medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-5-13-19medalphabet-1459Research ArticleСтатьиРоль молекулярно-генетических факторов в патогенезе и диагностике неалкогольной жировой болезни печени (обзор литературы и собственные данные)Role of molecular genetic factors in pathogenesis and diagnosis of non-alcoholic fatty liver disease (literature review and own data)СидоренкоД. В.SidorenkoD. V.

ординатор кафедры клинической лабораторной диагностики с курсом молекулярной медицины

г. Санкт-Петербург

Saint Petersburg

НазаровВ. Д.NazarovV. D.

к. м. н., м. н. с. лаборатории диагностики аутоиммунных заболеваний Научно-методического центра молекулярной медицины Минздрава России

г. Санкт-Петербург

Saint Petersburg

ЛапинС. В.LapinS. V.

к. м. н., зав. лабораторией диагностики аутоиммунных заболеваний Научно-методического центра молекулярной медицины Минздрава России

г. Санкт-Петербург

Saint Petersburg

ЭмануэльВ. Л.EmanuelV. L.

д. м. н. проф., зав. кафедрой клинической лабораторной диагностики с курсом молекулярной медицины, директор Научно-методического центра по молекулярной медицине Минздрава России

г. Санкт-Петербург

Saint Petersburg

ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Минздрава РоссииРоссияFirst Saint Petersburg State Medical University n. a. I. P. PavlovRussian Federation20201506202005Современная лаборатория1319Copyright © Сидоренко Д.В., Назаров В.Д., Лапин С.В., Эмануэль В.Л., 20202020Сидоренко Д.В., Назаров В.Д., Лапин С.В., Эмануэль В.Л.Sidorenko D.V., Nazarov V.D., Lapin S.V., Emanuel V.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1459

Неалкогольная жировая болезнь печени является самым распространенным заболеванием печени и, как правило, имеет доброкачественное течение. Но при формировании стеатогепатита значительно увеличивается вероятность развития фиброза, цирроза и гепатоцеллюлярной карциномы. На данный момент нет надежных предикторов агрессивного течения заболевания, но наиболее перспективными кандидатами на эту роль могут стать молекулярно-генетические методы. В статье рассматривается роль генов PNPLA3, TM6SF2, SERPINA1 и HFE в патогенезе и течение неалкогольной жировой болезни печени, а также приведены данные по распространенности патологических аллелей данных генов среди пациентов, проживающих в г. Санкт-Петербурге.

Non-alcoholic fatty liver disease is the most common liver disease, which usually has a benign course. After the occurrence of steatohepatitis the risk of developing fibrosis, cirrhosis and hepatocellular carcinoma significantly increases. At the moment, there are no reliable predictors of the aggressive course of this patients’ disease, but genetic aberrations are the most promising predictor markers. This article devoted to the role of the PNPLA3, TM6SF2, SERPINA1 and HFE genes in the pathogenesis and course of non-alcoholic fatty liver disease. Data of the prevalence of pathological alleles of these genes among patients living in St. Petersburg is also included.

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The authors declare that there are no conflicts of interest present.