medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»medalphabet-148Research ArticleСтатьиНиволумаб - ингибитор рецептора программированной смерти-1: роль в лечении злокачественных опухолейNivolumab is inhibitor of preprogrammed death-1 receptor: the role in malignant tumours treatmentТер-ОванесовМ. Д.Ter-OvanesovM. D.noemail@neicon.ruКукошМ. Ю.KukoshM. Yu.noemail@neicon.ruПименовИ. В.PimenovI. V.noemail@neicon.ruВалкинД. Л.ValkinD. L.noemail@neicon.ruЛевицкийА. В.LevitskyA. V.noemail@neicon.ruФГАОУ ВО «Российский университет дружбы народов»; ГБУЗ «Городская клиническая больница № 40» Департамента здравоохранения г. МосквыРоссияPeople’s Friendship University of Russia; Municipal Clinical Hospital No 40Russian FederationГБУЗ «Городская клиническая больница № 40» Департамента здравоохранения г. МосквыРоссияMunicipal Clinical Hospital No 40Russian Federation201725052017116Диагностика и онкотерапия2328Copyright © Тер-Ованесов М.Д., Кукош М.Ю., Пименов И.В., Валкин Д.Л., Левицкий А.В., 20172017Тер-Ованесов М.Д., Кукош М.Ю., Пименов И.В., Валкин Д.Л., Левицкий А.В.Ter-Ovanesov M.D., Kukosh M.Y., Pimenov I.V., Valkin D.L., Levitsky A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/148

Создание препаратов - ингибиторов точек иммунного контроля существенно изменило стандарты лечения распространенных онкологических заболеваний. Эти препараты не только показали клиническую активность против широкого спектра солидных опухолей, но и обладают благоприятным профилем безопасности. Значимое увеличение общей выживаемости по сравнению с другими подходами противоопухолевой терапии является основным преимуществом иммунотерапии. Ниволумаб является lgG4-антителом, которое блокирует взаимодействие рецептора PD-1 с его лигандами, нивелируя тем самым ингибирование противоопухолевого иммунного ответа. В России препарат одобрен для лечения распространенной меланомы, немелкоклеточного рака легкого и рака почки.

The creation of drugs - inhibitors of immune control points has significantly changed the standards for the treatment of common cancer. These drugs not only showed clinical activity against a wide range of solid tumors, but also have a favorable safety profile. A significant increase in overall survival compared to other antitumor approaches is the main advantage of immunotherapy. Nivolumab is an lgG4 antibody that blocks the interaction of the PD-1 receptor with its ligands, thereby negating the inhibition of the antitumor immune response. ln Russia, the drug is approved for the treatment of advanced melanoma, non-small cell lung cancer and kidney cancer.

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The authors declare that there are no conflicts of interest present.