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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2019-1-18(393)-13-23</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1266</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Анализ применения селективного модулятора костимуляции Т-лимфоцитов абатацепта в лечении ревматоидного артрита: данные международной клинической практики</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of the use of a selective modulator of cosmulation of T‑lymphocytes abatacept in the treatment of rheumatoid arthritis: data from international clinical practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>м. н. с. лаборатории изучения коморбидных инфекций и мониторинга безопасности лекарственной терапии</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукина</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukina</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф., зав. научно-исследовательским отделом ревматологии</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии имени В. А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии имени В. А. Насоновой»; ГБУЗ «Московский клинический научно-практический центр имени А. С. Логинова» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology; A. S. Loginov Moscow Clinical Scientific Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>26</day><month>11</month><year>2019</year></pub-date><volume>1</volume><issue>18</issue><issue-title>Ревматология в общей врачебной практике</issue-title><fpage>13</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Борисова М.А., Лукина Г.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Борисова М.А., Лукина Г.В.</copyright-holder><copyright-holder xml:lang="en">Borisova M.A., Lukina G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1266">https://www.med-alphabet.com/jour/article/view/1266</self-uri><abstract><p>В данной статье приведены результаты международных исследований, посвященных изучению эффективности, безопасности АБЦ и выявлению возможных предикторов хорошего ответа на терапию данным препаратом в условиях реальной клинической практики.</p></abstract><trans-abstract xml:lang="en"><p>This article presents the results of international studies of abatacept efficacy and safety and searching for possible predictors of a good response to the therapy with this drug in real clinical practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>абатацепт</kwd><kwd>генно‑инженерные биологические препараты</kwd><kwd>ревматоидный артрит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>abatacept</kwd><kwd>biologics</kwd><kwd>rheumatoid arthritis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Schiff M. 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