medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2019-1-16(391)-47-57medalphabet-1294Research ArticleСтатьиДозирование антибиотиков у пациентов с сепсисом, которым проводится заместительная почечная терапияDosing of antibiotics in patients with sepsis, including those undergoing renal replacement therapyШалгинскихА. О.ShalginskikhA. O.

г. Москва

Moscow

ЯковлевС. В.YakovlevS. V.

г. Москва

Moscow

ПроценкоД. Н.ProtsenkoD. N.СычевИ. Н.SychevI. N.СувороваМ. П.SuvorovaM. P.

г. Москва

Moscow

БыковА. О.BykovA. O.ФГБНУ «Российский научный центр хирургии имени акад. Б. В. Петровского»РоссияRussian Scientific Centre for Surgery n. a. acad. B. V. PetrovskyRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский университет)» Минздрава РоссииРоссияFirst Moscow State Medical University n. a. I. M. SechenovRussian FederationГБУЗ «Городская клиническая больница имени С. С. Юдина» Департамента здравоохранения города МосквыРоссияCity Clinical Hospital n. a. S. S. Yudin, MoscowRussian Federation201928112019116Неотложная медицина и кардиология4757Copyright © Шалгинских А.О., Яковлев С.В., Проценко Д.Н., Сычев И.Н., Суворова М.П., Быков А.О., 20192019Шалгинских А.О., Яковлев С.В., Проценко Д.Н., Сычев И.Н., Суворова М.П., Быков А.О.Shalginskikh A.O., Yakovlev S.V., Protsenko D.N., Sychev I.N., Suvorova M.P., Bykov A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1294

У больных, находящихся в критическом состоянии, адекватность стартовой эмпирической антимикробной терапии является определяющим фактором выживания пациентов с сепсисом. В статье рассмотрены основные аспекты эмпирического назначения антибиотиков у пациентов с сепсисом, находящихся на заместительной почечной терапии. Описаны изменения механизмов фармакокинетики и фармакодинамики, которые приводят к выбору особых режимов дозирования антибиотиков. Представлена информация об изменении дозирования для актуальных групп антибактериальных препаратов. Целью данной статьи является рационализация антибактериальной терапии у выбранной группы пациентов.

In critically ill patients the adequacy of starting empirical antimicrobial therapy is a determining factor of the survival of patients with sepsis This article describes the main aspects of the empirical prescription of antibiotics in patients with sepsis who are on renal replacement therapy. Changes in the pharmacokinetic and pharmacodynamic mechanisms that lead to the selection of specific dosing regimens for antibiotics are described. Information on dosing changes for current groups of antibacterial drugs is presented. The purpose of this article is to rationalize antibiotic therapy in a selected group of patients.

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The authors declare that there are no conflicts of interest present.