medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2020-5-5-8medalphabet-1457Research ArticleСтатьиГенетическая предрасположенность и устойчивость к некоторым инфекционным заболеваниям. II. Инфекции, передаваемые половым путемGenetic predisposition and resistance to certain infectious diseases. II. Sexually transmitted infectionsЩербоС. Н.ScherboS. N.

д. б. н., проф., зав. кафедрой клинической лабораторной диагностики ФДПО

г. Москва

Moscow

ЩербоД. С.ShcherboD. S.

к. б. н., доцент кафедры клинической лабораторной диагностики ФДПО

г. Москва

Moscow

ТищенкоА. Л.TishchenkoA. L.

д. м. н., проф., зав. кафедрой кожных и венерических болезней с курсом косметологии ФНМО медицинского института

г. Москва

Moscow

СавинаМ. И.SavinaM. I.

д. б. н., проф., проф. кафедры клинической лабораторной диагностики ФДПО

г. Москва

Moscow

ТуркинаТ. И.TurkinaT. I.

д. б. н., проф., проф. кафедры клинической лабораторной диагностики ФДПО

г. Москва

Moscow

ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава РоссииРоссияRussian National Research Medical University n. a. N. I. PirogovRussian FederationФГAОУ ВО «Российский университет дружбы народов»РоссияPeople’s Friendship University of RussiaRussian Federation20201506202005Современная лаборатория58Copyright © Щербо С.Н., Щербо Д.С., Тищенко А.Л., Савина М.И., Туркина Т.И., 20202020Щербо С.Н., Щербо Д.С., Тищенко А.Л., Савина М.И., Туркина Т.И.Scherbo S.N., Shcherbo D.S., Tishchenko A.L., Savina M.I., Turkina T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1457

В обзоре рассматриваются вопросы, связанные с генетической предрасположенностью и устойчивостью к инфекциям, передаваемым половым путем (ИППП). Генетические факторы в значительной мере определяют восприимчивость организма к различным заболеваниям, в том числе инфекционным. Основное влияние уделяется генам главного комплекса гистосовместимости и toll-подобных рецепторов. Рассмотрены некоторые ИППП и генетические полиморфизмы, ответственные за устойчивость и предрасположенность к инфекциям и связанным с ними клиническим последствиям. Знание молекулярно-генетических биомаркеров необходимо для выделения групп риска, проведения предиктивных мероприятий, в частности вакцинации.

The review addresses issues related to genetic predisposition and resistance to sexually transmitted infections (STI). Genetic factors largely determine the susceptibility of the body to various diseases, including infectious ones. The main influence is given to the genes of the main histocompatibility complex and toll-like receptors. Some STI and genetic polymorphisms responsible for resistance and susceptibility to infections and related clinical consequences are considered. Knowledge of molecular genetic biomarkers is necessary to identify risk groups, conduct predictive measures, in particular vaccination.

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The authors declare that there are no conflicts of interest present.