medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-26-30-36medalphabet-1766Research ArticleСтатьиВитамин D, менопауза и возраст: чего ожидать? (Обзор литературы)Витамин D, менопауза и возраст: чего ожидать? (Обзор литературы)ЗайдиеваЯ. З.ZaydievaYа. Z.

д.м.н., проф., рук. отделения гинекологической эндокринологии

г. Москва

Moscow

БаланВ. Е.BalanV. E.

д.м.н., проф., рук. поликлинического отделения

г. Москва

Moscow

ЦарьковаА. В.Tsar’kovaA. V.

врач поликлинического отделения

г. Москва

Moscow

КручининаЕ. В.KruchininaE. V.

к.м.н., н.с. отделения гинекологической эндокринологии

г. Москва

Moscow

ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»РоссияMoscow Regional Research Institute for Obstetrics and GynecologyRussian Federation202003122020026Современная гинекология (3)3036Copyright © Зайдиева Я.З., Балан В.Е., Царькова А.В., Кручинина Е.В., 20202020Зайдиева Я.З., Балан В.Е., Царькова А.В., Кручинина Е.В.Zaydieva Y.Z., Balan V.E., Tsar’kova A.V., Kruchinina E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1766

Менопауза и старение связаны с изменениями уровня гонадных стероидных гормонов, чувствительности к инсулину, массы тела, а также образа жизни и социальных координат. Витамин D влияет на различные метаболические процессы, помимо кальций-фосфорного и костного метаболизма. Основным маркером крови, используемым для измерения эндогенного витамина D, является 25-гидроксивитамин D. Старение связано с повышением содержания паратиреоидного гормона и щелочной фосфатазы в сыворотке крови, а также снижением содержания кальция, фосфора и метаболитов витамина D. На состояние 25-гидроксивитамина D также влияет круглогодичный ритм солнечного облучения. Результаты клинических ассоциативных исследований не коррелировали с интервенционными исследованиями, экспериментальными исследованиями и (или) метаанализами, касающимися роли витамина D в различных исходах у женщин в течение второй половины жизни, а также дозы витамина D, необходимой для улучшения клинических симптомов. Противоречивые результаты были связаны с методом, используемым для измерения витамина D, изучаемой популяцией (то есть социодемографией и этнической принадлежностью), проектами исследований и тенденциозностью анализа. Добавки витамина D, холекальциферола или кальцифедиола могут улучшить некоторые метаболические и клинические исходы у женщин в постменопаузе и пожилых. Исследования, по-видимому, предполагают, что кальцифедиол может иметь некоторые преимущества перед другими формами добавок витамина D.

Menopause and aging are associated with changes in circulating gonadal steroid hormones, insulin sensitivity, body composition, also lifestyle and social coordinates. Vitamin D status influences Different metabolic adjustments, aside from calcium–phosphorus and bone metabolism. The main blood marker used to measure endogenous vitamin D status is 25-hydroxyvitamin D. Aging is associated with increases in serum parathyroid hormone and alkaline phosphatase, and a Decrease of serum calcium, phosphorus, and vitamin D metabolites. 25-hydroxyvitamin D status is also influenced by the circannual rhythm of sun irradiation. Results of clinical association studies have not correlated with intervention trials, experimental studies, and/or meta-analyses regarding the role of vitamin D on Different outcomes in women During their second half of life and the vitamin D supplementation Dose needed to improve clinical endpoints. Discordant results have been related to the method used to measure vitamin D, the studied population (i.e. sociodemographics and ethnicity), study Designs, and biases of analyses. Vitamin D supplementation with cholecalciferol or calcifediol may improve some metabolic variables and clinical outcomes in young postmenopausal and older women. Studies seem to suggest that calcifediol may have some advantages over other forms of vitamin D supplementation.

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The authors declare that there are no conflicts of interest present.