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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2020-38-5-8</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1883</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Эффективность и переносимость эрибулина у пожилых больных</article-title><trans-title-group xml:lang="en"><trans-title>Efficacy and tolerability of eribulin in elderly patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коваленко</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalenko</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с. онкологического отделения лекарственных методов лечения (химиотерапевтического) № 1</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артамонова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Artamonova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., зав. онкологическим отделением лекарственных методов лечения (химиотерапевтическим) № 1; проф. кафедры</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Centre of Oncology n.a. N.N. Blokhin</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Минздрава России; Кафедра онкологии и лучевой терапии ФГБОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Centre of Oncology n.a. N.N. Blokhin; Russian National Research Medical University n.a. N.I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>22</day><month>01</month><year>2021</year></pub-date><volume>0</volume><issue>38</issue><issue-title>Диагностика и онкотерапия (4)</issue-title><fpage>5</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коваленко Е.И., Артамонова Е.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Коваленко Е.И., Артамонова Е.В.</copyright-holder><copyright-holder xml:lang="en">Kovalenko E.I., Artamonova E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1883">https://www.med-alphabet.com/jour/article/view/1883</self-uri><abstract><p>Пожилые онкологические пациенты представляют собой весьма гетерогенную популяцию не только по хронологическому возрасту, но и по функциональному статусу, сопутствующим заболеваниям и терапии, гериатрическим синдромам и, как следствие, по переносимости онкологического лечения. Выбор химиотерапии (ХТ) метастатического рака молочной железы у этой категории больных зачастую является сложной задачей для онкологов. Эрибулин – препарат с весьма хорошей переносимостью, он прекрасно зарекомендовал себя как в рандомизированных исследованиях, так и в реальной клинической практике, в том числе у пациентов старшей возрастной категории. Как показали объединенные анализы ряда исследований, частота гематологических нежелательных явлений у пожилых пациентов, получавших эрибулин, не превышает таковую у более молодых и в целом не влияет на запланированный объем лечения. При этом пожилые чаще склонны испытывать такие побочные эффекты, как слабость, утомляемость и полинейропатию, что необходимо учитывать при планировании ХТ. Только комплексный мультидисциплинарный подход с гериатрической оценкой позволит максимально индивидуализировать подход к лечению этой непростой категории пациентов.</p></abstract><trans-abstract xml:lang="en"><p>Elderly cancer patients represent a very heterogeneous pop ulation not only in chronological age, but also in functional status, concomitant diseases and therapy, geriatric syndromes and, as a consequence, in the tolerability of cancer treatment. The choice of chemotherapy (CT) for metastatic breast cancer in this category of patients is often a challenge for oncologists. Eribulin, a drug with a fairly good tolerance, has proven itself well both in randomized trials and in real clinical practice, including older patient population. Pooled analyzes of several studies have shown that the incidence of hematologic adverse events in elderly patients treated with eribulin does not exceed that in younger patients and does not generally affect the planned volume of treatment. At the same time, the elderly are more likely to experience side effects such as weakness, fatigue and polyneuropathy, which must be taken into account when planning CT. Only a comprehensive multidisciplinary approach with a geriatric assessment will make it possible to maximally individualize the approach to the treatment of this difficult category of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>метастатический рак молочной железы</kwd><kwd>пожилые пациенты</kwd><kwd>эрибулин</kwd><kwd>переносимость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metastatic breast cancer</kwd><kwd>elderly patients</kwd><kwd>eribulin</kwd><kwd>tolerance</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Данная публикация подготовлена при финансовой поддержке компании «Эйсай».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">The Surveillance, Epidemiology, and End Results (SEER) Program. SEER212013–2017, All Races, Females. 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