<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2019-3-28(403)-5-8</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1193</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Опыт применения дурвалумаба при III нерезектабельной стадии немелкоклеточного рака легкого в Иркутской области</article-title><trans-title-group xml:lang="en"><trans-title>Experience of using durvalumab in unresectable stage III non-small cell lung cancer in Irkutsk Region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юкальчук</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Yukalchuk</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-онколог химиотерапевтического отделения № 1</p><p>г. Иркутск</p></bio><bio xml:lang="en"><p>Irkutsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономаренко</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomarenko</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., зав. отделением химиотерапевтического отделения № 1</p><p>г. Иркутск</p></bio><bio xml:lang="en"><p>Irkutsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дворниченко</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dvornichenko</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., гл. врач</p><p>г. Иркутск</p></bio><bio xml:lang="en"><p>Irkutsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новопашин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Novopashin</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-рентгенолог</p><p>г. Иркутск</p></bio><bio xml:lang="en"><p>Irkutsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Областной онкологический диспансер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Oncology Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2019</year></pub-date><volume>3</volume><issue>28</issue><issue-title>Диагностика и онкотерапия</issue-title><fpage>5</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Юкальчук Д.Ю., Пономаренко Д.М., Дворниченко В.В., Новопашин А.М., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Юкальчук Д.Ю., Пономаренко Д.М., Дворниченко В.В., Новопашин А.М.</copyright-holder><copyright-holder xml:lang="en">Yukalchuk D.Y., Ponomarenko D.M., Dvornichenko V.V., Novopashin A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1193">https://www.med-alphabet.com/jour/article/view/1193</self-uri><abstract><p>Немелкоклеточный рак легкого (НМРЛ) продолжает занимать одно из лидирующих мест в структуре онкологической заболеваемости и смертности. В течение последних 10 лет благодаря появлению таргетной и иммунотерапии был достигнут значительный прогресс в лечении метастатических форм заболевания, однако до недавнего времени подходы к терапии более ранних стадий НМРЛ оставались неизменными. Так, стандартом лечения местнораспространенного нерезектабельного НМРЛ оставалась химиолучевая терапия (ХЛТ) в одновременном или последовательном вариантах. Первым исследованием, в котором была продемонстрирована возможность улучшения результатов терапии с использованием инновационного сочетания иммунотерапии препаратом дурвалумаб и химиолучевой терапии в едином лечебном комплексе у данной категории пациентов, включая улучшение отдаленных результатов, стало исследование PACIFIC. В России дурвалумаб был зарегистрирован для применения у пациентов с местнораспространенным НМРЛ, у которых не произошло прогрессирования после проведенной ХЛТ в июле 2019 года, поэтому опыт его применения в реальной клинической практике еще невелик. В данной статье мы обобщили наш локальный опыт применения данного препарата у семи пациентов и представили более подробно один из клинических случаев. Пациент с III нерезектабельной стадией НМРЛ начал получать терапию дурвалумабом в октябре 2018 года спустя 2 месяца после окончания курса последовательной ХЛТ. В настоящее время, спустя 12 месяцев терапии, сохраняется стабилизация заболевания, пациент продолжает лечение.</p></abstract><trans-abstract xml:lang="en"><p>Non-small cell lung cancer (NSCLC) continues be one of the most frequent oncological diseases both in incidence and mortality. Over the past ten years, due to the targeted and immunotherapy, significant success has been achieved in the treatment of metastatic forms NSCLC, but until recently, approaches to the treatment of earlier stages of NSCLC have remained unchanged. So, the standard treatment of locally-advanced unresectable NSCLC remained chemo-radiation (concurrent or sequential). The first study that has demonstrated the possibility of improving treatment results (including long term results) using an innovative approach from combination of durvalumab immunotherapy with chemo-radiation therapy (CRT) as an integrated treatment complex in this category of patients, has become the PACIFIC study. In Russia, durvalum ab was registered in July 2019 for using in patients with locally advanced NSCLC who have not progressed after CRT, so the experience of its administration in real clinical practice is still small. In this article, we summarized our local experience with durvalumab treatment in seven patients and presented more detailed one of the clinical cases. A patient with stage III unresectable NSCLC began receiving durvalumab therapy in October 2018, 2 months after completing a course of sequential CRT. Currently, after 12 months of therapy, the stabilization of the disease persists, the patient continues treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>III стадия НМРЛ</kwd><kwd>химиолучевая терапия</kwd><kwd>дурвалумаб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>III stage of NSCLC</kwd><kwd>chemo-radiation therapy</kwd><kwd>durvalumab</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Под ред. А. Д. Каприна, В. В. Старинского, Г. В. Петровой. Состояние онкологической помощи населению России в 2017 году. М.: МНИОИ им. П.А. Герцена, 2018.</mixed-citation><mixed-citation xml:lang="en">Под ред. А. Д. Каприна, В. В. Старинского, Г. В. Петровой. Состояние онкологической помощи населению России в 2017 году. М.: МНИОИ им. П.А. Герцена, 2018.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Antonia S.J. et al. Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med. 2018; 379: 2342–2350.</mixed-citation><mixed-citation xml:lang="en">Antonia S.J. et al. Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med. 2018; 379: 2342–2350.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Jhanelle E. Gray, presented at the American Society of Clinical Oncology (ASCO) Annual Meeting; Chicago, IL, USA; May 31 — June 4, 2019, poster 8526.</mixed-citation><mixed-citation xml:lang="en">Jhanelle E. Gray, presented at the American Society of Clinical Oncology (ASCO) Annual Meeting; Chicago, IL, USA; May 31 — June 4, 2019, poster 8526.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">O’Rourke N., Cochrane Database Syst Rev. 2010 Jun 16; (6): CD002140.</mixed-citation><mixed-citation xml:lang="en">O’Rourke N., Cochrane Database Syst Rev. 2010 Jun 16; (6): CD002140.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Senan S. et al. PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer. J Clin Oncol. 2016; 34: 953–962.</mixed-citation><mixed-citation xml:lang="en">Senan S. et al. PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer. J Clin Oncol. 2016; 34: 953–962.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Vokes E. E. et al. Induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for regionally advanced unresectable stage III Non-small-cell lung cancer: Cancer and Leukemia Group B. J Clin Oncol. 2007; 25: 1698–1704.</mixed-citation><mixed-citation xml:lang="en">Vokes E. E. et al. Induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for regionally advanced unresectable stage III Non-small-cell lung cancer: Cancer and Leukemia Group B. J Clin Oncol. 2007; 25: 1698–1704.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lilenbaum R. et al. A phase II study of induction chemotherapy followed by thoracic radiotherapy and erlotinib in poor risk stage III nonsmall cell lung cancer: Results of CALGB 30605 (Alliance) / RTOG 0972 (NRG), J Thorac Oncol. 2015; 10: 143–147.</mixed-citation><mixed-citation xml:lang="en">Lilenbaum R. et al. A phase II study of induction chemotherapy followed by thoracic radiotherapy and erlotinib in poor risk stage III nonsmall cell lung cancer: Results of CALGB 30605 (Alliance) / RTOG 0972 (NRG), J Thorac Oncol. 2015; 10: 143–147.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ahn J. S. et al. Multinational Randomized Phase III Trial With or Without Consolidation Chemotherapy Using Docetaxel and Cisplatin After Concurrent Chemoradiation in Inoperable Stage III Non-Small-Cell Lung Cancer: KCSGLU05–04. J Clin Oncol. 2015; 33: 2660–2666.</mixed-citation><mixed-citation xml:lang="en">Ahn J. S. et al. Multinational Randomized Phase III Trial With or Without Consolidation Chemotherapy Using Docetaxel and Cisplatin After Concurrent Chemoradiation in Inoperable Stage III Non-Small-Cell Lung Cancer: KCSGLU05–04. J Clin Oncol. 2015; 33: 2660–2666.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hanna N. et al. Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology. J Clin Oncol. 2008; 26: 5755–5760.</mixed-citation><mixed-citation xml:lang="en">Hanna N. et al. Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology. J Clin Oncol. 2008; 26: 5755–5760.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные опухоли: Практические рекомендации по лекарственному лечению злокачественных опухолей (RUSSCO) / Под редакцией В.М. Моисеенко.— М. Общероссийская общественная организация «Российское общество клинической онкологии», 2017.— 656 с.</mixed-citation><mixed-citation xml:lang="en">Злокачественные опухоли: Практические рекомендации по лекарственному лечению злокачественных опухолей (RUSSCO) / Под редакцией В.М. Моисеенко.— М. Общероссийская общественная организация «Российское общество клинической онкологии», 2017.— 656 с.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации ESMO. Портал Европейского общества медицинской онкологии. [Электронный ресурс] 10.02.2019. URL: www.esmo.org/Guidelines/ESMO-Guidelines.</mixed-citation><mixed-citation xml:lang="en">Клинические рекомендации ESMO. Портал Европейского общества медицинской онкологии. [Электронный ресурс] 10.02.2019. URL: www.esmo.org/Guidelines/ESMO-Guidelines.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">NCCN Guidelines. Non-Small Cell Lung cancer. Version 1,2019 Портал национальной всеобщей онкологической сети nccn.org. [Электронный ресурс], 25/10/2018. URL: www.nccn.org/professionals/physician_gls/pdf/nscl.pdf.</mixed-citation><mixed-citation xml:lang="en">NCCN Guidelines. Non-Small Cell Lung cancer. Version 1,2019 Портал национальной всеобщей онкологической сети nccn.org. [Электронный ресурс], 25/10/2018. URL: www.nccn.org/professionals/physician_gls/pdf/nscl.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Инструкция по применению лекарственного препарата для медицинского применения Имфинзи® (дурвалумаб) ЛП-005664–180719 от 18.07.2019.</mixed-citation><mixed-citation xml:lang="en">Инструкция по применению лекарственного препарата для медицинского применения Имфинзи® (дурвалумаб) ЛП-005664–180719 от 18.07.2019.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
