medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-38-29-33medalphabet-1888Research ArticleСтатьиМолекулярно-генетические методы диагностики и таргетная терапия в педиатрической онкологии (обзор литературы)Molecular diagnostics and targeted treatment approaches in pediatric oncology (literature review)РожковА. А.RozhkovA. A.

студент Клинического института детского здоровья

Москва

Moscow

НуриевР. И.NurievR. I.

аспирант кафедры онкологии, радиотерапии и пластической хирургии Института клинической медицины

Москва

Moscow

СекачеваМ. И.SekachevaM. I.

д.м.н., проф. кафедры онкологии, радиотерапии и пластической хирургии Института клинической медицины, директор Института персонализированной медицины

Москва

Moscow

ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияFirst Moscow State Medical University n.a. I.M. SechenovRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет); ФГБУ «Научно-исследовательский институт вакцин и сывороток имени И.И. Мечникова» Российской академии наукРоссияFirst Moscow State Medical University n.a. I.M. Sechenov; Scientific and Research Institute for Vaccines and Sera n.a. I.I. MechnikovRussian Federation202023012021038Диагностика и онкотерапия (4)2933Copyright © Рожков А.А., Нуриев Р.И., Секачева М.И., 20212021Рожков А.А., Нуриев Р.И., Секачева М.И.Rozhkov A.A., Nuriev R.I., Sekacheva M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1888

Непрерывная эволюция технологий в области молекулярной диагностики и геномного анализа, разработка новых подходов в фармакогенетике и появление целого спектра различных таргетных препаратов расширили возможности клинической практики, позволяя персонализировать подход к каждому конкретному пациенту. Диагностика и терапия педиатрических онкологических заболеваний являются одним из ярких примеров успешного применения персонализированного подхода в клинической практике. На сегодняшний день множество педиатрических опухолевых заболеваний успешно лечатся с помощью таргетных препаратов, что значительно увеличивает выживаемость пациентов. Таргетная терапия позволяет подобрать конкретный препарат для каждого больного, повышая тем самым эффективность лечения, снижая риск возникновения побочных эффектов, а также уменьшая вероятность развития рецидива заболевания.

The continuous evolution of new technologies in the field of molecular diagnostics and genome analysis, the development of new approaches in pharmacogenetics and the emergence of a range of different targeted drugs have expanded the possibilities of clinical practice, resulting in personalized approaches to treatment. The diagnosis and therapy of pediatric oncological diseases are some of the vivid examples of the successful application of a personalized approach in clinical practice. Today, many pediatric neoplastic diseases are successfully treated with targeted drugs, which significantly increases patient survival. Targeted therapy allows to choose a specific drug for each patient, thereby increasing the effectiveness of treatment, reducing the risk of side effects, and also reducing the likelihood of a relapse of the disease.

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The authors declare that there are no conflicts of interest present.