medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-33-58-61medalphabet-1851Research ArticleСтатьиНейропсихиатрические особенности текущей пандемии COVID‑19 (анализ зарубежных публикаций 2020 года)Neuropsychiatric features of current COVID-19 pandemic (analysis of foreign publications in 2020)МадоновП. Г.MadonovP. G.

д.м.н., проф., зав. кафедрой фармакологии, клинической фармакологии и доказательной медицины

г. Новосибирск

Novosibirsk

ХидироваЛ. Д.KhidirovaL. D.

д. м. н., доцент кафедры фармакологии, клинической фармакологии и доказательной медицины

г. Новосибирск

Novosibirsk

ДеришеваД. А.DerishevaD. A.

к. м. н., ассистент кафедры фармакологии, клинической фармакологии и доказательной медицины

г. Новосибирск

Novosibirsk

ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииРоссияNovosibirsk State Medical UniversityRussian Federation202014012021033Неврология и психиатрия (4)5861Copyright © Мадонов П.Г., Хидирова Л.Д., Деришева Д.А., 20212021Мадонов П.Г., Хидирова Л.Д., Деришева Д.А.Madonov P.G., Khidirova L.D., Derisheva D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1851

В статье представлен обзор научной литературы, содержащий данные об особенностях нейропсихиатрических расстройств – осложнениях со стороны нервной системы на фоне вирусной нагрузки, вызванной SARS-CoV-2 COVID-19, причинами возникновения которых могут быть чрезмерный иммунный ответ и повышение проницаемости ГЭБ. Непрямое действие вируса по типу энцефалопатии, миопатии, нейропатии критических состояний может быть обусловлено гипоксией, респираторным и метаболическим ацидозом, дисрегуляцией гомеостаза вследствие органной недостаточности, а также аутоиммунными воспалительными и демиелинизирующими процессами. Связываясь с рецепторами, АПФ2, который является сердечно-мозговым сосудистым фактором защиты различных органов, нервной системы и скелетных мышц и является мишенью для различных видов коронавирусов, в том числе SARS-CoV-2, могут вызывать повышение артериального давления основной фактор риска ОНМК. Таким образом, проспективный нейропсихиатрический мониторинг людей, подвергшихся воздействию SARS-CoV-2 на различных этапах жизненного цикла, а также их нейроиммунный статус необходимы для полного понимания долгосрочного воздействия COVID-19 и создания основы для интеграции психонейроиммунологии в эпидемиологические исследования пандемий.

The article presents a review of the scientific literature containing data on the features of neuropsychiatric disorders – complications from the nervous system against the background of viral load caused by SARS-CoV-2 COVID-19. Indirect effects of the virus such as encephalopathy, myopathy, and critical neuropathy can be caused by hypoxia, respiratory and metabolic acidosis, dysregulation of homeostasis due to organ failure, and autoimmune inflammatory and demyelinating processes. Binding to the receptors of APF2, which is a cardiovascular protection factor for various organs, the nervous system and skeletal muscles is a target for various types of coronaviruses, including SARS-CoV-2 can cause an increase in blood pressure- the main risk factor for ONMC. Thus, prospective neuropsychiatric monitoring of people exposed to SARS-CoV-2 at various stages of the life cycle, as well as their neuroimmune status, is necessary to fully understand the long-term impact of COVID-19 and to provide a basis for integrating psychoneuroimmunology into epidemiological studies of pandemics.

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The authors declare that there are no conflicts of interest present.