medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2019-2-19(394)-5-10medalphabet-1257Research ArticleСтатьиНарушения биологических ритмов при депрессииBiological rhythm disturbances in depressionПолуэктовМ. Г.PoluektovM. G.

к. м. н., доцент, кафедра нервных болезней и нейрохирургии

г. Москва

Moscow

ХаджаеваП. М.KhadzhaevaP. M.

аспирант, кафедра нервных болезней и нейрохирургии

г. Москва

Moscow

ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский университет)» Минздрава РоссииРоссияI. M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation201926112019219Неврология и психиатрия510Copyright © Полуэктов М.Г., Хаджаева П.М., 20192019Полуэктов М.Г., Хаджаева П.М.Poluektov M.G., Khadzhaeva P.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/1257

Депрессия относится к заболеваниям, сопровождающимся выраженными медико-социальными последствиями, к которым относятся инвалидность, снижение социального функционирования и суициды. Существует ряд доказательств тесной связи депрессивных проявлений с нарушениями циркадного периодизма и функций супрахиазменных ядер гипоталамуса — ведущего водителя биологических ритмов. Данная статья является литературным обзором, посвященным понятию биологических ритмов, хронотипа, десинхроноза, их роли в развитии и течении депрессии, опыте применения хронобиотических препаратов при депрессивном расстройстве.

Depression belongs to the diseases with pronounced medical and social consequences, which include disability, reduced social functioning and suicides. There is the evidence that the depressive manifestations are closely related to disorders of circadian periodism and the function of the suprachiasmatic nuclei of the hypothalamus, the leading driver of biological rhythms. Authors reviewed the possibility to apply the concept of biological rhythms to the development and clinical features of depressive disorder. The potential effects of chronobiotic drugs like melatonin agonists is discussed.

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The authors declare that there are no conflicts of interest present.