medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-36-55-60medalphabet-1832Research ArticleСтатьиВыбор оптимального нестероидного противовоспалительного препарата с позиции кардиологаChoice of optimal non-steroidal anti-inflammatory drug from position of cardiologistМельникМ. Г.MelnikM. G.

Кандидат медицинских наук, доцент кафедры терапии № 2 факультета повышения квалификации и профессиональной переподготовки специалистов

Краснодар

ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава РоссииРоссияKuban State Medical UniversityRussian Federation202013012021036Кардиология и неотложная помощь (4)5560Copyright © Мельник М.Г., 20212021Мельник М.Г.Melnik M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1832

Нестероидные противовоспалительные препараты (НПВП) – большая и крайне неоднородная группа лекарственных средств, обладающих единым механизмом действия и терапевтической активностью. В статье приведены их основные подгруппы по химической структуре и селективности действия, описаны наиболее характерные побочные эффекты, обусловленные фармакодинамическими особенностями препаратов, объяснены причины их формирования, охарактеризованы вызываемые ими сердечно-сосудистые осложнения. Учитывая отсутствие желаемой безопасности у классических НПВП для кардиологической практики, рассмотрена возможность оптимизации их переносимости с помощью современных поколений ингибиторов циклооксигеназы, а именно правовращающегося S-энантиомера кетопрофена – декскетопрофена трометамола (Декскетопрофен-СЗ, «Северная звезда», Россия). Препарат отличают высокая эффективность и низкий риск кардиоваскулярной токсичности, что позволяет широко использовать его при симптоматической терапии кардиологических больных.

Non-steroidal anti-inflammatory drugs (NSAIDs) are a large and extremely heterogeneous group of drugs that have a single mechanism of action and therapeutic activity. The article lists their main subgroups by chemical structure and selectivity of action, describes the most typical side effects due to the pharmacodynamic characteristics of drugs, explains the reasons for their formation, and describes the cardiovascular complications they cause. Taking into account the lack of the desired safety of classical NSAIDs for cardiological practice, the possibility of optimizing their tolerance with the help of modern generations of cyclooxygenase inhibitors, namely the dextrorotatory S-enantiomer of ketoprofen – dexketoprofen trometamol (Dexketoprofen-SZ, «Severnaya Zvezda», Russia) was considered. The drug is distinguished by high efficiency and low risk of cardiovascular toxicity, which makes it widely used in symptomatic therapy of cardiac patients.

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The authors declare that there are no conflicts of interest present.