medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-24-57-62medalphabet-1788Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУПоддерживающая терапия акне: профилактическая эффективность фиксированной комбинации адапалена и бензоила пероксидаMaintenance acne therapy: prophylactic efficacy of fixed combination of adapalene and benzoyl peroxideКругловаЛ. С.KruglovaL. S.

д.м.н., проф., проректор по учебной работе, зав. кафедрой дерматовенерологии и косметологии,

Москва

Moscow

ГрязеваН. В.GryazevaN. V.

к.м.н., доцент кафедры дерматовенерологии и косметологии,

Москва

Moscow

ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РоссииРоссияCentral State Medical Academy of the Administrative Department of the President of RussiaRussian Federation202018122020024Дерматология (2)5762Copyright © Круглова Л.С., Грязева Н.В., 20202020Круглова Л.С., Грязева Н.В.Kruglova L.S., Gryazeva N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1788

Акне является хроническим заболеванием, и даже надежные методы терапии полностью не обеспечивают отсутствие рецидивов. Рецидивы акне оказывают негативное психологическое воздействие на пациентов, так как они чувствуют себя неспособными контролировать болезнь и добиться полного и стойкого выздоровления. Поддерживающая терапия необходима для пролонгации ремиссии акне, достигнутой при первоначальном успешном лечении, и минимизации риска рецидива. Наиболее обоснованным в качестве поддерживающей терапии, по данным литературы, является использование топических ретиноидов, которые показали эффективность в отношении профилактики обострений акне. В настоящем исследовании участвовали 54 пациента, которые после активной терапии в качестве поддерживающего лечения использовали фиксированную комбинацию адапалена 0,1% и БПО 2,5%. Только у 1 (2,9%) пациента с акне средней степени тяжести и у 2 (5,8%) пациентов с акне тяжелой степени наблюдался рецидив в течение 6 месяцев поддерживающей терапии. Зафиксировано отсутствие нежелательных явлений в процессе лечения, а также высокая приверженность пациентов к лечению. В период активного наблюдения (6 месяцев после поддерживающей терапии) из числа пациентов без обострения в период поддерживающей терапии рецидив наступил у 2 (7,1%) пациентов первой группы (n = 28) и 2 (8,7%) пациентов – второй (n = 23). Полученные данные свидетельствуют о том, что поддерживающая терапия гелем Эффезел® может продлить достигнутую эффективность лечения и предупредить развитие рецидива.

Acne is a chronic disease and even reliable therapies do not completely ensure absence of relapses. Acne relapses have a negative psychological impact on patients, as they feel unable to control the disease and achieve complete and long-lasting recovery. Supportive therapy is necessary to prolong the remission of acne achieved with initial successful treatment and to minimize the risk of relapse. According to the literature sources, the most justified as a maintenance therapy is the use of topical retinoids, which have been shown to be effective in the prevention of exacerbations of acne. In the present study 54 patients were involved who after the active therapy used a fixed combination of adapalene 0.1% / BPO 2.5% as maintenance treatment. Only 1 patient (2.9%) with moderate acne and 2 patients (5.8%) with severe acne had a relapse within 6 months of maintenance therapy. The absence of adverse events during the course of treatment was recorded, as well as high adherence of patients to the treatment. During the period of post-treatment observation (6 months after maintenance therapy), among the patients without exacerbations during maintenance therapy, a relapse occurred in 2 (7.1%) patients of group 1 (n = 28) and 2 (8.7%) patients of group 2 (n = 23). The obtained data indicates that maintenance therapy with Effezel® gel can extend the achieved effectiveness of the treatment and prevent the development of relapses.

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The authors declare that there are no conflicts of interest present.