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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2019-2-26(401)-25-28</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-1142</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>Опыт применения нового методологического подхода к фотодинамической терапии в косметологии</article-title><trans-title-group xml:lang="en"><trans-title>Experience in applying new methodological approach to photodynamic therapy in cosmetology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бочкова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bochkova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-дерматовенеролог</p><p>г. Рязань</p></bio><bio xml:lang="en"><p>Ryazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Холупова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kholupova</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры, кафедра дерматовенерологии и косметологии </p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрченко</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Yurchenko</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-ординатор, кафедра дерматовенерологии и косметологии </p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ООО «Клиника актуальной косметологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinic of Actual Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of the Administrative Department of the President of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>18</day><month>11</month><year>2019</year></pub-date><volume>2</volume><issue>26</issue><issue-title>Дерматология</issue-title><fpage>25</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бочкова Н.В., Холупова Л.С., Юрченко Д.О., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Бочкова Н.В., Холупова Л.С., Юрченко Д.О.</copyright-holder><copyright-holder xml:lang="en">Bochkova N.V., Kholupova L.S., Yurchenko D.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/1142">https://www.med-alphabet.com/jour/article/view/1142</self-uri><abstract><p>Возрастные изменения кожи носят сочетанный характер и связаны как с внутренними, так и с внешними фаторами. Изучение механизмов старения способствует разработке и научному обоснованию применения различных способов коррекции инволютивных изменений. Особое место занимает разработка неинвазивных методов воздействия, а также их комбинации для достижения лучшего результата и повышения безопасности. Электропорация активно используется в косметологии для введения в эпидермис и в ряде случаев в дерму различных активных субстанций. Применение данного метода в сочетании с фотодинамической терапией позволяет добиться превосходных эстетических результатов и увеличивает комплаентность пациента.</p></abstract><trans-abstract xml:lang="en"><p>Age-related changes in the skin are combined and are associated with both internal and external factors. The study of aging mechanisms contributes to the development and scientific justification of the application of various methods of correction of involutive changes. A special place is occupied by the development of non-invasive methods of exposure, as well as their combination to achieve the best result and increase safety. Electroporation is actively used in cosmetology for the introduction of various active substances into the epidermis and, in some cases, into the dermis. The use of this method in combination with photodynamic therapy allows to achieve excellent aesthetic results and increases patient compliance.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фотодинамическая терапия</kwd><kwd>электропорация</kwd><kwd>хлорин Е6</kwd><kwd>инволютивные изменения кожи</kwd></kwd-group><kwd-group xml:lang="en"><kwd>photodynamic therapy</kwd><kwd>electroporation</kwd><kwd>chlorinum E 6</kwd><kwd>involutive skin changes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gilhar A, Ullmann Y, Karry R, et al. 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