medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-21-33-48medalphabet-1663Research ArticleСтатьиСочетанная терапия для лечения ОРВИ: анализ комбинированного комплекса АнвиМаксCombined therapy for treatment of acute respiratory viral infections: analysis of combined complex AnviMaxГромоваО. А.GromovaO. A.

д.м.н., проф., в.н.с;  научный руководитель

г. Москва

Moscow

ТоршинИ. Ю.TorshinI. Yu.

к. х.н., с.н.с.

г. Москва

Moscow

Институт фармакоинформатики ФГУ «Федеральный исследовательский центр „Информатика и управление“» Российской академии наук; Центр хранения и анализа больших данных ФГБОУ ВО «Московский государственный университет имени М. В. Ломоносова»РоссияFederal Research Centre ‘The Informatics and Management’; Big Data Storage and Analysis Centre of Moscow State University n.a. M.V. LomonosovRussian Federation202014102020021Современная поликлиника (2)3348Copyright © Громова О.А., Торшин И.Ю., 20202020Громова О.А., Торшин И.Ю.Gromova O.A., Torshin I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1663

Ежегодные подьемы заболевамости гриппом, ОРВИ и пандемия COVID‑19 указывают на необходимость проведения комплексных программ по поддержке врожденного противовирусного иммунитета. Для повышения эффективности терапии вирусных респираторных инфекций важны ослабление эффектов так называемого цитокинового шторма и усиленная компенсация имеющихся у пациента коморбидных патологий. Повышение обеспеченности цинком, витамином С и рутозидом может улучшать резистентность организма человека к вирусной инфекции. Кроме микронутриентов, для снижения активности аллергического воспаления можно использовать блокаторы Н1-гистаминовых рецепторов второго поколения (лоратадин и др.) и глюконат кальция. Для снижения температуры важно включать в терапию парацетамол.

The annual increase in the incidence of influenza, SARS, and the COVID‑19 pandemic indicate the need for comprehensive programs to support congenital antiviral immunity. To increase the effectiveness of the treatment of viral respiratory infections, it is important to attenuate the effects of the so-called cytokine storm and enhanced compensation of the patient’s comorbid pathologies. Increasing the availability of zinc, vitamin C and rutoside can improve the body’s resistance to viral infections. In addition to micronutrients, to reduce the activity of allergic inflammation, second-generation H1-histamine receptor blockers (loratadine, etc.) and calcium gluconate can be used. To lower the  temperature, it is important to include paracetamol in therapy.

гриппкоронавирусырутозидвитамин Слоратадинпарацетамолримантадининтерфероны первой группыАнвиМаксinfluenzacoronavirusesrutosidevitamin Cloratadineparacetamolrimantadineinterferons of the first groupAnviMaxReferencesTaubenberger J. K., Morens D. M. 1918 Influenza: the mother of all pandemics. Emerg Infect Dis. 2006 Jan; 12 (1): 15–22. DOI: 10,3201/eid1201.050979. PMID: 16494711.Taubenberger J. K., Morens D. M. 1918 Influenza: the mother of all pandemics. Emerg Infect Dis. 2006 Jan; 12 (1): 15–22. DOI: 10,3201/eid1201.050979. PMID: 16494711.Gromova OA, Torshin IY, Kobalava ZD, Sorokina MA, Villevalde SV, Galochkin SA, Gogoleva IV, Gracheva ON, Grishina TR, Gromov AN, Egorova EY, Kalacheva AG, Malyavskaya SI, Merai IA, Semenov VA. Deficit of Magnesium and States of Hypercoagulation: Intellectual Analysis of Data Obtained From a Sample of Patients Aged 18–50 years From Medical and Preventive Facilities in Russia. Kardiologiia. 2018 Nov 18; 58 (4): 22–35. DOI: 10,18087/cardio.2018.4.10106. PMID: 30704380.Gromova OA, Torshin IY, Kobalava ZD, Sorokina MA, Villevalde SV, Galochkin SA, Gogoleva IV, Gracheva ON, Grishina TR, Gromov AN, Egorova EY, Kalacheva AG, Malyavskaya SI, Merai IA, Semenov VA. Deficit of Magnesium and States of Hypercoagulation: Intellectual Analysis of Data Obtained From a Sample of Patients Aged 18–50 years From Medical and Preventive Facilities in Russia. Kardiologiia. 2018 Nov 18; 58 (4): 22–35. DOI: 10,18087/cardio.2018.4.10106. PMID: 30704380.Торшин И.Ю., Громова О.А., Тетруашвили Н.К., Коденцова В. М., Галустян А. Н., Курицына Н. А., Лавров Н.В., Гришина Т.Р., Лиманова О.А., Калачева А.Г., Федотова Л.Э., Лапочкина Н.П., Керимкулова Н. В., Мозговая Е. В., Тапильская Н. И., Семенов В. А., Малявская С. И., Лебедев А. В., Фролова Д. Е., Рубашкина А.Н., Рудаков К. В. Метрический анализ соотношений коморбидности между невынашиванием, эндометриозом, нарушениями менструального цикла и микронутриентной обеспеченностью в скрининге женщин репродуктивного возраста. Акушерство и гинекология. 2019; 5: 160–173. https://dx.doi. org/10,18565/aig.2019.5.Торшин И.Ю., Громова О.А., Тетруашвили Н.К., Коденцова В. М., Галустян А. Н., Курицына Н. А., Лавров Н.В., Гришина Т.Р., Лиманова О.А., Калачева А.Г., Федотова Л.Э., Лапочкина Н.П., Керимкулова Н. В., Мозговая Е. В., Тапильская Н. И., Семенов В. А., Малявская С. И., Лебедев А. В., Фролова Д. Е., Рубашкина А.Н., Рудаков К. В. Метрический анализ соотношений коморбидности между невынашиванием, эндометриозом, нарушениями менструального цикла и микронутриентной обеспеченностью в скрининге женщин репродуктивного возраста. Акушерство и гинекология. 2019; 5: 160–173. https://dx.doi. org/10,18565/aig.2019.5.О.А. Громова, И.Ю. Торшин, А.Н. Громов, Т.Р. Гришина, А. Г. Калачева, Н.В. Керимкулова, О.А. Лиманова, С.И. Малявская, Н.К. Тетруашвили, В.Н. Серов, В.М. Коденцова, Е.В. Мозговая, О.Н. Грачева. Интеллектуальный анализ данных по течению и исходу беременности: роли различных витаминно-минеральных комплексов. Медицинский алфавит. Современная гинекология. 2018; 6 (1): 10–23.О.А. Громова, И.Ю. Торшин, А.Н. Громов, Т.Р. Гришина, А. Г. Калачева, Н.В. Керимкулова, О.А. Лиманова, С.И. Малявская, Н.К. Тетруашвили, В.Н. Серов, В.М. Коденцова, Е.В. Мозговая, О.Н. Грачева. Интеллектуальный анализ данных по течению и исходу беременности: роли различных витаминно-минеральных комплексов. Медицинский алфавит. Современная гинекология. 2018; 6 (1): 10–23.Громова О. А., Торшин И. Ю. Витамин D. Смена парадигмы; под ред. Е. И. Гусева, И.Н. Захаровой. Москва: ГЭОТАР-Медиа, 2017. 568 с. ISBN 978–5– 9704–4058–2.Громова О. А., Торшин И. Ю. Витамин D. Смена парадигмы; под ред. Е. И. Гусева, И.Н. Захаровой. Москва: ГЭОТАР-Медиа, 2017. 568 с. ISBN 978–5– 9704–4058–2.Grant WB, Giovannucci E. The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918–1919 influenza pandemic in the United States. Dermatoendocrinol. 2009 Jul; 1 (4): 215–9. DOI: 10,4161/derm.1.4.9063. PMID: 20592793.Grant WB, Giovannucci E. The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918–1919 influenza pandemic in the United States. Dermatoendocrinol. 2009 Jul; 1 (4): 215–9. DOI: 10,4161/derm.1.4.9063. PMID: 20592793.О.А. Громова, И.Ю. Торшин, К. В. Рудаков, У. Е. Грустливая, А. Г. Калачева, Н. В. Юдина, Е.Ю. Егорова, О.А. Лиманова, Л.Э. Федотова, О.Н. Грачева, Н.В. Никифорова, Т.Е. Сатарина, И.В. Гоголева, Т.Р. Гришина, Д.Б. Курамшина, Л.Б. Новикова, Е.Ю. Лисицына, Н.В. Керимкулова, И.С. Владимирова, М.Н. Чекмарева, Е.В. Лялякина, Л.А. Шалаева, С.Ю. Талепоровская, Т.Б. Силинг, В.А. Семенов, О.В. Семенова, Н.А. Назарова, А.Н. Галустян, И.С. Сардарян. Недостаточность магния – достоверный фактор риска коморбидных состояний: результаты крупномасштабного скрининга магниевого статуса в регионах России. Фарматека, № 6, с. 116–129.О.А. Громова, И.Ю. Торшин, К. В. Рудаков, У. Е. Грустливая, А. Г. Калачева, Н. В. Юдина, Е.Ю. Егорова, О.А. Лиманова, Л.Э. Федотова, О.Н. Грачева, Н.В. Никифорова, Т.Е. Сатарина, И.В. Гоголева, Т.Р. Гришина, Д.Б. Курамшина, Л.Б. Новикова, Е.Ю. Лисицына, Н.В. Керимкулова, И.С. Владимирова, М.Н. Чекмарева, Е.В. Лялякина, Л.А. Шалаева, С.Ю. Талепоровская, Т.Б. Силинг, В.А. Семенов, О.В. Семенова, Н.А. Назарова, А.Н. Галустян, И.С. Сардарян. Недостаточность магния – достоверный фактор риска коморбидных состояний: результаты крупномасштабного скрининга магниевого статуса в регионах России. Фарматека, № 6, с. 116–129.Лиманова О. А., Торшин И.Ю., Сардарян И. С., Калачева А. Г., Hababpashev A., Karpuchin D., Kudrin A., Юдина Н.В., Егорова Е.Ю., Белинская А.Ю., Гришина Т.Р., Громов А.Н., Федотова Л.Э., Рудаков К.В., Громова О.А. Обеспеченность микронутриентами и женское здоровье: интеллектуальный анализ клинико-эпидемиологических данных. Вопросы гинекологии, акушерства и перинатологии. 2014; 13 (2): 5–15.Лиманова О. А., Торшин И.Ю., Сардарян И. С., Калачева А. Г., Hababpashev A., Karpuchin D., Kudrin A., Юдина Н.В., Егорова Е.Ю., Белинская А.Ю., Гришина Т.Р., Громов А.Н., Федотова Л.Э., Рудаков К.В., Громова О.А. Обеспеченность микронутриентами и женское здоровье: интеллектуальный анализ клинико-эпидемиологических данных. Вопросы гинекологии, акушерства и перинатологии. 2014; 13 (2): 5–15.Громова О.А., Торшин И.Ю. Микронутриенты и репродуктивное здоровье. Руководство. ГЭОТАР-Медиа, 2019, 672 c. ISBN978–5–9704–5149–6.Громова О.А., Торшин И.Ю. Микронутриенты и репродуктивное здоровье. Руководство. ГЭОТАР-Медиа, 2019, 672 c. ISBN978–5–9704–5149–6.Громова О. А., Торшин И. Ю. Магний и «болезни цивилизации». Москва: ГЭОТАР-Медиа, 2018. 800 с. ISBN978–5–9704–4527–3.Громова О. А., Торшин И. Ю. Магний и «болезни цивилизации». Москва: ГЭОТАР-Медиа, 2018. 800 с. ISBN978–5–9704–4527–3.Громова О.А., Торшин И.Ю. Витамины и минералы между Сциллой и Харибдой: о мисконцепциях и других чудовищах / Москва: Издательство МЦНМО, 2013. 693, ISBN978–5–4439–0088–9.Громова О.А., Торшин И.Ю. Витамины и минералы между Сциллой и Харибдой: о мисконцепциях и других чудовищах / Москва: Издательство МЦНМО, 2013. 693, ISBN978–5–4439–0088–9.Zhang L, Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol. 2020 May; 92 (5): 479–490. DOI: 10,1002/jmv.25707. Epub 2020 Mar 3. PMID: 32052466.Zhang L, Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol. 2020 May; 92 (5): 479–490. DOI: 10,1002/jmv.25707. Epub 2020 Mar 3. PMID: 32052466.Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the ImmuneSystem-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020 Jan 16; 12 (1). pii: E236. DOI: 10,3390/nu12010236. PMID: 31963293.Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the ImmuneSystem-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020 Jan 16; 12 (1). pii: E236. DOI: 10,3390/nu12010236. PMID: 31963293.Meo SA, Alhowikan AM, Al-Khlaiwi T, Meo IM, Halepoto DM, Iqbal M, Usmani AM, Hajjar W, Ahmed N. Novel coronavirus 2019-nCoV: prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV. Eur Rev Med Pharmacol Sci. 2020 Feb; 24 (4): 2012–2019. DOI: 10,26355/eurrev_202002_20379. PMID: 32141570.Meo SA, Alhowikan AM, Al-Khlaiwi T, Meo IM, Halepoto DM, Iqbal M, Usmani AM, Hajjar W, Ahmed N. Novel coronavirus 2019-nCoV: prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV. Eur Rev Med Pharmacol Sci. 2020 Feb; 24 (4): 2012–2019. DOI: 10,26355/eurrev_202002_20379. PMID: 32141570.Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Feb 28. DOI: 10,1056/NEJMoa2002032. PMID: 32109013.Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Feb 28. DOI: 10,1056/NEJMoa2002032. PMID: 32109013.Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV 2 may play a role in the respiratory failure of COVID 19 patients. J Med Virol. 2020 Feb 27. DOI: 10,1002/jmv.25728. PMID: 32104915.Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV 2 may play a role in the respiratory failure of COVID 19 patients. J Med Virol. 2020 Feb 27. DOI: 10,1002/jmv.25728. PMID: 32104915.Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus Disease 2019 (COVID 19): A Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol. 2020 Mar 14: 1–7. DOI: 10,2214/ AJR.20,23034. PMID: 32174129.Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus Disease 2019 (COVID 19): A Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol. 2020 Mar 14: 1–7. DOI: 10,2214/ AJR.20,23034. PMID: 32174129.Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, Liu ZS. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020 Mar 19. pii: 10,1007/s12519–020–00354–4. DOI: 10,1007/s12519–020–00354–4. PMID: 32193831.Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, Liu ZS. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020 Mar 19. pii: 10,1007/s12519–020–00354–4. DOI: 10,1007/s12519–020–00354–4. PMID: 32193831.25. Zhang X, Cai H, Hu J, Lian J, Gu J, Zhang S, Ye C, Lu Y, Jin C, Yu G, Jia H, Zhang Y, Sheng J, Li L, Yang Y. Epidemiological, clinical characteristics of cases of SARS-CoV 2 infection with abnormal imaging findings. Int J Infect Dis. 2020 Mar 20, pii: S1201–9712(20)30172–7. DOI: 10,1016/j.ijid.2020,03.040, PMID: 32205284.25. Zhang X, Cai H, Hu J, Lian J, Gu J, Zhang S, Ye C, Lu Y, Jin C, Yu G, Jia H, Zhang Y, Sheng J, Li L, Yang Y. Epidemiological, clinical characteristics of cases of SARS-CoV 2 infection with abnormal imaging findings. Int J Infect Dis. 2020 Mar 20, pii: S1201–9712(20)30172–7. DOI: 10,1016/j.ijid.2020,03.040, PMID: 32205284.Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID 19) in China [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 17; 41 (2): 145–51.Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID 19) in China [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 17; 41 (2): 145–51.CDC COVID 19 Response Team. Severe outcomes among patients with coronavirus disease 2019 (COVID 19): United States, February 12-March 16, 2020, MMWR Morb Mortal Wkly Rep. 2020 Mar 18.CDC COVID 19 Response Team. Severe outcomes among patients with coronavirus disease 2019 (COVID 19): United States, February 12-March 16, 2020, MMWR Morb Mortal Wkly Rep. 2020 Mar 18.www.rosminzdrav.ru, обращение на сайт 15.04.2020.www.rosminzdrav.ru, обращение на сайт 15.04.2020.Liu C, Jiang ZC, Shao CX, Zhang HG, Yue HM, Chen ZH, Ma BY, Liu WY, Huang HH, Yang J, Wang Y, Liu HY, Xu D, Wang JT, Yang JY, Pan HQ, Zou SQ, Li FJ, Lei JQ, Li X, He Q, Gu Y, Qi XL. [Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study]. Zhonghua Gan Zang Bing Za Zhi. 2020 Feb 20; 28 (2): 148–152. DOI: 10,3760/cm a.j.issn.1007–3418.2020,02.003. PMID: 32077660.Liu C, Jiang ZC, Shao CX, Zhang HG, Yue HM, Chen ZH, Ma BY, Liu WY, Huang HH, Yang J, Wang Y, Liu HY, Xu D, Wang JT, Yang JY, Pan HQ, Zou SQ, Li FJ, Lei JQ, Li X, He Q, Gu Y, Qi XL. [Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study]. Zhonghua Gan Zang Bing Za Zhi. 2020 Feb 20; 28 (2): 148–152. DOI: 10,3760/cm a.j.issn.1007–3418.2020,02.003. PMID: 32077660.Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, Hao SR, Jia HY, Cai H, Zhang XL, Yu GD, Xu KJ, Wang XY, Gu JQ, Zhang SY, Ye CY, Jin CL, Lu YF, Yu X, Yu XP, Huang JR, Xu KL, Ni Q, Yu CB, Zhu B, Li YT, Liu J, Zhao H, Zhang X, Yu L, Guo YZ, Su JW, Tao JJ, Lang GJ, Wu XX, Wu WR, Qv TT, Xiang DR, Yi P, Shi D, Chen Y, Ren Y, Qiu YQ, Li LJ, Sheng J, Yang Y. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID 19) with gastrointestinal symptoms. Gut. 2020 Mar 24. pii: gutjnl 2020–320926. DOI: 10,1136/gutjnl 2020–320926. PMID: 32213556.Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, Hao SR, Jia HY, Cai H, Zhang XL, Yu GD, Xu KJ, Wang XY, Gu JQ, Zhang SY, Ye CY, Jin CL, Lu YF, Yu X, Yu XP, Huang JR, Xu KL, Ni Q, Yu CB, Zhu B, Li YT, Liu J, Zhao H, Zhang X, Yu L, Guo YZ, Su JW, Tao JJ, Lang GJ, Wu XX, Wu WR, Qv TT, Xiang DR, Yi P, Shi D, Chen Y, Ren Y, Qiu YQ, Li LJ, Sheng J, Yang Y. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID 19) with gastrointestinal symptoms. Gut. 2020 Mar 24. pii: gutjnl 2020–320926. DOI: 10,1136/gutjnl 2020–320926. PMID: 32213556.Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020 Apr; 18 (4): 844–847. DOI: 10,1111/jth.14768. Epub 2020 Mar 13. PMID: 32073213.Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020 Apr; 18 (4): 844–847. DOI: 10,1111/jth.14768. Epub 2020 Mar 13. PMID: 32073213.Ji HL, Zhao R, Matalon S, Matthay MA. Elevated Plasmin (ogen) as a Common Risk Factor for COVID 19 Susceptibility. Physiol Rev. 2020 Jul 1; 100 (3): 1065–1075. DOI: 10,1152/physrev.00013.2020, Epub 2020 Mar 27. PMID: 32216698.Ji HL, Zhao R, Matalon S, Matthay MA. Elevated Plasmin (ogen) as a Common Risk Factor for COVID 19 Susceptibility. Physiol Rev. 2020 Jul 1; 100 (3): 1065–1075. DOI: 10,1152/physrev.00013.2020, Epub 2020 Mar 27. PMID: 32216698.Han H, Yang L, Liu R, Liu F, Wu KL, Li J, Liu XH, Zhu CL. Prominent changes in blood coagulation of patients with SARS-CoV 2 infection.Clin Chem Lab Med. 2020 Mar 16. pii: /j/cclm.ahead-of-print/cclm 2020–0188/cclm 2020– 0188.xml. DOI: 10,1515/cclm 2020–0188. PMID: 32172226.Han H, Yang L, Liu R, Liu F, Wu KL, Li J, Liu XH, Zhu CL. Prominent changes in blood coagulation of patients with SARS-CoV 2 infection.Clin Chem Lab Med. 2020 Mar 16. pii: /j/cclm.ahead-of-print/cclm 2020–0188/cclm 2020– 0188.xml. DOI: 10,1515/cclm 2020–0188. PMID: 32172226.Wang Z, Yang B, Li Q, Wen L, Zhang R. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Clin Infect Dis. 2020 Mar 16. pii: 5807944. DOI: 10,1093/cid/ciaa272. PMID: 32176772.Wang Z, Yang B, Li Q, Wen L, Zhang R. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Clin Infect Dis. 2020 Mar 16. pii: 5807944. DOI: 10,1093/cid/ciaa272. PMID: 32176772.Peng YD, Meng K, Guan HQ, Leng L, Zhu RR, Wang BY, He MA, Cheng LX, Huang K, Zeng QT. [Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV]. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Mar 2; 48 (0): E004. DOI: 10,3760/ cma.j.cn112148–20200220–00105. PMID: 32120458.Peng YD, Meng K, Guan HQ, Leng L, Zhu RR, Wang BY, He MA, Cheng LX, Huang K, Zeng QT. [Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV]. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Mar 2; 48 (0): E004. DOI: 10,3760/ cma.j.cn112148–20200220–00105. PMID: 32120458.Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol. 2020 Mar 27. pii: 2763846. DOI: 10,1001/jamacardio.2020,1286. PMID: 32219363.Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol. 2020 Mar 27. pii: 2763846. DOI: 10,1001/jamacardio.2020,1286. PMID: 32219363.Ma WX, Ran XW. [The Management of Blood Glucose Should be Emphasized in the Treatment of COVID 19]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 Mar; 51 (2): 146–150, DOI: 10,12182/20200360606. PMID: 32220179.Ma WX, Ran XW. [The Management of Blood Glucose Should be Emphasized in the Treatment of COVID 19]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 Mar; 51 (2): 146–150, DOI: 10,12182/20200360606. PMID: 32220179.Wu J, Li W, Shi X, Chen Z, Jiang B, Liu J, Wang D, Liu C, Meng Y, Cui L, Yu J, Cao H, Li L. Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID 19). J Intern Med. 2020 Mar 27. DOI: 10,1111/ joim.13063. PMID: 32220033.Wu J, Li W, Shi X, Chen Z, Jiang B, Liu J, Wang D, Liu C, Meng Y, Cui L, Yu J, Cao H, Li L. Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID 19). J Intern Med. 2020 Mar 27. DOI: 10,1111/ joim.13063. PMID: 32220033.Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, Liu XQ, Chen RC, Tang CL, Wang T, Ou CQ, Li L, Chen PY, Sang L, Wang W, Li JF, Li CC, Ou LM, Cheng B, Xiong S, Ni ZY, Xiang J, Hu Y, Liu L, Shan H, Lei CL, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Cheng LL, Ye F, Li SY, Zheng JP, Zhang NF, Zhong NS, He JX. Comorbidity and its impact on 1590 patients with Covid 19 in China: A Nationwide Analysis. Eur Respir J. 2020 Mar 26. pii: 13993003.00547–2020, DOI: 10,1183/13993003.00547–2020, PMID: 32217650.Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, Liu XQ, Chen RC, Tang CL, Wang T, Ou CQ, Li L, Chen PY, Sang L, Wang W, Li JF, Li CC, Ou LM, Cheng B, Xiong S, Ni ZY, Xiang J, Hu Y, Liu L, Shan H, Lei CL, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Cheng LL, Ye F, Li SY, Zheng JP, Zhang NF, Zhong NS, He JX. Comorbidity and its impact on 1590 patients with Covid 19 in China: A Nationwide Analysis. Eur Respir J. 2020 Mar 26. pii: 13993003.00547–2020, DOI: 10,1183/13993003.00547–2020, PMID: 32217650.Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, Ji R, Wang H, Wang Y, Zhou Y. Prevalence of comorbidities in the novel Wuhan coronavirus (COVID 19) infection: a systematic review and meta-analysis. Int J Infect Dis. 2020 Mar 12. pii: S1201–9712(20)30136–3. DOI: 10,1016/j. ijid.2020,03.017. PMID: 32173574.Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, Ji R, Wang H, Wang Y, Zhou Y. Prevalence of comorbidities in the novel Wuhan coronavirus (COVID 19) infection: a systematic review and meta-analysis. Int J Infect Dis. 2020 Mar 12. pii: S1201–9712(20)30136–3. DOI: 10,1016/j. ijid.2020,03.017. PMID: 32173574.Fung SY, Yuen KS, Ye ZW, Chan CP, Jin DY. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerg Microbes Infect. 2020 Mar 14; 9 (1): 558–570, DOI: 10,1080/22221751.2020,1736644. eCollection 2020, PMID: 32172672.Fung SY, Yuen KS, Ye ZW, Chan CP, Jin DY. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerg Microbes Infect. 2020 Mar 14; 9 (1): 558–570, DOI: 10,1080/22221751.2020,1736644. eCollection 2020, PMID: 32172672.Conti P, Ronconi G, Caraffa A, Gallenga CE, Ross R, Frydas I, Kritas SK. Induction of pro-inflammatory cytokines (IL 1 and IL 6) and lung inflammation by Coronavirus 19 (COVI 19 or SARS-CoV 2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020 Mar 14; 34 (2). DOI: 10,23812/CONTI-E. PMID: 32171193.Conti P, Ronconi G, Caraffa A, Gallenga CE, Ross R, Frydas I, Kritas SK. Induction of pro-inflammatory cytokines (IL 1 and IL 6) and lung inflammation by Coronavirus 19 (COVI 19 or SARS-CoV 2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020 Mar 14; 34 (2). DOI: 10,23812/CONTI-E. PMID: 32171193.Sindel A, Taylor T, Chesney A, Clark W, Fowler AA 3rd, Toor AA. Hematopoietic stem cell mobilization following PD 1 blockade: Cytokine release syndrome after transplantation managed with ascorbic acid. Eur J Haematol. 2019 Aug; 103 (2): 134–136. DOI: 10,1111/ejh.13248. Epub 2019 Jun 7. PMID: 31140644.Sindel A, Taylor T, Chesney A, Clark W, Fowler AA 3rd, Toor AA. Hematopoietic stem cell mobilization following PD 1 blockade: Cytokine release syndrome after transplantation managed with ascorbic acid. Eur J Haematol. 2019 Aug; 103 (2): 134–136. DOI: 10,1111/ejh.13248. Epub 2019 Jun 7. PMID: 31140644.Chen WH, Strych U, Hotez PJ, Bottazzi ME. The SARS-CoV 2 Vaccine Pipeline: an Overview.Curr Trop Med Rep. 2020 Mar 3: 1–4. DOI: 10,1007/s40475–020–00201–6. PMID: 32219057.Chen WH, Strych U, Hotez PJ, Bottazzi ME. The SARS-CoV 2 Vaccine Pipeline: an Overview.Curr Trop Med Rep. 2020 Mar 3: 1–4. DOI: 10,1007/s40475–020–00201–6. PMID: 32219057.Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, Kumar S, Bhattacharyya A, Kumar H, Bansal S, Medhi B. Drug targets for corona virus: A systematic review. Indian J Pharmacol. 2020 Jan-Feb; 52 (1): 56–65. DOI: 10,4103/ijp.IJP_115_20, Epub 2020 Mar 11. PMID: 32201449.Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, Kumar S, Bhattacharyya A, Kumar H, Bansal S, Medhi B. Drug targets for corona virus: A systematic review. Indian J Pharmacol. 2020 Jan-Feb; 52 (1): 56–65. DOI: 10,4103/ijp.IJP_115_20, Epub 2020 Mar 11. PMID: 32201449.Ortega JT, Serrano ML, Pujol FH, Rangel HR. Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target. EXCLI J. 2020 Mar 17; 19: 400–409. DOI: 10,17179/ excli2020–1189. eCollection 2020, PMID: 32210741.Ortega JT, Serrano ML, Pujol FH, Rangel HR. Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target. EXCLI J. 2020 Mar 17; 19: 400–409. DOI: 10,17179/ excli2020–1189. eCollection 2020, PMID: 32210741.Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid 19. N Engl J Med. 2020 Mar 18. DOI: 10,1056/ NEJMoa2001282. PMID: 32187464.Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid 19. N Engl J Med. 2020 Mar 18. DOI: 10,1056/ NEJMoa2001282. PMID: 32187464.Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020 Feb 15; 395 (10223): 473–475. DOI: 10,1016/S0140– 6736(20)30317–2. Epub 2020 Feb 7. PMID: 32043983.Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020 Feb 15; 395 (10223): 473–475. DOI: 10,1016/S0140– 6736(20)30317–2. Epub 2020 Feb 7. PMID: 32043983.Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. The cytokine release syndrome (CRS) ofsevere COVID 19 and Interleukin 6 receptor (IL 6R) antagonist Tocilizumab may bethe key to reduce the mortality. Int J Antimicrob Agents. 2020: 105954. DOI: 10,1016/j.ijantimicag.2020,105954. PMID: 32234467.Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. The cytokine release syndrome (CRS) ofsevere COVID 19 and Interleukin 6 receptor (IL 6R) antagonist Tocilizumab may bethe key to reduce the mortality. Int J Antimicrob Agents. 2020: 105954. DOI: 10,1016/j.ijantimicag.2020,105954. PMID: 32234467.Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID 19. J Crit Care. 2020 Mar 10, pii: S0883–9441(20)30390–7. DOI: 10,1016/j. jcrc.2020,03.005. PMID: 32173110.Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID 19. J Crit Care. 2020 Mar 10, pii: S0883–9441(20)30390–7. DOI: 10,1016/j. jcrc.2020,03.005. PMID: 32173110.Duan YJ, Liu Q, Zhao SQ, Huang F, Ren L, Liu L, Zhou YW. The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 COVID 19 and Its Research Progress in Forensic Toxicology. Fa Yi Xue Za Zhi. 2020 Mar 25; 36 (2). DOI: 10,12116/j.issn.1004–5619.2020,02.001. PMID: 32212513.Duan YJ, Liu Q, Zhao SQ, Huang F, Ren L, Liu L, Zhou YW. The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 COVID 19 and Its Research Progress in Forensic Toxicology. Fa Yi Xue Za Zhi. 2020 Mar 25; 36 (2). DOI: 10,12116/j.issn.1004–5619.2020,02.001. PMID: 32212513.Favalli EG, Ingegnoli F, De Lucia O, Cincinelli G, Cimaz R, Caporali R. COVID 19 infection and rheumatoid arthritis: Faraway, so close! Autoimmun Rev. 2020 Mar 20: 102523. DOI: 10,1016/j.autrev.2020,102523. PMID: 32205186.Favalli EG, Ingegnoli F, De Lucia O, Cincinelli G, Cimaz R, Caporali R. COVID 19 infection and rheumatoid arthritis: Faraway, so close! Autoimmun Rev. 2020 Mar 20: 102523. DOI: 10,1016/j.autrev.2020,102523. PMID: 32205186.Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020 Mar 27. DOI: 10,1111/ jth.14817. PMID: 32220112.Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020 Mar 27. DOI: 10,1111/ jth.14817. PMID: 32220112.Jóźwiak-Bebenista M, Nowak JZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014 Jan-Feb; 71 (1): 11–23. Review. PubMed PMID: 24779190.Jóźwiak-Bebenista M, Nowak JZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014 Jan-Feb; 71 (1): 11–23. Review. PubMed PMID: 24779190.Shiffman S, Battista DR, Kelly JP, Malone MK, Weinstein RB, Kaufman DW. Prevalence of exceeding maximum daily dose of paracetamol, and seasonal variations in cold-flu season. Br J Clin Pharmacol. 2018 Jun; 84 (6): 1250–1257. DOI: 10,1111/bcp.13551. Epub 2018 Mar 25. PubMed PMID: 29516533; PubMed Central PMCID: PMC5980528.Shiffman S, Battista DR, Kelly JP, Malone MK, Weinstein RB, Kaufman DW. Prevalence of exceeding maximum daily dose of paracetamol, and seasonal variations in cold-flu season. Br J Clin Pharmacol. 2018 Jun; 84 (6): 1250–1257. DOI: 10,1111/bcp.13551. Epub 2018 Mar 25. PubMed PMID: 29516533; PubMed Central PMCID: PMC5980528.www.fda.gov/drugs/information-drug-class/acetaminophen-information [обращение насайт 15апреля 2020].www.fda.gov/drugs/information-drug-class/acetaminophen-information [обращение насайт 15апреля 2020].Коденцова В. М. Градации уровней потребления витаминов: возможные риски при чрезмерном потреблении / В.М. Коденцова // Вопросы питания. 2014. Т. 83, № 3. С. 41–51.Коденцова В. М. Градации уровней потребления витаминов: возможные риски при чрезмерном потреблении / В.М. Коденцова // Вопросы питания. 2014. Т. 83, № 3. С. 41–51.Bennardello F, Fidone C, Spadola V, Cabibbo S, Travali S, Garozzo G, Antolino A, Tavolino G, Falla C, Bonomo P. The prevention of adverse reactions to transfusions in patients with haemoglobinopathies: a proposed algorithm. Blood Transfus. 2013 Jul; 11 (3): 377–84. DOI: 10,2450/2013.0017–12. Epub 2013 May 21. PubMed PMID: 23736930; PubMed Central PMCID: PMC3729128.Bennardello F, Fidone C, Spadola V, Cabibbo S, Travali S, Garozzo G, Antolino A, Tavolino G, Falla C, Bonomo P. The prevention of adverse reactions to transfusions in patients with haemoglobinopathies: a proposed algorithm. Blood Transfus. 2013 Jul; 11 (3): 377–84. DOI: 10,2450/2013.0017–12. Epub 2013 May 21. PubMed PMID: 23736930; PubMed Central PMCID: PMC3729128.Shetty AK. Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID 19)-Induced Pneumonia. Aging Dis. 2020 Mar 9; 11 (2): 462–464. DOI: 10,14336/AD.2020,0301. eCollection 2020 Apr. PubMed PMID: 32257554; PubMed Central PMCID: PMC7069463.Shetty AK. Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID 19)-Induced Pneumonia. Aging Dis. 2020 Mar 9; 11 (2): 462–464. DOI: 10,14336/AD.2020,0301. eCollection 2020 Apr. PubMed PMID: 32257554; PubMed Central PMCID: PMC7069463.Федоскова Т.Г. Особенности лечения ОРВИ у больных круглогодичным аллергическим ринитом Российский аллергологический журнал. 2010, № 5. С. 100–105.Федоскова Т.Г. Особенности лечения ОРВИ у больных круглогодичным аллергическим ринитом Российский аллергологический журнал. 2010, № 5. С. 100–105.Емельянов А. В., Кочергин Н. Г., Горячкина Л. А. К 100-летию открытия гистамина. История и современные подходы к клиническому применению антигистаминных препаратов. Клиническая дерматология и венерология. 2010, № 4. С. 62–70.Емельянов А. В., Кочергин Н. Г., Горячкина Л. А. К 100-летию открытия гистамина. История и современные подходы к клиническому применению антигистаминных препаратов. Клиническая дерматология и венерология. 2010, № 4. С. 62–70.Sessa M, Mascolo A, Dalhoff KP, Andersen M. The risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine. Expert Opin Drug Saf. 2020 Mar; 19 (3): 349–357. DOI: 10,1080/14740338.2020,1711882. Epub 2020 Jan 6. PMID: 31903798.Sessa M, Mascolo A, Dalhoff KP, Andersen M. The risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine. Expert Opin Drug Saf. 2020 Mar; 19 (3): 349–357. DOI: 10,1080/14740338.2020,1711882. Epub 2020 Jan 6. PMID: 31903798.Weiller P, Krauter H. [Not Available]. Poumon. 1948 JulAug; 4 (4): 215–31. Undetermined Language. PubMed PMID: 18891471.Weiller P, Krauter H. [Not Available]. Poumon. 1948 JulAug; 4 (4): 215–31. Undetermined Language. PubMed PMID: 18891471.Chen F, Chan KH, Jiang Y, Kao RY, Lu HT, Fan KW, Cheng VC, Tsui WH, Hung IF, Lee TS, Guan Y, Peiris JS, Yuen KY. In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds. J Clin Virol. 2004 Sep; 31 (1): 69–75. DOI: 10,1016/j.jcv.2004.03.003. PMID: 15288617.Chen F, Chan KH, Jiang Y, Kao RY, Lu HT, Fan KW, Cheng VC, Tsui WH, Hung IF, Lee TS, Guan Y, Peiris JS, Yuen KY. In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds. J Clin Virol. 2004 Sep; 31 (1): 69–75. DOI: 10,1016/j.jcv.2004.03.003. PMID: 15288617.Karako NI, Boreko EI, Kirillov VA, Votiakov VI. [Change in the influenza virus upon multiplication in the presence of high concentrations of remantadine]. Vopr Virusol. 1989 Jan-Feb; 34 (1): 43–6. PMID: 2728406.Karako NI, Boreko EI, Kirillov VA, Votiakov VI. [Change in the influenza virus upon multiplication in the presence of high concentrations of remantadine]. Vopr Virusol. 1989 Jan-Feb; 34 (1): 43–6. PMID: 2728406.Бурцева Е.И., Шевченко Е.С., Белякова Н.В. и др. Мониторинг чувствительности выделенных в России эпидемических штаммов вирусов гриппа к этиотропным химиопрепаратам. Вопросы вирусологии. 2009; 5: 24–7.Бурцева Е.И., Шевченко Е.С., Белякова Н.В. и др. Мониторинг чувствительности выделенных в России эпидемических штаммов вирусов гриппа к этиотропным химиопрепаратам. Вопросы вирусологии. 2009; 5: 24–7.Скаранович М.А., Скаранович М.О., Шишикина Л.Н., Бормотов Н.И., Рыжиков А.Б., Агафонов А.П., Определение чувствительности штамма вируса гриппа À (H7N9) к противовирусным препаратам in vitro и in vivo. Антибиотики и химиотерапия, 2019, 64; 11–12, DOI: 10,37489/0235–2990–2019–64–11–12–25–30.Скаранович М.А., Скаранович М.О., Шишикина Л.Н., Бормотов Н.И., Рыжиков А.Б., Агафонов А.П., Определение чувствительности штамма вируса гриппа À (H7N9) к противовирусным препаратам in vitro и in vivo. Антибиотики и химиотерапия, 2019, 64; 11–12, DOI: 10,37489/0235–2990–2019–64–11–12–25–30.Natsina VK, Drinevskii VP, Milkint KK. [Remantadine in the treatment of influenza in children].Vestn Ross Akad Med Nauk. 1994; (9): 51–5. PMID: 7532497.Natsina VK, Drinevskii VP, Milkint KK. [Remantadine in the treatment of influenza in children].Vestn Ross Akad Med Nauk. 1994; (9): 51–5. PMID: 7532497.Moyad MA, Combs MA, Vrablic AS, Velasquez J, Turner B, Bernal S. Vitamin C metabolites, independent of smoking status, significantly enhance leukocyte, but not plasma ascorbate concentrations. Adv Ther. 2008; 25 (10): 995–1009.Moyad MA, Combs MA, Vrablic AS, Velasquez J, Turner B, Bernal S. Vitamin C metabolites, independent of smoking status, significantly enhance leukocyte, but not plasma ascorbate concentrations. Adv Ther. 2008; 25 (10): 995–1009.Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013; (1): CD000980. 65. Yakoot M, Salem A. Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold. Int J Gen Med. 2011; 4: 45–51.Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013; (1): CD000980. 65. Yakoot M, Salem A. Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold. Int J Gen Med. 2011; 4: 45–51.Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013; (1): CD000980.Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013; (1): CD000980.Douglas RM, Hemila H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2007; (3): CD000980.Douglas RM, Hemila H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2007; (3): CD000980.Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013; (1): CD000980.Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013; (1): CD000980.Chakraborty S, Yadav SK, Saha B, Tyagi M, Singh Rathee J, Chattopadhyay S. A bis-resorcinol resveratrol congener prevents indomethacin-induced gastric ulceration by inhibiting TNF-alpha as well as NF-kappaB and JNK pathways. Free Radic Res. 2019 Jun; 53 (6): 596–610, DOI: 10,1080/10715762.2019.1572887. Epub 2019 Jun 19. PubMed ID: 31215272.Chakraborty S, Yadav SK, Saha B, Tyagi M, Singh Rathee J, Chattopadhyay S. A bis-resorcinol resveratrol congener prevents indomethacin-induced gastric ulceration by inhibiting TNF-alpha as well as NF-kappaB and JNK pathways. Free Radic Res. 2019 Jun; 53 (6): 596–610, DOI: 10,1080/10715762.2019.1572887. Epub 2019 Jun 19. PubMed ID: 31215272.Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S, Podlutsky A, Csiszar A. Resveratrol increases vascular oxidative stress resistance. Am J Physiol Heart Circ Physiol. 2007 May; 292 (5): H2417–24. DOI: 10,1152/ajpheart.01258.2006. Epub 2007 Jan 12. PubMed ID: 17220179.Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S, Podlutsky A, Csiszar A. Resveratrol increases vascular oxidative stress resistance. Am J Physiol Heart Circ Physiol. 2007 May; 292 (5): H2417–24. DOI: 10,1152/ajpheart.01258.2006. Epub 2007 Jan 12. PubMed ID: 17220179.Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods. 2020 Mar 14; 9 (3). pii: foods9030340, DOI: 10,3390/foods9030340, PubMed ID: 32183376.Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods. 2020 Mar 14; 9 (3). pii: foods9030340, DOI: 10,3390/foods9030340, PubMed ID: 32183376.Annunziata G, Maisto M, Schisano C, Ciampaglia R, Narciso V, Tenore GC, Novellino E. Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview. Viruses. 2018 Sep 3; 10 (9). pii: v10090473. DOI: 10,3390/v10090473. PubMed ID: 30177661.Annunziata G, Maisto M, Schisano C, Ciampaglia R, Narciso V, Tenore GC, Novellino E. Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview. Viruses. 2018 Sep 3; 10 (9). pii: v10090473. DOI: 10,3390/v10090473. PubMed ID: 30177661.Paemanee A, Hitakarun A, Roytrakul S, Smith DR. Screening of melatonin, alpha-tocopherol, folic acid, acetyl-L-carnitine and resveratrol for anti-dengue 2 virus activity. BMC Res Notes. 2018 May 16; 11 (1): 307. DOI: 10,1186/s13104–018–3417–3. PubMed ID: 29769094.Paemanee A, Hitakarun A, Roytrakul S, Smith DR. Screening of melatonin, alpha-tocopherol, folic acid, acetyl-L-carnitine and resveratrol for anti-dengue 2 virus activity. BMC Res Notes. 2018 May 16; 11 (1): 307. DOI: 10,1186/s13104–018–3417–3. PubMed ID: 29769094.Uchide N, Toyoda H. Antioxidant therapy as a potential approach to severe influenza-associated complications. Molecules. 2011 Feb 28; 16 (3): 2032–52. DOI: 10,3390/ molecules16032032. PubMed ID: 21358592.Uchide N, Toyoda H. Antioxidant therapy as a potential approach to severe influenza-associated complications. Molecules. 2011 Feb 28; 16 (3): 2032–52. DOI: 10,3390/ molecules16032032. PubMed ID: 21358592.Wen CC, Kuo YH, Jan JT, Liang PH, Wang SY, Liu HG, Lee CK, Chang ST, Kuo CJ, Lee SS, Hou CC, Hsiao PW, Chien SC, Shyur LF, Yang NS. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem. 2007 Aug 23; 50 (17): 4087–95. DOI: 10,1021/jm070295s. Epub 2007 Jul 31. PubMed ID: 17663539.Wen CC, Kuo YH, Jan JT, Liang PH, Wang SY, Liu HG, Lee CK, Chang ST, Kuo CJ, Lee SS, Hou CC, Hsiao PW, Chien SC, Shyur LF, Yang NS. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem. 2007 Aug 23; 50 (17): 4087–95. DOI: 10,1021/jm070295s. Epub 2007 Jul 31. PubMed ID: 17663539.Shrikanta A, Kumar A, Govindaswamy V. Resveratrol content and antioxidant properties of underutilized fruits. J Food Sci Technol. 2015 Jan; 52 (1): 383–90, DOI: 10,1007/s13197–013–0993-z. Epub 2013 May 4. PubMed PMID: 25593373; PubMed Central PMCID: PMC4288802.Shrikanta A, Kumar A, Govindaswamy V. Resveratrol content and antioxidant properties of underutilized fruits. J Food Sci Technol. 2015 Jan; 52 (1): 383–90, DOI: 10,1007/s13197–013–0993-z. Epub 2013 May 4. PubMed PMID: 25593373; PubMed Central PMCID: PMC4288802.Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 Jun; 5 (6): 493–506. Epub 2006 May 26. Review. PubMed PMID: 16732220.Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 Jun; 5 (6): 493–506. Epub 2006 May 26. Review. PubMed PMID: 16732220.da Rosa VM, Ariotti K, Bressan CA, da Silva EG, Dallaporta M, Junior GB, da Costa ST, de Vargas AC, Baldisserotto B, Finamor IA, Pavanato MA. Dietary addition of rutin impairs inflammatory response and protects muscle of silver catfish (Rhamdia quelen) from apoptosis and oxidative stress in Aeromonas hydrophila-induced infection. Comp Biochem Physiol C Toxicol Pharmacol. 2019 Dec; 226: 108611. DOI: 10,1016/j.cbpc.2019.108611. Epub 2019 Aug 24. PubMed ID: 31454703.da Rosa VM, Ariotti K, Bressan CA, da Silva EG, Dallaporta M, Junior GB, da Costa ST, de Vargas AC, Baldisserotto B, Finamor IA, Pavanato MA. Dietary addition of rutin impairs inflammatory response and protects muscle of silver catfish (Rhamdia quelen) from apoptosis and oxidative stress in Aeromonas hydrophila-induced infection. Comp Biochem Physiol C Toxicol Pharmacol. 2019 Dec; 226: 108611. DOI: 10,1016/j.cbpc.2019.108611. Epub 2019 Aug 24. PubMed ID: 31454703.Zhao B, Zhang W, Xiong Y, Zhang Y, Jia L, Xu X. Rutin protects human periodontal ligament stem cells from TNF-alpha induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environment. Arch Oral Biol. 2020 Jan; 109: 104584. DOI: 10,1016/j.archoralbio.2019.104584. Epub 2019 Oct 11. PubMed ID: 31630006.Zhao B, Zhang W, Xiong Y, Zhang Y, Jia L, Xu X. Rutin protects human periodontal ligament stem cells from TNF-alpha induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environment. Arch Oral Biol. 2020 Jan; 109: 104584. DOI: 10,1016/j.archoralbio.2019.104584. Epub 2019 Oct 11. PubMed ID: 31630006.Batiha GE, Beshbishy AM, Ikram M, Mulla ZS, El-Hack MEA, Taha AE, Algammal AM, Elewa YHA. The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin. Foods. 2020 Mar 23; 9 (3). pii: foods9030374. DOI: 10,3390/foods9030374. PubMed ID: 32210182.Batiha GE, Beshbishy AM, Ikram M, Mulla ZS, El-Hack MEA, Taha AE, Algammal AM, Elewa YHA. The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin. Foods. 2020 Mar 23; 9 (3). pii: foods9030374. DOI: 10,3390/foods9030374. PubMed ID: 32210182.Chiow KH, Phoon MC, Putti T, Tan BK, Chow VT. Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pac J Trop Med. 2016 Jan; 9 (1): 1–7. DOI: 10,1016/j.apjtm.2015.12.002. Epub 2015 Dec 19. PubMed ID: 26851778.Chiow KH, Phoon MC, Putti T, Tan BK, Chow VT. Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pac J Trop Med. 2016 Jan; 9 (1): 1–7. DOI: 10,1016/j.apjtm.2015.12.002. Epub 2015 Dec 19. PubMed ID: 26851778.Nile SH, Kim DH, Nile A, Park GS, Gansukh E, Kai G. Probing the effect of quercetin 3-glucoside from Dianthus superbus L against influenza virus infection. In vitro and in silico biochemical and toxicological screening. Food Chem Toxicol. 2020 Jan; 135: 110985. DOI: 10,1016/j. fct.2019.110985. Epub 2019 Nov 22. PubMed ID: 31765700.Nile SH, Kim DH, Nile A, Park GS, Gansukh E, Kai G. Probing the effect of quercetin 3-glucoside from Dianthus superbus L against influenza virus infection. In vitro and in silico biochemical and toxicological screening. Food Chem Toxicol. 2020 Jan; 135: 110985. DOI: 10,1016/j. fct.2019.110985. Epub 2019 Nov 22. PubMed ID: 31765700.Lopes BRP, da Costa MF, Genova Ribeiro A, da Silva TF, Lima CS, Caruso IP, de Araujo GC, Kubo LH, Iacovelli F, Falconi M, Desideri A, de Oliveira J, Regasini LO, de Souza FP, Toledo KA. Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion. Virus Res. 2020 Jan 15; 276: 197805. DOI: 10,1016/j.virusres.2019.197805. Epub 2019 Nov 9. PubMed ID: 31712123.Lopes BRP, da Costa MF, Genova Ribeiro A, da Silva TF, Lima CS, Caruso IP, de Araujo GC, Kubo LH, Iacovelli F, Falconi M, Desideri A, de Oliveira J, Regasini LO, de Souza FP, Toledo KA. Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion. Virus Res. 2020 Jan 15; 276: 197805. DOI: 10,1016/j.virusres.2019.197805. Epub 2019 Nov 9. PubMed ID: 31712123.Громова О.А., Ребров В. Г. Витамины, макро- и микроэлементы. Обучающие программы РСЦ института микроэлементов ЮНЕСКО. ISBN: 978–5–9704–0814– 8. Изд-во Гэотар-Медиа: 2008. 954.Громова О.А., Ребров В. Г. Витамины, макро- и микроэлементы. Обучающие программы РСЦ института микроэлементов ЮНЕСКО. ISBN: 978–5–9704–0814– 8. Изд-во Гэотар-Медиа: 2008. 954.Bai L, Li A, Gong C, Ning X, Wang Z. Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-beta1/alpha-SMA/Col I and III pathway. Biofactors. 2020 Mar 31. DOI: 10,1002/biof.1629. PubMed ID: 32233122.Bai L, Li A, Gong C, Ning X, Wang Z. Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-beta1/alpha-SMA/Col I and III pathway. Biofactors. 2020 Mar 31. DOI: 10,1002/biof.1629. PubMed ID: 32233122.Al-Shwaiyat MKEA, Miekh YV, Denisenko TA, Vishnikin AB, Andruch V, Bazel YR. Simultaneous determination of rutin and ascorbic acid in a sequential injection lab-at-valve system. J Pharm Biomed Anal. 2018 Feb 5; 149: 179–184. DOI: 10,1016/j. jpba.2017.11.006. Epub 2017 Nov 6. PubMed PMID: 29121572.Al-Shwaiyat MKEA, Miekh YV, Denisenko TA, Vishnikin AB, Andruch V, Bazel YR. Simultaneous determination of rutin and ascorbic acid in a sequential injection lab-at-valve system. J Pharm Biomed Anal. 2018 Feb 5; 149: 179–184. DOI: 10,1016/j. jpba.2017.11.006. Epub 2017 Nov 6. PubMed PMID: 29121572.Peters W, Kusche-Vihrog K, Oberleithner H, Schillers H. Cystic fibrosis transmembrane conductance regulator is involved in polyphenol-induced swelling of the endothelial glycocalyx. Nanomedicine. 2015 Aug; 11 (6): 1521–30, DOI: 10,1016/j. nano.2015.03.013. Epub 2015 Apr 14. PubMed PMID: 25881741.Peters W, Kusche-Vihrog K, Oberleithner H, Schillers H. Cystic fibrosis transmembrane conductance regulator is involved in polyphenol-induced swelling of the endothelial glycocalyx. Nanomedicine. 2015 Aug; 11 (6): 1521–30, DOI: 10,1016/j. nano.2015.03.013. Epub 2015 Apr 14. PubMed PMID: 25881741.Справочник Видаль 2020. Лекарственные препараты в России. Изд-во: Видаль Рус.Справочник Видаль 2020. Лекарственные препараты в России. Изд-во: Видаль Рус.

The authors declare that there are no conflicts of interest present.