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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2019-2-26(401)-44-48</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1146</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group></article-categories><title-group><article-title>Ранняя диагностика псориатического артрита и возможности контроля над заболеванием (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Early diagnosis of psoriatic arthritis and possibility of its control (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Круглова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruglova</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>проректор по учебной работе, зав. кафедрой дерматовенерологии и косметологии </p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Львов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lvov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф., рук. отдела клинической дерматовенерологии и косметологии</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of the Administrative Department of the President of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ г. Москвы «Московский научно-практический центр дерматовенерологии и косметологии» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>19</day><month>11</month><year>2019</year></pub-date><volume>2</volume><issue>26</issue><issue-title>Дерматология</issue-title><fpage>44</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Круглова Л.С., Львов А.Н., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Круглова Л.С., Львов А.Н.</copyright-holder><copyright-holder xml:lang="en">Kruglova L.S., Lvov A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1146">https://www.med-alphabet.com/jour/article/view/1146</self-uri><abstract><p>Статья носит обзорный характер и содержит современные данные о факторах рисках развития псориатического артрита у пациентов с псориазом. Приведены данные о диагностике, клинической картине ПсА и целесообразности раннего назначения генно-инженерных препаратов с целью повышения эффективности и улучшения прогноза заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The article is of an overview nature and contains current data on risk factors for the development of psoriatic arthritis in patients with psoriasis. The data on the diagnosis, clinical picture of PsA and the feasibility of the early appointment of biologics medicines in order to increase efficiency and improve the prognosis of the disease are given.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ИЛ-17</kwd><kwd>сигнальный путь</kwd><kwd>псориаз</kwd><kwd>псориатический артрит</kwd><kwd>секукинумаб</kwd><kwd>раннее назначение генно-инженерных препаратов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>IL-17</kwd><kwd>signaling pathway</kwd><kwd>psoriasis</kwd><kwd>psoriatic arthritis</kwd><kwd>secukinumab</kwd><kwd>early prescription of biologic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Coates L. C., Kavanaugh A., Mease P. J., et al. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): Treatment Recommendations for Psoriatic Arthritis 2015. 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