропатия при сахарном диабете и метаболическом синдроме: клинические проявления, диагностика и лечение. Эффективная фармакотерапия. 2017; № 2 (Эндокринология): 26–34.</mixed-citation><mixed-citation xml:lang="en">Barinov A.N. Autonomic neuropathy in patients with diabetes mellitus and metabolic syndrome. Effectivnaya farmakotherapia, 2017; N2 (Endocrinology): 26–34</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
