medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-26-6-11medalphabet-1763Research ArticleСтатьиСостояние нутритивного статуса женщины как одного из механизмов фетального программированияState of nutritional status of woman as one of mechanisms of fetal programmingОрловаС. В.OrlovaS. V.

д.м.н., проф., зав. кафедрой диетологии и клинической нутрициологии

Москва

Moscow

КоденцоваВ. М.KodentsovaV. V.

д.б.н., проф., гл. научный сотрудник лаборатории витаминов и минеральных веществ

Москва

Moscow

НикитинаЕ. А.NikitinaE. A.

к.м.н., доцент кафедры диетологии и клинической нутрициологии

Москва

Moscow

ПронинаО. Е.ProninaO. E.

ассистент кафедры диетологии и клинической нутрициологии

Москва

Moscow

ПрокопенкоЕ. В.ProkopenkoE. V.

врач-эндокринолог, диетолог, врач-методолог медицинского департамента

Москва

Moscow

ВодолазскаяА. Н.VodolazkayaA. N.

врач – диетолог-эндокринолог

Москва

Факультет непрерывного медицинского образования Медицинского института ФГАОУ ВО «Российский университет дружбы народов»РоссияPeoples’ Friendship University of RussiaRussian FederationФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»РоссияFederal Research Centre for Nutrition, Biotechnology and Food SafetyRussian FederationООО «МС Груп»РоссияMS Group Co.Russian FederationООО «Эль-Клиник»РоссияEl Clinic Co.Russian Federation202003122020026Современная гинекология (3)611Copyright © Орлова С.В., Коденцова В.М., Никитина Е.А., Пронина О.Е., Прокопенко Е.В., Водолазская А.Н., 20202020Орлова С.В., Коденцова В.М., Никитина Е.А., Пронина О.Е., Прокопенко Е.В., Водолазская А.Н.Orlova S.V., Kodentsova V.V., Nikitina E.A., Pronina O.E., Prokopenko E.V., Vodolazkaya A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1763

Сбалансированное питание является необходимым условием протекания физиологической беременности, развития и роста плода. Особенности современного образа жизни препятствуют формированию оптимального рациона, вследствие чего у беременных широко распространены различные нарушения питания, включая полигиповитаминозы и микроэлементозы. Дефицит микронутриентов, испытываемый плодом во время внутриутробного развития, способен изменить структуру тела, функцию стволовых клеток и регуляторных гормональных осей, что повышает вероятность развития неинфекционных заболеваний во взрослом возрасте. Наибольшее влияние на фетальное программирование оказывают фолиевая кислота и факторы метилирования, железо, цинк и магний. Для профилактики и коррекции микронутриентной недостаточности у беременных необходим комплексный подход с использованием витаминно-минеральных комплексов.

Balanced diet is a prerequisite for physiological pregnancy, fetal development and growth. The peculiarities of the modern lifestyle impede the formation of an optimal diet, as a result of which various nutritional disorders are widespread in pregnant women, including multihypovitaminosis and microelementosis. Micronutrient deficiencies experienced by the fetus during intrauterine development can alter body structure, the function of stem cells and regulatory hormonal axes, which increases the likelihood of developing noncommunicable diseases in adulthood. Folic acid and methylation factors, iron, zinc and magnesium have the greatest influence on fetal programming. For the prevention and correction of micronutrient deficiencies in pregnant women, an integrated approach is required using multivitamin and mineral complexes.

фетальное программированиенутритивный статусполигиповитаминозымикроэлементозымикронутриентная недостаточностьбеременностьплодfetal programmingnutritional statuspolyhypovitaminosismicroelementosismicronutrient deficiencypregnancyfetusПубликация выполнена при поддержке программы  стратегического академического лидерства РУДН.ReferencesBischoff AR, Cunha FD, Dalle Molle R, Maróstica PJ, Silveira PP. Is willingness to exercise programmed in utero? Reviewing sedentary behavior and the benefits of physical activity in intrauterine growth restricted individuals. J Pediatr (Rio J). 2018 Nov–Dec; 94 (6): 582–95.Bischoff AR, Cunha FD, Dalle Molle R, Maróstica PJ, Silveira PP. Is willingness to exercise programmed in utero? Reviewing sedentary behavior and the benefits of physical activity in intrauterine growth restricted individuals. J Pediatr (Rio J). 2018 Nov–Dec; 94 (6): 582–95.Adair LS. Long-term consequences of nutrition and growth in early childhood and possible preventive interventions. Nestle Nutr Inst Workshop Ser. 2014; 78: 111–20.Adair LS. Long-term consequences of nutrition and growth in early childhood and possible preventive interventions. Nestle Nutr Inst Workshop Ser. 2014; 78: 111–20.Marangoni F, Cetin I, Verduci E, Canzone G, Giovannini M, Scollo P, Corsello G, Poli A. Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus Document. Nutrients. 2016 Oct 14; 8 (10): 629.Marangoni F, Cetin I, Verduci E, Canzone G, Giovannini M, Scollo P, Corsello G, Poli A. Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus Document. Nutrients. 2016 Oct 14; 8 (10): 629.Kwon EJ, Kim YJ. What is fetal programming? A lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017 Nov; 60 (6): 506–519.Kwon EJ, Kim YJ. What is fetal programming? A lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017 Nov; 60 (6): 506–519.Mandy M, Nyirenda M. Developmental Origins of Health and Disease: the relevance to developing nations. Int Health. 2018 Mar; 10 (2): 66–70.Mandy M, Nyirenda M. Developmental Origins of Health and Disease: the relevance to developing nations. Int Health. 2018 Mar; 10 (2): 66–70.Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002; 31 (6): 1235–1239.Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002; 31 (6): 1235–1239.Takaya J. Small for Gestational Age and Magnesium: Intrauterine magnesium deficiency may induce metabolic syndrome in later life. AIMS Public Health. 2015; 2 (4): 793–803.Takaya J. Small for Gestational Age and Magnesium: Intrauterine magnesium deficiency may induce metabolic syndrome in later life. AIMS Public Health. 2015; 2 (4): 793–803.Cooper WN, Khulan B, Owens S, Elks CE, Seidel V, Prentice AM, et al. DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial. FASEB J. 2012; 26 (5): 1782–1790.Cooper WN, Khulan B, Owens S, Elks CE, Seidel V, Prentice AM, et al. DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial. FASEB J. 2012; 26 (5): 1782–1790.Seki Y, Williams L, Vuguin PM, Charron MJ. Minireview: epigenetic programming of diabetes and obesity: animal models. Endocrinology 2012; 153 (3): 1031–1038.Seki Y, Williams L, Vuguin PM, Charron MJ. Minireview: epigenetic programming of diabetes and obesity: animal models. Endocrinology 2012; 153 (3): 1031–1038.Xita N, Tsatsoulis A. Fetal origins of the metabolic syndrome. Ann NY Acad Sci. 2010; 1205 (1): 148–155.Xita N, Tsatsoulis A. Fetal origins of the metabolic syndrome. Ann NY Acad Sci. 2010; 1205 (1): 148–155.Hanson M.A., Gluckman P.D. Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev. 2014; 94 (4): 1027–76.Hanson M.A., Gluckman P.D. Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev. 2014; 94 (4): 1027–76.Levin EB. Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis. Phil. Trans. R. Soc. 2006; 361: 1107–1121.Levin EB. Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis. Phil. Trans. R. Soc. 2006; 361: 1107–1121.Yang N., Ray D.W., Matthews L.C. Current concepts in glucocorticoid resistance. Steroids. 2012 Sep; 77 (11): 1041–9.Yang N., Ray D.W., Matthews L.C. Current concepts in glucocorticoid resistance. Steroids. 2012 Sep; 77 (11): 1041–9.Lipton L.R., Brunst K.J., Kannan S. et al. Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months. J Dev Orig Health Dis. 2017; 8 (6): 638–648.Lipton L.R., Brunst K.J., Kannan S. et al. Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months. J Dev Orig Health Dis. 2017; 8 (6): 638–648.Hales CN. The thrifty phenotype hypothesis. British Medical Bulletin. 2001; 60 (1): 5–20.Hales CN. The thrifty phenotype hypothesis. British Medical Bulletin. 2001; 60 (1): 5–20.Sandovici I, Smith N, Niter D, et al. Maternal diet and aging alter the epigenetic control of promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. PNAS. 2011; 108 (13): 5449–5454.Sandovici I, Smith N, Niter D, et al. Maternal diet and aging alter the epigenetic control of promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. PNAS. 2011; 108 (13): 5449–5454.Мамонова Л.Г. Современные проблемы питания беременных и кормящих женщин. Вопросы современной педиатрии. М., 2006. Т. 5. № 4. С. 104–106.Мамонова Л.Г. Современные проблемы питания беременных и кормящих женщин. Вопросы современной педиатрии. М., 2006. Т. 5. № 4. С. 104–106.Савченко Т.Н., Дергачева И.А., Агаева М.И. Микронутриенты и беременность РМЖ. Мать и дитя, № 15 от 23.09.2016, стр. 1005–1008.Савченко Т.Н., Дергачева И.А., Агаева М.И. Микронутриенты и беременность РМЖ. Мать и дитя, № 15 от 23.09.2016, стр. 1005–1008.Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun; 135 (6): 1382–6.Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun; 135 (6): 1382–6.Егорова И.Э., Суслова А.И., Бахтаирова В.И. Биохимия Часть II Иркутск: ИГМУ, 2014. 83с.Егорова И.Э., Суслова А.И., Бахтаирова В.И. Биохимия Часть II Иркутск: ИГМУ, 2014. 83с.Neuringer M. Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results and implications. Am.J. Clin. Nutr. 2000; 71 (Suppl.): 256–267.Neuringer M. Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results and implications. Am.J. Clin. Nutr. 2000; 71 (Suppl.): 256–267.Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct; 111 (2): 510–21.Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct; 111 (2): 510–21.Rump P., Merisink R.P., Kester A.D.M., Hornstra G. Essential fatty acids composition of plasma phospholipids and birth weight: a study in term neonates. Am J Clin Nutr. 2001. Vol. 73. P. 797–806.Rump P., Merisink R.P., Kester A.D.M., Hornstra G. Essential fatty acids composition of plasma phospholipids and birth weight: a study in term neonates. Am J Clin Nutr. 2001. Vol. 73. P. 797–806.Elias S.L., Innis S.M. Infant plasma trans, n-6 and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation and birth weight and length. Am J Clin Nutr. 2001. Vol. 73. P. 807–814.Elias S.L., Innis S.M. Infant plasma trans, n-6 and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation and birth weight and length. Am J Clin Nutr. 2001. Vol. 73. P. 807–814.Dunstan JA, Roper J, Hartmann PE, et al. The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine level and fatty acid composition. Clin. Exp. Allergy. 2004; 34 (8): 1237–1242.Dunstan JA, Roper J, Hartmann PE, et al. The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine level and fatty acid composition. Clin. Exp. Allergy. 2004; 34 (8): 1237–1242.Furuhjelm C, Warstedt K, Fageras M, et al. Allergic disease in infants up to 2 years of age in relation to plsma omega3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr. Allergy Immunol. 2011; 22 (5): 505–514.Furuhjelm C, Warstedt K, Fageras M, et al. Allergic disease in infants up to 2 years of age in relation to plsma omega3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr. Allergy Immunol. 2011; 22 (5): 505–514.Громова О. А., Торшин И. Ю., Лиманова О. А. Омега-3 полиненасыщенные жирные кислоты и активные фолаты: перспективы комплексного применения для нутрициальной поддержки беременности и профилактики пороков развития (литературный обзор). Consilium Medicum. Гинекология. 2013. № 2. С. 71–77.Громова О. А., Торшин И. Ю., Лиманова О. А. Омега-3 полиненасыщенные жирные кислоты и активные фолаты: перспективы комплексного применения для нутрициальной поддержки беременности и профилактики пороков развития (литературный обзор). Consilium Medicum. Гинекология. 2013. № 2. С. 71–77.Davies GAL, Maxwell C, McLeod L; Maternal fetal medicine committee; Clinical practice obstetrics. Obesity in pregnancy. J Obstet Gynaecol Can. 2010 Feb; 32 (2): 165–173.Davies GAL, Maxwell C, McLeod L; Maternal fetal medicine committee; Clinical practice obstetrics. Obesity in pregnancy. J Obstet Gynaecol Can. 2010 Feb; 32 (2): 165–173.Surkan P.J., Forman M.R., Michels K.B. Reasons for increasing trends in large for gestational age births. Obstet. Gynecol. 2004. Vol. 104. Р. 720–726.Surkan P.J., Forman M.R., Michels K.B. Reasons for increasing trends in large for gestational age births. Obstet. Gynecol. 2004. Vol. 104. Р. 720–726.Schulz LC. The Dutch Hunger Winter and the developmental origins of health and disease. Proc Natl Acad Sci U S A. 2010 Sep 28; 107 (39): 16757–8.Schulz LC. The Dutch Hunger Winter and the developmental origins of health and disease. Proc Natl Acad Sci U S A. 2010 Sep 28; 107 (39): 16757–8.Syddall HE, Simmonds SJ, Carter SA, Robinson SM, Dennison EM, Cooper C; Hertfordshire Cohort Study Research Group. The Hertfordshire Cohort Study: an overview. F1000Res. 2019 Jan 21; 8: 82.Syddall HE, Simmonds SJ, Carter SA, Robinson SM, Dennison EM, Cooper C; Hertfordshire Cohort Study Research Group. The Hertfordshire Cohort Study: an overview. F1000Res. 2019 Jan 21; 8: 82.Громова О.А., Торшин И.Ю. Микронутриенты и репродуктивное здоровье. Руководство. Москва, 2019, 672 с.Громова О.А., Торшин И.Ю. Микронутриенты и репродуктивное здоровье. Руководство. Москва, 2019, 672 с.Коденцова В.М. Витамины и минералы как фактор предупреждения дефектов развития плода и осложнений беременности. Медицинский Совет. 2016; (9): 106–114.Коденцова В.М. Витамины и минералы как фактор предупреждения дефектов развития плода и осложнений беременности. Медицинский Совет. 2016; (9): 106–114.Коденцова В.М., Вржесинская О.А., Рисник Д.В., Никитюк Д.Б., Тутельян В.А. Обеспеченность населения России микронутриентами и возможности ее коррекции. Состояние проблемы. Вопросы питания. 2017; 86 (4): 113–124.Коденцова В.М., Вржесинская О.А., Рисник Д.В., Никитюк Д.Б., Тутельян В.А. Обеспеченность населения России микронутриентами и возможности ее коррекции. Состояние проблемы. Вопросы питания. 2017; 86 (4): 113–124.Yang Q., Cogswell M.E., Hamner H.C., Carriquiry A., Bailey L.B., Pfeiffer C.M., Berry R.J. Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2006. American Journal of Clinical Nutrition. 2010. January 91(1). P. 64–72.Yang Q., Cogswell M.E., Hamner H.C., Carriquiry A., Bailey L.B., Pfeiffer C.M., Berry R.J. Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2006. American Journal of Clinical Nutrition. 2010. January 91(1). P. 64–72.Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom PE, Heijmans BT. Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One. 2009 Nov 16; 4 (11): e7845.Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom PE, Heijmans BT. Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One. 2009 Nov 16; 4 (11): e7845.Koletzko B, Bauer CP, Bung P, Cremer M, Flothkötter M, Hellmers C, et al. German national consensus recommendations on nutrition and lifestyle in pregnancy by the ‘Healthy Start – Young Family Network’. Ann Nutr Metab. 2013; 63 (4): 311–22.Koletzko B, Bauer CP, Bung P, Cremer M, Flothkötter M, Hellmers C, et al. German national consensus recommendations on nutrition and lifestyle in pregnancy by the ‘Healthy Start – Young Family Network’. Ann Nutr Metab. 2013; 63 (4): 311–22.Yajnik CS, Deshmukh US. Fetal programming: maternal nutrition and role of one-carbon metabolism. Rev Endocr Metab Disord. 2012 Jun; 13 (2): 121–7.Yajnik CS, Deshmukh US. Fetal programming: maternal nutrition and role of one-carbon metabolism. Rev Endocr Metab Disord. 2012 Jun; 13 (2): 121–7.Малкоч А. В., Анастасевич Л. А., Филатова Н. Н. Железодефицитные состояния и железодефицитная анемия у женщин детородного возраста. Лечащий врач 2013, 04/13.Малкоч А. В., Анастасевич Л. А., Филатова Н. Н. Железодефицитные состояния и железодефицитная анемия у женщин детородного возраста. Лечащий врач 2013, 04/13.Chang S, Zeng L, Brouwer ID, Kok FJ, Yan H. Effect of iron deficiency anemia in pregnancy on child mental development in rural China. Pediatrics. 2013 Mar; 131 (3): e755–63.Chang S, Zeng L, Brouwer ID, Kok FJ, Yan H. Effect of iron deficiency anemia in pregnancy on child mental development in rural China. Pediatrics. 2013 Mar; 131 (3): e755–63.Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002; 140: 165–70.Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002; 140: 165–70.Congdon E.L., Westerlund A., Algarin C.R., et al. Iron deficiency in infancy is associated with altered neural correlates of recognition memory at 10 years. J Pediatr. 2012; 160 (6): 1027–33.Congdon E.L., Westerlund A., Algarin C.R., et al. Iron deficiency in infancy is associated with altered neural correlates of recognition memory at 10 years. J Pediatr. 2012; 160 (6): 1027–33.Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007; 28 (4 Suppl): S560–71.Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007; 28 (4 Suppl): S560–71.Lozoff B., Jimenez E., Smith J.B. Double burden of iron deficiency in infancy and low socio-economic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pe-diatr Adolesc Med. 2006; 160 (11): 1108–13.Lozoff B., Jimenez E., Smith J.B. Double burden of iron deficiency in infancy and low socio-economic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pe-diatr Adolesc Med. 2006; 160 (11): 1108–13.Fararouei M, Robertson C, Whittaker J, Sovio U, Ruokonen A, Pouta A, Hartikainen AL, Jarvelin MR, Hyppönen E. Maternal Hb during pregnancy and offspring’s educational achievement: a prospective cohort study over 30 years. Br J Nutr. 2010 Nov; 104 (9): 1363–8.Fararouei M, Robertson C, Whittaker J, Sovio U, Ruokonen A, Pouta A, Hartikainen AL, Jarvelin MR, Hyppönen E. Maternal Hb during pregnancy and offspring’s educational achievement: a prospective cohort study over 30 years. Br J Nutr. 2010 Nov; 104 (9): 1363–8.Alwan NA, Hamamy H. Maternal Iron Status in Pregnancy and Long-Term Health Outcomes in the Offspring. J Pediatr Genet. 2015 Jun; 4 (2): 111–23.Alwan NA, Hamamy H. Maternal Iron Status in Pregnancy and Long-Term Health Outcomes in the Offspring. J Pediatr Genet. 2015 Jun; 4 (2): 111–23.Wang C, Lin L, Su R, Zhu W, Wei Y, Yan J, Feng H, Li B, Li S, Yang H. Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: a retrospective study. BMC Pregnancy Childbirth. 2018 Jun 26; 18 (1): 263.Wang C, Lin L, Su R, Zhu W, Wei Y, Yan J, Feng H, Li B, Li S, Yang H. Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: a retrospective study. BMC Pregnancy Childbirth. 2018 Jun 26; 18 (1): 263.Patrícia Medeiros Falcão K, Pedrozo Campos Antunes T, do Nascimento Andrade Feitosa A, Victor EG, Nunes Alves de Sousa M, de Abreu LC, Vilar de Asis E, Barros de Quental O, Pinheiro Bezerra IM, Azevedo de Freitas Junior H. Association between hypertension and quality of life in pregnancy. Hypertens Pregnancy. 2016 Aug; 35 (3): 306–14.Patrícia Medeiros Falcão K, Pedrozo Campos Antunes T, do Nascimento Andrade Feitosa A, Victor EG, Nunes Alves de Sousa M, de Abreu LC, Vilar de Asis E, Barros de Quental O, Pinheiro Bezerra IM, Azevedo de Freitas Junior H. Association between hypertension and quality of life in pregnancy. Hypertens Pregnancy. 2016 Aug; 35 (3): 306–14.Catling LA, Abubakar I, Lake IR, Swift L, Hunter PR. A systematic review of analytical observational studies investigating the association between cardiovascular disease and drinking water hardness. J Water Health. 2008 Dec; 6 (4): 433–42.Catling LA, Abubakar I, Lake IR, Swift L, Hunter PR. A systematic review of analytical observational studies investigating the association between cardiovascular disease and drinking water hardness. J Water Health. 2008 Dec; 6 (4): 433–42.Józefczuk J, Kasprzycka W, Czarnecki R, Graczyk A, Józefczuk P, Magda K, Lampart U. Homocysteine as a Diagnostic and Etiopathogenic Factor in Children with Autism Spectrum Disorder. J Med Food. 2017 Aug; 20 (8): 744–749.Józefczuk J, Kasprzycka W, Czarnecki R, Graczyk A, Józefczuk P, Magda K, Lampart U. Homocysteine as a Diagnostic and Etiopathogenic Factor in Children with Autism Spectrum Disorder. J Med Food. 2017 Aug; 20 (8): 744–749.Caulfield LE, Zavaleta N, Chen P, Lazarte F, Albornoz C, Putnick DL, Bornstein MH, DiPietro JA. Maternal zinc supplementation during pregnancy affects autonomic function of Peruvian children assessed at 54 months of age. J Nutr. 2011 Feb; 141 (2): 327–32.Caulfield LE, Zavaleta N, Chen P, Lazarte F, Albornoz C, Putnick DL, Bornstein MH, DiPietro JA. Maternal zinc supplementation during pregnancy affects autonomic function of Peruvian children assessed at 54 months of age. J Nutr. 2011 Feb; 141 (2): 327–32.Желтикова Т.М., Денисов Д.Г., Мокроносова М.А. Гендерные и возрастные особенности статуса витамина D (25 (ОН) D) в России. РМЖ. 2019; 12: 51–56.Желтикова Т.М., Денисов Д.Г., Мокроносова М.А. Гендерные и возрастные особенности статуса витамина D (25 (ОН) D) в России. РМЖ. 2019; 12: 51–56.Петрушкина А.А., Пигарова Е.А., Рожинская Л.Я.. Эпидемиология витамина DDD в Российской Федерации. Остеопороз и остеопатии. 2018; 21 (3): 15–20.Петрушкина А.А., Пигарова Е.А., Рожинская Л.Я.. Эпидемиология витамина DDD в Российской Федерации. Остеопороз и остеопатии. 2018; 21 (3): 15–20.Шелепова Е.С., Хазова Е.Л., Новикова Т.В., Алиева К.Х., Кузнецова Л.В., Зазерская И.Е. Влияние дефицита витамина D на скорость костного обмена при беременности. Трансляционная медицина. 2016; 3 (4): 20–26.Шелепова Е.С., Хазова Е.Л., Новикова Т.В., Алиева К.Х., Кузнецова Л.В., Зазерская И.Е. Влияние дефицита витамина D на скорость костного обмена при беременности. Трансляционная медицина. 2016; 3 (4): 20–26.Bouillon R., Marcocci C., Carmeliet G., Bikle D., White J.H., Dawson-Hughes B. et al. Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocrine reviews. 2019; 40 (4): 1109–51.Bouillon R., Marcocci C., Carmeliet G., Bikle D., White J.H., Dawson-Hughes B. et al. Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocrine reviews. 2019; 40 (4): 1109–51.Palacios C., Kostiuk L. K., Pena-Rosas J. P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst. Rev. 2019; 7: CD008873.Palacios C., Kostiuk L. K., Pena-Rosas J. P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst. Rev. 2019; 7: CD008873.Dovnik A., Mujezinovic F. The association of vitamin D levels with common pregnancy complications. Nutrients. 2018; 10 (7): 867.Dovnik A., Mujezinovic F. The association of vitamin D levels with common pregnancy complications. Nutrients. 2018; 10 (7): 867.Holick MF. Vitamin D: extraskeletal health. Rheum Dis Clin North Am. 2012; 38 (1): 141–160.Holick MF. Vitamin D: extraskeletal health. Rheum Dis Clin North Am. 2012; 38 (1): 141–160.Hossein-nezhad A, Holick MF. Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care. 2012; 15 (6): 567–579.Hossein-nezhad A, Holick MF. Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care. 2012; 15 (6): 567–579.Smit E, Crespo CJ, Michael Y, et al. The effect of vitamin D and frailty on mortality among non-institutionalized US older adults. Eur J Clin Nutr. 2012; 66 (9): 1024–1028.Smit E, Crespo CJ, Michael Y, et al. The effect of vitamin D and frailty on mortality among non-institutionalized US older adults. Eur J Clin Nutr. 2012; 66 (9): 1024–1028.Holick MF. Nutrition: D-iabetes and D-eath D-efying vitamin D. Nat Rev Endocrinol. 2012 May 29; 8 (7): 388–90.Holick MF. Nutrition: D-iabetes and D-eath D-efying vitamin D. Nat Rev Endocrinol. 2012 May 29; 8 (7): 388–90.Lucas RM, Ponsonby AL, Pasco JA, Morley R. Future health implications of prenatal and early-life vitamin D status. Nutr Rev. 2008 Dec; 66 (12): 710–20.Lucas RM, Ponsonby AL, Pasco JA, Morley R. Future health implications of prenatal and early-life vitamin D status. Nutr Rev. 2008 Dec; 66 (12): 710–20.Vandevijvere S, Amsalkhir S, Van Oyen H, Moreno-Reyes R. High prevalence of vitamin D deficiency in pregnant women: a national cross-sectional survey. PLoS One. 2012; 7 (8): e43868.Vandevijvere S, Amsalkhir S, Van Oyen H, Moreno-Reyes R. High prevalence of vitamin D deficiency in pregnant women: a national cross-sectional survey. PLoS One. 2012; 7 (8): e43868.Maka, N., Makrakis, J., Parkington, H.C. et al. Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring. Pediatr Nephrol. 2008; 23: 55.Maka, N., Makrakis, J., Parkington, H.C. et al. Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring. Pediatr Nephrol. 2008; 23: 55.Nascimento FA, Ceciliano TC, Aguila MB, Mandarim-de-Lacerda CA. Maternal vitamin D deficiency delays glomerular maturity in F1 and F2 offspring. PLoS One. 2012; 7 (8): e41740.Nascimento FA, Ceciliano TC, Aguila MB, Mandarim-de-Lacerda CA. Maternal vitamin D deficiency delays glomerular maturity in F1 and F2 offspring. PLoS One. 2012; 7 (8): e41740.Karlic H, Varga F. Impact of vitamin D metabolism on clinical epigenetics. Clin Epigenetics. 2011; 2 (1): 55–61.Karlic H, Varga F. Impact of vitamin D metabolism on clinical epigenetics. Clin Epigenetics. 2011; 2 (1): 55–61.Martin R, Harvey NC, Crozier SR, et al. Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual. Bone. 2007; 40 (5): 1203–1208.Martin R, Harvey NC, Crozier SR, et al. Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual. Bone. 2007; 40 (5): 1203–1208.Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr. 2012; 36 (1 suppl): 9S-19S.Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr. 2012; 36 (1 suppl): 9S-19S.Lapillonne A. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Med Hypotheses. 2010; 74 (1): 71–75.Lapillonne A. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Med Hypotheses. 2010; 74 (1): 71–75.Студеникин В.М., Казакова К.А., Акоев Ю.С., Мигали А.В. Рахит, недостаточность витамина d и Всемирный консенсус по профилактике и лечению нутритивного рахита: взгляд российских педиатров. Российский педиатрический журнал. 2017. № 2, 117–122.Студеникин В.М., Казакова К.А., Акоев Ю.С., Мигали А.В. Рахит, недостаточность витамина d и Всемирный консенсус по профилактике и лечению нутритивного рахита: взгляд российских педиатров. Российский педиатрический журнал. 2017. № 2, 117–122.Коденцова В. М., Рисник Д. В. Множественная микронутриентная недостаточность у детей дошкольного возраста и способы ее коррекции. Лечащий врач № 6/2020; 52–57.Коденцова В. М., Рисник Д. В. Множественная микронутриентная недостаточность у детей дошкольного возраста и способы ее коррекции. Лечащий врач № 6/2020; 52–57.Large-scale food fortification. Global Alliance for Food Nutrition Programmes. https://www.gainhealth.org/impact/programmes/large-scale-food-fortification (дата обращения 01.02.2020).Large-scale food fortification. Global Alliance for Food Nutrition Programmes. https://www.gainhealth.org/impact/programmes/large-scale-food-fortification (дата обращения 01.02.2020).ФАО. Продовольственная и сельскохозяйственная организация Объединенных наций. http://www.fao.org/about/ru/ (дата обращения 30.01.2020).ФАО. Продовольственная и сельскохозяйственная организация Объединенных наций. http://www.fao.org/about/ru/ (дата обращения 30.01.2020).About Codex Alimentarius. Codex Alimentarius. International food standards. FAO/WHO. http://www.fao.org/faowho-codexalimentarius/about-codex/en/ (дата обращения 10.02.2020).About Codex Alimentarius. Codex Alimentarius. International food standards. FAO/WHO. http://www.fao.org/faowho-codexalimentarius/about-codex/en/ (дата обращения 10.02.2020).Guidelines on food fortification with micronutrients. Ed. by L. Allen, B. de Benoist, O. Dary, R. Hurrell. Geneva: World Health Organization and Food and Agriculture Organization of the United Nations; 2006. P. 331.Guidelines on food fortification with micronutrients. Ed. by L. Allen, B. de Benoist, O. Dary, R. Hurrell. Geneva: World Health Organization and Food and Agriculture Organization of the United Nations; 2006. P. 331.Standards. World Health Organization, Food and Agriculture Organization of the United Nations. http://www.fao.org/fao-who-codexalimentarius/codex-texts/list-standards/en/ (дата обращения 17.01.2020).Standards. World Health Organization, Food and Agriculture Organization of the United Nations. http://www.fao.org/fao-who-codexalimentarius/codex-texts/list-standards/en/ (дата обращения 17.01.2020).Biesalski, Hans & Tinz, Jana. (2018). Micronutrients in the life cycle: Requirements and sufficient supply. NFS Journal. 11.10.1016/j.nfs.2018.03.001.Biesalski, Hans & Tinz, Jana. (2018). Micronutrients in the life cycle: Requirements and sufficient supply. NFS Journal. 11.10.1016/j.nfs.2018.03.001.Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2017 Apr 13; 4 (4): CD004905.Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2017 Apr 13; 4 (4): CD004905.Keats EC, Haider BA, Tam E, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019 Mar 14; 3 (3): CD004905.Keats EC, Haider BA, Tam E, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019 Mar 14; 3 (3): CD004905.Iglesias L, Canals J, Arija V. Effects of prenatal iron status on child neurodevelopment and behavior: A systematic review. Crit Rev Food Sci Nutr. 2018 Jul 3; 58 (10): 1604–1614.Iglesias L, Canals J, Arija V. Effects of prenatal iron status on child neurodevelopment and behavior: A systematic review. Crit Rev Food Sci Nutr. 2018 Jul 3; 58 (10): 1604–1614.

The authors declare that there are no conflicts of interest present.