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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2020-31-38-42</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1815</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Клинические ассоциации псориаза, фибромиалгии и энтезиально-синовиального воспаления</article-title><trans-title-group xml:lang="en"><trans-title>Clinical associations of psoriasis, fibromyalgia, and enthesial-synovial inflammation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Притуло</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pritulo</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, заведующий кафедрой дерматовенерологии и косметологии, главный внештатный специалист-дерматовенеролог Минздрава Республики Крым.</p><p>Симферополь, Республика Крым</p></bio><bio xml:lang="en"><p>Simferopol, Republic of Crimea</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ординатор кафедры дерматовенерологии и косметологии.</p><p>Симферополь, Республика Крым</p></bio><bio xml:lang="en"><p>Simferopol, Republic of Crimea</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, профессор кафедры внутренней медицины № 2, главный внештатный специалист-ревматолог Минздрава Республики Крым.</p><p>Симферополь, Республика Крым</p></bio><bio xml:lang="en"><p>Simferopol, Republic of Crimea</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медицинская академия имени С.И. Георгиевского, ФГАОУ ВО Крымский федеральный университет имени В.И. Вернадского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Crimean Federal University n. a. V.I. Vernadsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>12</day><month>01</month><year>2021</year></pub-date><volume>0</volume><issue>31</issue><issue-title>Ревматология в общей практике (2)</issue-title><fpage>38</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Притуло О.А., Петров А.А., Петров А.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Притуло О.А., Петров А.А., Петров А.В.</copyright-holder><copyright-holder xml:lang="en">Pritulo O.A., Petrov A.A., Petrov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1815">https://www.med-alphabet.com/jour/article/view/1815</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Оценка частоты встречаемости фибромиалгии (ФМ), энтезита (Эн), синовита и теносиновита и других ревматических заболеваний суставов среди больных псориазом (ПсО) в ранние сроки после появления костно-мышечных симптомов на основании комплексного исследования с применением клинико-лабораторных, рентгенологического и ультрасонографического методов.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В основу работы положен анализ данных обследования 178 больных вульгарным ПсО с 2016 по 2019 год, cреди которых была выделена группа из 86 больных, которые имели болевые симптомы в области суставов и сухожильно-связочного аппарата. Длительность периода костно-мышечной боли у наблюдаемых больных не превышала 6 месяцев. Кроме общеклинического и лабораторного обследования, всем больным проводились исследование на наличие триггерных точек и ультрасонография болезненных и (или) припухших при пальпации суставов, сухожилий и связок с применением линейным датчиком (частота 12-18 МГц) с использованием аппарата EsaoteMyLab 50, что дополнялось доплеровским энергетическим исследованием с частотой импульсов 6,6 МГц.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. На основании данных комплексного обследования наблюдаемых больных ПсО диагноз ПсА был установлен у 29,78 %, ФМ - у 11,24%, остеоартрита - у 6,18 %, подагры -у 3,93%. Клинико-ультрасонографические признаки Эн были обнаружены у 29,78% больных, изолированный Эн был обнаружен у 10,67% больных, Эн и синовит - у 14,04 %, сочетание Эн и теносиновита - у 8,99% больных. Изолированная ФМ диагностировалась у 8,9% больных, сочетание ФМ, Эн и синовита - у 4,2% больных. У больных с ФМ, по сравнению с больными с клинико-ультрасонографическим признаками, чаще наблюдалось поражение кожи головы, шеи и лица и ладонно-подошвенной локализации и реже - верхних и нижних конечностей. Ультрасонографические признаки структурного повреждения энтезисов наблюдались у 8,43% пациентов без клинических и ультрасонографических признаков активного Эн, что может свидетельствовать о возможности субклинического течения энтезиального воспаления у больных с Пс О.</p></sec><sec><title>Заключение</title><p>Заключение. В раннем периоде вовлечения костно-мышечной системы у больных ПсО частота выявления ПсА составляет 29,78%, изолированной ФМ - 8,9%, изолированного Эн - 10,67%. Получены данные об особенностях поражения кожи у больных с различным типом поражения костно-мышечной системы.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. Evaluation of the incidence of fibromyalgia (FM), enthesitis (En), synovitis and tenosynovitis and other rheumatic diseases of the joints among patients with psoriasis (PsO) in the early stages after the onset of musculoskeletal symptoms based on a comprehensive study using clinical laboratory, X-ray and ultrasonographic methods.</p></sec><sec><title>Subjects and methods</title><p>Subjects and methods. The study is based on the analysis of survey data from 178 patients with PsO for the period of 2016-2019 years, among which was identified a group of 86 patients who had pain symptoms in the area of joints and tendon-ligamentous apparatus. The duration of the period of musculoskeletal pain in the observed patients did not exceed 6 months. In addition to general clinical and laboratory examination, all patients underwent an investigation for the presence of trigger points and ultrasonography of painful and/or swollen joints, tendons and ligaments on palpation using a linear sensor (frequency of 12-18 MHz) using the Esaote MyLab 50 apparatus and supplemented by Doppler energy study with a pulse frequency of 6.6 MHz.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. Based on the data of a comprehensive examination of the observed patients with PsO, the diagnosis of PsA was established in 29.78 %, osteoarthritis - in 6.18 %, gout -in 3.93 %, fibromyalgia - in 11.24 % of cases. Ultrasonographic signs of En were found in 29.78 %, isolated En was found in 10.67%, a combination of En and synovitis - in 14.04%, a combination of En and tenosynovitis - in 8.99% of patients. Isolated FM was diagnosed in 8.9%, a combination of FM, En and synovitis - in 4.2 % of patients. In patients with FM, in comparison with patients with clinical and ultrasonographic signs, lesions of the scalp, neck and face and palmar-plantar localization were more often observed and, less often, of the upper and lower extremities. Ultrasonographic signs of structural damage to enthesises were observed in 17.4% of patients without clinical and ultrasonographic signs of active EN, which may indicate the possibility of a subclinical course of enthesial inflammation in patients with Ps O.</p></sec><sec><title>Conclusion</title><p>Conclusion. In the early period of involvement of the musculoskeletal system in patients with PsO, the frequency of PsA was 29.78%, isolated FM - 8.9%, isolated EN - 10.67% of cases. The data on the features of skin lesions in patients with various types of lesions of the musculoskeletal system were obtained.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>псориаз</kwd><kwd>псориатический артрит</kwd><kwd>энтезит</kwd><kwd>синовит</kwd><kwd>теносиновит</kwd><kwd>фибромиалгия</kwd><kwd>ультрасонография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>psoriasis</kwd><kwd>psoriatic arthritis</kwd><kwd>enthesitis</kwd><kwd>synovitis</kwd><kwd>tenosynovitis</kwd><kwd>fibromyalgia</kwd><kwd>ultrasonography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Олисова О. Ю. Псориаз: эпидемиология, патогенез, клиника, лечение. Consilium medicum. Дерматология. 2010; 4:3-8.</mixed-citation><mixed-citation xml:lang="en">Олисова О. Ю. Псориаз: эпидемиология, патогенез, клиника, лечение. Consilium medicum. 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