medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-22-9-14medalphabet-1674Research ArticleСтатьиПостинфекционная эпилепсия (обзор литературы)Postinfectious epilepsy (literature review)ЛобзинС. В.LobzinS. V.

Доктор медицинских наук, профессор, акад. Петровской академии наук и искусств, вице-президент Ассоциации неврологов Санкт-Петербурга и Ленинградской области, заведующий кафедрой неврологии им. акад. С.Н. Давиденкова

Санкт-Петербург 

УлитинА. Ю.UlitinA. Yu.

Доктор медицинских наук, профессор, нейрохирург высшей квалификационной категории, заслуженный врач России, главный внештатный специалист-нейрохирург Комитета по здравоохранению Санкт-Петербурга, профессор кафедры нейрохирургии ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России, заведующий кафедрой нейрохирургии с курсом нейрофизиологии ИМО ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава России

Санкт-Петербург 

ВасиленкоА. В.VasilenkoA. V.

Кандидат медицинских наук, врач – невролог-эпилептолог, нейрофизиолог, психиатр, ассистент кафедры неврологии им. академика С.Н. Давиденкова ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России, заведующая учебной частью, доцент кафедры нейрохирургии с курсом нейрофизиологии ИМО ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава России

Санкт-Петербург 

ОнищенкоЛ. С.OnishchenkoL. S.

Кандидат биологических наук, старший научный сотрудник лаборатории электронной микроскопии и иммуногистохимии

Санкт-Петербург 

ГорловаЕ. А.GorlovaE. A.

Клинический ординатор кафедры нейрохирургии с курсом нейрофизиологии

Санкт-Петербург

ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical University n.a. I.I. MechnikovRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России; ИМО ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава РоссииРоссияNorth-Western State Medical University n.a. I.I. Mechnikov; National Medical Research Centre n.a. V.A. AlmazovRussian FederationФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова» Минобороны РоссииРоссияMilitary Medical Academy n.a. S.M. Kirov of the Ministry of Defense of RussiaRussian FederationИМО ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава РоссииРоссияNational Medical Research Centre n.a. V.A. AlmazovRussian Federation202019102020022Неврология и психиатрия (3)914Copyright © Лобзин С.В., Улитин А.Ю., Василенко А.В., Онищенко Л.С., Горлова Е.А., 20202020Лобзин С.В., Улитин А.Ю., Василенко А.В., Онищенко Л.С., Горлова Е.А.Lobzin S.V., Ulitin A.Y., Vasilenko A.V., Onishchenko L.S., Gorlova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1674

В последнее время получено большое количество доказательств о возможном участии воспалительных процессов в эпилептогенезе. Так, в ряде исследований было установлено увеличение синтеза специфических медиаторов воспаления в головном мозге пациентов и соответственно активации некоторых провоспалительных путей в очагах приступов, а также участие оксидативного стресса. Также появились сведения о том, что некоторые хронические инфекции, такие как нейроцистеркоз, ВИЧ и герпес, не вызывая острой церебральной патологии, способны провоцировать эпилептические приступы и даже формирование в дальнейшем рефрактерной эпилепсии. В обзоре суммируются экспериментальные и клинические данные исследований о связи эпилепсии с хронически протекающими инфекционными заболеваниями и нейровоспалением.

Recently, a large amount of evidence has been obtained on the possible involvement of inflammatory processes in epileptogenesis. Thus, in a number of studies, an increase in the synthesis of specific inflammatory mediators in the brain of patients and, accordingly, the activation of some pro-inflammatory pathways in the foci of seizures, as well as the participation of oxidative stress, was found. There was also information that some chronic infections, such as neurocistercosis, HIV and herpes, without causing acute cerebral pathology, can provoke epileptic seizures and even the formation of refractory epilepsy in the future. This review summarizes the experimental and clinical data from studies on the relationship between epilepsy and chronic infectious diseases and neuroinflammation.

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The authors declare that there are no conflicts of interest present.