medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2019-2-17(392)-8-11medalphabet-1274Research ArticleСтатьиПрименение комбинации пентоксифиллина и витамина Е в профилактике и лечении радиоиндуцированного фиброза мягких тканей: обзор литературыUse of a Combination of Pentoxifylline and Vitamin E in Prevention and Treatment of Radioinduced Soft Tissue Fibrosis: a Literature SurveyТкачевС. И.TkachevS. I.

д. м. н., проф.

г. Москва

Moscow

НазаренкоА. В.NazarenkoA. V.

к. м. н.

г. Москва

Moscow

ТимошкинаЕ. А.TimoshkinaE. V.

г. Москва

Moscow

ТрофимоваО. П.TrofimovaO. P.

д. м. н., проф.

г. Москва

Moscow

ГлебовскаяВ. В. GlebovskayaV. V.

к. м. н.

г. Москва

Moscow

ИвановС. М.IvanovS. M.

к. м. н.

г. Москва

Moscow

БорисоваТ.  Н.BorisovaT. N.

к. м. н.

г. Москва

Moscow

АлиеваС. Б.AliyevaS. B.

д. м. н.

г. Москва

Moscow

ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава РоссииРоссияNational Medical Research Centre of Oncology n. a. N. N. BlokhinRussian Federation201927112019217Диагностика и онкотерапия811Copyright © Ткачев С.И., Назаренко А.В., Тимошкина Е.А., Трофимова О.П., Глебовская В.В., Иванов С.М., Борисова Т.Н., Алиева С.Б., 20192019Ткачев С.И., Назаренко А.В., Тимошкина Е.А., Трофимова О.П., Глебовская В.В., Иванов С.М., Борисова Т.Н., Алиева С.Б.Tkachev S.I., Nazarenko A.V., Timoshkina E.V., Trofimova O.P., Glebovskaya V.V., Ivanov S.M., Borisova T.N., Aliyeva S.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1274

Поздние лучевые повреждения, возникающие спустя значительный срок от момента завершения лучевого лечения, могут затрагивать любую анатомическую структуру в пределах облучаемой области и тем самым значительно ухудшать качество жизни онкологических больных. Современные технологии лучевой терапии и научно обоснованные режимы фракционирования дозы лучевого воздействия поспособствовали значительному снижению частоты возникновения поздних лучевых повреждений, однако риск их появления по-прежнему сохраняется. В обзоре представлены данные литературы, посвященные как лечению, так и возможностям медикаментозной профилактики такого позднего лучевого повреждения, как радиоиндуцированный фиброз мягких тканей.

Late radiation injuries that occur after a significant period from the moment of completion of the radiation treatment can affect any anatomical structure within the irradiated area and thereby significantly impair the quality of life of cancer patients. Modern technologies of radiation therapy and scientifically based dose fractionation modes of radiation exposure have contributed to a significant reduction in the incidence of late radiation damage, but the risk of their appearance remains. The review presents literature data on both the treatment and the possibilities of drug prevention of late radiation damage, such as radio-induced soft tissue fibrosis.

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The authors declare that there are no conflicts of interest present.