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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Основные факторы риска и особенности ишемических инсультов у мужчин молодого возраста (по данным Ярославской области)</article-title><trans-title-group xml:lang="en"><trans-title>Main risk factors and characteristics of ischemic strokes in young men (according to Yaroslavl Region data)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пизов</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pizov</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пизова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pizova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Ярославский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yaroslavl State Mesical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>19</day><month>01</month><year>2017</year></pub-date><volume>1</volume><issue>2</issue><issue-title>Неврология и психиатрия</issue-title><fpage>28</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пизов Н.А., Пизова Н.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Пизов Н.А., Пизова Н.В.</copyright-holder><copyright-holder xml:lang="en">Pizov N.A., Pizova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/19">https://www.med-alphabet.com/jour/article/view/19</self-uri><abstract><p>Цереброваскулярные заболевания являются второй ведущей причиной смерти во всем мире. Результаты различных исследований продемонстрировали высокий процент лиц молодого возраста среди пациентов с инсультом. Мужчины испытывают более высокий риск развития инсульта большую часть жизни. Мужчины и женщины с ишемическим инсультом различаются по факторам риска развития инсульта. Этиология инсультов также отличается у мужчин и женщин. В ходе работы был проведен про- и ретроспективный анализ 90 историй болезни мужчин молодого возраста с ишемическим инсультом, пролеченных в сосудистых отделениях г. Ярославля в 2013-2015 годах. Среди обследованных пациентов средний возраст на момент развития ишемического инсульта составил 38,9 ± 4,9 года. В данной выборке регистрировались как первичные (n = 63; 70 %), так и повторные (n = 27; 30 %) инсульты. Согласно критериям TOAST при полном и углубленном обследовании этих пациентов выявлялись атеротромботический подтип (46,7 %), лакунарный подтип (25,6 %), кардиоэмболический подтип (4,5 %), ишемический инсульт другой известной этиологии (5,6 %) и неуточненный подтип (17,6 %). Среди пациентов молодого возраста в качестве значимых факторов риска определены курение (особенно в сочетании с гиперхолестеринемией), наличие артериальной гипертензии, ожирение (повышенный ИМТ), которые вносят наибольший вклад в развитие атеросклеротического поражения сонных артерий у мужчин до 45 лет.</p></abstract><trans-abstract xml:lang="en"><p>Cerebrovascular diseases are the second leading cause of death worldwide. The results of various studies showed a high percentage of young adults among stroke patients. Men have a higher risk of stroke most of their life. Men and women with ischemic stroke differ in risk factors for stroke. The etiology of stroke is also different in men and women. In the course of the work a pro- and retrospective analysis of 90 case histories of young age men with ischemic stroke treated at the vascular department of Yaroslavl city (Russia) in 2013-2015 years was done. Among the patients studied, the average age at the time of ischemic stroke was 38.9 ± 4.9 years. In the sample, there were recorded as primary (n = 63; 70 %) and repeated (n = 27; 30 %) strokes. According to the TOAST criteria with full and in-depth examination of these patients atherothrombotic subtype (46.7 %), lacunar subtype (25.6 %), cardioembolic subtype (4.5 %), ischemic stroke of other known etiology (5.6 %) and unspecified subtype (17.6 %) revealed. As important risk factors among the patients of young age were smoking (especially in combination with hypercholesterolaemia), presence of hypertension, obesity (increased BMI). They make the greatest contribution to the development of atherosclerotic lesions of the carotid arteries in men up to 45 years.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>молодой возраст</kwd><kwd>мужчины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>young age</kwd><kwd>men</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. The Top 10 Causes of Death. World Health Organization: Geneva, Switzerland; 2011. The 10 leading causes of death by broad income group, 2008.</mixed-citation><mixed-citation xml:lang="en">WHO. The Top 10 Causes of Death. World Health Organization: Geneva, Switzerland; 2011. The 10 leading causes of death by broad income group, 2008.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. The World Health Report 2002 - Reducing Risks, Promoting Healthy Life. World Health Organization: Geneva, Switzeland; 2002. Educ. Health (Abingdon). 2003; 16 (2): 230.</mixed-citation><mixed-citation xml:lang="en">WHO. The World Health Report 2002 - Reducing Risks, Promoting Healthy Life. World Health Organization: Geneva, Switzeland; 2002. Educ. Health (Abingdon). 2003; 16 (2): 230.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Roger V.L., Go A.S., Lloyd-Jones D.M. et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation. 2011; 123 (4): e18-e209.</mixed-citation><mixed-citation xml:lang="en">Roger V.L., Go A.S., Lloyd-Jones D.M. et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation. 2011; 123 (4): e18-e209.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gall S.L., Tran P.L., Martin K. et al. Sex differences in long-term outcomes after stroke: functional outcomes, handicap, and quality of life. Stroke. 2012; 43 (7): 1982-7.</mixed-citation><mixed-citation xml:lang="en">Gall S.L., Tran P.L., Martin K. et al. Sex differences in long-term outcomes after stroke: functional outcomes, handicap, and quality of life. Stroke. 2012; 43 (7): 1982-7.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Manolio T.A., Kronmal R.A., Burke G.L. et al. Short-term predictors of incident stroke in older adults. The Cardiovascular Health Study. Stroke. 1996; 27: 1479-1486.</mixed-citation><mixed-citation xml:lang="en">Manolio T.A., Kronmal R.A., Burke G.L. et al. Short-term predictors of incident stroke in older adults. The Cardiovascular Health Study. Stroke. 1996; 27: 1479-1486.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kleindorfer D., Broderick J., Khoury J. et al. The unchanging incidence and case-fatali-ty of stroke in the 1990s: a population-based study. Stroke. 2006; 37 (10): 2473-2478.</mixed-citation><mixed-citation xml:lang="en">Kleindorfer D., Broderick J., Khoury J. et al. The unchanging incidence and case-fatali-ty of stroke in the 1990s: a population-based study. Stroke. 2006; 37 (10): 2473-2478.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Putaala J., Metso A.J., Metso T.M. et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki young stroke registry. Stroke. 2009; 40 (4): 1195-203</mixed-citation><mixed-citation xml:lang="en">Putaala J., Metso A.J., Metso T.M. et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki young stroke registry. Stroke. 2009; 40 (4): 1195-203</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">González-Gómez F.J., Pérez-Torre P., DeFelipe A. et al. Stroke in young adults: Incidence rate, risk factors, treatment and prognosis. Rev. Clin. Esp. 2016 Jun 10. pii: S 0014-2565(16)30081-9. doi: 10.1016/j.rce.2016.05.008.</mixed-citation><mixed-citation xml:lang="en">González-Gómez F.J., Pérez-Torre P., DeFelipe A. et al. Stroke in young adults: Incidence rate, risk factors, treatment and prognosis. Rev. Clin. Esp. 2016 Jun 10. pii: S 0014-2565(16)30081-9. doi: 10.1016/j.rce.2016.05.008.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Rosamond W., Flegal K., Furie K. et al. Heart disease and stroke statistics - 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008; 117: e25-146.</mixed-citation><mixed-citation xml:lang="en">Rosamond W., Flegal K., Furie K. et al. Heart disease and stroke statistics - 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008; 117: e25-146.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Turtzo L.C., McCullough L.D. Sex-specific responses to stroke. Future Neurol. 2010; 5: 47-59.</mixed-citation><mixed-citation xml:lang="en">Turtzo L.C., McCullough L.D. Sex-specific responses to stroke. Future Neurol. 2010; 5: 47-59.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Jousilahti P., Vartiainen E., Tuomilehto J. et al. Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14786 middle-aged men and women in Finland. Circulation 1999; 99: 1465-72.</mixed-citation><mixed-citation xml:lang="en">Jousilahti P., Vartiainen E., Tuomilehto J. et al. Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14786 middle-aged men and women in Finland. Circulation 1999; 99: 1465-72.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong-Wells J., Johnston S.C., Wu Y.W. et al. Prevalence and predictors of perinatal hemorrhagic stroke: results from the Kaiser Pediatric Stroke Study. Pediatrics. 2009; 123 (3): 823-8.</mixed-citation><mixed-citation xml:lang="en">Armstrong-Wells J., Johnston S.C., Wu Y.W. et al. Prevalence and predictors of perinatal hemorrhagic stroke: results from the Kaiser Pediatric Stroke Study. Pediatrics. 2009; 123 (3): 823-8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bonduel M., Sciuccati G., Hepner M. et al. Arterial ischemic stroke and cerebral venous thrombosis in children: a 12-year Argentinean registry. Acta Haematol. 2006; 115 (3-4): 180-185.</mixed-citation><mixed-citation xml:lang="en">Bonduel M., Sciuccati G., Hepner M. et al. Arterial ischemic stroke and cerebral venous thrombosis in children: a 12-year Argentinean registry. Acta Haematol. 2006; 115 (3-4): 180-185.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Golomb M.R., Dick P.T., MacGregor D.L. et al. Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. J. Child Neurol. 2004; 19 (7): 493-497.</mixed-citation><mixed-citation xml:lang="en">Golomb M.R., Dick P.T., MacGregor D.L. et al. Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. J. Child Neurol. 2004; 19 (7): 493-497.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Golomb M.R., Fullerton H.J., Nowak-Gottl U., Deveber G.; International Pediatric Stroke Study Group.Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study. Stroke. 2009; 40 (1): 52-7.</mixed-citation><mixed-citation xml:lang="en">Golomb M.R., Fullerton H.J., Nowak-Gottl U., Deveber G.; International Pediatric Stroke Study Group.Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study. Stroke. 2009; 40 (1): 52-7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Raju T.N., Nelson K.B., Ferriero D., Lynch J.K. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics. 2007; 120 (3): 609-616.</mixed-citation><mixed-citation xml:lang="en">Raju T.N., Nelson K.B., Ferriero D., Lynch J.K. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics. 2007; 120 (3): 609-616.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Salih M.A., Abdel-Gader A.G., Al-Jarallah A.A. et al. Stroke in Saudi children. Epidemiology, clinical features and risk factors. Saudi. Med. J. 2006; 27 (1): 12-20.</mixed-citation><mixed-citation xml:lang="en">Salih M.A., Abdel-Gader A.G., Al-Jarallah A.A. et al. Stroke in Saudi children. Epidemiology, clinical features and risk factors. Saudi. Med. J. 2006; 27 (1): 12-20.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Di Carlo A., Lamassa M., Baldereschi M. et al. European BIOMED Study of Stroke Care Group. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke. 2003; 34: 1114-19.</mixed-citation><mixed-citation xml:lang="en">Di Carlo A., Lamassa M., Baldereschi M. et al. European BIOMED Study of Stroke Care Group. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke. 2003; 34: 1114-19.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Holroyd-Leduc J.M., Kapral M.K., Austin P.C., Tu J.V. Sex differences and similarities in the management and outcome of stroke patients. Stroke. 2000; 31: 1833-37.</mixed-citation><mixed-citation xml:lang="en">Holroyd-Leduc J.M., Kapral M.K., Austin P.C., Tu J.V. Sex differences and similarities in the management and outcome of stroke patients. Stroke. 2000; 31: 1833-37.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kapral M.K., Fang J., Hill M.D. et al. Investigators of the Registry of the Canadian Stroke Network. Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke. 2005; 36: 809-14.</mixed-citation><mixed-citation xml:lang="en">Kapral M.K., Fang J., Hill M.D. et al. Investigators of the Registry of the Canadian Stroke Network. Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke. 2005; 36: 809-14.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Niewada M., Kobayashi A., Sandercock P.A. et al. International Stroke Trial Collaborative Group. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005; 24: 123-28.</mixed-citation><mixed-citation xml:lang="en">Niewada M., Kobayashi A., Sandercock P.A. et al. International Stroke Trial Collaborative Group. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005; 24: 123-28.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Roquer J., Campello A.R., Gomis M. Sex differences in first-ever acute stroke. Stroke. 2003; 34: 1581-85.</mixed-citation><mixed-citation xml:lang="en">Roquer J., Campello A.R., Gomis M. Sex differences in first-ever acute stroke. Stroke. 2003; 34: 1581-85.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Arboix A., Oliveres M., Garcia-Eroles L. et al. Acute cerebrovascular disease in women. Eur. Neurol. 2001; 45: 199-205.</mixed-citation><mixed-citation xml:lang="en">Arboix A., Oliveres M., Garcia-Eroles L. et al. Acute cerebrovascular disease in women. Eur. Neurol. 2001; 45: 199-205.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Gray L.J., Sprigg N., Bath P.M. et al. TAIST Investigators. Sex differences in quality of life in stroke survivors: data from the tinzaparin in Acute Ischaemic Stroke Trial (TAIST) Stroke. 2007; 38: 2960-64.</mixed-citation><mixed-citation xml:lang="en">Gray L.J., Sprigg N., Bath P.M. et al. TAIST Investigators. Sex differences in quality of life in stroke survivors: data from the tinzaparin in Acute Ischaemic Stroke Trial (TAIST) Stroke. 2007; 38: 2960-64.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kolominsky-Rabas P.L., Weber M., Gefeller O. et al. Epidemiology of ischemic stroke subtypes according to TOAST criteria - incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke. 2001; 32: 2735-40.</mixed-citation><mixed-citation xml:lang="en">Kolominsky-Rabas P.L., Weber M., Gefeller O. et al. Epidemiology of ischemic stroke subtypes according to TOAST criteria - incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke. 2001; 32: 2735-40.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Group SCotPHSR. Final report on the aspirin component of the ongoing physicians' health study. Steering Committee of the Physicians' Health Study Research Group. N. Engl. J. Med. 1989; 321 (3): 129-135.</mixed-citation><mixed-citation xml:lang="en">Group SCotPHSR. Final report on the aspirin component of the ongoing physicians' health study. Steering Committee of the Physicians' Health Study Research Group. N. Engl. J. Med. 1989; 321 (3): 129-135.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ridker P.M., Cook N.R., Lee I.M. et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N. Engl. J. Med. 2005; 352 (13): 1293-1304.</mixed-citation><mixed-citation xml:lang="en">Ridker P.M., Cook N.R., Lee I.M. et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N. Engl. J. Med. 2005; 352 (13): 1293-1304.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Berger J. S., Roncaglioni M. C., Avanzini F. et al. Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials. JAMA. 2006; 295 (3): 306-313.</mixed-citation><mixed-citation xml:lang="en">Berger J. S., Roncaglioni M. C., Avanzini F. et al. Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials. JAMA. 2006; 295 (3): 306-313.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zuern C.S., Lindemann S., Gawaz M. Platelet function and response to aspirin: gender-specific features and implications for female thrombotic risk and management. Semin. Thromb. Hemost. 2009; 35 (3): 295-306.</mixed-citation><mixed-citation xml:lang="en">Zuern C.S., Lindemann S., Gawaz M. Platelet function and response to aspirin: gender-specific features and implications for female thrombotic risk and management. Semin. Thromb. Hemost. 2009; 35 (3): 295-306.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gray-Weale A.C., Graham J.C., Burnett J.R. et al. Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J. Cardiovasc. Surg. 1988; 29 (6): 676-81.</mixed-citation><mixed-citation xml:lang="en">Gray-Weale A.C., Graham J.C., Burnett J.R. et al. Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J. Cardiovasc. Surg. 1988; 29 (6): 676-81.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Haapaniemi H., Hillbom M., Juvela S. Lifestyle-associated risk factors for acute brain infarction among persons of working age. Stroke. 1997; 28: 26-30.</mixed-citation><mixed-citation xml:lang="en">Haapaniemi H., Hillbom M., Juvela S. Lifestyle-associated risk factors for acute brain infarction among persons of working age. Stroke. 1997; 28: 26-30.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kittner S.J., McCarter R.J., Sherwin R.W. et al. Black-white differences in stroke risk among young adults. Stroke. 1993; 24 (1): I-13-5.</mixed-citation><mixed-citation xml:lang="en">Kittner S.J., McCarter R.J., Sherwin R.W. et al. Black-white differences in stroke risk among young adults. Stroke. 1993; 24 (1): I-13-5.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kittner S.J., Stern B.J., Wozniak M. et al. Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology. 1998; 50: 890-4.</mixed-citation><mixed-citation xml:lang="en">Kittner S.J., Stern B.J., Wozniak M. et al. Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology. 1998; 50: 890-4.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Appelros P., Stegmayr B., Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke. 2009; 40 (4): 1082-90.</mixed-citation><mixed-citation xml:lang="en">Appelros P., Stegmayr B., Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke. 2009; 40 (4): 1082-90.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Adams H.P., Bendixen B.H., Kappelle L.J. et al. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Stroke. 1993; 24 (1): 35-41.</mixed-citation><mixed-citation xml:lang="en">Adams H.P., Bendixen B.H., Kappelle L.J. et al. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Stroke. 1993; 24 (1): 35-41.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kwon S.U., Kim J.S., Lee J.H., Lee M.C. Ischemic stroke in Korean young adults. Acta Neurol. Scand. 2000; 101: 19-24.</mixed-citation><mixed-citation xml:lang="en">Kwon S.U., Kim J.S., Lee J.H., Lee M.C. Ischemic stroke in Korean young adults. Acta Neurol. Scand. 2000; 101: 19-24.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Lee T.H., Hsu W.C., Chen C.J., Chen ST. Etiologic study of young ischemic stroke in Taiwan. Stroke. 2002; 33: 1950-5.</mixed-citation><mixed-citation xml:lang="en">Lee T.H., Hsu W.C., Chen C.J., Chen ST. Etiologic study of young ischemic stroke in Taiwan. Stroke. 2002; 33: 1950-5.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Nedeltchev K., der Maur T.A., Georgiadis D. et al. Ischaemic stroke in young adults: predictors of outcome and recurrence. J. Neurol. Neurosurg. Psychiatry. 2005; 76: 191-5.</mixed-citation><mixed-citation xml:lang="en">Nedeltchev K., der Maur T.A., Georgiadis D. et al. Ischaemic stroke in young adults: predictors of outcome and recurrence. J. Neurol. Neurosurg. Psychiatry. 2005; 76: 191-5.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Förster A., Gass A., Kern R. et al. Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke. 2009; 40 (7): 2428-32.</mixed-citation><mixed-citation xml:lang="en">Förster A., Gass A., Kern R. et al. Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke. 2009; 40 (7): 2428-32.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Galassi A., Reynolds K., He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am. J. Med. 2006; 119: 812-19.</mixed-citation><mixed-citation xml:lang="en">Galassi A., Reynolds K., He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am. J. Med. 2006; 119: 812-19.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B., McGee D.L. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979; 241:.2035-38.</mixed-citation><mixed-citation xml:lang="en">Kannel W.B., McGee D.L. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979; 241:.2035-38.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. JAMA 1990; 264 (23): 3018-24.</mixed-citation><mixed-citation xml:lang="en">Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. JAMA 1990; 264 (23): 3018-24.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Wissler R.W., Vesselinovitch D. An update on the pathogenesis of atherosclerosis (principles of prevention, intervention, retardation, and regression). Hawaii Med. J. 1990; 49 (7): 237-40.</mixed-citation><mixed-citation xml:lang="en">Wissler R.W., Vesselinovitch D. An update on the pathogenesis of atherosclerosis (principles of prevention, intervention, retardation, and regression). Hawaii Med. J. 1990; 49 (7): 237-40.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. European Carotid Surgery Trial-ists' Collaborative Group. Lancet 1991; 337 (8752): 1235-43.</mixed-citation><mixed-citation xml:lang="en">MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. European Carotid Surgery Trial-ists' Collaborative Group. Lancet 1991; 337 (8752): 1235-43.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Volkow N.D., Mullani N., Gould K.L. et al. Cerebral blood flow in chronic cocaine users: a study with positron emission tomography. Br. J. Psychiatry. 1988; 152: 641-8.</mixed-citation><mixed-citation xml:lang="en">Volkow N.D., Mullani N., Gould K.L. et al. Cerebral blood flow in chronic cocaine users: a study with positron emission tomography. Br. J. Psychiatry. 1988; 152: 641-8.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Кузьмина Л.П., Тарасов А.А., Хайбулина А.З. Клинико-биохимические изменения при воздействии производственных стресс-факторов у шахтеров-угольщиков. Медицина труда и промышленная экология 2001; (8): 42-5.</mixed-citation><mixed-citation xml:lang="en">Кузьмина Л.П., Тарасов А.А., Хайбулина А.З. Клинико-биохимические изменения при воздействии производственных стресс-факторов у шахтеров-угольщиков. Медицина труда и промышленная экология 2001; (8): 42-5.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoproteins of plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972; 18 (6): 499-502.</mixed-citation><mixed-citation xml:lang="en">Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoproteins of plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972; 18 (6): 499-502.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">McGill H.C. Jr., McMahan C.A., Malcom G.T. et al. Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler. Thromb. Vasc. Biol. 1997; 17 (1): 95-106.</mixed-citation><mixed-citation xml:lang="en">McGill H.C. Jr., McMahan C.A., Malcom G.T. et al. Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler. Thromb. Vasc. Biol. 1997; 17 (1): 95-106.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Persson J., Stavenow L., Wikstrand J. et al. Noninvasive quantification of atherosclerotic lesions. Reproducibility of ultrasonographic measurement of arterial wall thickness and plaque size. Arterioscler. Tromb. 1992; 12 (2): 261-6.</mixed-citation><mixed-citation xml:lang="en">Persson J., Stavenow L., Wikstrand J. et al. Noninvasive quantification of atherosclerotic lesions. Reproducibility of ultrasonographic measurement of arterial wall thickness and plaque size. Arterioscler. Tromb. 1992; 12 (2): 261-6.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Strong J.P. Natural history and risk factors for early human atherogenesis. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Clin. Chem. 1995; 41 (1): 134-8.</mixed-citation><mixed-citation xml:lang="en">Strong J.P. Natural history and risk factors for early human atherogenesis. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Clin. Chem. 1995; 41 (1): 134-8.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Пизова Н.В. Заболевания сердца и инсульты у лиц молодого возраста. Неврология, нейропсихиатрия, психосоматика 2014; 2: 62-69.</mixed-citation><mixed-citation xml:lang="en">Пизова Н.В. Заболевания сердца и инсульты у лиц молодого возраста. Неврология, нейропсихиатрия, психосоматика 2014; 2: 62-69.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Пизов Н.А., Пизова Н.В. Роль липопротеина (а) в развитии ишемического инсульта и других сердечно-сосудистых заболеваний. Неврология, нейропсихиатрия, психосоматика. 2016; 8 (1): 90-95.</mixed-citation><mixed-citation xml:lang="en">Пизов Н.А., Пизова Н.В. Роль липопротеина (а) в развитии ишемического инсульта и других сердечно-сосудистых заболеваний. Неврология, нейропсихиатрия, психосоматика. 2016; 8 (1): 90-95.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Пизова Н.В. Острые нарушения мозгового кровообращения у лиц с недифференцированноыми дисплазиями соединительной ткани в молодом возраста. Невроньюс 2015; 6 (9): 5-9.</mixed-citation><mixed-citation xml:lang="en">Пизова Н.В. Острые нарушения мозгового кровообращения у лиц с недифференцированноыми дисплазиями соединительной ткани в молодом возраста. Невроньюс 2015; 6 (9): 5-9.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Пизова Н.В., Дружинин Д.С. Атеросклеротическое поражение сонных артерий у пациентов молодого возраста. Клиницист. 2014; 1: 28-34.</mixed-citation><mixed-citation xml:lang="en">Пизова Н.В., Дружинин Д.С. Атеросклеротическое поражение сонных артерий у пациентов молодого возраста. Клиницист. 2014; 1: 28-34.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Пизова Н.В. Наследственные тромбофилии и инсульт. Журн. неврологии и психиатрии им. С.С. Корсакова, 2013: 8 (113): 76-81.</mixed-citation><mixed-citation xml:lang="en">Пизова Н.В. Наследственные тромбофилии и инсульт. Журн. неврологии и психиатрии им. С.С. Корсакова, 2013: 8 (113): 76-81.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
