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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2019-3-25(400)-6-10</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1162</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Переходный период эстроген-гестагенной гормональной терапии</article-title><trans-title-group xml:lang="en"><trans-title>Transition period of estrogen-progestogen hormone therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф. кафедры акушерства и гинекологии № 1, Институт клинической медицины</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский университет)» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University n. a. I. M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>19</day><month>11</month><year>2019</year></pub-date><volume>3</volume><issue>25</issue><issue-title>Современная гинекология</issue-title><fpage>6</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузнецова И.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Кузнецова И.В.</copyright-holder><copyright-holder xml:lang="en">Kuznetsova I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1162">https://www.med-alphabet.com/jour/article/view/1162</self-uri><abstract><p>Комбинированная гормональная контрацепция является эффективным методом предохранения от беременности и вместе с тем обладает рядом терапевтических эффектов. Потребность в контрацепции сохраняется вплоть до окончательного прекращения менструальной функции, но в старшем фертильном возрасте подбор гормонального средства становится непростой задачей. За предшествовавшие годы у женщины накапливаются факторы, которые могут осложнить применение гормональных препаратов, и, с другой стороны, в переходном периоде жизни возникают новые проблемы, разрешить которые способны комбинированные противозачаточные средства. Не менее актуальной темой становится вопрос о прекращении приема комбинированных гормональных контрацептивов и инициации менопаузальной гормональной терапии. Все перечисленные аспекты использования гормональных препаратов требуют глубокого осмысления для адекватного ведения женщин, вступающих в завершающую фазу репродуктивной жизни.</p></abstract><trans-abstract xml:lang="en"><p>Combined hormonal contraception is an effective method of preventing pregnancy and at the same time has a number of therapeutic effects. The need for contraception persists until the final cessation of menstrual function, but at an older fertile age, the selection of a hormonal agent becomes a daunting task. Over the past years, a woman has accumulated factors that can complicate the use of hormonal drugs, and, on the other hand, new problems arise in the transitional period of life, which combined contraceptives can solve. An equally relevant topic is the question of stopping the use of combined hormonal contraceptives and initiating menopausal hormone therapy. All of the above aspects of the use of hormonal drugs require deep understanding for the adequate management of women entering the final phase of reproductive life.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>контрацепция</kwd><kwd>перименопауза</kwd><kwd>аномальные маточные кровотечения</kwd><kwd>гиперплазия эндометрия</kwd><kwd>контроль менструального цикла</kwd><kwd>тромботический риск</kwd><kwd>оральные контрацептивы</kwd><kwd>комбинированные гормональные контрацептивы</kwd><kwd>прогестины</kwd><kwd>прогестагенные контрацептивы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>contraception</kwd><kwd>perimenopause</kwd><kwd>abnormal uterine bleeding</kwd><kwd>endometrial hyperplasia</kwd><kwd>control of the menstrual cycle</kwd><kwd>thrombotic risk</kwd><kwd>oral contraceptives</kwd><kwd>combined hormonal contraceptives</kwd><kwd>progestins</kwd><kwd>progestogen contraceptives</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mosher WD, Jones J. 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