medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-15-15-21medalphabet-1596Research ArticleСтатьиЭволюция методов иммунотерапии псориаза и псориатического артрита: от тотальной иммуносупрессии к избирательному воздействию на терапевтические мишениEvolution of immunotherapy methods for psoriasis and psoriatic arthritis: from total immunosuppression to selective treatment of therapeutic targetsПритулоО. А.PrituloO. A.

Доктор медицинских наук, профессор, заведующий кафедрой дерматовенерологии и косметологии, главный внештатный специалист-дерматовенеролог Минздрава Республики Крым

Симферополь, Республика Крым 

ПетровА. А.PetrovA. A.

Ординатор кафедры дерматовенерологии и косметологии

Симферополь, Республика Крым

ПетровА. В.PetrovA. V.

Доктор медицинских наук, профессор, профессор кафедры внутренней медицины № 2, главный внештатный специалист-ревматолог Минздрава Республики Крым Медицинская академия имени С.И. Георгиевского

Симферополь, Республика Крым

ФГАОУ ВО «Крымский федеральный университет имени В.И. Вернадского»РоссияMedical academy n.a. S.I. Georgievsky of V.I. Vernadsky Crimean Federal UniversityRussian Federation202012092020015 (2020)Ревматология в общей практике1521Copyright © Притуло О.А., Петров А.А., Петров А.В., 20202020Притуло О.А., Петров А.А., Петров А.В.Pritulo O.A., Petrov A.A., Petrov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1596

В литературном обзоре представлены данные о существующих методах лечения псориаза (П) и псориатического артрита (ПсА). Актуальность работы связана с трудностями выбора практическим врачом того или иного терапевтического средства в зависимости от особенностей течения кожного патологического процесса, поражения костно-мышечной системы, позвоночника и сопутствующих заболеваний. Синтетические и таргетные препараты описаны в историческом аспекте, в обзоре представлены накопленные сведения об их эффективности в отношении различных проявлений П и ПсА, рассмотрены вопросы безопасности их применения. В заключение обсуждены существующие рекомендации по дифференцированному применению различных средств на основании комплексной оценки клинической характеристики больных с учетом, в том числе, риска проявления побочных эффектов терапии.

The literature review presents data on existing treatments for psoriasis (P) and psoriatic arthritis (PsA). The relevance of the work is rationale with the difficulties of choosing a particular therapeutic agent by a specialist, depending on the peculiarities of the course of the skin pathological process, damage to the musculoskeletal system, spine and related diseases. Synthetic and targeted drugs are described in a chronological consequences, the review provides accumulated information about their effectiveness in relation to various manifestations of P and PsA, and the safety of their use. In conclusion, current recommendations on the differentiated use of various agents for target therapy based on a comprehensive assessment of the clinical characteristics of patients as well as mechanism of action and side effects of the drugs, are discussed.

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The authors declare that there are no conflicts of interest present.