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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2020-33-26-34</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1843</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Астенический синдром в контексте пандемии COVID‑19</article-title><trans-title-group xml:lang="en"><trans-title>Asthenic syndrome in context of COVID-19 pandemic</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьева</surname><given-names>Ю. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobyova</surname><given-names>Yu. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры неврологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дюкова</surname><given-names>Г. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Diukova</surname><given-names>G. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>проф. кафедры неврологии; в. н. с. неврологического отделения</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт профессионального образования ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова» Минздрава России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I. M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт профессионального образования ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова» Минздрава России (Сеченовский университет); ГБУЗ «Московский клинический научно-практический центр имени А. С. Логинова Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I. M. Sechenov First Moscow State Medical University (Sechenov University); A. S. Loginov Moscow Clinical Scientific Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>01</month><year>2021</year></pub-date><volume>0</volume><issue>33</issue><issue-title>Неврология и психиатрия (4)</issue-title><fpage>26</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Воробьева Ю.Д., Дюкова Г.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Воробьева Ю.Д., Дюкова Г.М.</copyright-holder><copyright-holder xml:lang="en">Vorobyova Y.D., Diukova G.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1843">https://www.med-alphabet.com/jour/article/view/1843</self-uri><abstract><p>Статья посвящена актуальным проблемам астении в период пандемии новой коронавирусной инфекции. Рассмотрены патогенетические механизмы формирования астении в остром периоде, а также приведены потенциальные механизмы и факторы, влияющие на формирование поствирусной астении после перенесенной инфекции COVID-19. Предлагается биопсихосоциальный подход к патогенезу и лечению поствирусной астении. В заключении рассматриваются факторы, способствующие формированию карантинной астении и методы ее терапии.</p></abstract><trans-abstract xml:lang="en"><p>The article is devoted to the current problems of fatigue during the new coronavirus infection pandemic. The pathogenetic mechanisms of fatigue in the acute period of infection are considered, as well as potential mechanisms and factors influencing post-viral fatigue development after COVID-19 infection. A biopsychosocial approach to the pathogenesis and treatment of post-viral fatigue is proposed. In conclusion, the factors contributing to quarantine fatigue development and methods of its therapy are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>астения</kwd><kwd>поствирусная астения</kwd><kwd>синдром хронической усталости</kwd><kwd>карантинная астения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>fatigue</kwd><kwd>post-viral fatigue</kwd><kwd>chronic fatigue syndrome</kwd><kwd>quarantine fatigue</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kazuhiro K. Post-Infectious Fatigue. JMAJ. 49 (1): 27–33, 2006.</mixed-citation><mixed-citation xml:lang="en">Kazuhiro K. Post-Infectious Fatigue. JMAJ. 49 (1): 27–33, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Дюкова Г. М. Астенический синдром: проблемы диагностики и терапии. Эффективная фармакотерапия. Неврология и психиатрия. 2012. № 1. C. 16–22</mixed-citation><mixed-citation xml:lang="en">Diukova G. M. Asthenic syndrome: problems of diagnostics and treatment. Effective pharmacotherapy. Neurology and psychiatry. 2012. № 1. S. 16–22 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Borsook D, Youssef AM, Simons L, Elman I, Eccleston C. When pain gets stuck: the evolution of pain chronification and treatment resistance. Pain. 2018; 159 (12): 2421–2436. DOI: 10.1097/j.pain.0000000000001401.</mixed-citation><mixed-citation xml:lang="en">Borsook D, Youssef AM, Simons L, Elman I, Eccleston C. When pain gets stuck: the evolution of pain chronification and treatment resistance. Pain. 2018; 159 (12): 2421–2436. DOI: 10.1097/j.pain.0000000000001401.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Intel from an outpatient COVID-19 clinic Harvard health https://news.harvard.edu/gazette/story/2020/05/why-it-is-critical-to-distinguish-covid-19-from-otherinfections/</mixed-citation><mixed-citation xml:lang="en">Intel from an outpatient COVID-19 clinic Harvard health https://news.harvard.edu/gazette/story/2020/05/why-it-is-critical-to-distinguish-covid-19-from-otherinfections/</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Временные методические рекомендации МЗ ФР Версия 6 (26.04.2020) «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)».</mixed-citation><mixed-citation xml:lang="en">Временные методические рекомендации МЗ ФР Версия 6 (26.04.2020) «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)».</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical care guidelines. Centers for disease control and prevention. https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html</mixed-citation><mixed-citation xml:lang="en">Clinical care guidelines. Centers for disease control and prevention. https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lechien JR, Chiesa-Estomba CM, Place S, et al. Clinical and Epidemiological Characteristics of 1,420 European Patients with mild-to-moderate Coronavirus Disease 2019 [published online ahead of print, 2020 Apr 30]. J Intern Med. 2020; 10.1111/joim.13089. DOI: 10.1111/joim.13089.</mixed-citation><mixed-citation xml:lang="en">Lechien JR, Chiesa-Estomba CM, Place S, et al. Clinical and Epidemiological Characteristics of 1,420 European Patients with mild-to-moderate Coronavirus Disease 2019 [published online ahead of print, 2020 Apr 30]. J Intern Med. 2020; 10.1111/joim.13089. DOI: 10.1111/joim.13089.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Abbas H. Panju, David Kelvin, Mark D. Minden, Shabbir M. H. Alibhai; Relationship between Fatigue and Cytokine Levels in Patients Age 50+ with Acute Myeloid Leukemia (AML). Blood 2006; 108 (11): 4507. DOI: https://doi.org/10.1182/blood.V108.11.4507.4507</mixed-citation><mixed-citation xml:lang="en">Abbas H. Panju, David Kelvin, Mark D. Minden, Shabbir M. H. Alibhai; Relationship between Fatigue and Cytokine Levels in Patients Age 50+ with Acute Myeloid Leukemia (AML). Blood 2006; 108 (11): 4507. DOI: https://doi.org/10.1182/blood.V108.11.4507.4507</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bower JE. Cancer-related fatigue–mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014; 11 (10): 597–609. DOI: 10.1038/nrclinonc.2014.127.</mixed-citation><mixed-citation xml:lang="en">Bower JE. Cancer-related fatigue–mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014; 11 (10): 597–609. DOI: 10.1038/nrclinonc.2014.127.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Zielinski MR, Systrom DM, Rose NR. Fatigue, Sleep, and Autoimmune and Related Disorders. Front Immunol. 2019; 10: 1827. Published 2019 Aug 6. DOI: 10.3389/fimmu.2019.01827/</mixed-citation><mixed-citation xml:lang="en">Zielinski MR, Systrom DM, Rose NR. Fatigue, Sleep, and Autoimmune and Related Disorders. Front Immunol. 2019; 10: 1827. Published 2019 Aug 6. DOI: 10.3389/fimmu.2019.01827/</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Yamato M, Kataoka Y. Fatigue sensation following peripheral viral infection is triggered by neuroinflammation: who will answer these questions? Neural Regen Res. 2015; 10 (2): 203–204. DOI: 10.4103/1673–5374.152369.</mixed-citation><mixed-citation xml:lang="en">Yamato M, Kataoka Y. Fatigue sensation following peripheral viral infection is triggered by neuroinflammation: who will answer these questions? Neural Regen Res. 2015; 10 (2): 203–204. DOI: 10.4103/1673–5374.152369.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007; 45 (2): 27–37. DOI: 10.1097/AIA.0b013e318034194e.</mixed-citation><mixed-citation xml:lang="en">Zhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007; 45 (2): 27–37. DOI: 10.1097/AIA.0b013e318034194e.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Neri S, Pistone G, Saraceno B, Pennisi G, Luca S, Malaguarnera M. L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C. Neuropsychobiology. 2003; 35: 94–97.</mixed-citation><mixed-citation xml:lang="en">Neri S, Pistone G, Saraceno B, Pennisi G, Luca S, Malaguarnera M. L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C. Neuropsychobiology. 2003; 35: 94–97.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Katafuchi T, Kondo T, Take S, Yoshimura M. Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats. Eur J Neurosci. 2005; 22 (11): 2817–2826. DOI: 10.1111/j.1460–9568.2005.04478.x.</mixed-citation><mixed-citation xml:lang="en">Katafuchi T, Kondo T, Take S, Yoshimura M. Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats. Eur J Neurosci. 2005; 22 (11): 2817–2826. DOI: 10.1111/j.1460–9568.2005.04478.x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Archer MI. The post-viral syndrome: a review. J R Coll Gen Pract. 1987; 37 (298): 212–214.</mixed-citation><mixed-citation xml:lang="en">Archer MI. The post-viral syndrome: a review. J R Coll Gen Pract. 1987; 37 (298): 212–214.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rasa S, Nora-Krukle Z, Henning N, et al. Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). J Transl Med. 2018; 16 (1): 268. Published 2018 Oct 1. DOI: 10.1186/s12967–018–1644-y.</mixed-citation><mixed-citation xml:lang="en">Rasa S, Nora-Krukle Z, Henning N, et al. Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). J Transl Med. 2018; 16 (1): 268. Published 2018 Oct 1. DOI: 10.1186/s12967–018–1644-y.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Moldofsky H, Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurol. 2011; 11: 37. Published 2011 Mar 24. DOI: 10.1186/1471–2377–11–37.</mixed-citation><mixed-citation xml:lang="en">Moldofsky H, Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurol. 2011; 11: 37. Published 2011 Mar 24. DOI: 10.1186/1471–2377–11–37.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lorusso L, Mikhaylova SV, Capelli E, Ferrari D, Ngonga GK, Ricevuti G. Immunological aspects of chronic fatigue syndrome. Autoimmun Rev. 2009; 8 (4): 287–291. DOI: 10.1016/j.autrev.2008.08.003.</mixed-citation><mixed-citation xml:lang="en">Lorusso L, Mikhaylova SV, Capelli E, Ferrari D, Ngonga GK, Ricevuti G. Immunological aspects of chronic fatigue syndrome. Autoimmun Rev. 2009; 8 (4): 287–291. DOI: 10.1016/j.autrev.2008.08.003.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Filler K, Lyon D, Bennett J, et al. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature. BBA Clin. 2014; 1: 12–23. DOI: 10.1016/j.bbacli.2014.04.001.</mixed-citation><mixed-citation xml:lang="en">Filler K, Lyon D, Bennett J, et al. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature. BBA Clin. 2014; 1: 12–23. DOI: 10.1016/j.bbacli.2014.04.001.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Smits B., van den Heuvel L., Knoop H., Kusters B., Janssen A., Borm G., van Engelen B. Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome. Mitochondrion. 2011; 11 (5): 735–738.</mixed-citation><mixed-citation xml:lang="en">Smits B., van den Heuvel L., Knoop H., Kusters B., Janssen A., Borm G., van Engelen B. Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome. Mitochondrion. 2011; 11 (5): 735–738.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Booth N. E., Myhill S., McLaren-Howard J. Mitochondrial dysfunction and the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/ CFS) Int. J. Clin. Exp. Med. 2012; 5 (3) 208–220.</mixed-citation><mixed-citation xml:lang="en">Booth N. E., Myhill S., McLaren-Howard J. Mitochondrial dysfunction and the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/ CFS) Int. J. Clin. Exp. Med. 2012; 5 (3) 208–220.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Cope H, Mann A, Pelosi A, David A. Psychosocial risk factors for chronic fatigue and chronic fatigue syndrome following presumed viral illness: a case-control study. Psychol Med. 1996; 26 (6): 1197–1209. DOI: 10.1017/s0033291700035923.</mixed-citation><mixed-citation xml:lang="en">Cope H, Mann A, Pelosi A, David A. Psychosocial risk factors for chronic fatigue and chronic fatigue syndrome following presumed viral illness: a case-control study. Psychol Med. 1996; 26 (6): 1197–1209. DOI: 10.1017/s0033291700035923.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Chen R, Liang FX, Moriya J, et al. Chronic fatigue syndrome and the central nervous system. J Int Med Res. 2008; 36 (5): 867–874. DOI: 10.1177/147323000803600501.</mixed-citation><mixed-citation xml:lang="en">Chen R, Liang FX, Moriya J, et al. Chronic fatigue syndrome and the central nervous system. J Int Med Res. 2008; 36 (5): 867–874. DOI: 10.1177/147323000803600501.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. 2006; 333 (7568): 575. DOI: 10.1136/bmj.38933.585764.AE.</mixed-citation><mixed-citation xml:lang="en">Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. 2006; 333 (7568): 575. DOI: 10.1136/bmj.38933.585764.AE.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lim, E., Ahn, Y., Jang, E. et al. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med 18, 100 (2020). https://doi.org/10.1186/s12967–020–02269–0</mixed-citation><mixed-citation xml:lang="en">Lim, E., Ahn, Y., Jang, E. et al. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med 18, 100 (2020). https://doi.org/10.1186/s12967–020–02269–0</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Price JR, Mitchell E, Tidy E, Hunot V. Cognitive behaviour therapy for chronic fatigue syndrome in adults. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD 001027. DOI: 10.1002/14651858.CD001027.pub2.</mixed-citation><mixed-citation xml:lang="en">Price JR, Mitchell E, Tidy E, Hunot V. Cognitive behaviour therapy for chronic fatigue syndrome in adults. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD 001027. DOI: 10.1002/14651858.CD001027.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Salamone JD, Correa M. The mysterious motivational functions of mesolimbic dopamine. Neuron. 2012; 76 (3): 470–485. DOI: 10.1016/j.neuron.2012.10.021</mixed-citation><mixed-citation xml:lang="en">Salamone JD, Correa M. The mysterious motivational functions of mesolimbic dopamine. Neuron. 2012; 76 (3): 470–485. DOI: 10.1016/j.neuron.2012.10.021</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">P. O. Behan, B.A.G. Haniffah, D. P. Doogan, M. Loudon, A Pilot Study of Sertraline for the Treatment of Chronic Fatigue Syndrome, Clinical Infectious Diseases, Volume 18, Issue Supplement_1, January 1994, Page S 111, https://doi.org/10.1093/clinids/18.Supplement_1.S111</mixed-citation><mixed-citation xml:lang="en">P. O. Behan, B.A.G. Haniffah, D. P. Doogan, M. Loudon, A Pilot Study of Sertraline for the Treatment of Chronic Fatigue Syndrome, Clinical Infectious Diseases, Volume 18, Issue Supplement_1, January 1994, Page S 111, https://doi.org/10.1093/clinids/18.Supplement_1.S111</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ronfeld R. A., Tremaine L. M., Wilner K. D. Pharmacokinetics of sertralin and N-demethyl metabolite in elderly and young male and female volunteers. Clin. Pharmacokinet. 1997. Vol. 32. Suppl. 1. P. 22–30.</mixed-citation><mixed-citation xml:lang="en">Ronfeld R. A., Tremaine L. M., Wilner K. D. Pharmacokinetics of sertralin and N-demethyl metabolite in elderly and young male and female volunteers. Clin. Pharmacokinet. 1997. Vol. 32. Suppl. 1. P. 22–30.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Maric D, Brkic S, Tomic S, Novakov Mikic A, Cebovic T, Turkulov V. Multivitamin mineral supplementation in patients with chronic fatigue syndrome. Med Sci Monit. 2014; 20: 47–53. Published 2014 Jan 14. DOI: 10.12659/MSM.889333</mixed-citation><mixed-citation xml:lang="en">Maric D, Brkic S, Tomic S, Novakov Mikic A, Cebovic T, Turkulov V. Multivitamin mineral supplementation in patients with chronic fatigue syndrome. Med Sci Monit. 2014; 20: 47–53. Published 2014 Jan 14. DOI: 10.12659/MSM.889333</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Earl KE, Sakellariou GK, Sinclair M, et al. Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England. BMJ Open. 2017; 7 (11): e015296. Published 2017 Nov 8. DOI: 10.1136/bmjopen-2016–015296.</mixed-citation><mixed-citation xml:lang="en">Earl KE, Sakellariou GK, Sinclair M, et al. Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England. BMJ Open. 2017; 7 (11): e015296. Published 2017 Nov 8. DOI: 10.1136/bmjopen-2016–015296.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Plescheva A, Pigarova E Dzeranova L. Changes in anxiety and depression symptoms in patients with chronic fatigue syndrome treated with vitamin D. Endocrine Abstracts.2013; 32: 119 Effect of vitamin D 3 on self-perceived fatigue A double-blind randomized placebo-controlled trial.</mixed-citation><mixed-citation xml:lang="en">Plescheva A, Pigarova E Dzeranova L. Changes in anxiety and depression symptoms in patients with chronic fatigue syndrome treated with vitamin D. Endocrine Abstracts.2013; 32: 119 Effect of vitamin D 3 on self-perceived fatigue A double-blind randomized placebo-controlled trial.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Nowak A, Boesch L, Andres E, et al. Effect of vitamin D 3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial [published correction appears in Medicine (Baltimore). 2017 Jan 20; 96 (3): e6038]. Medicine (Baltimore). 2016; 95 (52): e5353. DOI: 10.1097/MD.0000000000005353.</mixed-citation><mixed-citation xml:lang="en">Nowak A, Boesch L, Andres E, et al. Effect of vitamin D 3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial [published correction appears in Medicine (Baltimore). 2017 Jan 20; 96 (3): e6038]. Medicine (Baltimore). 2016; 95 (52): e5353. DOI: 10.1097/MD.0000000000005353.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Vanherwegen AS, Gysemans C, Mathieu C. Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am. 2017; 46 (4): 1061–1094. DOI: 10.1016/j.ecl.2017.07.010.</mixed-citation><mixed-citation xml:lang="en">Vanherwegen AS, Gysemans C, Mathieu C. Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am. 2017; 46 (4): 1061–1094. DOI: 10.1016/j.ecl.2017.07.010.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Jayedi A, Rashidy-Pour A, Shab-Bidar S. Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response †. Nutr Neurosci. 2019; 22 (11): 750–759. DOI: 10.1080/1028415X.2018.1436639.</mixed-citation><mixed-citation xml:lang="en">Jayedi A, Rashidy-Pour A, Shab-Bidar S. Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response †. Nutr Neurosci. 2019; 22 (11): 750–759. DOI: 10.1080/1028415X.2018.1436639.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Кузнецов И. А., Смирнов А. М., Куралева О. О., Быстрякова Е. А., Лакейкина И. А., Бегметова М. Х. Биологические и фармакологические свойства Трекрезана. Современные проблемы науки и образования. 2015. № 1–1.</mixed-citation><mixed-citation xml:lang="en">Kuznetzov I. A., Smirnov A. M., Kuraleva O. O., Bistryakova E. A., Laleikina I. A., Begmetove M. H. Biological and pharmacological properties of Trekresan. Modern problems of science and educarion. 2015, № 1–1 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395 (10227): 912–20 DOI: https://doi.org/10.1016/S0140–6736(20)30460–8/.</mixed-citation><mixed-citation xml:lang="en">Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395 (10227): 912–20 DOI: https://doi.org/10.1016/S0140–6736(20)30460–8/.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
